Gene Symbol: A930011O12Rik
Description: RIKEN cDNA A930011O12 gene
Alias: Rncr3
Species: mouse

Top Publications

  1. Zhao Y, Jiang H, Liu X, Xiang L, Zhou D, Chen J. MiR-124 promotes bone marrow mesenchymal stem cells differentiation into neurogenic cells for accelerating recovery in the spinal cord injury. Tissue Cell. 2015;47:140-6 pubmed publisher
    ..In conclusion, our research shows that the miR-124 promoted the differentiation of neuronal cells from BMMSCs, and this mechanism was miR-124 reduced the expression of PTBP1, increased the expression of PTBP2. ..
  2. Schouten M, Fratantoni S, Hubens C, Piersma S, Pham T, Bielefeld P, et al. MicroRNA-124 and -137 cooperativity controls caspase-3 activity through BCL2L13 in hippocampal neural stem cells. Sci Rep. 2015;5:12448 pubmed publisher
  3. Shan K, Jiang Q, Wang X, Wang Y, Yang H, Yao M, et al. Role of long non-coding RNA-RNCR3 in atherosclerosis-related vascular dysfunction. Cell Death Dis. 2016;7:e2248 pubmed publisher
    ..Here we show that lncRNA-RNCR3 is expressed in ECs and VSMCs...
  4. Shan K, Li C, Liu C, Liu X, Yan B. RNCR3: A regulator of diabetes mellitus-related retinal microvascular dysfunction. Biochem Biophys Res Commun. 2017;482:777-783 pubmed publisher
    ..Herein, we report the role of lncRNA-RNCR3 in diabetes mellitus-induced retinal microvascular abnormalities...
  5. Fang J, Zhang T, Liu Y, Li Y, Zhou S, Song D, et al. PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation. Stem Cells Dev. 2014;23:2297-310 pubmed publisher
    ..Therefore, we propose a novel PAX6-miR-124 pathway that controls ES cell migration. Our findings may provide important information for studies on ES cell differentiation and embryonic development. ..
  6. Gong X, Wang Y, Zeng J, Li S, Luo Y. Computational identification and experimental validation of microRNAs binding to the fragile X syndrome gene Fmr1. Neurochem Res. 2015;40:109-17 pubmed publisher
    ..Our results imply that miR-124 plays an important role in the proliferation of mouse embryonic stem cells by promoting Cdk4 and cyclin D1 expression through directly inhibiting Fmr1 expression. ..
  7. Huyghe A, Van den Ackerveken P, Sacheli R, Prévot P, Thelen N, Renauld J, et al. MicroRNA-124 Regulates Cell Specification in the Cochlea through Modulation of Sfrp4/5. Cell Rep. 2015;13:31-42 pubmed publisher
    ..Thus, our work emphasizes the importance of miR-124 as an epigenetic safeguard that fine-tunes the expression of genes critical for cell patterning during cochlear differentiation. ..
  8. Masoud A, Bihaqi S, Machan J, Zawia N, RENEHAN W. Early-Life Exposure to Lead (Pb) Alters the Expression of microRNA that Target Proteins Associated with Alzheimer's Disease. J Alzheimers Dis. 2016;51:1257-64 pubmed publisher
    ..In summary, we show that exposure to the heavy metal Pb in early life has a significant impact on the short- and long-term expression of miRNA that target epigenetic mediators and neurotoxic proteins. ..
  9. Sun Y, Qin Z, Li Q, Wan J, Cheng M, Wang P, et al. MicroRNA-124 negatively regulates LPS-induced TNF-? production in mouse macrophages by decreasing protein stability. Acta Pharmacol Sin. 2016;37:889-97 pubmed publisher
    ..miR-124, targeting USP2 and USP14, negatively regulates LPS-induced TNF-? production in mouse macrophages, suggesting miR-124 as a new therapeutic target in inflammation-related diseases. ..

More Information


  1. Shtukmaster S, Narasimhan P, El Faitwri T, Stubbusch J, Ernsberger U, Rohrer H, et al. MiR-124 is differentially expressed in derivatives of the sympathoadrenal cell lineage and promotes neurite elongation in chromaffin cells. Cell Tissue Res. 2016;365:225-32 pubmed publisher
    ..Thus, our data indicate that miR-124 contributes to the establishment of specific neuronal features in developing sympathoadrenal cells. ..
  2. Jiang D, Du J, Zhang X, Zhou W, Zong L, Dong C, et al. miR-124 promotes the neuronal differentiation of mouse inner ear neural stem cells. Int J Mol Med. 2016;38:1367-1376 pubmed publisher
    ..Our findings indicate that miR?124 plays a role in the neuronal differentiation of inner ear NSCs. This finding may lead to the development of novel strategies for restoring hearing in neurodegenerative diseases. ..
  3. Santos M, Tegge A, Correa B, Mahesula S, Kohnke L, Qiao M, et al. miR-124, -128, and -137 Orchestrate Neural Differentiation by Acting on Overlapping Gene Sets Containing a Highly Connected Transcription Factor Network. Stem Cells. 2016;34:220-32 pubmed publisher
    ..In summary, our results show that miRNAs can act cooperatively and synergistically to regulate complex biological processes like neurogenesis and that transcription factors are heavily targeted to branch out their regulatory effect. ..
  4. Wang D, Shi L, Xin W, Xu J, Xu J, Li Q, et al. Activation of PPAR? inhibits pro-inflammatory cytokines production by upregulation of miR-124 in vitro and in vivo. Biochem Biophys Res Commun. 2017;486:726-731 pubmed publisher
  5. Gu X, Li A, Liu S, Lin L, Xu S, Zhang P, et al. MicroRNA124 Regulated Neurite Elongation by Targeting OSBP. Mol Neurobiol. 2016;53:6388-6396 pubmed publisher
    ..Our results suggested that OSBP may be a target and downstream effector of miR-124 for regulating neurite outgrowth and elongation. ..
  6. Xue Q, Yu C, Wang Y, Liu L, Zhang K, Fang C, et al. miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a. Sci Rep. 2016;6:26781 pubmed publisher
    ..Our results reveal a novel pathway in which miR-9 and miR-124 synergistically repress expression of Rap2a to sustain homeostatic dendritic complexity during neuronal development and maturation. ..