14 3 3gamma


Gene Symbol: 14 3 3gamma
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Alias: 14-3-3gamma, D7Bwg1348e, 14-3-3 protein gamma, 14-3-3 gamma, 14-3-3 protein gamma subtype, 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide, 3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide, 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
Species: mouse
Products:     14 3 3gamma

Top Publications

  1. Chen X, Chen J, Zhang Y, Hsiao W, Yu A. 14-3-3gamma is upregulated by in vitro ischemia and binds to protein kinase Raf in primary cultures of astrocytes. Glia. 2003;42:315-24 pubmed
  2. Steinacker P, Schwarz P, Reim K, Brechlin P, Jahn O, Kratzin H, et al. Unchanged survival rates of 14-3-3gamma knockout mice after inoculation with pathological prion protein. Mol Cell Biol. 2005;25:1339-46 pubmed
    ..These results indicate that 14-3-3gamma is unlikely to play a causal role in CJD and related diseases. ..
  3. Yacoubian T, Slone S, Harrington A, Hamamichi S, Schieltz J, Caldwell K, et al. Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease. Cell Death Dis. 2010;1:e2 pubmed publisher
  4. Nichols R, Dzamko N, Morrice N, Campbell D, Deak M, Ordureau A, et al. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010;430:393-404 pubmed publisher
    ..These results provide the first evidence suggesting that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease...
  5. Liang X, Peters K, Butterworth M, Frizzell R. 14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels. J Biol Chem. 2006;281:16323-32 pubmed
    ..Our studies show that aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 to block its interaction with ENaC, thus enhancing sodium absorption by increasing apical membrane ENaC density. ..
  6. Czirják G, Vuity D, Enyedi P. Phosphorylation-dependent binding of 14-3-3 proteins controls TRESK regulation. J Biol Chem. 2008;283:15672-80 pubmed publisher
    ..This kind of direct control of channel regulation by 14-3-3 is unique within the two-pore domain K(+) channel family. ..
  7. Aghazadeh Y, Ye X, Blonder J, Papadopoulos V. Protein modifications regulate the role of 14-3-3? adaptor protein in cAMP-induced steroidogenesis in MA-10 Leydig cells. J Biol Chem. 2014;289:26542-53 pubmed publisher
    ..14-3-3? Ser(58) phosphorylation is required for STAR interactions under control conditions, and 14-3-3? Lys(49) acetylation is important for the cAMP-dependent induction of these interactions. ..
  8. Godde N, D Abaco G, Paradiso L, Novak U. Efficient ADAM22 surface expression is mediated by phosphorylation-dependent interaction with 14-3-3 protein family members. J Cell Sci. 2006;119:3296-305 pubmed
    ..These results reveal a role for 14-3-3 proteins in targeting ADAM22 to the membrane by masking ER retention signals. ..
  9. Wachi T, Cornell B, Marshall C, Zhukarev V, Baas P, Toyo oka K. Ablation of the 14-3-3gamma Protein Results in Neuronal Migration Delay and Morphological Defects in the Developing Cerebral Cortex. Dev Neurobiol. 2016;76:600-14 pubmed publisher
    ..The findings underscore the pathological phenotypes of brain development associated with the disruption of different 14-3-3 proteins and will advance the preclinical data regarding disorders caused by neuronal migration defects. ..

