Genomes and Genes
Gene Symbol: 7630403G23Rik
Description: RIKEN cDNA 7630403G23 gene
- Chuang J, Perello M, Sakata I, Osborne Lawrence S, Savitt J, Lutter M, et al. Ghrelin mediates stress-induced food-reward behavior in mice. J Clin Invest. 2011;121:2684-92 pubmed publisher..Thus, this mouse model has allowed us to ascribe a role for ghrelin-engaged catecholaminergic neurons in stress-induced eating. ..
- Heidt T, Sager H, Courties G, Dutta P, Iwamoto Y, Zaltsman A, et al. Chronic variable stress activates hematopoietic stem cells. Nat Med. 2014;20:754-758 pubmed publisher..When atherosclerosis-prone Apoe(-/-) mice were subjected to chronic stress, accelerated hematopoiesis promoted plaque features associated with vulnerable lesions that cause myocardial infarction and stroke in humans. ..
- Dodd G, Worth A, Nunn N, Korpal A, Bechtold D, Allison M, et al. The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014;20:639-49 pubmed publisher..Cre-recombinase-mediated reactivation of PrRP in brainstem rescues the anorectic actions of CCK, but reactivation in the hypothalamus is required to re-establish the thermogenic effect of leptin. ..
- Ben Shaanan T, Azulay Debby H, Dubovik T, Starosvetsky E, Korin B, Schiller M, et al. Activation of the reward system boosts innate and adaptive immunity. Nat Med. 2016;22:940-4 pubmed publisher..Thus, our findings establish a causal relationship between the activity of the VTA and the immune response to bacterial infection. ..
- Zhang S, Johnson C, Cui N, Xing H, Zhong W, Wu Y, et al. An optogenetic mouse model of rett syndrome targeting on catecholaminergic neurons. J Neurosci Res. 2016;94:896-906 pubmed publisher..2016 Wiley Periodicals, Inc. ..
- Kim T, Kerschensteiner D. Inhibitory Control of Feature Selectivity in an Object Motion Sensitive Circuit of the Retina. Cell Rep. 2017;19:1343-1350 pubmed publisher..Cell-type-specific silencing reveals that temporally coded inhibition from TH2-ACs cancels W3-RGC spike responses to global but not local motion stimuli and, thus, controls the feature selectivity of OMS signals sent to the brain. ..
- Amini M, Ma C, Farazifard R, Zhu G, Zhang Y, Vanderluit J, et al. Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury. J Neurosci. 2013;33:5773-84 pubmed publisher..These findings unequivocally establish two central roles of calpain-1/calpain-2 in CNS function in plasticity and neuronal death. ..
- Wachowiak M, Economo M, Díaz Quesada M, Brunert D, Wesson D, White J, et al. Optical dissection of odor information processing in vivo using GCaMPs expressed in specified cell types of the olfactory bulb. J Neurosci. 2013;33:5285-300 pubmed publisher..These results suggest multiple circuit elements with distinct roles in transforming odor representations in the OB and provide a framework for further study of early olfactory processing using optical and genetic tools. ..
- Vuong H, PÃ©rez de Sevilla MÃ¼ller L, Hardi C, McMahon D, Brecha N. Heterogeneous transgene expression in the retinas of the TH-RFP, TH-Cre, TH-BAC-Cre and DAT-Cre mouse lines. Neuroscience. 2015;307:319-37 pubmed publisher..These mouse lines with their distinctive cellular labeling patterns will be useful tools for future studies of retinal function and visual processing. ..
- Gabanyi I, Muller P, Feighery L, Oliveira T, Costa Pinto F, Mucida D. Neuro-immune Interactions Drive Tissue Programming in Intestinal Macrophages. Cell. 2016;164:378-91 pubmed publisher..Our results reveal unique intra-tissue macrophage specialization and identify neuro-immune communication between enteric neurons and macrophages that induces rapid tissue-protective responses to distal perturbations. ..
