F

Summary

Gene Symbol: F
Description: type I transmembrane glycoprotein; synthesized as precurser peptide F0; cleaved to a disulphide linked F1-F2 complex by furin-like protease; acylated
Alias: type I transmembrane glycoprotein, synthesized as precurser peptide F0, cleaved to a disulphide linked F1-F2 complex by furin-like protease, acylated, fusion protein
Species: Measles virus
Products:     F

Top Publications

  1. Ghannam A, Hammache D, Matias C, Louwagie M, Garin J, Gerlier D. High-density rafts preferentially host the complement activator measles virus F glycoprotein but not the regulators of complement activation. Mol Immunol. 2008;45:3036-44 pubmed publisher
    ..Plumet, S., Gerlier, D., 2004. Cell surface activation of the alternative complement pathway by the fusion protein of measles virus. J. Gen. Virol. 85, 1665-1673]...
  2. Rima B, Duprex W. The measles virus replication cycle. Curr Top Microbiol Immunol. 2009;329:77-102 pubmed
  3. Runkler N, Dietzel E, Moll M, Klenk H, Maisner A. Glycoprotein targeting signals influence the distribution of measles virus envelope proteins and virus spread in lymphocytes. J Gen Virol. 2008;89:687-96 pubmed publisher
    ..the presence of tyrosine-dependent motifs for specific sorting of two measles virus (MV) glycoproteins, H and F, to the basolateral surface in polarized epithelial cells...
  4. Brindley M, Plattet P, Plemper R. Efficient replication of a paramyxovirus independent of full zippering of the fusion protein six-helix bundle domain. Proc Natl Acad Sci U S A. 2014;111:E3795-804 pubmed publisher
    ..Using a paramyxovirus fusion (F) protein, we tested this paradigm by engineering covalently restricted F proteins that are predicted to be unable to ..
  5. Ayata M, Shingai M, Ning X, Matsumoto M, Seya T, Otani S, et al. Effect of the alterations in the fusion protein of measles virus isolated from brains of patients with subacute sclerosing panencephalitis on syncytium formation. Virus Res. 2007;130:260-8 pubmed
    ..We report here on the effect of mutations in the fusion (F) proteins of three MV SSPE strains on syncytium formation...
  6. Xu S, Wu H, Zhu Z. [The genetic characteristics analysis of fusion gene of 13 strains measles viruses in China]. Zhongguo Yi Miao He Mian Yi. 2009;15:1-7 pubmed
    ..in China mainland during 1999-2003 had no sig-nificant vibration, and known important functional sites in Fusion protein didn't have deviation, it could be postulated that the structure and functions of F protein of wild Measles ..
  7. M hlebach M, Leonard V, Cattaneo R. The measles virus fusion protein transmembrane region modulates availability of an active glycoprotein complex and fusion efficiency. J Virol. 2008;82:11437-45 pubmed publisher
    ..In particular, the measles virus (MV) fusion (F) protein executes membrane fusion, after receptor binding by the hemagglutinin (H) protein...
  8. Watanabe S, Ohno S, Shirogane Y, Suzuki S, Koga R, Yanagi Y. Measles virus mutants possessing the fusion protein with enhanced fusion activity spread effectively in neuronal cells, but not in other cells, without causing strong cytopathology. J Virol. 2015;89:2710-7 pubmed publisher
    ..Recently, we have reported that enhanced fusion activity of MV through the mutations in its fusion protein is a major determinant of efficient virus spread in human neuronal cells and brains of suckling hamsters...
  9. Brindley M, Chaudhury S, Plemper R. Measles virus glycoprotein complexes preassemble intracellularly and relax during transport to the cell surface in preparation for fusion. J Virol. 2015;89:1230-41 pubmed publisher
    ..The attachment (H) protein mediates receptor binding, followed by triggering of the fusion (F) protein, which leads to merger of the viral envelope with target cell membranes...

