H

Summary

Gene Symbol: H
Description: type II transmembrane glycoprotein; attachment glycoprotein that interacts directly with entry receptors
Alias: type II transmembrane glycoprotein, attachment glycoprotein that interacts directly with entry receptors, hemagglutinin protein
Species: Measles virus

Top Publications

  1. Tahara M, Takeda M, Shirogane Y, Hashiguchi T, Ohno S, Yanagi Y. Measles virus infects both polarized epithelial and immune cells by using distinctive receptor-binding sites on its hemagglutinin. J Virol. 2008;82:4630-7 pubmed publisher
    ..The ability of MV to infect polarized epithelial cells and its exclusive release from the apical surface may facilitate its efficient transmission via aerosol droplets, resulting in its highly contagious nature. ..
  2. Hashiguchi T, Kajikawa M, Maita N, Takeda M, Kuroki K, Sasaki K, et al. Crystal structure of measles virus hemagglutinin provides insight into effective vaccines. Proc Natl Acad Sci U S A. 2007;104:19535-40 pubmed
    ..Our findings suggest that sugar moieties in the MV hemagglutinin critically modulate virus-receptor interaction as well as antiviral antibody responses, differently from sugars of the HIV gp120, which allow for immune evasion. ..
  3. Paal T, Brindley M, St Clair C, Prussia A, Gaus D, Krumm S, et al. Probing the spatial organization of measles virus fusion complexes. J Virol. 2009;83:10480-93 pubmed publisher
    ..N-glycans indicates close proximity of a membrane-distal, but not membrane-proximal, section of the MeV attachment (H) protein stalk domain to F...
  4. Navaratnarajah C, Leonard V, Cattaneo R. Measles virus glycoprotein complex assembly, receptor attachment, and cell entry. Curr Top Microbiol Immunol. 2009;329:59-76 pubmed
    ..Two glycoproteins mediate this process: the hemagglutinin (H) and fusion (F) proteins...
  5. Navaratnarajah C, Vongpunsawad S, Oezguen N, Stehle T, Braun W, Hashiguchi T, et al. Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150). J Biol Chem. 2008;283:11763-71 pubmed publisher
    ..These studies identified one hemagglutinin protein residue, isoleucine 194, which is essential for primary binding...
  6. Bellini W, Englund G, Rozenblatt S, Arnheiter H, Richardson C. Measles virus P gene codes for two proteins. J Virol. 1985;53:908-19 pubmed
    ..Using immunofluorescent microscopy, we localized the C protein in the nucleus and in cytoplasmic inclusions within the infected cells...
  7. Hashiguchi T, Ose T, Kubota M, Maita N, Kamishikiryo J, Maenaka K, et al. Structure of the measles virus hemagglutinin bound to its cellular receptor SLAM. Nat Struct Mol Biol. 2011;18:135-41 pubmed publisher
    ..Here we present crystal structures of measles virus hemagglutinin (MV-H), the receptor-binding glycoprotein, in complex with SLAM...
  8. Wakimoto H, Shimodo M, Satoh Y, Kitagawa Y, Takeuchi K, Gotoh B, et al. F-actin modulates measles virus cell-cell fusion and assembly by altering the interaction between the matrix protein and the cytoplasmic tail of hemagglutinin. J Virol. 2013;87:1974-84 pubmed publisher
    ..M (M-WT) protein associated strongly with F-actin but only weakly with the cytoplasmic tail of the hemagglutinin (H) protein...
  9. Takeuchi K, Miyajima N, Kobune F, Tashiro M. Comparative nucleotide sequence analyses of the entire genomes of B95a cell-isolated and vero cell-isolated measles viruses from the same patient. Virus Genes. 2000;20:253-7 pubmed
    ..No nucleotide difference was found in the envelope H gene...

