PB1 F2


Gene Symbol: PB1 F2
Description: PB1-F2 protein
Species: Influenza A virus (A/Puerto Rico/8/1934(H1N1))

Top Publications

  1. Dudek S, Wixler L, Nordhoff C, Nordmann A, Anhlan D, Wixler V, et al. The influenza virus PB1-F2 protein has interferon antagonistic activity. Biol Chem. 2011;392:1135-44 pubmed publisher
    ..In summary, we demonstrate that the PB1-F2 protein of IAVs exhibits a type I IFN-antagonistic function by interfering with the RIG-I/MAVS complex, which contributes to an enhanced pathogenicity in vivo. ..
  2. Varga Z, Grant A, Manicassamy B, Palese P. Influenza virus protein PB1-F2 inhibits the induction of type I interferon by binding to MAVS and decreasing mitochondrial membrane potential. J Virol. 2012;86:8359-66 pubmed publisher
    ..Interestingly, PB1-F2 66S affected the MMP more efficiently than wild-type PB1-F2. In summary, the results of our study identify the molecular mechanism by which the influenza virus PB1-F2 N66S protein increases virulence. ..
  3. Weeks Gorospe J, Hurtig H, Iverson A, Schuneman M, Webby R, McCullers J, et al. Naturally occurring swine influenza A virus PB1-F2 phenotypes that contribute to superinfection with Gram-positive respiratory pathogens. J Virol. 2012;86:9035-43 pubmed publisher
    ..These findings support efforts to increase influenza virus surveillance to consider viral genotypes that could be used to predict increased severity of superinfections with specific Gram-positive respiratory pathogens...
  4. Bruns K, Studtrucker N, Sharma A, Fossen T, Mitzner D, Eissmann A, et al. Structural characterization and oligomerization of PB1-F2, a proapoptotic influenza A virus protein. J Biol Chem. 2007;282:353-63 pubmed
    ..The consequences of the strong oligomerization and helical propensities of the molecule are discussed and used to formulate a hypothetical model of its interaction with the mitochondrial membrane. ..
  5. Mazur I, Anhlan D, Mitzner D, Wixler L, Schubert U, Ludwig S. The proapoptotic influenza A virus protein PB1-F2 regulates viral polymerase activity by interaction with the PB1 protein. Cell Microbiol. 2008;10:1140-52 pubmed publisher
    ..Thus, we have identified a novel function of PB1-F2 as an indirect regulator of the influenza virus polymerase activity via its interaction with PB1. ..
  6. McAuley J, Zhang K, McCullers J. The effects of influenza A virus PB1-F2 protein on polymerase activity are strain specific and do not impact pathogenesis. J Virol. 2010;84:558-64 pubmed publisher
    ..Alternate mechanisms besides alterations to replication are likely responsible for the enhanced virulence in mammalian hosts attributed to PB1-F2 in previous studies. ..
  7. Varga Z, Ramos I, Hai R, Schmolke M, Garcia Sastre A, Fernandez Sesma A, et al. The influenza virus protein PB1-F2 inhibits the induction of type I interferon at the level of the MAVS adaptor protein. PLoS Pathog. 2011;7:e1002067 pubmed publisher
    ..In summary, we have characterized the anti-interferon function of PB1-F2 and we suggest that this activity contributes to the enhanced pathogenicity seen with PB1-F2 N66S- expressing influenza viruses. ..
  8. Le Goffic R, Leymarie O, Chevalier C, Rebours E, Da Costa B, Vidic J, et al. Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein. PLoS Pathog. 2011;7:e1002202 pubmed publisher
    ..Collectively, these data demonstrate that PB1-F2 strongly influences the early host response during IAV infection and provides new insights into the mechanisms by which PB1-F2 mediates virulence. ..
  9. Meunier I, von Messling V. PB1-F2 modulates early host responses but does not affect the pathogenesis of H1N1 seasonal influenza virus. J Virol. 2012;86:4271-8 pubmed publisher
    ..However, the three viruses did not differ in their virulence or clinical course in ferrets, supporting speculations that PB1-F2 is of limited importance for the pathogenesis of primary viral infection with human seasonal H1N1 viruses. ..

