MEP2

Summary

Gene Symbol: MEP2
Description: Mep2p
Species:

Top Publications

  1. ncbi A family of ammonium transporters in Saccharomyces cerevisiae
    A M Marini
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Cell Biol 17:4282-93. 1997
  2. ncbi The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
    M C Lorenz
    Departments of Genetics, Duke University Medical Center, 322 CARL Building, Research Drive, Durham, NC 27710, USA
    EMBO J 17:1236-47. 1998
  3. ncbi Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains
    M C Lorenz
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 150:1443-57. 1998
  4. ncbi Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae
    M Gagiano
    Institute for Wine Biotechnology, University of Stellenbosch, South Africa
    Mol Microbiol 31:103-16. 1999
  5. ncbi In vivo N-glycosylation of the mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus
    A M Marini
    Laboratoire de Physiologie Cellulaire, Universite Libre de Bruxelles, CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Mol Microbiol 38:552-64. 2000
  6. ncbi Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast
    An Van Nuland
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium
    Mol Microbiol 59:1485-505. 2006
  7. ncbi The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium
    Mélanie Boeckstaens
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Mol Microbiol 64:534-46. 2007
  8. ncbi A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae
    Julian C Rutherford
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 19:3028-39. 2008

Scientific Experts

  • A-M Marini
  • Julian C Rutherford
  • Mélanie Boeckstaens
  • M C Lorenz
  • An Van Nuland
  • Joseph Heitman
  • M Gagiano
  • Timothy Hughes
  • Gordon Chua
  • Maria E Cardenas
  • Bruno Andre
  • Artur Lourenço
  • Edgar Quintino
  • J Heitman
  • Johan M Thevelein
  • Monica Donaton
  • Marta Alenquer
  • Matthias Versele
  • Patrick Vandormael
  • M G Lambrechts
  • I S Pretorius
  • F F Bauer
  • D van Dyk

Detail Information

Publications8

  1. ncbi A family of ammonium transporters in Saccharomyces cerevisiae
    A M Marini
    Laboratoire de Physiologie Cellulaire et de Genetique des Levures, Universite Libre de Bruxelles, Brussels, Belgium
    Mol Cell Biol 17:4282-93. 1997
    ..The Mep2 protein displays the highest affinity for NH4+ (Km, 1 to 2 microM), followed closely by Mep1p (Km, 5 to 10 microM) ..
  2. ncbi The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae
    M C Lorenz
    Departments of Genetics, Duke University Medical Center, 322 CARL Building, Research Drive, Durham, NC 27710, USA
    EMBO J 17:1236-47. 1998
    ..We have found that MEP2, a high affinity ammonium permease, is required for pseudohyphal differentiation in response to ammonium limitation...
  3. ncbi Regulators of pseudohyphal differentiation in Saccharomyces cerevisiae identified through multicopy suppressor analysis in ammonium permease mutant strains
    M C Lorenz
    Department of Genetics, Duke University Medical Center, Durham, North Carolina 27710, USA
    Genetics 150:1443-57. 1998
    ..Multicopy expression of TEC1, PHD1, PHD2 (MSS10/MSN1/FUP4), MSN5, CDC6, MSS11, MGA1, SKN7, DOT6, HMS1, HMS2, or MEP2 each restored filamentation in a Deltamep1/Deltamep1 Deltamep2/Deltamep2 strain...
  4. ncbi Msn1p/Mss10p, Mss11p and Muc1p/Flo11p are part of a signal transduction pathway downstream of Mep2p regulating invasive growth and pseudohyphal differentiation in Saccharomyces cerevisiae
    M Gagiano
    Institute for Wine Biotechnology, University of Stellenbosch, South Africa
    Mol Microbiol 31:103-16. 1999
    ..We also show that starch metabolism in S. cerevisiae is subject to regulation by components of the MAP kinase cascade...
  5. ncbi In vivo N-glycosylation of the mep2 high-affinity ammonium transporter of Saccharomyces cerevisiae reveals an extracytosolic N-terminus
    A M Marini
    Laboratoire de Physiologie Cellulaire, Universite Libre de Bruxelles, CP300, Institut de Biologie et de Médecine Moléculaires, rue des Pr Jeener et Brachet, 12, 6041 Gosselies, Belgium
    Mol Microbiol 38:552-64. 2000
    Saccharomyces cerevisiae possesses three related ammonium transporters, Mep1, Mep2 and Mep3, differing in their kinetic properties and in the level and regulation of their gene expression...
  6. ncbi Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast
    An Van Nuland
    Laboratory of Molecular Cell Biology, Institute of Botany and Microbiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B 3001 Leuven Heverlee, Flanders, Belgium
    Mol Microbiol 59:1485-505. 2006
    ..cells, ammonium transport and activation of trehalase are most active in strains expressing either the Mep2 or Mep1 ammonium permease, as opposed to Mep3...
  7. ncbi The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium
    Mélanie Boeckstaens
    Laboratoire de Physiologie Moléculaire de la Cellule, Institut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles CP300, Rue des Professeurs Jeener et Brachet 12, 6041 Gosselies, Belgium
    Mol Microbiol 64:534-46. 2007
    ..A specific sensor role has further been proposed for Mep2 in the stimulation of pseudohyphal development during ammonium limitation...
  8. ncbi A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae
    Julian C Rutherford
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Biol Cell 19:3028-39. 2008
    The ammonium permease Mep2 is required for the induction of pseudohyphal growth, a process in Saccharomyces cerevisiae that occurs in response to nutrient limitation...