More Information

Publications41

  1. Centeno R, Fuji N, Okamoto M, Dapat C, Saito M, Tandoc A, et al. Genetic characterization of measles virus in the Philippines, 2008-2011. BMC Res Notes. 2015;8:211 pubmed publisher
    ..2008 to 2011 were analyzed by sequencing the C-terminal region of nucleocapsid (N) gene and partial hemagglutinin (H) gene and by inferring the phylogenetic trees...
  2. Xu Q, Zhang P, Hu C, Liu X, Qi Y, Liu Y. Identification of amino acid residues involved in the interaction between measles virus Haemagglutin (MVH) and its human cell receptor (signaling lymphocyte activation molecule, SLAM). J Biochem Mol Biol. 2006;39:406-11 pubmed
    ..At the same time, K58, S59 and H61 of SLAM was also identified to be critical for MVH and SLAM binding. Further, these residues may be useful targets for the development of measles therapy...
  3. Bellini W, Englund G, Richardson C, Rozenblatt S, Lazzarini R. Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences, and deduced amino acid sequences. J Virol. 1986;58:408-16 pubmed
    ..Giorgi, and D. Kolakofsky, J. Virol. 52:656-663; Y. Hidaka, T. Kanda, K. Iwasaki, A. Nomoto, T. Shioda, and H. Shibuta, Nucleic Acids Res...
  4. Tahara M, Ito Y, Brindley M, Ma X, He J, Xu S, et al. Functional and structural characterization of neutralizing epitopes of measles virus hemagglutinin protein. J Virol. 2013;87:666-75 pubmed publisher
    ..The hemagglutinin (H) protein, which binds to two discrete proteinaceous receptors, is the major neutralizing target...
  5. Navaratnarajah C, Rosemarie Q, Cattaneo R. A Structurally Unresolved Head Segment of Defined Length Favors Proper Measles Virus Hemagglutinin Tetramerization and Efficient Membrane Fusion Triggering. J Virol. 2016;90:68-75 pubmed publisher
    ..The MeV membrane fusion apparatus consists of a receptor binding protein (hemagglutinin [H]) tetramer and a fusion (F) protein trimer...
  6. Rima B, Duprex W. The measles virus replication cycle. Curr Top Microbiol Immunol. 2009;329:77-102 pubmed
  7. Tahara M, Ohno S, Sakai K, Ito Y, Fukuhara H, Komase K, et al. The receptor-binding site of the measles virus hemagglutinin protein itself constitutes a conserved neutralizing epitope. J Virol. 2013;87:3583-6 pubmed publisher
    Here, we provide direct evidence that the receptor-binding site of measles virus (MV) hemagglutinin protein itself forms an effective conserved neutralizing epitope (CNE). Several receptor-interacting residues constitute the CNE...
  8. Nakashima M, Shirogane Y, Hashiguchi T, Yanagi Y. Mutations in the putative dimer-dimer interfaces of the measles virus hemagglutinin head domain affect membrane fusion triggering. J Biol Chem. 2013;288:8085-91 pubmed publisher
    ..the cell through membrane fusion mediated by two viral envelope proteins, an attachment protein hemagglutinin (H) and a fusion (F) protein...
  9. Brindley M, Chaudhury S, Plemper R. Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion. J Virol. 2015;89:1230-41 pubmed publisher
    ..The attachment (H) protein mediates receptor binding, followed by triggering of the fusion (F) protein, which leads to merger of the ..
  10. Iwasa T, Suga S, Qi L, Komada Y. Apoptosis of human peripheral blood mononuclear cells by wild-type measles virus infection is induced by interaction of hemagglutinin protein and cellular receptor, SLAM via caspase-dependent pathway. Microbiol Immunol. 2010;54:405-16 pubmed publisher
    ..These data suggest that induction of apoptosis in MV-infected PBMC is triggered by interaction between hemagglutinin protein of MV and receptor, without other viral components...
  11. Navaratnarajah C, Negi S, Braun W, Cattaneo R. Membrane fusion triggering: three modules with different structure and function in the upper half of the measles virus attachment protein stalk. J Biol Chem. 2012;287:38543-51 pubmed publisher
    The measles virus (MV) fusion apparatus consists of a fusion protein and an attachment protein named hemagglutinin (H)...
