Gene Symbol: MTH_RS07660
Description: ATPase AAA
Alias: MTH1599
Species: Methanothermobacter thermautotrophicus str. Delta H

Top Publications

  1. Grabowski B, Kelman Z. Autophosphorylation of archaeal Cdc6 homologues is regulated by DNA. J Bacteriol. 2001;183:5459-64 pubmed
    ..Yeast Cdc18 was also found to autophosphorylate, suggesting that this function of Cdc6 may play a widely conserved and essential role in replication initiation. ..
  2. Capaldi S, Berger J. Biochemical characterization of Cdc6/Orc1 binding to the replication origin of the euryarchaeon Methanothermobacter thermoautotrophicus. Nucleic Acids Res. 2004;32:4821-32 pubmed
    ..Our observations also indicate that the origin-binding properties of Cdc6/Orc1 proteins closely resemble those of bacterial DnaA...
  3. Kasiviswanathan R, Shin J, Kelman Z. Interactions between the archaeal Cdc6 and MCM proteins modulate their biochemical properties. Nucleic Acids Res. 2005;33:4940-50 pubmed publisher
    ..The results also suggest that MCM and DNA may compete for Cdc6-1 protein binding. The implications of these observations for the initiation of archaeal DNA replication are discussed...
  4. Kasiviswanathan R, Shin J, Kelman Z. DNA binding by the Methanothermobacter thermautotrophicus Cdc6 protein is inhibited by the minichromosome maintenance helicase. J Bacteriol. 2006;188:4577-80 pubmed publisher
    ..Using minichromosome maintenance (MCM) helicase mutant proteins unable to bind DNA, it was found that the interaction of MCM with Cdc6 inhibits the DNA binding activity of Cdc6...
  5. Shin J, Heo G, Kelman Z. The Methanothermobacter thermautotrophicus Cdc6-2 protein, the putative helicase loader, dissociates the minichromosome maintenance helicase. J Bacteriol. 2008;190:4091-4 pubmed publisher
    ..It is shown here that Cdc6-2 protein dissociates the MCM complex. This observation supports the hypothesis that the Cdc6-2 protein functions as a helicase loader. ..