MKC7

Summary

Gene Symbol: MKC7
Description: Mkc7p
Alias: YPS2
Species:

Top Publications

  1. ncbi Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae
    Damian J Krysan
    Division of Pediatric Infectious Disease, Department of Pediatrics and Communicable Diseases, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
    Eukaryot Cell 4:1364-74. 2005
  2. ncbi Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast
    H Komano
    Department of Biochemistry, Stanford University School of Medicine, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 92:10752-6. 1995
  3. ncbi Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae
    Eun Young Cho
    Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    J Biotechnol 149:1-7. 2010
  4. ncbi Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast
    Nadia Vadaie
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Cell Biol 181:1073-81. 2008
  5. ncbi Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae
    N Tomishige
    Department of Biotechnology, University of Tokyo, Bunkyo ku, 113 8657 Tokyo, Japan
    Mol Genet Genomics 269:562-73. 2003
  6. ncbi YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins
    Elena Friedmann
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:35274-81. 2002
  7. ncbi Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p)
    H Komano
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 274:24431-7. 1999
  8. ncbi Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification
    Y E Oluwatosin
    Department of Biochemistry and Molecular Biology, SUNY Health Science Center at Syracuse, New York 13210, USA
    Mol Cell Biol 18:1534-43. 1998
  9. ncbi Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases
    W Zhang
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Biochim Biophys Acta 1359:110-22. 1997
  10. ncbi Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae
    Kelly A Miller
    Departments of Pediatrics and Microbiology Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Eukaryot Cell 9:1669-79. 2010

Scientific Experts

  • Damian J Krysan
  • Eun Young Cho
  • Kelly A Miller
  • Nadia Vadaie
  • H Komano
  • N Tomishige
  • Elena Friedmann
  • Hyun Ah Kang
  • Dong Jik Lee
  • Bong Hyun Chung
  • Jeong Yoon Kim
  • Sang Ki Rhee
  • Hyunah Kim
  • Jinho Choo
  • Seon Ah Cheon
  • Ho Myung Ryu
  • Louis Didone
  • Darowan S Akajagbor
  • Paul J Cullen
  • Seth R Nickerson
  • Heather Dionne
  • Y E Oluwatosin
  • W Zhang
  • R S Fuller
  • A Takatsuki
  • K Yoda
  • H Shimoi
  • Y Noda
  • H Adachi
  • Adina Weinberger
  • Jeffrey E Gerst
  • Shmuel Shaltiel
  • Yehuda Salzberg
  • N Rockwell
  • G A Krafft
  • G T Wang
  • P M Kane
  • P Mehta
  • D Espinoza
  • V Hines
  • D L Miller
  • M Innis

Detail Information

Publications10

  1. ncbi Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae
    Damian J Krysan
    Division of Pediatric Infectious Disease, Department of Pediatrics and Communicable Diseases, University of Michigan Hospitals, Ann Arbor, Michigan 48109, USA
    Eukaryot Cell 4:1364-74. 2005
    ..Taken together, these data indicate that the yapsins play an important role in glucan homeostasis in S. cerevisiae and that yapsin homologues may play a similar role in the pathogenic yeasts C. albicans and C. glabrata...
  2. ncbi Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast
    H Komano
    Department of Biochemistry, Stanford University School of Medicine, CA 94305 5307, USA
    Proc Natl Acad Sci U S A 92:10752-6. 1995
    The MKC7 gene was isolated as a multicopy suppressor of the cold-sensitive growth phenotype of a yeast kex2 mutant, which lacks the protease that cleaves pro-alpha-factor and other secretory proproteins at pairs of basic residues in a ..
  3. ncbi Multiple-yapsin-deficient mutant strains for high-level production of intact recombinant proteins in Saccharomyces cerevisiae
    Eun Young Cho
    Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea
    J Biotechnol 149:1-7. 2010
    ..The present data strongly indicate the involvement of other yapsin members besides Yps1p in the proteolysis of secretory recombinant proteins, particularly under high-density growth conditions...
  4. ncbi Cleavage of the signaling mucin Msb2 by the aspartyl protease Yps1 is required for MAPK activation in yeast
    Nadia Vadaie
    Department of Biological Sciences, State University of New York at Buffalo, Buffalo, NY 14260, USA
    J Cell Biol 181:1073-81. 2008
    ..We postulate that cleavage-dependent activation is a general feature of signaling mucins, which brings to light a novel regulatory aspect of this class of signaling adhesion molecule...
  5. ncbi Mutations that are synthetically lethal with a gas1Delta allele cause defects in the cell wall of Saccharomyces cerevisiae
    N Tomishige
    Department of Biotechnology, University of Tokyo, Bunkyo ku, 113 8657 Tokyo, Japan
    Mol Genet Genomics 269:562-73. 2003
    ..A cell wall defect was also found in the kex2Delta mutant, which was suppressible by multiple copies of the MKC7 or YAP3 gene, both of which encode other GPI-anchored proteases...
  6. ncbi YOS9, the putative yeast homolog of a gene amplified in osteosarcomas, is involved in the endoplasmic reticulum (ER)-Golgi transport of GPI-anchored proteins
    Elena Friedmann
    Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel
    J Biol Chem 277:35274-81. 2002
    ..Yos9 binds directly to Gas1 and Mkc7 and accelerates Gas1 transport and processing in cells overexpressing YOS9...
  7. ncbi Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p)
    H Komano
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109 0606, USA
    J Biol Chem 274:24431-7. 1999
    The Saccharomyces cerevisiae YPS2 (formerly MKC7) gene product is a glycosylphosphatidylinositol-linked aspartyl protease that functions as a yeast secretase...
  8. ncbi Mutations in the yeast KEX2 gene cause a Vma(-)-like phenotype: a possible role for the Kex2 endoprotease in vacuolar acidification
    Y E Oluwatosin
    Department of Biochemistry and Molecular Biology, SUNY Health Science Center at Syracuse, New York 13210, USA
    Mol Cell Biol 18:1534-43. 1998
    ..This is the first time a mutation of this type has been identified...
  9. ncbi Characterization of beta-amyloid peptide precursor processing by the yeast Yap3 and Mkc7 proteases
    W Zhang
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island 10314, USA
    Biochim Biophys Acta 1359:110-22. 1997
    ..Deletions of the genes encoding the GPI-linked aspartyl proteases Yap3 and Mkc7 decreased alpha-secretase activity by 56 and 29%, respectively; whereas, the double deletion decreased the activity ..
  10. ncbi Extracellular secretion of overexpressed glycosylphosphatidylinositol-linked cell wall protein Utr2/Crh2p as a novel protein quality control mechanism in Saccharomyces cerevisiae
    Kelly A Miller
    Departments of Pediatrics and Microbiology Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Eukaryot Cell 9:1669-79. 2010
    ..cerevisiae. This model provides an explanation for the deleterious effects of Yps1/2p on the industrial production of some recombinant proteins in S. cerevisiae...