Abca7

Summary

Gene Symbol: Abca7
Description: ATP-binding cassette, sub-family A (ABC1), member 7
Alias: ABCX, Abc51, ATP-binding cassette sub-family A member 7
Species: mouse
Products:     Abca7

Top Publications

  1. Wang N, Lan D, Gerbod Giannone M, Linsel Nitschke P, Jehle A, Chen W, et al. ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. J Biol Chem. 2003;278:42906-12 pubmed
    ..Based on a high degree of sequence homology between ABCA1 and ABCA7, a transporter of unknown function, we investigated the possibility that ABCA7 might be involved in apolipoprotein ..
  2. Kim W, Fitzgerald M, Kang K, Okuhira K, Bell S, Manning J, et al. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem. 2005;280:3989-95 pubmed
    ..Although the functions of the other 10 ABCA class transporters identified in the human genome remain obscure, ABCA7-transfected cells have been shown to efflux lipids in response to stimulation by apolipoprotein A-I...
  3. Jehle A, Gardai S, Li S, Linsel Nitschke P, Morimoto K, Janssen W, et al. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol. 2006;174:547-56 pubmed
    ..Using RNA interference or gene targeting, we show that knock down of macrophage ABCA7 but not -A1 results in defective engulfment of apoptotic cells...
  4. Broccardo C, Osorio J, Luciani M, Schriml L, Prades C, Shulenin S, et al. Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. Cytogenet Cell Genet. 2001;92:264-70 pubmed
    ..genomic and transcriptional characterization in mouse and man of a novel transporter of the ABCA subclass, named ABCA7. As it is the case for other ABCA genes, the predicted protein encoded by ABCA7 is a full symmetric transporter, ..
  5. Linsel Nitschke P, Jehle A, Shan J, Cao G, Bacic D, Lan D, et al. Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res. 2005;46:86-92 pubmed
    b>ABCA7 is homologous to ABCA1 and has recently been shown in cell culture to bind apolipoprotein A-I (apoA-I) and to promote the efflux of phospholipids. However, it is not known if ABCA7 promotes lipid efflux in vivo...
  6. Chan S, Kim W, Kwok J, Hill A, Cappai R, Rye K, et al. ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. J Neurochem. 2008;106:793-804 pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and, like its closest homolog ABCA1, belongs to the ABCA subfamily of full-length ABC transporters...
  7. Tanaka N, Abe Dohmae S, Iwamoto N, Fitzgerald M, Yokoyama S. Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7. J Lipid Res. 2010;51:2591-9 pubmed publisher
    ..Therefore we investigated the molecular basis of this reaction in association with the function of ABCA7. Similar to ABCA1, ABCA7 was degraded, likely by calpain, and apoA-I and apoA-II stabilize ABCA7 against ..
  8. Kim W, Li H, Ruberu K, Chan S, Elliott D, Low J, et al. Deletion of Abca7 increases cerebral amyloid-? accumulation in the J20 mouse model of Alzheimer's disease. J Neurosci. 2013;33:4387-94 pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons...
  9. Schriml L, Dean M. Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus. Genomics. 2000;64:24-31 pubmed
    ..The mouse ABC genes could be grouped into the seven previously described human ABC subfamilies. Three mouse ABC genes mapped to regions implicated in cholesterol gallstone susceptibility...

More Information

Publications19

  1. Li H, Karl T, Garner B. Abca7 deletion does not affect adult neurogenesis in the mouse. Biosci Rep. 2016;36: pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain...
  2. Morales C, Marat A, Ni X, Yu Y, Oko R, Smith B, et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. Biochem Biophys Res Commun. 2008;376:472-7 pubmed publisher
    ..Candidate transporters are members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCG1 and ABCG4, which have all been implicated in the transport of sterols and phospholipids to apolipoproteins ..
  3. Tanaka N, Abe Dohmae S, Iwamoto N, Fitzgerald M, Yokoyama S. HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7. Atherosclerosis. 2011;217:407-14 pubmed publisher
    ..We therefore examined the effect of statins on phagocytosis in vitro and in vivo through the SREBP-ABCA7. Phagocytosis was found to be enhanced by pravastatin, rosuvastatin and simvastatin and cyclodextrin in J774 ..
  4. Schriml L, Peterson R, Gerrard B, Dean M. Use of denaturing HPLC to map human and murine genes and to validate single-nucleotide polymorphisms. Biotechniques. 2000;28:740-5 pubmed
    ..The same approach has been applied to the mapping of murine genes in interspecies backcross animals. This strategy is rapid, accurate and superior in several respects to other technologies. ..
  5. Satoh K, Abe Dohmae S, Yokoyama S, St George Hyslop P, Fraser P. ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem. 2015;290:24152-65 pubmed publisher
    The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility factor of late onset Alzheimer disease in genome-wide association studies...
  6. Meurs I, Calpe Berdiel L, Habets K, Zhao Y, Korporaal S, Mommaas A, et al. Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1. PLoS ONE. 2012;7:e30984 pubmed publisher
    b>ABCA7, a close relative of ABCA1 which facilitates cholesterol efflux to lipid-poor apoproteins, has been implicated in macrophage lipid efflux and clearance of apoptotic cells in in vitro studies...
  7. Wakaumi M, Ishibashi K, Ando H, Kasanuki H, Tsuruoka S. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Clin Exp Pharmacol Physiol. 2005;32:1034-41 pubmed
    ..Similar reductions in ABCA5, ABCA7, ABCA8b and ABCA9 mRNA were also observed...
  8. Honarpour N, Gilbert S, Lahn B, Wang X, Herz J. Apaf-1 deficiency and neural tube closure defects are found in fog mice. Proc Natl Acad Sci U S A. 2001;98:9683-7 pubmed
    ..Because a complete deficiency in Apaf-1 usually results in perinatal lethality and fog/fog mice more readily survive into adulthood, these mutants serve as a valuable model with which apoptotic cell death can be studied in vivo. ..
  9. Logge W, Cheng D, Chesworth R, Bhatia S, Garner B, Kim W, et al. Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases. PLoS ONE. 2012;7:e45959 pubmed publisher
    ..Recent studies suggest that the ABC transporter ABCA7 may play a role in the development of brain disorders such as schizophrenia and Alzheimer's disease...
  10. Sakae N, Liu C, Shinohara M, Frisch Daiello J, Ma L, Yamazaki Y, et al. ABCA7 Deficiency Accelerates Amyloid-? Generation and Alzheimer's Neuronal Pathology. J Neurosci. 2016;36:3848-59 pubmed publisher
    ..b>ABCA7 is homologous to a major lipid transporter ABCA1 and is highly expressed in neurons and microglia in the brain...