Gene Symbol: L
Description: large subunit of RNA dependent RNA polymerase (RdRp); RNA synthesis, capping, and polyadenylation
Alias: large subunit of RNA dependent RNA polymerase (RdRp), RNA synthesis, capping, and polyadenylation, large polymerase protein
Species: Measles virus
Wardrop E, Briedis D. Characterization of V protein in measles virus-infected cells. J Virol. 1991;65:3421-8 pubmed
Cattaneo R, Kaelin K, Baczko K, Billeter M. Measles virus editing provides an additional cysteine-rich protein. Cell. 1989;56:759-64 pubmed
..A smaller fraction of transcripts contain several additional G residues...
Bellini W, Englund G, Richardson C, Rozenblatt S, Lazzarini R. Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences, and deduced amino acid sequences. J Virol. 1986;58:408-16 pubmed
..M. Blumberg, K. Rose, M. G. Simona, L. Roux, C. Giorgi, and D. Kolakofsky, J. Virol. 52:656-663; Y. Hidaka, T. Kanda, K. Iwasaki, A. Nomoto, T...
Krumm S, Takeda M, Plemper R. The measles virus nucleocapsid protein tail domain is dispensable for viral polymerase recruitment and activity. J Biol Chem. 2013;288:29943-53 pubmed publisher
..Dispensable for polymerase recruitment, N-MoRE binding to P-tail stabilizes the advancing polymerase-RNP complex and may rearrange unstructured central tail sections to facilitate polymerase access to the template. ..
Bellini W, Englund G, Rozenblatt S, Arnheiter H, Richardson C. Measles virus P gene codes for two proteins. J Virol. 1985;53:908-19 pubmed
..Using immunofluorescent microscopy, we localized the C protein in the nucleus and in cytoplasmic inclusions within the infected cells...
Rima B, Duprex W. The measles virus replication cycle. Curr Top Microbiol Immunol. 2009;329:77-102 pubmed
Takeuchi K, Miyajima N, Kobune F, Tashiro M. Comparative nucleotide sequence analyses of the entire genomes of B95a cell-isolated and vero cell-isolated measles viruses from the same patient. Virus Genes. 2000;20:253-7 pubmed
..These results indicated that nucleotide difference(s) in the P/V/C or/and M gene, and not H gene, was responsible for the different cell tropism and pathogenicity of MV in this case...
Cevik B, Holmes D, Vrotsos E, Feller J, Smallwood S, Moyer S. The phosphoprotein (P) and L binding sites reside in the N-terminus of the L subunit of the measles virus RNA polymerase. Virology. 2004;327:297-306 pubmed
Measles virus encodes an RNA-dependent RNA polymerase composed of the L and P proteins. Recent studies have shown that the L proteins of both Sendai virus and parainfluenza virus 3 form an L-L complex [Cevik, B., Smallwood, S., Moyer, S...