inlA

Summary

Gene Symbol: inlA
Description: internalin A
Species: Listeria monocytogenes EGD-e

Top Publications

  1. ncbi Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin
    Wolf Dieter Schubert
    Department of Structural Biology, German Research Center for Biotechnology GBF, Mascheroder Weg 1, D 38124, Braunschweig, Germany
    Cell 111:825-36. 2002
  2. doi Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Olivier Disson
    Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 455:1114-8. 2008
  3. pmc Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin
    Thomas Wollert
    Molecular Host Pathogen Interactions, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Proc Natl Acad Sci U S A 104:13960-5. 2007
  4. ncbi Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci
    J L Gaillard
    Laboratoire de Microbiologie, Faculte de Medecine Necker Enfants Malades, Paris, France
    Cell 65:1127-41. 1991
  5. doi The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrier
    Tim Gründler
    Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Microbes Infect 15:291-301. 2013
  6. doi Low potential virulence associated with mutations in the inlA and prfA genes in Listeria monocytogenes isolated from raw retail poultry meat
    Victoria Lopez
    Departamento de Tecnologia de Alimentos, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Autopista A 6 km 7 5, 28040 Madrid, Spain
    J Food Prot 76:129-32. 2013
  7. pmc Select Listeria monocytogenes subtypes commonly found in foods carry distinct nonsense mutations in inlA, leading to expression of truncated and secreted internalin A, and are associated with a reduced invasion phenotype for human intestinal epithelial ce
    K K Nightingale
    Cornell University, Department of Food Science, 412 Stocking Hall, Ithaca, NY 14853
    Appl Environ Microbiol 71:8764-72. 2005
  8. pmc Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model
    Ian R Monk
    Alimentary Pharmabiotic Centre and Department of Microbiology, University College Cork, Western Road, Cork, Ireland
    BMC Microbiol 10:318. 2010
  9. pmc Listeria monocytogenes internalin and E-cadherin: from bench to bedside
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
    Cold Spring Harb Perspect Biol 1:a003087. 2009
  10. ncbi Expression of internalin A and biofilm formation among Listeria monocytogenes clinical isolates
    G Franciosa
    Department of Food Safety and Veterinary Public Health, Unit of Microorganisms and Food Technologies, Istituto Superiore di Sanita, Rome, Italy
    Int J Immunopathol Pharmacol 22:183-93. 2009

Research Grants

Scientific Experts

  • M Wiedmann
  • Hadewig Werbrouck
  • G Franciosa
  • Alejandro P Rooney
  • Pascale Cossart
  • Victoria Lopez
  • Tim Gründler
  • M Graciela Pucciarelli
  • Wolf Dieter Schubert
  • Ian R Monk
  • Helene Bierne
  • Matteo Bonazzi
  • Marc Lecuit
  • Olivier Disson
  • Satoko Handa-Miya
  • Thomas Wollert
  • Maiwenn Olier
  • K K Nightingale
  • Dirk W Heinz
  • Francisco Garcia-del Portillo
  • Terri S Hamrick
  • Steven Cai
  • Veronique Orian-Rousseau
  • Tobias Tenenbaum
  • Carolin Stump
  • Joaquin V Martinez-Suarez
  • Hiroshi Ishikawa
  • Christian Schwerk
  • Jaime Navas
  • Hartwig Wolburg
  • Horst Schroten
  • Natascha Quednau
  • Pat G Casey
  • Cormac G M Gahan
  • G Dhar
  • Colin Hill
  • Alban Le Monnier
  • Olivier Dussurget
  • Georgios Nikitas
  • Charles Babinet
  • Francina Langa-Vives
  • Marie Ragon
  • Solène Grayo
  • Eugénie Huillet
  • Kazunori Igarashi
  • Bon Kimura
  • Tateo Fujii
  • Miki Sato
  • Tatsuya Ishikawa
  • Hajime Takahashi
  • A Vines
  • Christophe Sabet
  • Dominique Garmyn
  • K Windham
  • Jean Paul Lemaitre
  • Enrique Calvo
  • Pascal Piveteau
  • K E Martin
  • Sandrine Rousseaux
  • Jean Guzzo
  • M Yeung
  • Ida W Smoak
  • Edward A Havell
  • John R Horton
  • Paul E Orndorff
  • Patricia A Spears
  • Viola Beier
  • Sarkis K Mazmanian
  • Trinad Chakraborty
  • Matthias P Machner
  • Lothar Jänsch
  • Dirce Yorika Kabuki
  • Thilo Ziehm
  • Olaf Schneewind
  • Matthias Trost
  • Gwen Liu
  • Michael S Chung
  • Arnaldo Yoshiteru Kuaye
  • Rasmus Nielsen
  • Theresa Gina Cargioli
  • Pierre Dehoux
  • Claus Urbanke
  • Eugen Domann
  • Jurgen Wehland
  • K F Faull
  • O Schneewind
  • B Swaminathan
  • S Dramsi
  • P Cossart
  • P Dehoux

