M2

Summary

Gene Symbol: M2
Description: M2
Alias: matrix protein 2
Species: Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Products:     M2

Top Publications

  1. Gannage M, Dormann D, Albrecht R, Dengjel J, Torossi T, Rämer P, et al. Matrix protein 2 of influenza A virus blocks autophagosome fusion with lysosomes. Cell Host Microbe. 2009;6:367-80 pubmed publisher
    ..causes accumulation of autophagosomes by blocking their fusion with lysosomes, and one viral protein, matrix protein 2, is necessary and sufficient for this inhibition of autophagosome degradation...
  2. Bhowmick S, Chakravarty C, Sellathamby S, Lal S. The influenza A virus matrix protein 2 undergoes retrograde transport from the endoplasmic reticulum into the cytoplasm and bypasses cytoplasmic proteasomal degradation. Arch Virol. 2017;162:919-929 pubmed publisher
    The matrix protein 2 (M2) is a spliced product of segment 7 genome of influenza A virus. Previous studies indicate its role in uncoating of the viral ribonucleoprotein complex during viral entry and in membrane scission while budding...
  3. McCown M, Pekosz A. The influenza A virus M2 cytoplasmic tail is required for infectious virus production and efficient genome packaging. J Virol. 2005;79:3595-605 pubmed publisher
    The M2 integral membrane protein encoded by influenza A virus possesses an ion channel activity that is required for efficient virus entry into host cells...
  4. Yang W, Yang G, Wang Q, Huang H, Jiang Y, Shi C, et al. Protective efficacy of Fc targeting conserved influenza virus M2e antigen expressed by Lactobacillus plantarum. Antiviral Res. 2017;138:9-21 pubmed publisher
  5. Desuzinges Mandon E, Traversier A, Champagne A, Benier L, Audebert S, Balme S, et al. Expression and purification of native and functional influenza A virus matrix 2 proton selective ion channel. Protein Expr Purif. 2017;131:42-50 pubmed publisher
    ..Influenza matrix protein 2 (M2) is a membrane protein of the viral envelope that forms a proton selective ion channel...
  6. Zhu P, Liang L, Shao X, Luo W, Jiang S, Zhao Q, et al. Host Cellular Protein TRAPPC6A? Interacts with Influenza A Virus M2 Protein and Regulates Viral Propagation by Modulating M2 Trafficking. J Virol. 2017;91: pubmed
    Influenza A virus (IAV) matrix protein 2 (M2) plays multiple roles in the early and late phases of viral infection...
  7. Manor J, Mukherjee P, Lin Y, Leonov H, Skinner J, Zanni M, et al. Gating mechanism of the influenza A M2 channel revealed by 1D and 2D IR spectroscopies. Structure. 2009;17:247-54 pubmed publisher
    The pH-controlled M2 protein from influenza A is a critical component of the virus and serves as a target for the aminoadamantane antiflu agents that block its H+ channel activity...
  8. Hu S, Yin L, Mei S, Li J, Xu F, Sun H, et al. BST-2 restricts IAV release and is countered by the viral M2 protein. Biochem J. 2017;474:715-730 pubmed publisher
    ..This relatively weaker inhibition of IAV is associated with reduction in BST-2 levels, which is caused by the M2 protein that interacts with BST-2 and leads to down-regulation of cell surface BST-2 via the proteasomal pathway...
  9. Thaa B, Siche S, Herrmann A, Veit M. Acylation and cholesterol binding are not required for targeting of influenza A virus M2 protein to the hemagglutinin-defined budozone. FEBS Lett. 2014;588:1031-6 pubmed publisher
    ..The viral protein M2 localizes to the budozone edge for virus particle scission...

More Information

Publications20

  1. Bourmakina S, Garc a Sastre A. The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells. J Virol. 2005;79:7926-32 pubmed publisher
    We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells...
  2. Claridge J, Aittoniemi J, Cooper D, Schnell J. Isotropic bicelles stabilize the juxtamembrane region of the influenza M2 protein for solution NMR studies. Biochemistry. 2013;52:8420-9 pubmed publisher
    The protein M2 from influenza is a tetrameric membrane protein with several roles in the viral life cycle. The transmembrane helix (TMH) of M2 has proton channel activity that is required for unpackaging the viral genome...
  3. Huang S, Green B, Thompson M, Chen R, Thomaston J, Degrado W, et al. C-terminal juxtamembrane region of full-length M2 protein forms a membrane surface associated amphipathic helix. Protein Sci. 2015;24:426-9 pubmed publisher
    The influenza A M2 protein is a 97-residue integral membrane protein involved in viral budding and proton conductance...
  4. Zhirnov O, Klenk H. Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells. J Virol. 2013;87:13107-14 pubmed publisher
    ..experiments revealed that NS1 expressed alone was unable to upregulate autophagy, whereas hemagglutinin (HA) and M2 were. Proteolytic cleavage of HA increased autophagy...
  5. Lee Y, Lee Y, Kim M, Hwang H, Lee J, Kim K, et al. Fc receptor is not required for inducing antibodies but plays a critical role in conferring protection after influenza M2 vaccination. Immunology. 2014;143:300-9 pubmed publisher
    The ectodomain of matrix protein 2 (M2e) of influenza virus is considered a rational target for a universal influenza A vaccine...
  6. Dong H, Fiorin G, Degrado W, Klein M. Proton release from the histidine-tetrad in the M2 channel of the influenza A virus. J Phys Chem B. 2014;118:12644-51 pubmed publisher
    The activity of the M2 proton channel of the influenza A virus is controlled by pH. The tautomeric state and conformation of His37, a key residue in the M2 transmembrane four-helix bundle, controls the gating of the channel...
  7. Leiding T, Wang J, Martinsson J, Degrado W, Arsk ld S. Proton and cation transport activity of the M2 proton channel from influenza A virus. Proc Natl Acad Sci U S A. 2010;107:15409-14 pubmed publisher
    The M2 protein is a small, single-span transmembrane (TM) protein from the influenza A virus...
  8. Beale R, Wise H, Stuart A, Ravenhill B, Digard P, Randow F. A LC3-interacting motif in the influenza A virus M2 protein is required to subvert autophagy and maintain virion stability. Cell Host Microbe. 2014;15:239-47 pubmed publisher
    ..The ability of influenza A virus (IAV) to evade autophagy depends on the Matrix 2 (M2) ion-channel protein...
  9. Cheung T, Guan Y, Ng S, Chen H, Wong C, Peiris J, et al. Generation of recombinant influenza A virus without M2 ion-channel protein by introduction of a point mutation at the 5' end of the viral intron. J Gen Virol. 2005;86:1447-54 pubmed publisher
    The aim of this study was to inhibit influenza virus M2 protein expression by mutating the splicing signal of the M gene...
  10. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
    ..Via the UAS/Gal4 system we ectopically expressed the influenza virus M2 gene in Drosophila melanogaster and generated dose-sensitive phenotypes in the eye and wing...
  11. Winter G, Fields S. Cloning of influenza cDNA ino M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein. Nucleic Acids Res. 1980;8:1965-74 pubmed
    ..In addition, there is a second long reading frame which partly overlaps the reading frame of the matrix protein...