orotidine 5 monophosphate decarboxylase

Summary

Gene Symbol: orotidine 5 monophosphate decarboxylase
Description: orotidine 5' monophosphate decarboxylase
Species: Methanothermobacter thermautotrophicus str. Delta H

Top Publications

  1. pmc Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase
    N Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, ON Canada M5S 1A8
    Proc Natl Acad Sci U S A 97:2017-22. 2000
  2. ncbi Purification, crystallization and preliminary X-ray study of orotidine 5'-monophosphate decarboxylase
    N Wu
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Acta Crystallogr D Biol Crystallogr 56:912-4. 2000
  3. ncbi Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography
    Ning Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Biochemistry 41:4002-11. 2002
  4. ncbi Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase
    Ning Wu
    Department of Biochemistry, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:28080-7. 2002
  5. ncbi An unprecedented twist to ODCase catalytic activity
    Masahiro Fujihashi
    Molecular Design and Information Technology Center, Leslie Dan Faculty of Pharmacy, Toronto, ON M5S 2S2 Canada
    J Am Chem Soc 127:15048-50. 2005
  6. ncbi A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity
    Angelica M Bello
    Center for Molecular Design and Preformulations, Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G 2C4 Canada
    J Med Chem 50:915-21. 2007
  7. pmc An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms
    Krisztina Toth
    Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260 3000, USA
    Biochemistry 48:8006-13. 2009

Detail Information

Publications7

  1. pmc Electrostatic stress in catalysis: structure and mechanism of the enzyme orotidine monophosphate decarboxylase
    N Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, ON Canada M5S 1A8
    Proc Natl Acad Sci U S A 97:2017-22. 2000
    ..The computational results are consistent with a catalytic mechanism that is characterized by Jencks's Circe effect...
  2. ncbi Purification, crystallization and preliminary X-ray study of orotidine 5'-monophosphate decarboxylase
    N Wu
    Department of Biochemistry, University of Toronto, 1 King s College Circle, Toronto, Ontario, M5S 1A8, Canada
    Acta Crystallogr D Biol Crystallogr 56:912-4. 2000
    ..0, b = 98.6, c = 73.3 A, gamma = 104.0 degrees ), with four molecules in the asymmetric unit; the crystals diffract to 1.5 A resolution...
  3. ncbi Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography
    Ning Wu
    Department of Biochemistry, Centres of Excellence, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Biochemistry 41:4002-11. 2002
    ..Consequently, orotidine 5'-monophosphate decarboxylases seem to require the presence of a negative charge at this position for catalysis as well as for correct and stable folding...
  4. ncbi Crystal structures of inhibitor complexes reveal an alternate binding mode in orotidine-5'-monophosphate decarboxylase
    Ning Wu
    Department of Biochemistry, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:28080-7. 2002
    ..The XMP and CMP complexes reveal a ligand-binding mode that is distinct from the one identified previously with the aromatic rings located outside the binding pocket. A potential pathway for ligand binding is discussed...
  5. ncbi An unprecedented twist to ODCase catalytic activity
    Masahiro Fujihashi
    Molecular Design and Information Technology Center, Leslie Dan Faculty of Pharmacy, Toronto, ON M5S 2S2 Canada
    J Am Chem Soc 127:15048-50. 2005
    ..This potential of ODCase is very useful in the design of novel inhibitors...
  6. ncbi A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity
    Angelica M Bello
    Center for Molecular Design and Preformulations, Toronto General Research Institute, Toronto General Hospital, Toronto, ON M5G 2C4 Canada
    J Med Chem 50:915-21. 2007
    ..2 +/- 0.7 microM against P. falciparum ItG and 3D7 isolates, respectively. 6-Iodouridine 5'-monophosphate is a novel covalent inhibitor of ODCase, and its nucleoside analogue paves the way to a new class of inhibitors against malaria...
  7. pmc An examination of the relationship between active site loop size and thermodynamic activation parameters for orotidine 5'-monophosphate decarboxylase from mesophilic and thermophilic organisms
    Krisztina Toth
    Department of Chemistry, University at Buffalo, SUNY, Buffalo, New York 14260 3000, USA
    Biochemistry 48:8006-13. 2009
    ....