Gene Symbol: Abca1
Description: ATP-binding cassette, sub-family A (ABC1), member 1
Alias: ABC-1, Abc1, ATP-binding cassette sub-family A member 1, ATP-binding cassette 1, ATP-binding cassette transporter 1
Species: mouse
Products:     Abca1

Top Publications

  1. Wang Y, Oram J. Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C delta pathway. J Lipid Res. 2007;48:1062-8 pubmed
    ..b>ABCA1 mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins and thus modulates HDL ..
  2. Wellington C, Walker E, Suarez A, Kwok A, Bissada N, Singaraja R, et al. ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation. Lab Invest. 2002;82:273-83 pubmed
    Mutations in ABCA1 cause the allelic disorders familial hypolipoproteinemia and Tangier Disease...
  3. Bojanic D, Tarr P, Gale G, Smith D, Bok D, Chen B, et al. Differential expression and function of ABCG1 and ABCG4 during development and aging. J Lipid Res. 2010;51:169-81 pubmed publisher
    ..Finally, behavioral tests show that Abcg4(-/-) mice have a general deficit in associative fear memory. Together, these data indicate that loss of ABCG1 and/or ABCG4 from the CNS results in changes in metabolic pathways and in behavior...
  4. Koseki M, Hirano K, Masuda D, Ikegami C, Tanaka M, Ota A, et al. Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factor-alpha secretion in Abca1-deficient macrophages. J Lipid Res. 2007;48:299-306 pubmed
    ..We investigated macrophages with defective lipid efflux from ATP binding cassette transporter A1-deficient (Abca1-KO) mice...
  5. Singaraja R, Bocher V, James E, Clee S, Zhang L, Leavitt B, et al. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X receptor response elements in intron 1. J Biol Chem. 2001;276:33969-79 pubmed
    By using BAC transgenic mice, we have shown that increased human ABCA1 protein expression results in a significant increase in cholesterol efflux in different tissues and marked elevation in high density lipoprotein (HDL)-cholesterol ..
  6. Smith J, Waelde C, Horwitz A, Zheng P. Evaluation of the role of phosphatidylserine translocase activity in ABCA1-mediated lipid efflux. J Biol Chem. 2002;277:17797-803 pubmed
    The following two theories for the mechanism of ABCA1 in lipid efflux to apolipoprotein acceptors have been proposed: 1) that ABCA1 directly binds the apolipoprotein ligand and then facilitates lipid efflux and 2) that ABCA1 acts as a ..
  7. Schmitz G, Langmann T. Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. Biochim Biophys Acta. 2005;1735:1-19 pubmed
    The ATP-binding cassette transporters, ABCA1 and ABCG1, are major players in mediating cellular efflux of phospholipids and cholesterol to apoA-I containing lipoproteins including prebeta-HDL and alphaHDL and thereby exert important ..
  8. Vedhachalam C, Duong P, Nickel M, Nguyen D, Dhanasekaran P, Saito H, et al. Mechanism of ATP-binding cassette transporter A1-mediated cellular lipid efflux to apolipoprotein A-I and formation of high density lipoprotein particles. J Biol Chem. 2007;282:25123-30 pubmed
    The ATP-binding cassette transporter A1 (ABCA1) plays a critical role in the biogenesis of high density lipoprotein (HDL) particles and in mediating cellular cholesterol efflux...
  9. McNeish J, Aiello R, Guyot D, Turi T, Gabel C, Aldinger C, et al. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1. Proc Natl Acad Sci U S A. 2000;97:4245-50 pubmed
    Recently, the human ATP-binding cassette transporter-1 (ABC1) gene has been demonstrated to be mutated in patients with Tangier disease...

More Information


  1. Joyce C, Amar M, Lambert G, Vaisman B, Paigen B, Najib Fruchart J, et al. The ATP binding cassette transporter A1 (ABCA1) modulates the development of aortic atherosclerosis in C57BL/6 and apoE-knockout mice. Proc Natl Acad Sci U S A. 2002;99:407-12 pubmed
    Identification of mutations in the ABCA1 transporter (ABCA1) as the genetic defect in Tangier disease has generated interest in modulating atherogenic risk by enhancing ABCA1 gene expression...
