Gene Symbol: prsA
Description: peptidylprolyl isomerase
Species: Lactococcus lactis subsp. cremoris
Haandrikman A, Kok J, Venema G. Lactococcal proteinase maturation protein PrtM is a lipoprotein. J Bacteriol. 1991;173:4517-25 pubmed
..This mutation did not affect proteinase activity...
Kok J, Leenhouts K, Haandrikman A, Ledeboer A, Venema G. Nucleotide sequence of the cell wall proteinase gene of Streptococcus cremoris Wg2. Appl Environ Microbiol. 1988;54:231-8 pubmed
..cremoris Wg2 proteinase. The homologous sequences are separated by nonhomologous regions which contain several inserts, most notably a sequence of approximately 200 amino acids between the His and Ser residues of the active site. ..
Haandrikman A, Kok J, Laan H, Soemitro S, Ledeboer A, Konings W, et al
. Identification of a gene required for maturation of an extracellular lactococcal serine proteinase. J Bacteriol. 1989;171:2789-94 pubmed
..Furthermore, deletion of the 130 C-terminal amino acids of the Wg2 proteinase prevented attachment of the enzyme to lactococcal cells...
Haandrikman A, van Leeuwen C, Kok J, Vos P, de Vos W, Venema G. Insertion elements on lactococcal proteinase plasmids. Appl Environ Microbiol. 1990;56:1890-6 pubmed
..On pWV05, ISS1W is flanked on one side by only part of a second IS element, indicating that pWV05 evolved as a deletion derivative of a precursor plasmid that carried at least two IS elements. ..
Vos P, Simons G, Siezen R, de Vos W. Primary structure and organization of the gene for a procaryotic, cell envelope-located serine proteinase. J Biol Chem. 1989;264:13579-85 pubmed
..Furthermore, a region was identified in the Lactococcus proteinase, which shows homology to the membrane-anchoring domains of a number of proteins from other Gram-positive bacteria...
Kiwaki M, Ikemura H, Shimizu Kadota M, Hirashima A. Molecular characterization of a cell wall-associated proteinase gene from Streptococcus lactis NCDO763. Mol Microbiol. 1989;3:359-69 pubmed
Christensson C, Pillidge C, Ward L, O Toole P. Nucleotide sequence and characterization of the cell envelope proteinase plasmid in Lactococcus lactis subsp. cremoris HP. J Appl Microbiol. 2001;91:334-43 pubmed
..This is the first complete sequence reported for a lactocepin plasmid, and provides the basis for better understanding, or manipulation, of lactocepin production...
Vos P, van Asseldonk M, van Jeveren F, Siezen R, Simons G, de Vos W. A maturation protein is essential for production of active forms of Lactococcus lactis SK11 serine proteinase located in or secreted from the cell envelope. J Bacteriol. 1989;171:2795-802 pubmed
..Expression studies of L. lactis clones containing these plasmids showed that the prtM gene encodes a trans-acting activity involved in the maturation of cell envelope-located and -secreted forms of the SK11 proteinase...