ORF57

Summary

Gene Symbol: ORF57
Description: post-transcriptional regulator
Species: Kaposi's sarcoma-associated herpesvirus - Human herpesvirus 8

Top Publications

  1. ncbi Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein
    Diana Palmeri
    Department of Microbiology and Molecular Genetics and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Virol 81:13299-314. 2007
  2. ncbi Identification and characterization of a new Kaposi's sarcoma-associated herpesvirus replication and transcription activator (RTA)-responsive element involved in RTA-mediated transactivation
    Hui Ju Wen
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    J Gen Virol 90:944-53. 2009
  3. ncbi Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:11297-307. 2010
  4. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways
    Brooke B Sahin
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 6:e1000799. 2010
  5. ncbi Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Virology 407:206-12. 2010
  6. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 85:1528-40. 2011
  7. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
  8. ncbi Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization
    Adam Taylor
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 85:7881-91. 2011
  9. ncbi Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity
    Emi Sei
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Virology 419:107-16. 2011

Scientific Experts

  • Zhi Ming Zheng
  • Vladimir Majerciak
  • Michael Kruhlak
  • Jeong Gu Kang
  • Adam Taylor
  • Emi Sei
  • Nicholas K Conrad
  • Brooke B Sahin
  • Hui Ju Wen
  • Diana Palmeri
  • Jenifer Bear
  • Maria Julia Massimelli
  • David J Hughes
  • George N Pavlakis
  • Mark Harris
  • Adrian Whitehouse
  • Hiroaki Uranishi
  • Barbara K Felber
  • Guy R Pilkington
  • Natalia Pripuzova
  • Brian R Jackson
  • James R Boyne
  • Shu Yun LE
  • Marko Noerenberg
  • Mark Verow
  • Denish Patel
  • Merlyn Deng
  • J Philip McCoy
  • Pradeep K Dagur
  • Charles Wood
  • Veenu Minhas
  • David M Lukac
  • Kyla Driscoll Carroll
  • Sophia Spadavecchia

Detail Information

Publications9

  1. ncbi Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein
    Diana Palmeri
    Department of Microbiology and Molecular Genetics and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Virol 81:13299-314. 2007
    ..We propose that one molecular mechanism of Mta-mediated transactivation is a direct effect on transcription by direct and indirect promoter association...
  2. ncbi Identification and characterization of a new Kaposi's sarcoma-associated herpesvirus replication and transcription activator (RTA)-responsive element involved in RTA-mediated transactivation
    Hui Ju Wen
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    J Gen Virol 90:944-53. 2009
    ..RRE2) containing AT-rich sequences have been identified previously in the promoter of one of the KSHV lytic genes, ORF57, which can be strongly activated by RTA...
  3. ncbi Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:11297-307. 2010
    Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a viral early protein essential for KSHV multiplication...
  4. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways
    Brooke B Sahin
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 6:e1000799. 2010
    ..Here we report that the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein binds to a unique KSHV polyadenylated nuclear RNA, called PAN RNA, and protects it from degradation by ..
  5. ncbi Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Virology 407:206-12. 2010
    ..how RNA export factors UAP56 and URH49, and RNA export cofactors RBM15 and OTT3, function in modulating KSHV ORF57 expression. We found that knockdown of each factor by RNAi led to decreased ORF57 expression...
  6. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 85:1528-40. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV) encodes ORF57, which promotes the accumulation of specific KSHV mRNA targets, including ORF59 mRNA...
  7. ncbi Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
    ..Here, we report genome-wide analysis of viral RNA targets of KSHV ORF57 by a novel UV-cross-linking and immunoprecipitation (CLIP) assay...
  8. ncbi Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization
    Adam Taylor
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 85:7881-91. 2011
    The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is essential for virus lytic replication...
  9. ncbi Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity
    Emi Sei
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Virology 419:107-16. 2011
    The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is an essential multifunctional regulator of gene expression...