Gene Symbol: MM_RS13565
Description: proteasome endopeptidase complex,subunit alpha
Alias: MM_2620
Species: Methanosarcina mazei Go1

Top Publications

  1. Maupin Furlow J, Ferry J. A proteasome from the methanogenic archaeon Methanosarcina thermophila. J Biol Chem. 1995;270:28617-22 pubmed
    ..The results suggest that proteasomes are more widespread in the Archaea than previously proposed. Southern blotting experiments suggested the presence of ubiquitin-like sequences in M. thermophila. ..
  2. Yamada S, Niwa J, Ishigaki S, Takahashi M, Ito T, Sone J, et al. Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells. J Biol Chem. 2006;281:23842-51 pubmed
    ..Our study showed that archaeal proteasomes can degrade aggregation-prone proteins whose toxic gain of function causes neurodegradation and reduce protein cellular toxicity. ..