  2. Westerterp M, Gourion Arsiquaud S, Murphy A, Shih A, Cremers S, Levine R, et al. Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways. Cell Stem Cell. 2012;11:195-206 pubmed publisher
    ..Mice with defects in cholesterol efflux pathways due to deficiencies of the ATP binding cassette transporters ABCA1 and ABCG1 displayed a dramatic increase in HSPC mobilization and extramedullary hematopoiesis...
  3. Oram J. ATP-binding cassette transporter A1 and cholesterol trafficking. Curr Opin Lipidol. 2002;13:373-81 pubmed
    ..A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway...
  4. Adorni M, Zimetti F, Billheimer J, Wang N, Rader D, Phillips M, et al. The roles of different pathways in the release of cholesterol from macrophages. J Lipid Res. 2007;48:2453-62 pubmed
    ..Using macrophages from scavenger receptor class B type I (SR-BI)-, ABCA1-, and ABCG1-knockout mice, together with inhibitors of SR-BI- and ABCA1-mediated efflux, we were able to ..
  5. Bensinger S, Bradley M, Joseph S, Zelcer N, Janssen E, Hausner M, et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 2008;134:97-111 pubmed publisher
    ..These results implicate LXR signaling in a metabolic checkpoint that modulates cell proliferation and immunity. ..
  6. Kruit J, Kremer P, Dai L, Tang R, Ruddle P, de Haan W, et al. Cholesterol efflux via ATP-binding cassette transporter A1 (ABCA1) and cholesterol uptake via the LDL receptor influences cholesterol-induced impairment of beta cell function in mice. Diabetologia. 2010;53:1110-9 pubmed publisher
    ..Absence of the cholesterol transporter ATP-binding cassette transporter A1 (ABCA1) results in increased islet cholesterol and impaired insulin secretion, indicating that impaired cholesterol ..
  7. Wang N, Lan D, Chen W, Matsuura F, Tall A. ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A. 2004;101:9774-9 pubmed
    ..The ATP-binding cassette transporter A1 (ABCA1) mediates efflux of cellular cholesterol to lipid-poor apolipoproteins but not to HDL particles that constitute ..
  8. Out R, Hoekstra M, Habets K, Meurs I, De Waard V, Hildebrand R, et al. Combined deletion of macrophage ABCA1 and ABCG1 leads to massive lipid accumulation in tissue macrophages and distinct atherosclerosis at relatively low plasma cholesterol levels. Arterioscler Thromb Vasc Biol. 2008;28:258-64 pubmed
    The purpose of this study was to evaluate the effect of the combined deletion of ABCA1 and ABCG1 expression in macrophages on foam cell formation and atherosclerosis.
  9. Zhu X, Lee J, Timmins J, Brown J, Boudyguina E, Mulya A, et al. Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem. 2008;283:22930-41 pubmed publisher
    Macrophage-specific Abca1 knock-out (Abca1(-)(M)(/-)(M)) mice were generated to determine the role of macrophage ABCA1 expression in plasma lipoprotein concentrations and the innate immune response of macrophages...
  10. Zhu X, Owen J, Wilson M, Li H, Griffiths G, Thomas M, et al. Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res. 2010;51:3196-206 pubmed publisher
    We previously showed that macrophages from macrophage-specific ATP-binding cassette transporter A1 (ABCA1) knockout (Abca1(-M/-M)) mice had an enhanced proinflammatory response to the Toll-like receptor (TLR) 4 agonist, ..
  11. Lammers B, Zhao Y, Hoekstra M, Hildebrand R, Ye D, Meurs I, et al. Augmented atherogenesis in LDL receptor deficient mice lacking both macrophage ABCA1 and ApoE. PLoS ONE. 2011;6:e26095 pubmed publisher
    b>ABCA1 protects against atherosclerosis by facilitating cholesterol efflux from macrophage foam cells in the arterial wall to extracellular apolipoprotein (apo) A-I...
