Gene Symbol: PA-X
Description: PA-X protein
Species: Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
- Xu X, Cox N, Guo Y. Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology. 1999;261:15-9 pubmed..These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen...
- Gao H, Sun H, Hu J, Qi L, Wang J, Xiong X, et al. Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity. J Gen Virol. 2015;96:2036-49 pubmed publisher..Furthermore, aa 233-252 at the C terminus of PA-X strongly suppressed co-transfected gene expression by âˆ¼ 50%, suggesting that these terminal 20 aa could play a role in enhancing viral replication and contribute to virulence. ..
- Li Q, Yuan X, Wang Q, Chang G, Wang F, Liu R, et al. Interactomic landscape of PA-X-chicken protein complexes of H5N1 influenza A virus. J Proteomics. 2016;148:20-5 pubmed publisher..Our study reveals the viral-host interactome of PA-X and uncovers interactions between host proteins and PA-X which might have crucial roles in viral infection. ..