More Information


  1. Ramakrishnan M, Gramer M, Goyal S, Sreevatsan S. A Serine12Stop mutation in PB1-F2 of the 2009 pandemic (H1N1) influenza A: a possible reason for its enhanced transmission and pathogenicity to humans. J Vet Sci. 2009;10:349-51 pubmed
    ..This finding is expected to lead to a better understanding of the transmission and pathogenesis of the 2009 pandemic strain. ..
  2. Winter G, Fields S. Nucleotide sequence of human influenza A/PR/8/34 segment 2. Nucleic Acids Res. 1982;10:2135-43 pubmed
    ..The sequence of segment 2 completes the sequence of the virus (total 13,588 nucleotides). ..
  3. Guan Z, Zhang M, Hou P, Duan M, Cui Y, Wang X. Identification of cellular proteins interacting with influenza A virus PB1-F2 protein. Acta Virol. 2012;56:199-207 pubmed
    ..The novel interactions between PB1-F2 and host proteins provide further pieces of evidence in the investigation of the pathogenic mechanism of IAV. influenza A virus; PB1-F2; yeast two-hybrid; protein-protein interaction...
  4. Jaworska J, Coulombe F, Downey J, Tzelepis F, Shalaby K, Tattoli I, et al. NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein. Proc Natl Acad Sci U S A. 2014;111:E2110-9 pubmed publisher
  5. Pena L, Vincent A, Loving C, Henningson J, Lager K, Lorusso A, et al. Restored PB1-F2 in the 2009 pandemic H1N1 influenza virus has minimal effects in swine. J Virol. 2012;86:5523-32 pubmed publisher
    ..Together, our results indicate that PB1-F2 in the context of pH1N1 moderately modulates viral replication, lung histopathology, and local cytokine response in pigs...
  6. Yoshizumi T, Ichinohe T, Sasaki O, Otera H, Kawabata S, Mihara K, et al. Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity. Nat Commun. 2014;5:4713 pubmed publisher
    ..PB1-F2 translocation into mitochondria strongly correlates with impaired cellular innate immunity, making this translocation event a potential therapeutic target. ..
  7. Smith A, Adler F, McAuley J, Gutenkunst R, Ribeiro R, McCullers J, et al. Effect of 1918 PB1-F2 expression on influenza A virus infection kinetics. PLoS Comput Biol. 2011;7:e1001081 pubmed publisher
    ..We discuss the implications these mechanisms have during an infection with a virus expressing a virulent PB1-F2 on the possibility of a pandemic and on the importance of antiviral treatments...
  8. Reis A, McCauley J. The influenza virus protein PB1-F2 interacts with IKK? and modulates NF-?B signalling. PLoS ONE. 2013;8:e63852 pubmed publisher
    ..Neither the N-terminal 57 amino acid truncated forms nor the C-terminus of PB1-F2 were able to inhibit NF-?B dependent signalling, indicating that the full length protein is necessary for the inhibition. ..
  9. Gooskens J, Zevenhoven Dobbe J, Claas E, Kroes A, Posthuma C. Mass spectrometry-based comparative sequence analysis for the genetic monitoring of influenza A(H1N1)pdm09 virus. PLoS ONE. 2014;9:e92970 pubmed publisher
    ..The low sensitivity for the detection of H275Y mutation in mixed viral populations suggests that MSCSA is not suitable for antiviral resistance monitoring in the clinical setting. ..
  10. Cui Y, Hou P, Zhang M, Duan M, Guan Z. [PB1-F2 protein of influenza A virus interacts with human MOAP-1 protein]. Wei Sheng Wu Xue Bao. 2012;52:1122-8 pubmed
    ..PB1-F2 could upregulate exogenous MOAP-1 protein level. These results suggested that influenza virus PB1-F2 interacted with MOAP-1 and it might be involved in the regulation of cell growth and apoptosis via association with MOAP-1. ..
  11. Chevalier C, Le Goffic R, Jamme F, Leymarie O, Réfrégiers M, Delmas B. Synchrotron Infrared and Deep UV Fluorescent Microspectroscopy Study of PB1-F2 β-Aggregated Structures in Influenza A Virus-infected Cells. J Biol Chem. 2016;291:9060-72 pubmed publisher
    ..Altogether, our results constitute an important step forward in the understanding of the cell type-dependent function of PB1-F2. ..