  12. Martinez L, Agerholm Larsen B, Wang N, Chen W, Tall A. Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I. J Biol Chem. 2003;278:37368-74 pubmed
    ATP-binding cassette transporter A1 (ABCA1), the defective molecule in Tangier disease, mediates the apoAI-dependent efflux of excess cholesterol from cells...
  13. Temel R, Lee R, Kelley K, Davis M, Shah R, Sawyer J, et al. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. J Lipid Res. 2005;46:2423-31 pubmed
    ..Because ABCA1 mRNA expression was increased 3-fold in the small intestine of ACAT2 KO mice, we hypothesized that ABCA1-dependent ..
  14. Iwamoto N, Abe Dohmae S, Sato R, Yokoyama S. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J Lipid Res. 2006;47:1915-27 pubmed
    ABCA7 is highly homologous to ABCA1 and mediates cellular cholesterol and phospholipid release by apolipoproteins when transfected in vitro...
  15. Orso E, Broccardo C, Kaminski W, Bottcher A, Liebisch G, Drobnik W, et al. Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice. Nat Genet. 2000;24:192-6 pubmed
    Mutations in the gene encoding ATP-binding cassette transporter 1 ( ABC1) have been reported in Tangier disease (TD), an autosomal recessive disorder that is characterized by almost complete absence of plasma high-density lipoprotein (HDL)..
  16. Favari E, Calabresi L, Adorni M, Jessup W, Simonelli S, Franceschini G, et al. Small discoidal pre-beta1 HDL particles are efficient acceptors of cell cholesterol via ABCA1 and ABCG1. Biochemistry. 2009;48:11067-74 pubmed publisher
    ..Cholesterol efflux to rHDL was evaluated in pathway-specific cell models for ABCA1-, ABCG1-, and SR-BI-mediated efflux. ABCA1-mediated efflux was efficiently promoted by the 7...
  17. Linsel Nitschke P, Jehle A, Shan J, Cao G, Bacic D, Lan D, et al. Potential role of ABCA7 in cellular lipid efflux to apoA-I. J Lipid Res. 2005;46:86-92 pubmed
    ABCA7 is homologous to ABCA1 and has recently been shown in cell culture to bind apolipoprotein A-I (apoA-I) and to promote the efflux of phospholipids. However, it is not known if ABCA7 promotes lipid efflux in vivo...
  18. Higgins C. ABC transporters: from microorganisms to man. Annu Rev Cell Biol. 1992;8:67-113 pubmed
  19. Kruit J, Wijesekara N, Fox J, Dai X, Brunham L, Searle G, et al. Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes. 2011;60:3186-96 pubmed publisher
    The ATP-binding cassette transporter A1 (ABCA1) is essential for normal insulin secretion from ?-cells. The aim of this study was to elucidate the mechanisms underlying the impaired insulin secretion in islets lacking ?-cell ABCA1.
  20. Timmins J, Lee J, Boudyguina E, Kluckman K, Brunham L, Mulya A, et al. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest. 2005;115:1333-42 pubmed
    ..low plasma HDL concentrations resulting from mutations in the ATP-binding cassette, sub-family A, member 1 (ABCA1) protein...
  21. Ma L, Dong F, Zaid M, Kumar A, Zha X. ABCA1 protein enhances Toll-like receptor 4 (TLR4)-stimulated interleukin-10 (IL-10) secretion through protein kinase A (PKA) activation. J Biol Chem. 2012;287:40502-12 pubmed publisher
    b>ABCA1 is known to suppress proinflammatory cytokines.
  22. Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen I, Zhao Y, et al. Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Circ Res. 2008;102:113-20 pubmed
    ..b>ABCA1 and ABCG1 are two cholesterol transporters that may act sequentially to remove cellular cholesterol, but currently ..
  23. Zhao Y, Pennings M, Hildebrand R, Ye D, Calpe Berdiel L, Out R, et al. Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res. 2010;107:e20-31 pubmed publisher
    ..Important mediators of macrophage cholesterol efflux are ATP-binding cassette transporter 1 (ABCA1), which mediates the efflux of cholesterol to lipid-poor apolipoprotein AI, and scavenger receptor class B type I (..
