Gene Symbol: inlA
Description: internalin A
Species: Listeria monocytogenes EGD-e

Top Publications

  1. Gaillard J, Berche P, Frehel C, Gouin E, Cossart P. Entry of L. monocytogenes into cells is mediated by internalin, a repeat protein reminiscent of surface antigens from gram-positive cocci. Cell. 1991;65:1127-41 pubmed
    We report the identification of a previously unknown gene, inlA, which is necessary for the gram-positive intracellular pathogen Listeria monocytogenes to invade cultured epithelial cells...
  2. Disson O, Grayo S, Huillet E, Nikitas G, Langa Vives F, Dussurget O, et al. Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis. Nature. 2008;455:1114-8 pubmed publisher
    ..Several studies have helped to characterize the bacterial invasion proteins InlA and InlB. However, their respective species specificity has complicated investigations on their in vivo role...
  3. Schubert W, Urbanke C, Ziehm T, Beier V, Machner M, Domann E, et al. Structure of internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-cadherin. Cell. 2002;111:825-36 pubmed
    ..The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction ..
  4. Wollert T, Heinz D, Schubert W. Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin. Proc Natl Acad Sci U S A. 2007;104:13960-5 pubmed
    ..Based on the crystal structure of the bacterial invasion protein internalin (InlA) of Listeria monocytogenes in complex with its human receptor E-cadherin (hEC1), we analyzed the interface to ..
  5. Vines A, Swaminathan B. Identification and characterization of nucleotide sequence differences in three virulence-associated genes of listeria monocytogenes strains representing clinically important serotypes. Curr Microbiol. 1998;36:309-18 pubmed
    ..genes (hly encoding listeriolysin, plcA encoding phosphotidylinositol-specific phospholipase C, and inlA encoding internalin) of two serotype 4b and two serotype 1/2b strains...
  6. Bierne H, Mazmanian S, Trost M, Pucciarelli M, Liu G, Dehoux P, et al. Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence. Mol Microbiol. 2002;43:869-81 pubmed
    ..Inactivation of srtA abolishes anchoring of the invasion protein InlA to the bacterial surface...
  7. Dramsi S, Dehoux P, Cossart P. Common features of gram-positive bacterial proteins involved in cell recognition. Mol Microbiol. 1993;9:1119-21 pubmed
  8. Gr ndler T, Quednau N, Stump C, Orian Rousseau V, Ishikawa H, Wolburg H, et al. The surface proteins InlA and InlB are interdependently required for polar basolateral invasion by Listeria monocytogenes in a human model of the blood-cerebrospinal fluid barrier. Microbes Infect. 2013;15:291-301 pubmed publisher
    ..has to invade and cross diverse cellular barriers involving the functions of the surface proteins Internalin (InlA) and InlB...
  9. Pucciarelli M, Calvo E, Sabet C, Bierne H, Cossart P, Garc a del Portillo F. Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis. Proteomics. 2005;5:4808-17 pubmed publisher
    ..Taken together, these data demonstrate that non-gel proteomics is a powerful technique to rapidly identify sortase substrates and to gain insights on potential sorting motifs...

