Gene Symbol: gag-pol
Description: Polyprotein
Alias: Polyprotein, Pr180
Species: Moloney murine leukemia virus

Top Publications

  1. Wu S, Sj berg M, Wallin M, Lindqvist B, Ekstr m M, Hebert H, et al. Turning of the receptor-binding domains opens up the murine leukaemia virus Env for membrane fusion. EMBO J. 2008;27:2799-808 pubmed publisher
    ..This might subsequently guide the fusion peptides in extended TM subunits into the target membrane...
  2. D Souza V, Summers M. Structural basis for packaging the dimeric genome of Moloney murine leukaemia virus. Nature. 2004;431:586-90 pubmed publisher
    ..Both processes are mediated by the nucleocapsid domain (NC) of the retroviral Gag polyprotein. Here we show that dimerization-induced register shifts in base pairing within the Psi-RNA packaging signal of ..
  3. Malik O, Khamis H, Rudnizky S, Kaplan A. The mechano-chemistry of a monomeric reverse transcriptase. Nucleic Acids Res. 2017;45:12954-12962 pubmed publisher
    ..Finally, our results indicate that the enzyme enters the recently characterized backtracking state from the pre-translocation complex. ..
  4. Andersen K, Diep H, Zedeler A. Murine leukemia virus transmembrane protein R-peptide is found in small virus core-like complexes in cells. J Gen Virol. 2006;87:1583-8 pubmed publisher
    ..23 g ml(-1) and a size of 150-200 S. Our results suggest that TM associates with the assembling core particle through the R-peptide before budding and that this is the mechanism by which the budding virus acquires the envelope proteins...
  5. Schultz S, Champoux J. RNase H activity: structure, specificity, and function in reverse transcription. Virus Res. 2008;134:86-103 pubmed publisher
    ..Finally, the RNase H activity of HIV-1 is considered as a target for anti-virals as well as a participant in drug resistance...
  6. Schultz S, Zhang M, Champoux J. Preferred sequences within a defined cleavage window specify DNA 3' end-directed cleavages by retroviral RNases H. J Biol Chem. 2009;284:32225-38 pubmed publisher
    ..These data demonstrate that all three modes of retroviral RNase H cleavage share sequence determinants that may be useful in designing assays to identify inhibitors of retroviral RNases H...
  7. Shinnick T, Lerner R, Sutcliffe J. Nucleotide sequence of Moloney murine leukaemia virus. Nature. 1981;293:543-8 pubmed
  8. Guan R, Aiyer S, Coté M, Xiao R, Jiang M, Acton T, et al. X-ray crystal structure of the N-terminal region of Moloney murine leukemia virus integrase and its implications for viral DNA recognition. Proteins. 2017;85:647-656 pubmed publisher
    ..Proteins 2017; 85:647-656. © 2016 Wiley Periodicals, Inc. ..