  24. Ramírez C, Davalos A, Goedeke L, Salerno A, Warrier N, Cirera Salinas D, et al. MicroRNA-758 regulates cholesterol efflux through posttranscriptional repression of ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2011;31:2707-14 pubmed publisher
    The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage cholesterol efflux and protects cells from excess intracellular cholesterol accumulation; however, the mechanism involved in posttranscriptional ..
  25. Brunham L, Kruit J, Pape T, Timmins J, Reuwer A, Vasanji Z, et al. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med. 2007;13:340-7 pubmed
    ..We examined the role of Abca1, a cellular cholesterol transporter, in cholesterol homeostasis and insulin secretion in beta-cells...
  26. Wang M, Franklin V, Sundaram M, Kiss R, Ho K, Gallant M, et al. Differential regulation of ATP binding cassette protein A1 expression and ApoA-I lipidation by Niemann-Pick type C1 in murine hepatocytes and macrophages. J Biol Chem. 2007;282:22525-33 pubmed lipid accumulation in late endosomes and lysosomes, leading to a defect of ATP binding cassette protein A1 (Abca1)-mediated lipid efflux to apolipoprotein A-I (apoA-I) in macrophages and fibroblasts...
  27. Chung S, Timmins J, Duong M, Degirolamo C, Rong S, Sawyer J, et al. Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism. J Biol Chem. 2010;285:12197-209 pubmed publisher
    Loss of ABCA1 activity in Tangier disease (TD) is associated with abnormal apoB lipoprotein (Lp) metabolism in addition to the complete absence of high density lipoprotein (HDL)...
  28. Yvan Charvet L, Welch C, Pagler T, Ranalletta M, Lamkanfi M, Han S, et al. Increased inflammatory gene expression in ABC transporter-deficient macrophages: free cholesterol accumulation, increased signaling via toll-like receptors, and neutrophil infiltration of atherosclerotic lesions. Circulation. 2008;118:1837-47 pubmed publisher
    Two macrophage ABC transporters, ABCA1 and ABCG1, have a major role in promoting cholesterol efflux from macrophages. Peritoneal macrophages deficient in ABCA1, ABCG1, or both show enhanced expression of inflammatory and chemokine genes...
  29. Chapman L, Epton M, Buckingham J, Morris J, Christian H. Evidence for a role of the adenosine 5'-triphosphate-binding cassette transporter A1 in the externalization of annexin I from pituitary folliculo-stellate cells. Endocrinology. 2003;144:1062-73 pubmed
    ..RT-PCR revealed mRNA and Western blotting demonstrated protein for the ATP binding cassette A1 (ABCA1) transporter in mouse FS, TtT/GF, and A549 lung adenocarcinoma cells from which glucocorticoids also induce ..
  30. Cui H, Grant A, Mukhamedova N, Pushkarsky T, Jennelle L, Dubrovsky L, et al. HIV-1 Nef mobilizes lipid rafts in macrophages through a pathway that competes with ABCA1-dependent cholesterol efflux. J Lipid Res. 2012;53:696-708 pubmed publisher
    HIV infection, through the actions of viral accessory protein Nef, impairs activity of cholesterol transporter ABCA1, inhibiting cholesterol efflux from macrophages and elevating the risk of atherosclerosis...
  31. Mukhamedova N, Escher G, D Souza W, Tchoua U, Grant A, Krozowski Z, et al. Enhancing apolipoprotein A-I-dependent cholesterol efflux elevates cholesterol export from macrophages in vivo. J Lipid Res. 2008;49:2312-22 pubmed publisher
    Eight proteins potentially involved in cholesterol efflux [ABCA1, ABCG1, CYP27A1, phospholipid transfer protein (PLTP), scavenger receptor type BI (SR-BI), caveolin-1, cholesteryl ester transfer protein, and apolipoprotein A-I (apoA-I)] ..
  32. Murphy A, Akhtari M, Tolani S, Pagler T, Bijl N, Kuo C, et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J Clin Invest. 2011;121:4138-49 pubmed publisher
    ..progenitor cells (HSPCs) in mice with deficiencies of the cholesterol efflux-promoting ABC transporters ABCA1 and ABCG1 in BM cells...