  12. Wardrop E, Briedis D. Characterization of V protein in measles virus-infected cells. J Virol. 1991;65:3421-8 pubmed
    ..The protein was found to be phosphorylated and to be maximally synthesized at 16 h postinfection, when MV-specific structural protein synthesis was also maximal...
  13. Takeuchi K, Nagata N, Kato S, Ami Y, Suzaki Y, Suzuki T, et al. Wild-type measles virus with the hemagglutinin protein of the edmonston vaccine strain retains wild-type tropism in macaques. J Virol. 2012;86:3027-37 pubmed publisher
    ..in vitro is the wider cell specificity of vaccine strains, resulting from the receptor usage of the hemagglutinin (H) protein...
  14. Mateo M, Navaratnarajah C, Syed S, Cattaneo R. The measles virus hemagglutinin ?-propeller head ?4-?5 hydrophobic groove governs functional interactions with nectin-4 and CD46 but not those with the signaling lymphocytic activation molecule. J Virol. 2013;87:9208-16 pubmed publisher
    ..Recently solved cocrystal structures of the MV attachment protein (hemagglutinin [H]) with each receptor indicate that all three bind close to a hydrophobic groove located between blades 4 and 5 (?4-?..
  15. Ader N, Brindley M, Avila M, rvell C, Horvat B, Hiltensperger G, et al. Mechanism for active membrane fusion triggering by morbillivirus attachment protein. J Virol. 2013;87:314-26 pubmed publisher
    ..that tightly cooperate to achieve membrane fusion for cell entry: the tetrameric attachment protein (HN, H, or G, depending on the paramyxovirus genus) and the trimeric fusion protein (F)...
  16. Talekar A, Moscona A, Porotto M. Measles virus fusion machinery activated by sialic acid binding globular domain. J Virol. 2013;87:13619-27 pubmed publisher
    ..The MV receptor binding protein (hemagglutinin [H]) attaches to proteinaceous receptors on host cells, while the receptor binding protein of NDV (hemagglutinin-..
  17. Moeller Ehrlich K, Ludlow M, Beschorner R, Meyermann R, Rima B, Duprex W, et al. Two functionally linked amino acids in the stem 2 region of measles virus haemagglutinin determine infectivity and virulence in the rodent central nervous system. J Gen Virol. 2007;88:3112-20 pubmed publisher
    ..virus (MV) strains, such as CAM/RB and recombinant MVs based on the Edmonston strain containing the haemagglutinin (H) of CAM/RB, cause acute encephalitis after intracerebral infection of newborn rodents...
  18. Seki F, Takeda M, Minagawa H, Yanagi Y. Recombinant wild-type measles virus containing a single N481Y substitution in its haemagglutinin cannot use receptor CD46 as efficiently as that having the haemagglutinin of the Edmonston laboratory strain. J Gen Virol. 2006;87:1643-8 pubmed
    ..This may be a reason why few CD46-using MVs are detected in vivo. ..
  19. Navaratnarajah C, Oezguen N, Rupp L, Kay L, Leonard V, Braun W, et al. The heads of the measles virus attachment protein move to transmit the fusion-triggering signal. Nat Struct Mol Biol. 2011;18:128-34 pubmed publisher
    The measles virus entry system, consisting of attachment (hemagglutinin, H) and fusion proteins, operates by means of a variety of natural and targeted receptors; however, the mechanism that triggers fusion of the viral envelope with the ..
  20. Zhang X, Lu G, Qi J, Li Y, He Y, Xu X, et al. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. Nat Struct Mol Biol. 2013;20:67-72 pubmed publisher
    ..have been identified so far, and the structures of the first two in complex with measles virus hemagglutinin (MV-H) have been reported...
  21. Brindley M, Suter R, Schestak I, Kiss G, Wright E, Plemper R. A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion. J Virol. 2013;87:11693-703 pubmed publisher
    ..The measles virus (MeV) attachment (H) protein stalk domain is thought to directly engage F for fusion promotion...