Detail Information

Publications21

  1. ncbi Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin
    Wolf Dieter Schubert
    Department of Structural Biology, German Research Center for Biotechnology GBF, Mascheroder Weg 1, D 38124, Braunschweig, Germany
    Cell 111:825-36. 2002
    ..The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction ..
  2. doi Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Olivier Disson
    Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 455:1114-8. 2008
    ..Several studies have helped to characterize the bacterial invasion proteins InlA and InlB. However, their respective species specificity has complicated investigations on their in vivo role...
  3. pmc Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin
    Thomas Wollert
    Molecular Host Pathogen Interactions, Helmholtz Centre for Infection Research, Inhoffenstrasse 7, D 38124 Braunschweig, Germany
    Proc Natl Acad Sci U S A 104:13960-5. 2007
    ..Based on the crystal structure of the bacterial invasion protein internalin (InlA) of Listeria monocytogenes in complex with its human receptor E-cadherin (hEC1), we analyzed the interface to ..
  4. ncbi Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci
    J L Gaillard
    Laboratoire de Microbiologie, Faculte de Medecine Necker Enfants Malades, Paris, France
    Cell 65:1127-41. 1991
    We report the identification of a previously unknown gene, inlA, which is necessary for the gram-positive intracellular pathogen Listeria monocytogenes to invade cultured epithelial cells...
  5. doi The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrier
    Tim Gründler
    Pediatric Infectious Diseases, Department of Pediatrics, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, D 68167 Mannheim, Germany
    Microbes Infect 15:291-301. 2013
    ..has to invade and cross diverse cellular barriers involving the functions of the surface proteins Internalin (InlA) and InlB...
  6. doi Low potential virulence associated with mutations in the inlA and prfA genes in Listeria monocytogenes isolated from raw retail poultry meat
    Victoria Lopez
    Departamento de Tecnologia de Alimentos, Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria INIA, Autopista A 6 km 7 5, 28040 Madrid, Spain
    J Food Prot 76:129-32. 2013
    ..monocytogenes subtypes as defined by pulsed-field gel electrophoresis and sequencing of virulence genes actA and inlA. Two of the subtypes accounted for 51% of the isolates...
  7. pmc Select Listeria monocytogenes subtypes commonly found in foods carry distinct nonsense mutations in inlA, leading to expression of truncated and secreted internalin A, and are associated with a reduced invasion phenotype for human intestinal epithelial ce
    K K Nightingale
    Cornell University, Department of Food Science, 412 Stocking Hall, Ithaca, NY 14853
    Appl Environ Microbiol 71:8764-72. 2005
    The surface protein internalin A (InlA) contributes to the invasion of human intestinal epithelial cells by Listeria monocytogenes. Screening of L...
  8. pmc Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model
    Ian R Monk
    Alimentary Pharmabiotic Centre and Department of Microbiology, University College Cork, Western Road, Cork, Ireland
    BMC Microbiol 10:318. 2010
    Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts...
  9. pmc Listeria monocytogenes internalin and E-cadherin: from bench to bedside
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
    Cold Spring Harb Perspect Biol 1:a003087. 2009
    ..To invade host cells, Listeria uses two proteins, InlA and InlB, which have specific receptors on the host-cell surface, E-cadherin and Met, respectively...
  10. ncbi Expression of internalin A and biofilm formation among Listeria monocytogenes clinical isolates
    G Franciosa
    Department of Food Safety and Veterinary Public Health, Unit of Microorganisms and Food Technologies, Istituto Superiore di Sanita, Rome, Italy
    Int J Immunopathol Pharmacol 22:183-93. 2009
    Internalin A (InlA), a cell wall-bound protein of Listeria monocytogenes, is among the major components involved in the adhesion to and invasion of host cells expressing specific forms of E-cadherin. Some L...
  11. doi Birth-and-death evolution of the internalin multigene family in Listeria
    Alejandro P Rooney
    National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, 1815 N University Street, Peoria, IL 61604, USA
