blaCTX-M-16

Summary

Gene Symbol: blaCTX-M-16
Description: beta-lactamase CTX-M-16
Species: Klebsiella pneumoniae

Top Publications

  1. ncbi CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loop
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 45:3355-61. 2001
  2. ncbi Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China
    Aroonwadee Chanawong
    Division of Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Antimicrob Agents Chemother 46:630-7. 2002
  3. ncbi ColE1-like plasmid pIP843 of Klebsiella pneumoniae encoding extended-spectrum beta-lactamase CTX-M-17
    Van Cao
    Unite des Agents Antibacteriens, Institut Pasteur, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 46:1212-7. 2002
  4. ncbi Insertion sequence ISEcp1B is involved in expression and mobilization of a bla(CTX-M) beta-lactamase gene
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 47:2938-45. 2003
  5. ncbi CTX-M and plasmid-mediated AmpC-producing Enterobacteriaceae Singapore
    Tse Hsien Koh
    Emerg Infect Dis 10:1172-4. 2004
  6. ncbi Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
    J Mol Biol 348:349-62. 2005
  7. ncbi Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143 2240, USA
    J Am Chem Soc 127:5423-34. 2005
  8. ncbi The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th Street, MC 2550, San Francisco, California 94158-2330, USA
    J Am Chem Soc 129:5378-80. 2007
  9. ncbi DNA sequence analysis of the genetic environment of various blaCTX-M genes
    C Eckert
    Laboratoire de Bacteriologie, UPRES EA 2392, Faculte de Medecine Pierre et Marie Curie, Universite Paris VI, 27 rue de Chaligny, 75012 Paris, France
    J Antimicrob Chemother 57:14-23. 2006

Detail Information

Publications9

  1. ncbi CTX-M-type extended-spectrum beta-lactamase that hydrolyzes ceftazidime through a single amino acid substitution in the omega loop
    L Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 45:3355-61. 2001
    ..The bla(CTX-M-18) and bla(CTX-M-19) genes were located on transferable plasmids that varied in size (ca. 60 and 50 kb, respectively) but that showed similar restriction patterns...
  2. ncbi Three cefotaximases, CTX-M-9, CTX-M-13, and CTX-M-14, among Enterobacteriaceae in the People's Republic of China
    Aroonwadee Chanawong
    Division of Microbiology, University of Leeds, Leeds LS2 9JT, United Kingdom
    Antimicrob Agents Chemother 46:630-7. 2002
    ..A more comprehensive survey of the ESBL types from China is urgently needed...
  3. ncbi ColE1-like plasmid pIP843 of Klebsiella pneumoniae encoding extended-spectrum beta-lactamase CTX-M-17
    Van Cao
    Unite des Agents Antibacteriens, Institut Pasteur, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 46:1212-7. 2002
    ..Results of primer extension experiments indicated that ISEcp1 provides the promoter for expression of bla(CTX-M-17) and may contribute to dissemination of this gene...
  4. ncbi Insertion sequence ISEcp1B is involved in expression and mobilization of a bla(CTX-M) beta-lactamase gene
    Laurent Poirel
    Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, Faculte de Medecine Paris Sud, 94275 Le Kremlin Bicetre cedex, France
    Antimicrob Agents Chemother 47:2938-45. 2003
    ..The ability of ISEcp1-like elements to mobilize and to promote the expression of beta-lactamase genes may explain, in part, the current spread of CTX-M-type enzymes worldwide...
  5. ncbi CTX-M and plasmid-mediated AmpC-producing Enterobacteriaceae Singapore
    Tse Hsien Koh
    Emerg Infect Dis 10:1172-4. 2004
  6. ncbi Atomic resolution structures of CTX-M beta-lactamases: extended spectrum activities from increased mobility and decreased stability
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, CA 94143 2240, USA
    J Mol Biol 348:349-62. 2005
    ..The unusually high resolution of these structures that makes such analyses possible also makes them good templates for inhibitor discovery...
  7. ncbi Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California, San Francisco, Genentech Hall, 600 16th Street, San Francisco, California 94143 2240, USA
    J Am Chem Soc 127:5423-34. 2005
    ..The structure of its complex with CTX-M enzyme and the structural view of the reaction coordinate described here provide templates for inhibitor design and intervention to combat this family of antibiotic resistance enzymes...
  8. ncbi The acylation mechanism of CTX-M beta-lactamase at 0.88 a resolution
    Yu Chen
    Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th Street, MC 2550, San Francisco, California 94158-2330, USA
    J Am Chem Soc 129:5378-80. 2007
  9. ncbi DNA sequence analysis of the genetic environment of various blaCTX-M genes
    C Eckert
    Laboratoire de Bacteriologie, UPRES EA 2392, Faculte de Medecine Pierre et Marie Curie, Universite Paris VI, 27 rue de Chaligny, 75012 Paris, France
    J Antimicrob Chemother 57:14-23. 2006
    ..This study was conducted to analyse the genetic environment of these 28 bla(CTX-M) genes...