Gene Symbol: A4galt
Description: alpha 1,4-galactosyltransferase
Alias: lactosylceramide 4-alpha-galactosyltransferase, Gb3 synthase, Gb3/CD77 synthase, UDP-galactose:beta-D-galactosyl-beta1-R 4-alpha-D-galactosyltransferase, alpha-1,4-N-acetylglucosaminyltransferase, alpha4Gal-T1, globotriaosylceramide synthase
Okuda T, Tokuda N, Numata S, Ito M, Ohta M, Kawamura K, et al
. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem. 2006;281:10230-5 pubmed
..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs. ..
Fujii Y, Numata S, Nakamura Y, Honda T, Furukawa K, Urano T, et al
. Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products. Glycobiology. 2005;15:1257-67 pubmed
..The expression patterns of two genes and their products almost corresponded with some exception. The results would provide essential information for the functional studies of globo-series glycolipids. ..
Porubsky S, Speak A, Salio M, Jennemann R, Bonrouhi M, Zafarulla R, et al
. Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells. J Immunol. 2012;189:3007-17 pubmed publisher
..Moreover, in ?GalA(-/-) mice, it is the Gb3 storage that is responsible for the decreased iNKT cell numbers and impeded Ag presentation on DCs. ..
Porubsky S, Luckow B, Bonrouhi M, Speak A, Cerundolo V, Platt F, et al
. [Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function]. Pathologe. 2008;29 Suppl 2:297-302 pubmed publisher
..2) In contrast to previous indirect implications, iGb3 cannot be regarded as an endogenous ligand responsible for the positive selection of iNKT cells. ..
Kondo Y, Tokuda N, Fan X, Yamashita T, Honke K, Takematsu H, et al
. Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. Biochem Biophys Res Commun. 2009;378:179-81 pubmed publisher
..5 microg) of SubAB as well as wild type mice. These results indicated none of glycolipids are not pivotal receptor for SubAB in the body. ..
Porubsky S, Federico G, Muthing J, Jennemann R, Gretz N, Büttner S, et al
. Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure. J Pathol. 2014;234:120-33 pubmed publisher
..Specifically in young adults, an excellent outcome can be achieved by supportive therapy only. ..
von Gerichten J, Schlosser K, Lamprecht D, Morace I, Eckhardt M, Wachten D, et al
. Diastereomer-specific quantification of bioactive hexosylceramides from bacteria and mammals. J Lipid Res. 2017;58:1247-1258 pubmed publisher
..We further confirm ?-GalCer as substrate of globotriaosylceramide synthase for galabiaosylceramide synthesis and identify additional members of the human gut microbiome to ..