Gene Symbol: ospC
Description: outer membrane lipoprotein
Alias: outer membrane lipoprotein, OspC
Species: Lyme disease spirochete
Rhodes D, Earnhart C, Mather T, Meeus P, Marconi R. Identification of Borrelia burgdorferi ospC genotypes in canine tissue following tick infestation: implications for Lyme disease vaccine and diagnostic assay design. Vet J. 2013;198:412-8 pubmed publisher
..6%. The outer surface protein C (OspC) of Lyme disease spirochetes is an important virulence factor required for the establishment of infection in ..
Norek A, Janda L. Epitope mapping of Borrelia burgdorferi OspC protein in homodimeric fold. Protein Sci. 2017;26:796-806 pubmed publisher
In current work, we used recombinant OspC protein derived from B...
Tilly K, Bestor A, Rosa P. Lipoprotein succession in Borrelia burgdorferi: similar but distinct roles for OspC and VlsE at different stages of mammalian infection. Mol Microbiol. 2013;89:216-27 pubmed publisher
..These adaptations include shifting among the major outer surface lipoproteins OspA, OspC, and VlsE at different stages of the infectious cycle...
Stanek G, Lusa L, Ogrinc K, Markowicz M, Strle F. Intrathecally produced IgG and IgM antibodies to recombinant VlsE, VlsE peptide, recombinant OspC and whole cell extracts in the diagnosis of Lyme neuroborreliosis. Med Microbiol Immunol. 2014;203:125-32 pubmed publisher
..The highest sensitivity and specificity were achieved by the antibody detection assay using VlsE IR6 peptide. Detection of IgM-AI yielded heterogenous results and did not support the laboratory diagnosis of LNB. ..
Carrasco S, Troxell B, Yang Y, Brandt S, Li H, Sandusky G, et al
. Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages. Infect Immun. 2015;83:4848-60 pubmed publisher
Outer surface protein C (OspC) is one of the major lipoproteins expressed on the surface of Borrelia burgdorferi during tick feeding and the early phase of mammalian infection. OspC is required for B...
Tilly K, Bestor A, Rosa P. Functional Equivalence of OspA and OspB, but Not OspC, in Tick Colonization by Borrelia burgdorferi. Infect Immun. 2016;84:1565-1573 pubmed publisher
..burgdorferi in which the ospA open reading frame, on lp54, was replaced with the ospC gene or the ospB gene, encoding a mammal-specific or tick-specific lipoprotein, respectively...