More Information

Publications25

  1. Paal T, Brindley M, St Clair C, Prussia A, Gaus D, Krumm S, et al. Probing the spatial organization of measles virus fusion complexes. J Virol. 2009;83:10480-93 pubmed publisher
    The spatial organization of metastable paramyxovirus fusion (F) and attachment glycoprotein hetero-oligomers is largely unknown...
  2. Wardrop E, Briedis D. Characterization of V protein in measles virus-infected cells. J Virol. 1991;65:3421-8 pubmed
  3. Bellini W, Englund G, Rozenblatt S, Arnheiter H, Richardson C. Measles virus P gene codes for two proteins. J Virol. 1985;53:908-19 pubmed
    ..Using immunofluorescent microscopy, we localized the C protein in the nucleus and in cytoplasmic inclusions within the infected cells...
  4. Sato Y, Watanabe S, Fukuda Y, Hashiguchi T, Yanagi Y, Ohno S. Cell-to-Cell Measles Virus Spread between Human Neurons Is Dependent on Hemagglutinin and Hyperfusogenic Fusion Protein. J Virol. 2018;92: pubmed publisher
    ..We have previously shown that fusion-enhancing substitutions in the fusion protein of MVs isolated from SSPE patients contribute to MV spread in neurons...
  5. Pohl C, Duprex W, Krohne G, Rima B, Schneider Schaulies S. Measles virus M and F proteins associate with detergent-resistant membrane fractions and promote formation of virus-like particles. J Gen Virol. 2007;88:1243-50 pubmed publisher
    ..found to co-float with detergent-resistant membrane fractions (DRM) and this was enhanced upon co-expression of the F protein...
  6. Doyle J, Prussia A, White L, Sun A, Liotta D, Snyder J, et al. Two domains that control prefusion stability and transport competence of the measles virus fusion protein. J Virol. 2006;80:1524-36 pubmed
    ..confirmed in transient assays and in the context of recombinant virions and were in all cases located in the fusion protein. Several mutations emerged independently at F position 462, which is located in the C-terminal heptad repeat (..
  7. Navaratnarajah C, Leonard V, Cattaneo R. Measles virus glycoprotein complex assembly, receptor attachment, and cell entry. Curr Top Microbiol Immunol. 2009;329:59-76 pubmed
    ..Two glycoproteins mediate this process: the hemagglutinin (H) and fusion (F) proteins. The H-protein binds to receptors, while the F-protein mediates fusion of the viral and cellular membranes...
  8. Jurgens E, Mathieu C, Palermo L, Hardie D, Horvat B, Moscona A, et al. Measles fusion machinery is dysregulated in neuropathogenic variants. MBio. 2015;6: pubmed publisher
    ..actions of the two viral envelope glycoproteins, the receptor binding protein (hemagglutinin [H]) and the fusion (F) protein...
  9. Ader N, Brindley M, Avila M, rvell C, Horvat B, Hiltensperger G, et al. Mechanism for active membrane fusion triggering by morbillivirus attachment protein. J Virol. 2013;87:314-26 pubmed publisher
    ..entry: the tetrameric attachment protein (HN, H, or G, depending on the paramyxovirus genus) and the trimeric fusion protein (F)...
  10. Takeuchi K, Miyajima N, Kobune F, Tashiro M. Comparative nucleotide sequence analyses of the entire genomes of B95a cell-isolated and vero cell-isolated measles viruses from the same patient. Virus Genes. 2000;20:253-7 pubmed
    ..These results indicated that nucleotide difference(s) in the P/V/C or/and M gene, and not H gene, was responsible for the different cell tropism and pathogenicity of MV in this case...
  11. Wu H, Xu S, Zhou J. [The genetic characteristic analysis of fusion gene measles wild viruses of China in 2006]. Zhongguo Yi Miao He Mian Yi. 2009;15:211-4 pubmed
    ..genetic diversity was not predominance comparing with strains of 1999-2003, and important functional sites in Fusion protein didn't change, the measles epidemic was not correlate with the F gene variation...
  12. Bolt G. The measles virus (MV) glycoproteins interact with cellular chaperones in the endoplasmic reticulum and MV infection upregulates chaperone expression. Arch Virol. 2001;146:2055-68 pubmed
    ..Both the haemagglutinin (H) and fusion (F) glycoproteins interacted with calnexin and GRP78, whereas interaction with calreticulin was only demonstrated for ..
  13. Brindley M, Suter R, Schestak I, Kiss G, Wright E, Plemper R. A stabilized headless measles virus attachment protein stalk efficiently triggers membrane fusion. J Virol. 2013;87:11693-703 pubmed publisher
    Paramyxovirus attachment and fusion (F) envelope glycoprotein complexes mediate membrane fusion required for viral entry. The measles virus (MeV) attachment (H) protein stalk domain is thought to directly engage F for fusion promotion...
  14. Cattaneo R, Kaelin K, Baczko K, Billeter M. Measles virus editing provides an additional cysteine-rich protein. Cell. 1989;56:759-64 pubmed
    ..A smaller fraction of transcripts contain several additional G residues...
  15. Satoh Y, Hirose M, Shogaki H, Wakimoto H, Kitagawa Y, Gotoh B, et al. Intramolecular complementation of measles virus fusion protein stability confers cell-cell fusion activity at 37 °C. FEBS Lett. 2015;589:152-8 pubmed publisher
    The fusion (F) protein of measles virus mediates membrane fusion. In this study, we investigated the molecular basis of the cell-cell fusion activity of the F protein...
  16. Bellini W, Englund G, Richardson C, Rozenblatt S, Lazzarini R. Matrix genes of measles virus and canine distemper virus: cloning, nucleotide sequences, and deduced amino acid sequences. J Virol. 1986;58:408-16 pubmed
    ..Secondary-structure analyses of this shared region indicated a structurally conserved, hydrophobic sequence which possibly interacted with the lipid bilayer. ..