Scientific Experts

More Information


  1. Sadik G, Tanaka T, Kato K, Yamamori H, Nessa B, Morihara T, et al. Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. J Neurochem. 2009;108:33-43 pubmed publisher
    ..Also as the phosphorylation at Ser214 is up-regulated in Alzheimer's disease brain, tau's interaction with 14-3-3 might be involved in the pathology of this disease. ..
  2. Ye S, Zhou X, Lai X, Zheng L, Chen X. Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin. 2009;30:913-8 pubmed publisher
    ..Ngb contributes to neuronal defensive machinery against oxidative injuries by regulating 14-3-3gamma expression.Acta Pharmacologica Sinica (2009) 30: 913-918; doi: 10.1038/aps.2009.70. ..
  3. Radhakrishnan V, Martinez J. 14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling. PLoS ONE. 2010;5:e11433 pubmed publisher
    ..Overall, our studies establish 14-3-3gamma as an oncogene and implicate MAPK and PI3K signaling as important for 14-3-3gamma induced transformation. ..
  4. Kosaka Y, Cieslik K, Li L, Lezin G, Maguire C, Saijoh Y, et al. 14-3-3? plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol. 2012;32:5089-102 pubmed publisher
    ..These data are consistent with the long-held view that human LVNC may result from compaction arrest, and they implicate 14-3-3? as a new candidate gene in congenital human cardiomyopathies. ..
  5. Aghazadeh Y, Rone M, Blonder J, Ye X, Veenstra T, Hales D, et al. Hormone-induced 14-3-3? adaptor protein regulates steroidogenic acute regulatory protein activity and steroid biosynthesis in MA-10 Leydig cells. J Biol Chem. 2012;287:15380-94 pubmed publisher
    ..Over time 14-3-3? homodimerizes and dissociates from STAR, allowing this protein to induce maximal mitochondrial steroid formation...
  6. Chen X, Yu A. The association of 14-3-3gamma and actin plays a role in cell division and apoptosis in astrocytes. Biochem Biophys Res Commun. 2002;296:657-63 pubmed
  7. Eilers A, Sundwall E, Lin M, Sullivan A, Ayer D. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. Mol Cell Biol. 2002;22:8514-26 pubmed
    ..Second, an extracellular signal(s) must overcome the cytoplasmic localization function imparted by CRM1 and 14-3-3 binding to the N terminus of MondoA. ..
  8. Challen G, Gardiner B, Caruana G, Kostoulias X, Martinez G, Crowe M, et al. Temporal and spatial transcriptional programs in murine kidney development. Physiol Genomics. 2005;23:159-71 pubmed
  9. Li H, Guo Y, Teng J, Ding M, Yu A, Chen J. 14-3-3gamma affects dynamics and integrity of glial filaments by binding to phosphorylated GFAP. J Cell Sci. 2006;119:4452-61 pubmed
    ..This data demonstrates that 14-3-3gamma contributes to the regulation of dynamics of GFAP filaments, which may contribute to the stability of the cytoskeleton and the mechanisms of central nervous system neurodegenerative disease. ..
  10. Lee J, Jin Y, He G, Zeng S, Wang Y, Wahl G, et al. Hypoxia activates tumor suppressor p53 by inducing ATR-Chk1 kinase cascade-mediated phosphorylation and consequent 14-3-3? inactivation of MDMX protein. J Biol Chem. 2012;287:20898-903 pubmed publisher
    ..These results demonstrate that hypoxia can activate p53 through inactivation of MDMX by the ATR-Chk1-MDMX-14-3-3? pathway. ..
  11. Sehgal L, Mukhopadhyay A, Rajan A, Khapare N, Sawant M, Vishal S, et al. 14-3-3?-Mediated transport of plakoglobin to the cell border is required for the initiation of desmosome assembly in vitro and in vivo. J Cell Sci. 2014;127:2174-88 pubmed publisher
    ..Our results suggest that loss of 14-3-3? leads to decreased desmosome formation and a decrease in cell-cell adhesion in vitro, and in the mouse testis in vivo, leading to defects in testis organization and spermatogenesis. ..
  12. Li G, White C, Lam T, Pone E, Tran D, Hayama K, et al. Combinatorial H3K9acS10ph histone modification in IgH locus S regions targets 14-3-3 adaptors and AID to specify antibody class-switch DNA recombination. Cell Rep. 2013;5:702-714 pubmed publisher
    ..Thus, H3K9acS10ph is a histone code that is "written" specifically in S regions and is "read" by 14-3-3 adaptors to target AID for CSR as an important biological outcome. ..
  13. Lonic A, Barry E, Quach C, Kobe B, Saunders N, Guthridge M. Fibroblast growth factor receptor 2 phosphorylation on serine 779 couples to 14-3-3 and regulates cell survival and proliferation. Mol Cell Biol. 2008;28:3372-85 pubmed publisher
