Genomes and Genes
Gene Symbol: inlA
Description: internalin A
Species: Listeria monocytogenes EGD-e
- Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherinWolf Dieter Schubert
Department of Structural Biology, German Research Center for Biotechnology GBF, Mascheroder Weg 1, D 38124, Braunschweig, Germany
Cell 111:825-36. 2002..The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction ..
- Conjugated action of two species-specific invasion proteins for fetoplacental listeriosisOlivier Disson
Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
Nature 455:1114-8. 2008..Several studies have helped to characterize the bacterial invasion proteins InlA and InlB. However, their respective species specificity has complicated investigations on their in vivo role...
- Thermodynamically reengineering the listerial invasion complex InlA/E-cadherinThomas Wollert
Molecular Host Pathogen Interactions, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
Proc Natl Acad Sci U S A 104:13960-5. 2007..Based on the crystal structure of the bacterial invasion protein internalin (InlA) of Listeria monocytogenes in complex with its human receptor E-cadherin (hEC1), we analyzed the interface to ..
- Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocciJ L Gaillard
Laboratoire de Microbiologie, Faculte de Medecine Necker Enfants Malades, Paris, France
Cell 65:1127-41. 1991We report the identification of a previously unknown gene, inlA, which is necessary for the gram-positive intracellular pathogen Listeria monocytogenes to invade cultured epithelial cells...
- The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrierTim Gründler
Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
Microbes Infect 15:291-301. 2013..has to invade and cross diverse cellular barriers involving the functions of the surface proteins Internalin (InlA) and InlB...
- Low potential virulence associated with mutations in the inlA and prfA genes in Listeria monocytogenes isolated from raw retail poultry meatVictoria Lopez
Departamento de Tecnologia de Alimentos, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Autopista A 6 km 7 5, 28040 Madrid, Spain
J Food Prot 76:129-32. 2013..monocytogenes subtypes as defined by pulsed-field gel electrophoresis and sequencing of virulence genes actA and inlA. Two of the subtypes accounted for 51% of the isolates...
- Select Listeria monocytogenes subtypes commonly found in foods carry distinct nonsense mutations in inlA, leading to expression of truncated and secreted internalin A, and are associated with a reduced invasion phenotype for human intestinal epithelial ceK K Nightingale
Cornell University, Department of Food Science, 412 Stocking Hall, Ithaca, NY 14853
Appl Environ Microbiol 71:8764-72. 2005The surface protein internalin A (InlA) contributes to the invasion of human intestinal epithelial cells by Listeria monocytogenes. Screening of L...
- Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection modelIan R Monk
Alimentary Pharmabiotic Centre and Department of Microbiology, University College Cork, Western Road, Cork, Ireland
BMC Microbiol 10:318. 2010Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts...
- Listeria monocytogenes internalin and E-cadherin: from bench to bedsideMatteo Bonazzi
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
Cold Spring Harb Perspect Biol 1:a003087. 2009..To invade host cells, Listeria uses two proteins, InlA and InlB, which have specific receptors on the host-cell surface, E-cadherin and Met, respectively...
- Expression of internalin A and biofilm formation among Listeria monocytogenes clinical isolatesG Franciosa
Department of Food Safety and Veterinary Public Health, Unit of Microorganisms and Food Technologies, Istituto Superiore di Sanita, Rome, Italy
Int J Immunopathol Pharmacol 22:183-93. 2009Internalin A (InlA), a cell wall-bound protein of Listeria monocytogenes, is among the major components involved in the adhesion to and invasion of host cells expressing specific forms of E-cadherin. Some L...
- Birth-and-death evolution of the internalin multigene family in ListeriaAlejandro P Rooney
National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, 1815 N University Street, Peoria, IL 61604, USA
Gene 427:124-8. 2008....
- Nonsense-mutated inlA and prfA not widely distributed in Listeria monocytogenes isolates from ready-to-eat seafood products in JapanSatoko Handa-Miya
Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Japan
Int J Food Microbiol 117:312-8. 2007b>InlA is a surface protein participating in the entry of Listeria monocytogenes into mammalian non-phagocytic cells. PrfA is a positive regulatory factor that regulates the expression of a set of virulence genes...
- Differential inlA and inlB expression and interaction with human intestinal and liver cells by Listeria monocytogenes strains of different originsHadewig Werbrouck
Institute for Agricultural and Fisheries Research, Unit Technology and Food Product Quality and Food Safety, Brusselsesteenweg 370, 9090 Melle, Belgium
Appl Environ Microbiol 72:3862-71. 2006..This observation led us to study the mRNA expression levels of inlA, inlB, and ami, important virulence genes mediating adhesion and invasion of eukaryotic cells, by real-time reverse ..
- Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysisM Graciela Pucciarelli
Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas CSIC, 28049 Madrid, Spain
Proteomics 5:4808-17. 2005..Taken together, these data demonstrate that non-gel proteomics is a powerful technique to rapidly identify sortase substrates and to gain insights on potential sorting motifs...
- Truncated internalin A and asymptomatic Listeria monocytogenes carriage: in vivo investigation by allelic exchangeMaiwenn Olier
Laboratoire de Microbiologie, UMR INRA 1232, Universite de Bourgogne, 1 Esplanade Erasme, 21000 Dijon, France
Infect Immun 73:644-8. 2005Allelic exchange of the region coding for the C terminus of InlA between one epidemic (with an 80-kDa InlA) and one asymptomatic (with a 47-kDa InlA) carriage Listeria monocytogenes strain confirmed the need for this region for internalin ..
- Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastricallyTerri S Hamrick
College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
Infect Immun 71:5202-9. 2003....
- Rational design of DNA sequence-based strategies for subtyping Listeria monocytogenesSteven Cai
Department of Food Science, Cornell University, Ithaca, New York 14853, USA
J Clin Microbiol 40:3319-25. 2002..Two housekeeping genes (recA and prs), one stress response gene (sigB), two virulence genes (actA and inlA), and two intergenic regions (hly-mpl and plcA-hly) were sequenced for 15 L. monocytogenes isolates...
- Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulenceHelene Bierne
Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
Mol Microbiol 43:869-81. 2002..Inactivation of srtA abolishes anchoring of the invasion protein InlA to the bacterial surface...
- Anchor structure of cell wall surface proteins in Listeria monocytogenesG Dhar
Departments of Microbiology and Immunology and of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
Biochemistry 39:3725-33. 2000..A methionine and six histidines (MH(6)) were inserted upstream of the LPXTG motif of internalin A (InlA), a cell-wall-anchored surface protein of L. monocytogenes...
- Identification and characterization of nucleotide sequence differences in three virulence-associated genes of listeria monocytogenes strains representing clinically important serotypesA Vines
Department of Biology, Clark Atlanta University, Atlanta, GA 30314, USA
Curr Microbiol 36:309-18. 1998..genes (hly encoding listeriolysin, plcA encoding phosphotidylinositol-specific phospholipase C, and inlA encoding internalin) of two serotype 4b and two serotype 1/2b strains...
- Common features of gram-positive bacterial proteins involved in cell recognitionS Dramsi
Mol Microbiol 9:1119-21. 1993
- L. MONOCYTOGENES CLONAL GROUPS: ECOLOGY AND TRANSMISSIONMartin Wiedmann; Fiscal Year: 2004..4. Determine the phenotypes of L. monocytogenes clonal groups associated with specific environments and hosts and determine the genetic basis for phenotypes associated with a preference for specific habitats...