Gene Symbol: MTH_RS03810
Description: DEAD/DEAH box helicase
Alias: MTH810
Species: Methanothermobacter thermautotrophicus str. Delta H

Top Publications

  1. Guy C, Bolt E. Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands. Nucleic Acids Res. 2005;33:3678-90 pubmed publisher
    ..We speculate that removal of lagging strands at stalled forks by Hel308 promotes the formation of initiation zones, priming restart of lagging strand synthesis...
  2. Woodman I, Brammer K, Bolt E. Physical interaction between archaeal DNA repair helicase Hel308 and Replication Protein A (RPA). DNA Repair (Amst). 2011;10:306-13 pubmed publisher
    ..This supports a model for RPA localising Hel308 to DNA damage sites in archaea, rather than it directly stimulating the mechanism of helicase unwinding...
  3. Woodman I, Briggs G, Bolt E. Archaeal Hel308 domain V couples DNA binding to ATP hydrolysis and positions DNA for unwinding over the helicase ratchet. J Mol Biol. 2007;374:1139-44 pubmed publisher
    ..We describe crucial roles for domain V as a brake on ATP hydrolysis by coupling it to binding single-stranded DNA and in positioning DNA relative to the helicase ratchet domain IV for efficient unwinding of forked DNA...
  4. Woodman I, Bolt E. Molecular biology of Hel308 helicase in archaea. Biochem Soc Trans. 2009;37:74-8 pubmed publisher
    ..We review the emerging molecular biology of Hel308, drawing together ideas of how it may contribute to genome stability through the control of recombination, with reference to paradigms developed in bacteria...