More Information


  1. Nightingale K, Windham K, Martin K, Yeung M, Wiedmann M. Select Listeria monocytogenes subtypes commonly found in foods carry distinct nonsense mutations in inlA, leading to expression of truncated and secreted internalin A, and are associated with a reduced invasion phenotype for human intestinal epitheli. Appl Environ Microbiol. 2005;71:8764-72 pubmed publisher
    The surface protein internalin A (InlA) contributes to the invasion of human intestinal epithelial cells by Listeria monocytogenes. Screening of L...
  2. Hamrick T, Horton J, Spears P, Havell E, Smoak I, Orndorff P. Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically. Infect Immun. 2003;71:5202-9 pubmed
  3. Cai S, Kabuki D, Kuaye A, Cargioli T, Chung M, Nielsen R, et al. Rational design of DNA sequence-based strategies for subtyping Listeria monocytogenes. J Clin Microbiol. 2002;40:3319-25 pubmed
    ..Two housekeeping genes (recA and prs), one stress response gene (sigB), two virulence genes (actA and inlA), and two intergenic regions (hly-mpl and plcA-hly) were sequenced for 15 L. monocytogenes isolates...
  4. Werbrouck H, Grijspeerdt K, Botteldoorn N, Van Pamel E, Rijpens N, Van Damme J, et al. Differential inlA and inlB expression and interaction with human intestinal and liver cells by Listeria monocytogenes strains of different origins. Appl Environ Microbiol. 2006;72:3862-71 pubmed publisher
    ..This observation led us to study the mRNA expression levels of inlA, inlB, and ami, important virulence genes mediating adhesion and invasion of eukaryotic cells, by real-time reverse ..
  5. Franciosa G, Maugliani A, Scalfaro C, Floridi F, Aureli P. Expression of internalin A and biofilm formation among Listeria monocytogenes clinical isolates. Int J Immunopathol Pharmacol. 2009;22:183-93 pubmed
    Internalin A (InlA), a cell wall-bound protein of Listeria monocytogenes, is among the major components involved in the adhesion to and invasion of host cells expressing specific forms of E-cadherin. Some L...
  6. Bonazzi M, Lecuit M, Cossart P. Listeria monocytogenes internalin and E-cadherin: from bench to bedside. Cold Spring Harb Perspect Biol. 2009;1:a003087 pubmed publisher
    ..To invade host cells, Listeria uses two proteins, InlA and InlB, which have specific receptors on the host-cell surface, E-cadherin and Met, respectively...
  7. Olier M, Garmyn D, Rousseaux S, Lema tre J, Piveteau P, Guzzo J. Truncated internalin A and asymptomatic Listeria monocytogenes carriage: in vivo investigation by allelic exchange. Infect Immun. 2005;73:644-8 pubmed publisher
    Allelic exchange of the region coding for the C terminus of InlA between one epidemic (with an 80-kDa InlA) and one asymptomatic (with a 47-kDa InlA) carriage Listeria monocytogenes strain confirmed the need for this region for internalin ..
  8. Handa Miya S, Kimura B, Takahashi H, Sato M, Ishikawa T, Igarashi K, et al. Nonsense-mutated inlA and prfA not widely distributed in Listeria monocytogenes isolates from ready-to-eat seafood products in Japan. Int J Food Microbiol. 2007;117:312-8 pubmed publisher
    b>InlA is a surface protein participating in the entry of Listeria monocytogenes into mammalian non-phagocytic cells. PrfA is a positive regulatory factor that regulates the expression of a set of virulence genes...
  9. Monk I, Casey P, Hill C, Gahan C. Directed evolution and targeted mutagenesis to murinize Listeria monocytogenes internalin A for enhanced infectivity in the murine oral infection model. BMC Microbiol. 2010;10:318 pubmed publisher
    Internalin A (InlA) is a critical virulence factor which mediates the initiation of Listeria monocytogenes infection by the oral route in permissive hosts...
  10. Lopez V, Navas J, Martínez Suárez J. Low potential virulence associated with mutations in the inlA and prfA genes in Listeria monocytogenes isolated from raw retail poultry meat. J Food Prot. 2013;76:129-32 pubmed publisher
    ..monocytogenes subtypes as defined by pulsed-field gel electrophoresis and sequencing of virulence genes actA and inlA. Two of the subtypes accounted for 51% of the isolates...
  11. Dhar G, Faull K, Schneewind O. Anchor structure of cell wall surface proteins in Listeria monocytogenes. Biochemistry. 2000;39:3725-33 pubmed
    ..A methionine and six histidines (MH(6)) were inserted upstream of the LPXTG motif of internalin A (InlA), a cell-wall-anchored surface protein of L. monocytogenes...
  12. Rooney A, Ward T. Birth-and-death evolution of the internalin multigene family in Listeria. Gene. 2008;427:124-8 pubmed publisher