MTH_RS05555

Summary

Gene Symbol: MTH_RS05555
Description: methyl-coenzyme M reductase
Alias: MTH1168
Species: Methanothermobacter thermautotrophicus str. Delta H

Top Publications

  1. Bokranz M, Bäumner G, Allmansberger R, Ankel Fuchs D, Klein A. Cloning and characterization of the methyl coenzyme M reductase genes from Methanobacterium thermoautotrophicum. J Bacteriol. 1988;170:568-77 pubmed
    ..Sequence analysis revealed two more open reading frames of unknown function located between two of the methyl coenzyme M reductase genes. ..
  2. Pihl T, Sharma S, Reeve J. Growth phase-dependent transcription of the genes that encode the two methyl coenzyme M reductase isoenzymes and N5-methyltetrahydromethanopterin:coenzyme M methyltransferase in Methanobacterium thermoautotrophicum delta H. J Bacteriol. 1994;176:6384-91 pubmed
  3. Rospert S, Linder D, Ellermann J, Thauer R. Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H. Eur J Biochem. 1990;194:871-7 pubmed
    ..When the cultures were supplied with sufficient H2 and and CO2 and the cells grew exponentially, essentially only MCR II was found. When growth was limited by the gas supply, MCR I predominated...
  4. Knaub S, Klein A. Specific transcription of cloned Methanobacterium thermoautotrophicum transcription units by homologous RNA polymerase in vitro. Nucleic Acids Res. 1990;18:1441-6 pubmed
    ..The 5'-terminus of the product has been mapped. Deletion analyses of the promoter region show the limits of the sequences essential for the promoter function. ..
  5. Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer R. Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation. Science. 1997;278:1457-62 pubmed
    ..Together with a second structurally characterized enzyme state (MCRsilent) containing the heterodisulfide of coenzymes M and B, a reaction mechanism is proposed that uses a radical intermediate and a nickel organic compound...
  6. Grabarse W, Mahlert F, Duin E, Goubeaud M, Shima S, Thauer R, et al. On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding. J Mol Biol. 2001;309:315-30 pubmed publisher
    ..The three different enzymatically inactive enzyme states are discussed with respect to their enzymatically active precursors and with respect to the catalytic mechanism...