Gene Symbol: A3galt2
Description: alpha 1,3-galactosyltransferase 2 (isoglobotriaosylceramide synthase)
Alias: Gm433, iGb3, iGb3S, alpha-1,3-galactosyltransferase 2, iGb3 synthase
Porubsky S, Speak A, Salio M, Jennemann R, Bonrouhi M, Zafarulla R, et al
. Globosides but not isoglobosides can impact the development of invariant NKT cells and their interaction with dendritic cells. J Immunol. 2012;189:3007-17 pubmed publisher
..Isoglobotrihexosylceramide (iGb3) has been implicated as this endogenous selecting ligand and recently suggested to control overstimulation and ..
Milland J, Christiansen D, Lazarus B, Taylor S, Xing P, Sandrin M. The molecular basis for galalpha(1,3)gal expression in animals with a deletion of the alpha1,3galactosyltransferase gene. J Immunol. 2006;176:2448-54 pubmed
..As iGb3 synthase (iGb3S) is a candidate glycosyltransferase, we cloned iGb3S cDNA from GGTA1(-/-) mouse thymus and confirmed ..
Porubsky S, Speak A, Luckow B, Cerundolo V, Platt F, Grone H. Normal development and function of invariant natural killer T cells in mice with isoglobotrihexosylceramide (iGb3) deficiency. Proc Natl Acad Sci U S A. 2007;104:5977-82 pubmed
..to directly investigate the role of iGb3 in iNKT cell selection, we have generated mice deficient in iGb3 synthase [iGb3S, also known as alpha1-3galactosyltransferase 2 (A3galt2)]...
De Santo C, Salio M, Masri S, Lee L, Dong T, Speak A, et al
. Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans. J Clin Invest. 2008;118:4036-48 pubmed publisher
..These findings identify what we believe to be a novel immunomodulatory role of iNKT cells, which we suggest could be harnessed to abolish the immunosuppressive activity of MDSCs during IAV infection. ..
Sørensen D, Dahl K, Ersbøll A, Kirkeby S, d Apice A, Hansen A. Aggression in cataract-bearing alpha-1,3-galactosyltransferase knockout mice. Lab Anim. 2008;42:34-44 pubmed publisher
..Apart from this, the agonistic behaviour was not influenced by genotype. Neither did the genotype affect anxiety or perception of light. ..
Porubsky S, Luckow B, Bonrouhi M, Speak A, Cerundolo V, Platt F, et al
. [Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function]. Pathologe. 2008;29 Suppl 2:297-302 pubmed publisher
The glycosphingolipids globotrihexosylceramide (Gb3, CD77) and isoglobotrihexosylceramide (iGb3) are isomers differing only in one glycosidic bond and have been implicated in several processes of the innate and adaptive immune system...
Zhou D, Mattner J, Cantu C, Schrantz N, Yin N, Gao Y, et al
. Lysosomal glycosphingolipid recognition by NKT cells. Science. 2004;306:1786-9 pubmed
..We show that a lysosomal glycosphingolipid of previously unknown function, isoglobotrihexosylceramide (iGb3), is recognized both by mouse and human NKT cells...
Okuda T, Tokuda N, Numata S, Ito M, Ohta M, Kawamura K, et al
. Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem. 2006;281:10230-5 pubmed
..The lethal kinetics were similar regardless of lipopolysaccharide elimination in VT preparation, suggesting that basal Gb3/CD77 levels are sufficient for lethal effects of VTs. ..