NA

Summary

Gene Symbol: NA
Description: neuraminidase
Species: Influenza A virus (A/Goose/Guangdong/1/96(H5N1))
Products:     NA

Top Publications

  1. Ju X, Yan Y, Liu Q, Li N, Sheng M, Zhang L, et al. Neuraminidase of Influenza A Virus Binds Lysosome-Associated Membrane Proteins Directly and Induces Lysosome Rupture. J Virol. 2015;89:10347-58 pubmed publisher
    ..Here, we show that the neuraminidase (NA) of H5N1 influenza A virus markedly deglycosylates and degrades lysosome-associated membrane proteins (LAMPs; the ..
  2. Matsuoka Y, Swayne D, Thomas C, Rameix Welti M, Naffakh N, Warnes C, et al. Neuraminidase stalk length and additional glycosylation of the hemagglutinin influence the virulence of influenza H5N1 viruses for mice. J Virol. 2009;83:4704-8 pubmed publisher
    ..and H7 viruses in poultry, the hemagglutinin (HA) can acquire additional glycosylation sites, and the neuraminidase (NA) stalk becomes shorter...
  3. Nayak B, Kumar S, DiNapoli J, Paldurai A, Perez D, Collins P, et al. Contributions of the avian influenza virus HA, NA, and M2 surface proteins to the induction of neutralizing antibodies and protective immunity. J Virol. 2010;84:2408-20 pubmed publisher
    ..contributions of each of the three HPAIV surface proteins, namely, the hemagglutinin (HA), the neuraminidase (NA), and the M2 proteins, to the induction of HPAIV-neutralizing serum antibodies and protective immunity in chickens...
  4. Ilyushina N, Seiler J, Rehg J, Webster R, Govorkova E. Effect of neuraminidase inhibitor-resistant mutations on pathogenicity of clade 2.2 A/Turkey/15/06 (H5N1) influenza virus in ferrets. PLoS Pathog. 2010;6:e1000933 pubmed publisher
    The acquisition of neuraminidase (NA) inhibitor resistance by H5N1 influenza viruses has serious clinical implications, as this class of drugs can be an essential component of pandemic control measures...
  5. Chen W, Zhong Y, Qin Y, Sun S, Li Z. The evolutionary pattern of glycosylation sites in influenza virus (H5N1) hemagglutinin and neuraminidase. PLoS ONE. 2012;7:e49224 pubmed publisher
    Two glycoproteins, hemagglutinin (HA) and neuraminidase (NA), on the surface of influenza viruses play crucial roles in transfaunation, membrane fusion and the release of progeny virions...
  6. Xu X, Cox N, Guo Y. Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong. Virology. 1999;261:15-9 pubmed
    ..These data suggest that the H5N1 viruses isolated from the Hong Kong outbreaks derived their HA genes from a virus similar to the A/Goose/Guangdong/1/96 virus or shared a progenitor with this goose pathogen...
  7. . Evolution of H5N1 avian influenza viruses in Asia. Emerg Infect Dis. 2005;11:1515-21 pubmed publisher
    ..An updated nonpathogenic H5N1 reference virus, lacking the polybasic cleavage site in the hemagglutinin gene, was produced by reverse genetics in anticipation of the possible need to vaccinate humans...
  8. Karthick V, Ramanathan K. Insight into the oseltamivir resistance R292K mutation in H5N1 influenza virus: a molecular docking and molecular dynamics approach. Cell Biochem Biophys. 2014;68:291-9 pubmed publisher
    ..and selective antiviral drug employed to fight the flu virus in infected individuals by inhibiting neuraminidase (NA), a flu protein responsible for the release and spread of the progeny virions...
  9. Wu J, Wang T, Zhang L, Ye Z, Lv J. [Virological impact of stalk region of neuraminidase in influenza A/Anhui/1/05 (H5N1) and A/Ohio/07/2009 (H1N1) viruses]. Bing Du Xue Bao. 2014;30:238-45 pubmed
    This study aims to investigate the virological impact of the stalk region and cysteine (C) in neuraminidase (NA) of influenza A/Anhui/1/05 (H5N1) and A/Ohio/07/2009 (H1N1) viruses...

More Information

Publications13

  1. Wang Q, Long J, Hu S, Wu Y, Liu X. [Biological significance of amino acids deletion in NA stalk of H5N1 avian influenza virus]. Wei Sheng Wu Xue Bao. 2006;46:542-6 pubmed
    It has been reported that NA gene of some H1N1 Influenza A virus strains isolated since 1933 is characterized by a deletion of 11 to 16 amino acids in the stalk...
  2. Chen Q, Huang S, Chen J, Zhang S, Chen Z. NA proteins of influenza A viruses H1N1/2009, H5N1, and H9N2 show differential effects on infection initiation, virus release, and cell-cell fusion. PLoS ONE. 2013;8:e54334 pubmed publisher
    Two surface glycoproteins of influenza virus, haemagglutinin (HA) and neuraminidase (NA), play opposite roles in terms of their interaction with host sialic acid receptors...
  3. Kalthoff D, R hrs S, H per D, Hoffmann B, Bogs J, Stech J, et al. Truncation and sequence shuffling of segment 6 generate replication-competent neuraminidase-negative influenza H5N1 viruses. J Virol. 2013;87:13556-68 pubmed publisher
    ..The resulting mutant acquired major alterations in the neuraminidase (NA)-encoding segment...
  4. Qian G, Wang S, Chi X, Li H, Wei H, Zhu X, et al. The amino-terminal region of the neuraminidase protein from avian H5N1 influenza virus is important for its biosynthetic transport to the host cell surface. Vet J. 2014;202:612-7 pubmed publisher
    Influenza virus neuraminidase (NA) is a major viral envelope glycoprotein, which plays a critical role in viral infection...