Gene Symbol: Abcb10
Description: ATP-binding cassette, sub-family B (MDR/TAP), member 10
Alias: Abc-me, Abcb12, ATP-binding cassette sub-family B member 10, mitochondrial, ABC-mitochondrial erythroid protein, ATP-binding cassette transporter 10
Species: mouse
Products:     Abcb10

Top Publications

  1. Shirihai O, Gregory T, Yu C, Orkin S, Weiss M. ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J. 2000;19:2492-502 pubmed
    ..We speculate that ABC-me, a newly identified erythroid-expressed ABC superfamily member, may mediate critical mitochondrial transport functions related to heme biosynthesis...
  2. Hyde B, Liesa M, Elorza A, Qiu W, Haigh S, Richey L, et al. The mitochondrial transporter ABC-me (ABCB10), a downstream target of GATA-1, is essential for erythropoiesis in vivo. Cell Death Differ. 2012;19:1117-26 pubmed publisher
    The mitochondrial transporter ATP binding cassette mitochondrial erythroid (ABC-me/ABCB10) is highly induced during erythroid differentiation by GATA-1 and its overexpression increases hemoglobin production rates in vitro...
  3. Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, et al. Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. PLoS ONE. 2012;7:e37378 pubmed publisher
    ..We confirm the mitochondrial localization of ABCB7, ABCB8 and ABCB10, suggesting that only three ABC transporters should be classified as mitochondrial proteins...
  4. Sajja R, Prasad S, Tang S, Kaisar M, Cucullo L. Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10?. Neurosci Lett. 2017;653:152-158 pubmed publisher
    ..brain Nrf2 in correlation with BBB permeability and 2) Nrf2-dependent regulation of the mitochondrial transporter ABCB10, an essential player in mitochondrial function and redox balance at BBB endothelium...
  5. Chen W, Dailey H, Paw B. Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood. 2010;116:628-30 pubmed publisher
    ..Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation...
  6. Liesa M, Luptak I, Qin F, Hyde B, Sahin E, Siwik D, et al. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011;124:806-13 pubmed publisher
    ..ATP binding cassette mitochondrial erythroid (ABC-me; ABCB10; mABC2) is a mitochondrial transporter highly induced during erythroid differentiation and predominantly expressed ..
  7. Liesa M, Qiu W, Shirihai O. Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim Biophys Acta. 2012;1823:1945-57 pubmed publisher
    ..ATP-binding cassette (ABC) transporters have been described to date in mammals: ABCB6, ABCB8, ABCB7 and ABCB10. ABCB10 is located in the inner mitochondrial membrane forming homodimers, with the ATP binding domain facing the ..
  8. Chen C, Garcia Santos D, Ishikawa Y, Seguin A, Li L, Fegan K, et al. Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab. 2013;17:343-52 pubmed publisher
    ..Our findings uncover a role of Snx3 in regulating Tfrc recycling, iron homeostasis, and erythropoiesis. Thus, the identification of Snx3 provides a genetic tool for exploring erythropoiesis and disorders of iron metabolism. ..
  9. Graf S, Haigh S, Corson E, Shirihai O. Targeting, import, and dimerization of a mammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem. 2004;279:42954-63 pubmed
    ..Here we examine these processes in ABCB10 (ABC-me), a mitochondrial inner membrane erythroid transporter involved in heme biosynthesis...

More Information


  1. Tallack M, Whitington T, Yuen W, Wainwright E, Keys J, Gardiner B, et al. A global role for KLF1 in erythropoiesis revealed by ChIP-seq in primary erythroid cells. Genome Res. 2010;20:1052-63 pubmed publisher
    ..Additionally, we suggest new mechanisms for KLF1 cooperation with other transcription factors, in particular the erythroid transcription factor GATA1, to maintain homeostasis in the erythroid compartment...
  2. Yamamoto M, Arimura H, Fukushige T, Minami K, Nishizawa Y, Tanimoto A, et al. Abcb10 role in heme biosynthesis in vivo: Abcb10 knockout in mice causes anemia with protoporphyrin IX and iron accumulation. Mol Cell Biol. 2014;34:1077-84 pubmed publisher
    b>Abcb10, member 10 of the ABC transporter family, is reportedly a part of a complex in the mitochondrial inner membrane with mitoferrin-1 (Slc25a37) and ferrochelatase (Fech) and is responsible for heme biosynthesis in utero...
  3. Qiu W, Liesa M, Carpenter E, Shirihai O. ATP Binding and Hydrolysis Properties of ABCB10 and Their Regulation by Glutathione. PLoS ONE. 2015;10:e0129772 pubmed publisher
    b>ABCB10 (ATP binding cassette sub-family B10) is a mitochondrial inner-membrane ABC transporter...
  4. Chen W, Paradkar P, Li L, Pierce E, Langer N, Takahashi Makise N, et al. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A. 2009;106:16263-8 pubmed publisher
    ..b>Abcb10, a mitochondrial inner membrane ATP-binding cassette transporter highly induced during erythroid maturation in ..