  33. Tang C, Kanter J, Bornfeldt K, LeBoeuf R, Oram J. Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys. J Lipid Res. 2010;51:1719-28 pubmed publisher
    ..The ATP-binding cassette transporter ABCA1 is a cardioprotective membrane protein that mediates cholesterol export from macrophages...
  34. Vaisman B, Lambert G, Amar M, Joyce C, Ito T, Shamburek R, et al. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice. J Clin Invest. 2001;108:303-9 pubmed
    The discovery of the ABCA1 lipid transporter has generated interest in modulating human plasma HDL levels and atherogenic risk by enhancing ABCA1 gene expression...
  35. Yvan Charvet L, Pagler T, Gautier E, Avagyan S, Siry R, Han S, et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science. 2010;328:1689-93 pubmed publisher
    ..Mice deficient in the adenosine triphosphate-binding cassette (ABC) transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in hypercholesterolemic ..
  36. de la Llera Moya M, Drazul Schrader D, Asztalos B, Cuchel M, Rader D, Rothblat G. The ability to promote efflux via ABCA1 determines the capacity of serum specimens with similar high-density lipoprotein cholesterol to remove cholesterol from macrophages. Arterioscler Thromb Vasc Biol. 2010;30:796-801 pubmed publisher
    ..Thus, we wanted to elucidate why efflux capacity could be independent of total HDL-C or apolipoprotein A-I (apoA-I)...
  37. Yvan Charvet L, Ranalletta M, Wang N, Han S, Terasaka N, Li R, et al. Combined deficiency of ABCA1 and ABCG1 promotes foam cell accumulation and accelerates atherosclerosis in mice. J Clin Invest. 2007;117:3900-8 pubmed
    ..can promote cholesterol efflux from macrophage foam cells via the ATP-binding cassette transporters ABCA1 and ABCG1...
  38. Van Eck M, Bos I, Kaminski W, Orso E, Rothe G, Twisk J, et al. Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues. Proc Natl Acad Sci U S A. 2002;99:6298-303 pubmed
    The ATP-binding cassette transporter 1 (ABCA1) has recently been identified as a key regulator of high-density lipoprotein (HDL) metabolism, which is defective in familial HDL-deficiency syndromes such as Tangier disease...
  39. Brunham L, Singaraja R, Duong M, Timmins J, Fievet C, Bissada N, et al. Tissue-specific roles of ABCA1 influence susceptibility to atherosclerosis. Arterioscler Thromb Vasc Biol. 2009;29:548-54 pubmed publisher
    The ATP-binding cassette transporter, subfamily A, member 1 (ABCA1) plays a key role in HDL cholesterol metabolism. However, the role of ABCA1 in modulating susceptibility to atherosclerosis is controversial.
  40. Denis M, Landry Y, Zha X. ATP-binding cassette A1-mediated lipidation of apolipoprotein A-I occurs at the plasma membrane and not in the endocytic compartments. J Biol Chem. 2008;283:16178-86 pubmed publisher
    ..This process is proposed to occur through a retro-endocytosis pathway in which apoA-I internalizes with ABCA1 and generates HDL from the endosomal compartments before resecretion...
  41. Hamon Y, Broccardo C, Chambenoit O, Luciani M, Toti F, Chaslin S, et al. ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Nat Cell Biol. 2000;2:399-406 pubmed
    ATP-binding-cassette transporter 1 (ABC1) has been implicated in processes related to membrane-lipid turnover...
  42. Zhao W, Haller V, Ritsch A. The polyphenol PGG enhances expression of SR-BI and ABCA1 in J774 and THP-1 macrophages. Atherosclerosis. 2015;242:611-7 pubmed publisher
    ..We showed that PGG not only induced expression of SR-BI and ABCA1 in J774 and THP-1 macrophages, but was able to reverse the ox-LDL down-regulated expression of SR-BI and ABCA1 in ..
  43. Tang C, Houston B, Storey C, LeBoeuf R. Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages. J Lipid Res. 2016;57:848-57 pubmed publisher
    b>ABCA1 exports excess cholesterol from cells to apoA-I and is essential for HDL synthesis. Genetic studies have shown that ABCA1 protects against cardiovascular disease...