    ..In this regard, we have identified conserved putative phosphotyrosine/phosphoserine motifs in the cytoplasmic domains of diverse cell surface receptors, suggesting that they may perform important functional roles beyond the FGFRs. ..
  14. Ajjappala B, Kim Y, Kim M, Lee M, Lee K, Ki H, et al. 14-3-3 gamma is stimulated by IL-3 and promotes cell proliferation. J Immunol. 2009;182:1050-60 pubmed
    ..These results indicate that deregulated expression of 14-3-3gamma may contribute to malignant transformation, possibly providing a new target for therapeutic intervention in hematopoietic neoplasms...
  15. Czirják G, Enyedi P. TRESK background K(+) channel is inhibited by phosphorylation via two distinct pathways. J Biol Chem. 2010;285:14549-57 pubmed publisher
    ..In conclusion, two distinct inhibitory kinase pathways converge on TRESK, and their effect on the calcineurin-dependent regulation is differentially modulated by the functional availability of 14-3-3. ..
  16. Lee J, Lu H. 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53. J Biol Chem. 2011;286:5136-42 pubmed publisher
    ..Hence, our study as presented here unravels a new role for 14-3-3? in protecting p21 from MDMX-mediated proteasomal turnover, which may partially account for DNA damage-induced elevation of p21 levels independent of p53. ..
  17. Li X, Wang Q, Pan N, Lee S, Zhao Y, Chait B, et al. Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease. PLoS ONE. 2011;6:e17153 pubmed publisher
    ..Furthermore, the reduction of phosphorylation/14-3-3 binding of LRRK2 due to the common familial PD-related mutations provides novel insight into the pathogenic mechanism of LRRK2-linked PD. ..
  18. Xu Z, Fulop Z, Wu G, Pone E, Zhang J, Mai T, et al. 14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination. Nat Struct Mol Biol. 2010;17:1124-35 pubmed publisher
    ..Finally, 14-3-3 proteins interacted directly with AID and enhanced AID-mediated in vitro DNA deamination, further emphasizing the important role of these adaptors in CSR. ..
  19. Challen G, Martinez G, Davis M, Taylor D, Crowe M, Teasdale R, et al. Identifying the molecular phenotype of renal progenitor cells. J Am Soc Nephrol. 2004;15:2344-57 pubmed
    ..These findings may assist in the isolation and characterization of potential renal stem cells for use in cellular therapies for kidney disease. ..
  20. Yam P, Kent C, Morin S, Farmer W, Alchini R, Lepelletier L, et al. 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron. 2012;76:735-49 pubmed publisher
    ..Therefore, we identify a 14-3-3 protein-dependent mechanism for a cell-intrinsic temporal switch in the polarity of axon turning responses. ..
  21. He G, Zhang Y, Lee J, Zeng S, Wang Y, Luo Z, et al. AMP-activated protein kinase induces p53 by phosphorylating MDMX and inhibiting its activity. Mol Cell Biol. 2014;34:148-57 pubmed publisher
    ..Together, the results unveil a mechanism by which metabolic stresses activate AMPK, which, in turn, phosphorylates and inactivates MDMX, resulting in p53 stabilization and activation. ..
  22. Cho C, Kim E, Lee Y, Yarishkin O, Yoo J, Park J, et al. Depletion of 14-3-3? reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death. Mol Brain. 2014;7:52 pubmed publisher
  23. Satchell M, Zhang X, Kochanek P, Dixon C, Jenkins L, Melick J, et al. A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3gamma. J Neurochem. 2003;85:697-708 pubmed
  24. Herrmann D, Straubinger M, Hashemolhosseini S. Protein kinase CK2 interacts at the neuromuscular synapse with Rapsyn, Rac1, 14-3-3γ, and Dok-7 proteins and phosphorylates the latter two. J Biol Chem. 2015;290:22370-84 pubmed publisher
    ..Additionally, we mapped the interacting epitopes of all four binding partners to CK2 and thereby gained insights into the potential role of the CK2/Rapsyn interaction. ..
  25. Kathiresan T, Harvey M, Orchard S, Sakai Y, Sokolowski B. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Mol Cell Proteomics. 2009;8:1972-87 pubmed publisher
    ..The studies described herein provide insights into BK-related functions that include not only cell excitation, but also cell signaling and apoptosis, and involve proteins concerned with Ca(2+) regulation, structure, and hearing loss. ..