- Rothermel M, Brunert D, Zabawa C, Díaz Quesada M, Wachowiak M. Transgene expression in target-defined neuron populations mediated by retrograde infection with adeno-associated viral vectors. J Neurosci. 2013;33:15195-206 pubmed publisher..These results establish a widely accessible tool for achieving combinatorial specificity and stable, long-term transgene expression to isolate precisely defined neuron populations in the intact animal. ..
- Andrews Z, Erion D, Beiler R, Liu Z, Abizaid A, Zigman J, et al. Ghrelin promotes and protects nigrostriatal dopamine function via a UCP2-dependent mitochondrial mechanism. J Neurosci. 2009;29:14057-65 pubmed publisher..Finally, we discuss the potential implications of these studies on the link between obesity and neurodegeneration. ..
- Lammel S, Steinberg E, Földy C, Wall N, Beier K, Luo L, et al. Diversity of transgenic mouse models for selective targeting of midbrain dopamine neurons. Neuron. 2015;85:429-38 pubmed publisher..This Matters Arising paper is in response to Stamatakis et al. (2013), published in Neuron. See also the Matters Arising Response paper by Stuber et al. (2015), published concurrently with this Matters Arising in Neuron. ..
- Yamaguchi T, Qi J, Wang H, Zhang S, Morales M. Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area. Eur J Neurosci. 2015;41:760-72 pubmed publisher..Under normal conditions, the translation of TH protein is suppressed in the mouse mesohabenular TH neurons. ..
- Daher J, Ying M, Banerjee R, McDonald R, Hahn M, Yang L, et al. Conditional transgenic mice expressing C-terminally truncated human alpha-synuclein (alphaSyn119) exhibit reduced striatal dopamine without loss of nigrostriatal pathway dopaminergic neurons. Mol Neurodegener. 2009;4:34 pubmed publisher
- Vingill S, Brockelt D, Lancelin C, Tatenhorst L, Dontcheva G, Preisinger C, et al. Loss of FBXO7 (PARK15) results in reduced proteasome activity and models a parkinsonism-like phenotype in mice. EMBO J. 2016;35:2008-25 pubmed publisher..Taken together, our study establishes a vital role for FBXO7 in neurons, which is required for proper motor control and accentuates the importance of FBXO7 in proteasome function. ..
- Rajagopalan S, Rane A, Chinta S, Andersen J. Regulation of ATP13A2 via PHD2-HIF1Î± Signaling Is Critical for Cellular Iron Homeostasis: Implications for Parkinson's Disease. J Neurosci. 2016;36:1086-95 pubmed publisher..Mechanistically, this was due to ATP13A2's role in maintaining lysosomal iron stores. This constitutes a novel mechanism by which alterations in ATP13A2 activity may be driving PD-related neuropathology. ..
- Bolton A, Murata Y, Kirchner R, Kim S, Young A, Dang T, et al. A Diencephalic Dopamine Source Provides Input to the Superior Colliculus, where D1 and D2 Receptors Segregate to Distinct Functional Zones. Cell Rep. 2015;13:1003-15 pubmed publisher..We surmise that A13 mimics dopaminergic effects that we observed in SC slices, which suggests that dopamine in the SC may reduce the tendency of an animal to orient or attend to salient stimuli. ..
- Zhang X, van den Pol A. Dopamine/Tyrosine Hydroxylase Neurons of the Hypothalamic Arcuate Nucleus Release GABA, Communicate with Dopaminergic and Other Arcuate Neurons, and Respond to Dynorphin, Met-Enkephalin, and Oxytocin. J Neurosci. 2015;35:14966-82 pubmed publisher..TH-containing neurons appeared to release synaptic GABA within the ARC onto dopamine neurons and unidentified neurons, suggesting that the cells not only control pituitary hormones but also may modulate nearby neurons. ..
- Takeuchi T, Duszkiewicz A, Sonneborn A, Spooner P, Yamasaki M, Watanabe M, et al. Locus coeruleus and dopaminergic consolidation of everyday memory. Nature. 2016;537:357-362 pubmed publisher..Thus, locus coeruleus TH+ neurons can mediate post-encoding memory enhancement in a manner consistent with possible co-release of dopamine in the hippocampus. ..