  44. Du X, Kim M, Hou L, Le Goff W, Chapman M, Van Eck M, et al. HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export. Circ Res. 2015;116:1133-42 pubmed publisher
    ..The ATP binding cassette transporter A1 (ABCA1) facilitates cholesterol efflux to lipid-free apolipoprotein A-I, but the majority of apolipoprotein A-I in the ..
  45. Passarelli M, Tang C, McDonald T, O Brien K, Gerrity R, Heinecke J, et al. Advanced glycation end product precursors impair ABCA1-dependent cholesterol removal from cells. Diabetes. 2005;54:2198-205 pubmed
    ..The ATP-binding cassette transporter A1 (ABCA1) is an atheroprotective cell protein that mediates cholesterol transport from cells to apolipoprotein (apo) A-I, ..
  46. Annema W, Dikkers A, de Boer J, Gautier T, Rensen P, Rader D, et al. ApoE promotes hepatic selective uptake but not RCT due to increased ABCA1-mediated cholesterol efflux to plasma. J Lipid Res. 2012;53:929-40 pubmed publisher
    ..Similar results were obtained using hApoE3 overexpression in human CETP transgenic mice. However, blocking ABCA1-mediated cholesterol efflux from hepatocytes in AdhApoE3-injected mice using probucol increased biliary ..
  47. Chroni A, Liu T, Gorshkova I, Kan H, Uehara Y, von Eckardstein A, et al. The central helices of ApoA-I can promote ATP-binding cassette transporter A1 (ABCA1)-mediated lipid efflux. Amino acid residues 220-231 of the wild-type ApoA-I are required for lipid efflux in vitro and high density lipoprotein formation in vivo. J Biol Chem. 2003;278:6719-30 pubmed
    ..Similar results were obtained in HEK293 cells transfected with an ATP-binding cassette transporter A1 (ABCA1) expression plasmid...
  48. Liu L, Bortnick A, Nickel M, Dhanasekaran P, Subbaiah P, Lund Katz S, et al. Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem. 2003;278:42976-84 pubmed
    ..of formation of high density lipoprotein (HDL) particles by the action of ATP-binding cassette transporter A1 (ABCA1) is not defined completely...
  49. Shrestha E, Hussein M, Savas J, Ouimet M, Barrett T, Leone S, et al. Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. J Biol Chem. 2016;291:11172-84 pubmed publisher a central role in reverse cholesterol transport through up-regulation of ATP-binding cassette transporters (ABCA1 and ABCG1) that mediate cellular cholesterol efflux...
  50. Yamaguchi S, Zhang B, Tomonaga T, Seino U, Kanagawa A, Segawa M, et al. Selective evaluation of high density lipoprotein from mouse small intestine by an in situ perfusion technique. J Lipid Res. 2014;55:905-18 pubmed publisher
    ..Nascent HDL particles were detected in SI lymph perfusates in WT mice, but not in ABCA1 KO mice. SI-HDL had a high protein content and was smaller than plasma HDL...
  51. Grau G, Chimini G. Immunopathological consequences of the loss of engulfment genes: the case of ABCA1. J Soc Biol. 2005;199:199-206 pubmed
    ..elegans. ABCA1 and its ortholog CED-7 in the nematode are key players of engulfment...
  52. Ragozin S, Niemeier A, Laatsch A, Loeffler B, Merkel M, Beisiegel U, et al. Knockdown of hepatic ABCA1 by RNA interference decreases plasma HDL cholesterol levels and influences postprandial lipemia in mice. Arterioscler Thromb Vasc Biol. 2005;25:1433-8 pubmed
    To investigate the impact of hepatic ABCA1 on systemic lipoprotein metabolism in vivo by an adenovirus-mediated RNA interference approach.
  53. Wang M, Kiss R, Franklin V, McBride H, Whitman S, Marcel Y. Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathways. J Lipid Res. 2007;48:633-45 pubmed
    ..b>ABCA1-mediated cholesterol efflux to apolipoprotein A-I (apoA-I) was much greater for AcLDL-loaded macrophages compared ..