    Gene 427:124-8. 2008
    ....
  12. ncbi Nonsense-mutated inlA and prfA not widely distributed in Listeria monocytogenes isolates from ready-to-eat seafood products in Japan
    Satoko Handa-Miya
    Department of Food Science and Technology, Tokyo University of Marine Science and Technology, Japan
    Int J Food Microbiol 117:312-8. 2007
    b>InlA is a surface protein participating in the entry of Listeria monocytogenes into mammalian non-phagocytic cells. PrfA is a positive regulatory factor that regulates the expression of a set of virulence genes...
  13. pmc Differential inlA and inlB expression and interaction with human intestinal and liver cells by Listeria monocytogenes strains of different origins
    Hadewig Werbrouck
    Institute for Agricultural and Fisheries Research, Unit Technology and Food Product Quality and Food Safety, Brusselsesteenweg 370, 9090 Melle, Belgium
    Appl Environ Microbiol 72:3862-71. 2006
    ..This observation led us to study the mRNA expression levels of inlA, inlB, and ami, important virulence genes mediating adhesion and invasion of eukaryotic cells, by real-time reverse ..
  14. ncbi Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis
    M Graciela Pucciarelli
    Departamento de Biotecnologia Microbiana, Centro Nacional de Biotecnologia Consejo Superior de Investigaciones Cientificas CSIC, 28049 Madrid, Spain
    Proteomics 5:4808-17. 2005
    ..Taken together, these data demonstrate that non-gel proteomics is a powerful technique to rapidly identify sortase substrates and to gain insights on potential sorting motifs...
  15. pmc Truncated internalin A and asymptomatic Listeria monocytogenes carriage: in vivo investigation by allelic exchange
    Maiwenn Olier
    Laboratoire de Microbiologie, UMR INRA 1232, Universite de Bourgogne, 1 Esplanade Erasme, 21000 Dijon, France
    Infect Immun 73:644-8. 2005
    Allelic exchange of the region coding for the C terminus of InlA between one epidemic (with an 80-kDa InlA) and one asymptomatic (with a 47-kDa InlA) carriage Listeria monocytogenes strain confirmed the need for this region for internalin ..
  16. pmc Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically
    Terri S Hamrick
    College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Infect Immun 71:5202-9. 2003
    ....
  17. pmc Rational design of DNA sequence-based strategies for subtyping Listeria monocytogenes
    Steven Cai
    Department of Food Science, Cornell University, Ithaca, New York 14853, USA
    J Clin Microbiol 40:3319-25. 2002
    ..Two housekeeping genes (recA and prs), one stress response gene (sigB), two virulence genes (actA and inlA), and two intergenic regions (hly-mpl and plcA-hly) were sequenced for 15 L. monocytogenes isolates...
  18. ncbi Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
    Helene Bierne
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 43:869-81. 2002
    ..Inactivation of srtA abolishes anchoring of the invasion protein InlA to the bacterial surface...
  19. ncbi Anchor structure of cell wall surface proteins in Listeria monocytogenes
    G Dhar
    Departments of Microbiology and Immunology and of Psychiatry and Biobehavioral Sciences, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    Biochemistry 39:3725-33. 2000
    ..A methionine and six histidines (MH(6)) were inserted upstream of the LPXTG motif of internalin A (InlA), a cell-wall-anchored surface protein of L. monocytogenes...
  20. ncbi Identification and characterization of nucleotide sequence differences in three virulence-associated genes of listeria monocytogenes strains representing clinically important serotypes
    A Vines
    Department of Biology, Clark Atlanta University, Atlanta, GA 30314, USA
    Curr Microbiol 36:309-18. 1998
    ..genes (hly encoding listeriolysin, plcA encoding phosphotidylinositol-specific phospholipase C, and inlA encoding internalin) of two serotype 4b and two serotype 1/2b strains...
  21. ncbi Common features of gram-positive bacterial proteins involved in cell recognition
    S Dramsi
    Mol Microbiol 9:1119-21. 1993

Research Grants1

  1. L. MONOCYTOGENES CLONAL GROUPS: ECOLOGY AND TRANSMISSION
    Martin Wiedmann; Fiscal Year: 2004
    ..4. Determine the phenotypes of L. monocytogenes clonal groups associated with specific environments and hosts and determine the genetic basis for phenotypes associated with a preference for specific habitats...