ORF57

Summary

Gene Symbol: ORF57
Description: post-transcriptional regulator
Species: Kaposi's sarcoma-associated herpesvirus - Human herpesvirus 8

Top Publications

  1. pmc Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein
    Diana Palmeri
    Department of Microbiology and Molecular Genetics and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Virol 81:13299-314. 2007
  2. pmc Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication
    James R Boyne
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    PLoS Pathog 4:e1000194. 2008
  3. pmc Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export
    Michael Nekorchuk
    UF Shands Cancer Center, University of Florida, 1376 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:9990-8. 2007
  4. pmc Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA
    Maria J Massimelli
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:243-56. 2013
  5. pmc Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor
    Guy R Pilkington
    Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    J Virol 86:13089-94. 2012
  6. pmc Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication
    Da Jiang Li
    Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Virol 86:9866-74. 2012
  7. pmc Chromatin immunoprecipitation and microarray analysis suggest functional cooperation between Kaposi's Sarcoma-associated herpesvirus ORF57 and K-bZIP
    Olga V Hunter
    UT Southwestern Medical Center, Department of Microbiology, Dallas, Texas, USA
    J Virol 87:4005-16. 2013
  8. pmc Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Virology 407:206-12. 2010
  9. pmc Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
  10. pmc Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization
    Adam Taylor
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 85:7881-91. 2011

Scientific Experts

  • Zhi Ming Zheng
  • Vladimir Majerciak
  • Michael Kruhlak
  • Guy R Pilkington
  • Emi Sei
  • Nicholas K Conrad
  • James R Boyne
  • Maria J Massimelli
  • Olga V Hunter
  • Da Jiang Li
  • Barbara K Felber
  • Hiroaki Uranishi
  • Jenifer Bear
  • Jeong Gu Kang
  • Adam Taylor
  • Brooke B Sahin
  • Sankar Swaminathan
  • Adrian Whitehouse
  • Hui Ju Wen
  • Diana Palmeri
  • Michael Nekorchuk
  • R Blake Richardson
  • Dinesh Verma
  • David J Hughes
  • Marko Noerenberg
  • Brian R Jackson
  • George N Pavlakis
  • Shu Yun LE
  • Natalia Pripuzova
  • Mark Verow
  • Mark Harris
  • Maria Julia Massimelli
  • Denish Patel
  • Pradeep K Dagur
  • J Philip McCoy
  • Merlyn Deng
  • Charles Wood
  • Veenu Minhas
  • Kevin J Colgan
  • David M Lukac
  • Kyla Driscoll Carroll
  • Sophia Spadavecchia
  • Zhao Han
  • Ting Ting Hsieh

