Gene Symbol: MTBMA_RS07570
Description: methyl-coenzyme M reductase
Alias: MTBMA_c15520
Species: Methanothermobacter marburgensis str. Marburg

Top Publications

  1. Rospert S, Linder D, Ellermann J, Thauer R. Two genetically distinct methyl-coenzyme M reductases in Methanobacterium thermoautotrophicum strain Marburg and delta H. Eur J Biochem. 1990;194:871-7 pubmed
    ..When the cultures were supplied with sufficient H2 and and CO2 and the cells grew exponentially, essentially only MCR II was found. When growth was limited by the gas supply, MCR I predominated...
  2. Bokranz M, Bäumner G, Allmansberger R, Ankel Fuchs D, Klein A. Cloning and characterization of the methyl coenzyme M reductase genes from Methanobacterium thermoautotrophicum. J Bacteriol. 1988;170:568-77 pubmed
    ..Sequence analysis revealed two more open reading frames of unknown function located between two of the methyl coenzyme M reductase genes. ..
  3. Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer R. Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation. Science. 1997;278:1457-62 pubmed
    ..Together with a second structurally characterized enzyme state (MCRsilent) containing the heterodisulfide of coenzymes M and B, a reaction mechanism is proposed that uses a radical intermediate and a nickel organic compound...
  4. Grabarse W, Mahlert F, Duin E, Goubeaud M, Shima S, Thauer R, et al. On the mechanism of biological methane formation: structural evidence for conformational changes in methyl-coenzyme M reductase upon substrate binding. J Mol Biol. 2001;309:315-30 pubmed publisher
    ..The three different enzymatically inactive enzyme states are discussed with respect to their enzymatically active precursors and with respect to the catalytic mechanism...
  5. Wongnate T, Ragsdale S. The reaction mechanism of methyl-coenzyme M reductase: how an enzyme enforces strict binding order. J Biol Chem. 2015;290:9322-34 pubmed publisher
    ..This first rapid kinetics study of MCR with its natural substrates describes how an enzyme can enforce a strictly ordered ternary complex mechanism and serves as a template for identification of the reaction intermediates. ..

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