  54. Lindegaard M, Wassif C, Vaisman B, Amar M, Wasmuth E, Shamburek R, et al. Characterization of placental cholesterol transport: ABCA1 is a potential target for in utero therapy of Smith-Lemli-Opitz syndrome. Hum Mol Genet. 2008;17:3806-13 pubmed publisher
    ..The cholesterol transporters Abca1, Abcg1, and Sr-b1 are present in placenta; however, their potential role in placental transport remains ..
  55. Pohl A, Devaux P, Herrmann A. Function of prokaryotic and eukaryotic ABC proteins in lipid transport. Biochim Biophys Acta. 2005;1733:29-52 pubmed
    ..In particular, further purification and reconstitution experiments with an unambiguous role of ATP hydrolysis are needed to demonstrate a clear involvement of ABC proteins in lipid transbilayer asymmetry...
  56. Iadevaia V, Rinaldi A, Falasca L, Pucillo L, Alonzi T, Chimini G, et al. ATP-binding cassette transporter 1 and transglutaminase 2 act on the same genetic pathway in the apoptotic cell clearance. Cell Death Differ. 2006;13:1998-2001 pubmed
  57. Fan J, Shimizu Y, Chan J, Wilkinson A, Ito A, Tontonoz P, et al. Hormonal modulators of glial ABCA1 and apoE levels. J Lipid Res. 2013;54:3139-50 pubmed publisher
    ..Intriguingly, lynestrenol also increases expression of the cholesterol transporter ABCA1 in CCF-STTG1 astrocytoma cells, primary murine glia, and immortalized murine astrocytes that express human apoE3...
  58. Reboul E, Trompier D, Moussa M, Klein A, Landrier J, Chimini G, et al. ATP-binding cassette transporter A1 is significantly involved in the intestinal absorption of alpha- and gamma-tocopherol but not in that of retinyl palmitate in mice. Am J Clin Nutr. 2009;89:177-84 pubmed publisher
    ..It has long been assumed that newly absorbed vitamin A and E enter the body only via enterocyte-produced chylomicrons. However, recent results in cell cultures have shown that a fraction of alpha-tocopherol is secreted with intestinal HDL...
  59. Natarajan P, Forte T, Chu B, Phillips M, Oram J, Bielicki J. Identification of an apolipoprotein A-I structural element that mediates cellular cholesterol efflux and stabilizes ATP binding cassette transporter A1. J Biol Chem. 2004;279:24044-52 pubmed
    ..apo) A-I that stimulates cellular cholesterol efflux and stabilizes the ATP binding cassette transporter A1 (ABCA1)...
  60. Francone O, Subbaiah P, Van Tol A, Royer L, Haghpassand M. Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry. 2003;42:8569-78 pubmed
    Recent studies have demonstrated that the ATP-binding cassette transporter A1 (ABCA1) facilitates the efflux of phospholipids and cholesterol to apoprotein acceptors, leading to the synthesis of HDL...
  61. Wijesekara N, Zhang L, Kang M, Abraham T, Bhattacharjee A, Warnock G, et al. miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes. 2012;61:653-8 pubmed publisher
    ..deletion or loss-of-function mutations in the cholesterol efflux transporter ATP-binding cassette transporter A1 (ABCA1) result in impaired glucose tolerance and ?-cell dysfunction...
  62. Tang C, Liu Y, Kessler P, Vaughan A, Oram J. The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem. 2009;284:32336-43 pubmed publisher
    ATP-binding cassette transporter A1 (ABCA1) is a cell membrane protein that exports excess cholesterol from cells to apolipoprotein (apo) A-I, the major protein in high density lipoproteins...
  63. Cattelotte J, André P, Ouellet M, Bourasset F, Scherrmann J, Cisternino S. In situ mouse carotid perfusion model: glucose and cholesterol transport in the eye and brain. J Cereb Blood Flow Metab. 2008;28:1449-59 pubmed publisher
    ..The transport of cholesterol to the brain and eye was significantly enhanced by adding the Abca1 inhibitor probucol, suggesting an Abca1-mediated efflux at the mouse brain and eye blood barriers...