  22. Mateo M, Navaratnarajah C, Willenbring R, Maroun J, Iankov I, Lopez M, et al. Different roles of the three loops forming the adhesive interface of nectin-4 in measles virus binding and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1. J Virol. 2014;88:14161-71 pubmed publisher
    ..the same key residues in the BC and FG loops of nectin-4 govern binding to the MeV attachment protein hemagglutinin (H) and cell entry, nectin-4 homodimerization, and heterodimerization with nectin-1...
  23. Zhou J, Du Z, Chang X. [Hemogglutinin gene and amino acid characteristic of measles virus in Jilin province, 2001-2008]. Zhongguo Yi Miao He Mian Yi. 2009;15:417-22 pubmed
    To study the genetic characteristic and amino acid mutation of hemogglutinin (H) protein of measles viruses circulated in Jilin provine in 2001-2008...
  24. Cattaneo R, Kaelin K, Baczko K, Billeter M. Measles virus editing provides an additional cysteine-rich protein. Cell. 1989;56:759-64 pubmed
    ..A smaller fraction of transcripts contain several additional G residues...
  25. Runkler N, Dietzel E, Moll M, Klenk H, Maisner A. Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes. J Gen Virol. 2008;89:687-96 pubmed publisher
    ..demonstrated the presence of tyrosine-dependent motifs for specific sorting of two measles virus (MV) glycoproteins, H and F, to the basolateral surface in polarized epithelial cells...
  26. Ennis M, Hu C, Naik S, Hallak L, Peng K, Russell S, et al. Mutations in the stalk region of the measles virus hemagglutinin inhibit syncytium formation but not virus entry. J Virol. 2010;84:10913-7 pubmed publisher
    Measles virus (MV) entry requires at least 2 viral proteins, the hemagglutinin (H) and fusion (F) proteins...
  27. Rasbach A, Abel T, Münch R, Boller K, Schneider Schaulies J, Buchholz C. The receptor attachment function of measles virus hemagglutinin can be replaced with an autonomous protein that binds Her2/neu while maintaining its fusion-helper function. J Virol. 2013;87:6246-56 pubmed publisher
    ..Measles virus (MV) attachment to its receptor is mediated by the hemagglutinin (H), which is thought to produce conformational changes in the membrane fusion protein (F) that trigger insertion of ..
  28. Santiago C, Gutiérrez Rodríguez A, Tucker P, Stehle T, Casasnovas J. Crystallization and preliminary crystallographic analysis of the measles virus hemagglutinin in complex with the CD46 receptor. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010;66:91-4 pubmed publisher
    The measles virus (MV) hemagglutinin (MV-H) mediates the attachment of MV particles to cell-surface receptors for entry into host cells...
  29. Apte Sengupta S, Navaratnarajah C, Cattaneo R. Hydrophobic and charged residues in the central segment of the measles virus hemagglutinin stalk mediate transmission of the fusion-triggering signal. J Virol. 2013;87:10401-4 pubmed publisher
    The pH-independent measles virus membrane fusion process begins when the attachment protein H binds to a receptor...
  30. Ader Ebert N, Khosravi M, Herren M, Avila M, Alves L, Bringolf F, et al. Sequential conformational changes in the morbillivirus attachment protein initiate the membrane fusion process. PLoS Pathog. 2015;11:e1004880 pubmed publisher
    ..The MeV and CDV cell entry system relies on two interacting envelope glycoproteins: the attachment protein (H), consisting of stalk and head domains, co-operates with the fusion protein (F) to mediate membrane fusion...
  31. Kimura H, Saitoh M, Kobayashi M, Ishii H, Saraya T, Kurai D, et al. Molecular evolution of haemagglutinin (H) gene in measles virus. Sci Rep. 2015;5:11648 pubmed publisher
    We studied the molecular evolution of the haemagglutinin (H) gene (full length) in all genotypes (24 genotypes, 297 strains) of measles virus (MeV)...
  32. Sato Y, Watanabe S, Fukuda Y, Hashiguchi T, Yanagi Y, Ohno S. Cell-to-Cell Measles Virus Spread between Human Neurons Is Dependent on Hemagglutinin and Hyperfusogenic Fusion Protein. J Virol. 2018;92: pubmed publisher
    ..The findings help us better understand the disease process of SSPE. ..