Detail Information

Publications15

  1. pmc Promoter- and cell-specific transcriptional transactivation by the Kaposi's sarcoma-associated herpesvirus ORF57/Mta protein
    Diana Palmeri
    Department of Microbiology and Molecular Genetics and Graduate School of Biomedical Sciences, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, New Jersey, USA
    J Virol 81:13299-314. 2007
    ..We propose that one molecular mechanism of Mta-mediated transactivation is a direct effect on transcription by direct and indirect promoter association...
  2. pmc Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication
    James R Boyne
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    PLoS Pathog 4:e1000194. 2008
    ..of Kaposi's sarcoma-associated herpesvirus (KSHV) lytic mRNAs lack introns and are exported by the virus-encoded ORF57 protein...
  3. pmc Kaposi's sarcoma-associated herpesvirus ORF57 protein enhances mRNA accumulation independently of effects on nuclear RNA export
    Michael Nekorchuk
    UF Shands Cancer Center, University of Florida, 1376 Mowry Road, Gainesville, FL 32610 3633, USA
    J Virol 81:9990-8. 2007
    The ORF57 protein expressed by Kaposi's sarcoma-associated herpesvirus (KSHV) during lytic replication is essential for KSHV virion production. ORF57 enhances gene expression by increasing accumulation of target gene mRNAs...
  4. pmc Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA
    Maria J Massimelli
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Virol 87:243-56. 2013
    ..We report that PABPC1 forms a complex with the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein, which allows ORF57 to interact with a 9-nucleotide (nt) core element of KSHV polyadenylated nuclear (PAN) ..
  5. pmc Kaposi's sarcoma-associated herpesvirus ORF57 is not a bona fide export factor
    Guy R Pilkington
    Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA
    J Virol 86:13089-94. 2012
    Kaposi's sarcoma-associated herpesvirus (KSHV [human herpesvirus 8; HHV-8]) open reading frame 57 (ORF57) is a viral early protein participating in posttranscriptional regulatory events, such as splicing, RNA stabilization, and protein ..
  6. pmc Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication
    Da Jiang Li
    Division of Infectious Diseases, Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Virol 86:9866-74. 2012
    Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is expressed early during lytic KSHV replication, enhances expression of many KSHV genes, and is essential for virus production...
  7. pmc Chromatin immunoprecipitation and microarray analysis suggest functional cooperation between Kaposi's Sarcoma-associated herpesvirus ORF57 and K-bZIP
    Olga V Hunter
    UT Southwestern Medical Center, Department of Microbiology, Dallas, Texas, USA
    J Virol 87:4005-16. 2013
    The Kaposi's sarcoma-associated herpesvirus (KSHV) open reading frame 57 (ORF57)-encoded protein (Mta) is a multifunctional regulator of viral gene expression...
  8. pmc Requirement of UAP56, URH49, RBM15, and OTT3 in the expression of Kaposi sarcoma-associated herpesvirus ORF57
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892 1868, USA
    Virology 407:206-12. 2010
    ..how RNA export factors UAP56 and URH49, and RNA export cofactors RBM15 and OTT3, function in modulating KSHV ORF57 expression. We found that knockdown of each factor by RNAi led to decreased ORF57 expression...
  9. pmc Kaposi's sarcoma-associated herpesvirus ORF57 promotes escape of viral and human interleukin-6 from microRNA-mediated suppression
    Jeong Gu Kang
    Tumor Virus RNA Biology Laboratory, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, 10 Center Dr, Rm 6N106, Bethesda, MD 20892 1868, USA
    J Virol 85:2620-30. 2011
    ..Here, we report genome-wide analysis of viral RNA targets of KSHV ORF57 by a novel UV-cross-linking and immunoprecipitation (CLIP) assay...
  10. pmc Mutation of a C-terminal motif affects Kaposi's sarcoma-associated herpesvirus ORF57 RNA binding, nuclear trafficking, and multimerization
    Adam Taylor
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Virol 85:7881-91. 2011
    The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is essential for virus lytic replication...
  11. pmc Delineation of a core RNA element required for Kaposi's sarcoma-associated herpesvirus ORF57 binding and activity
    Emi Sei
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Virology 419:107-16. 2011
    The Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is an essential multifunctional regulator of gene expression...
  12. pmc Kaposi's sarcoma-associated herpesvirus ORF57 protein binds and protects a nuclear noncoding RNA from cellular RNA decay pathways
    Brooke B Sahin
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS Pathog 6:e1000799. 2010
    ..Here we report that the Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein binds to a unique KSHV polyadenylated nuclear RNA, called PAN RNA, and protects it from degradation by ..
  13. pmc Caspase-7 cleavage of Kaposi sarcoma-associated herpesvirus ORF57 confers a cellular function against viral lytic gene expression
    Vladimir Majerciak
    HIV and AIDS Malignancy Branch, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 285:11297-307. 2010
    Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a viral early protein essential for KSHV multiplication...
  14. pmc Identification and characterization of a new Kaposi's sarcoma-associated herpesvirus replication and transcription activator (RTA)-responsive element involved in RTA-mediated transactivation
    Hui Ju Wen
    Nebraska Center for Virology, University of Nebraska Lincoln, Lincoln, NE 68583, USA
    J Gen Virol 90:944-53. 2009
    ..RRE2) containing AT-rich sequences have been identified previously in the promoter of one of the KSHV lytic genes, ORF57, which can be strongly activated by RTA...
  15. pmc Kaposi's sarcoma-associated herpesvirus ORF57 interacts with cellular RNA export cofactors RBM15 and OTT3 to promote expression of viral ORF59
    Vladimir Majerciak
    Tumor Virus RNA Biology Section, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Virol 85:1528-40. 2011
    Kaposi's sarcoma-associated herpesvirus (KSHV) encodes ORF57, which promotes the accumulation of specific KSHV mRNA targets, including ORF59 mRNA...