Genomes and Genes
Gene Symbol: A930011O12Rik
Description: RIKEN cDNA A930011O12 gene
- Shtukmaster S, Narasimhan P, El Faitwri T, Stubbusch J, Ernsberger U, Rohrer H, et al. MiR-124 is differentially expressed in derivatives of the sympathoadrenal cell lineage and promotes neurite elongation in chromaffin cells. Cell Tissue Res. 2016;365:225-32 pubmed publisher..Thus, our data indicate that miR-124 contributes to the establishment of specific neuronal features in developing sympathoadrenal cells. ..
- Jiang D, Du J, Zhang X, Zhou W, Zong L, Dong C, et al. miR-124 promotes the neuronal differentiation of mouse inner ear neural stem cells. Int J Mol Med. 2016;38:1367-1376 pubmed publisher..Our findings indicate that miR?124 plays a role in the neuronal differentiation of inner ear NSCs. This finding may lead to the development of novel strategies for restoring hearing in neurodegenerative diseases. ..
- Santos M, Tegge A, Correa B, Mahesula S, Kohnke L, Qiao M, et al. miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network. Stem Cells. 2016;34:220-32 pubmed publisher..In summary, our results show that miRNAs can act cooperatively and synergistically to regulate complex biological processes like neurogenesis and that transcription factors are heavily targeted to branch out their regulatory effect. ..
- Gu X, Li A, Liu S, Lin L, Xu S, Zhang P, et al. MicroRNA124 Regulated Neurite Elongation by Targeting OSBP. Mol Neurobiol. 2016;53:6388-6396 pubmed publisher..Our results suggested that OSBP may be a target and downstream effector of miR-124 for regulating neurite outgrowth and elongation. ..
- Xue Q, Yu C, Wang Y, Liu L, Zhang K, Fang C, et al. miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3Î² pathway by targeting Rap2a. Sci Rep. 2016;6:26781 pubmed publisher..Our results reveal a novel pathway in which miR-9 and miR-124 synergistically repress expression of Rap2a to sustain homeostatic dendritic complexity during neuronal development and maturation. ..