Gene Symbol: M1
Description: M1
Alias: matrix protein 1
Species: Influenza A virus (A/Puerto Rico/8/1934(H1N1))
Products:     M1

Top Publications

  1. Shimizu T, Takizawa N, Watanabe K, Nagata K, Kobayashi N. Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP. FEBS Lett. 2011;585:41-6 pubmed publisher
    ..The influenza virus NS2 protein has a nuclear export signal (NES) and binds to M1. It is therefore postulated that vRNP is exported from the nucleus by binding to NS2 through M1...
  2. Gao S, Wu J, Liu R, Li J, Song L, Teng Y, et al. Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells. J Virol. 2015;89:300-11 pubmed publisher
    ..Interestingly, AIMP2 had no significant effect on NS2 but enhanced the stability of the matrix protein M1. Further, we provide evidence that AIMP2 recruitment switches the modification of M1 from ubiquitination to ..
  3. Ma W, Liu Q, Bawa B, Qiao C, Qi W, Shen H, et al. The neuraminidase and matrix genes of the 2009 pandemic influenza H1N1 virus cooperate functionally to facilitate efficient replication and transmissibility in pigs. J Gen Virol. 2012;93:1261-8 pubmed publisher
    ..These results demonstrate that the right combination of NA and M genes is critical for the replication and transmissibility of influenza viruses in pigs...
  4. Su W, Chen Y, Tseng C, Hsu P, Tung K, Jeng K, et al. Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry. Proc Natl Acad Sci U S A. 2013;110:17516-21 pubmed publisher
    ..Furthermore, Itch interacted with viral M1 protein and ubiquitinated M1 protein...
  5. Wang S, Zhao Z, Bi Y, Sun L, Liu X, Liu W. Tyrosine 132 phosphorylation of influenza A virus M1 protein is crucial for virus replication by controlling the nuclear import of M1. J Virol. 2013;87:6182-91 pubmed publisher
    ..By using mass spectrometry, we identified tyrosine 132 (Y132) as a phosphorylation site of the matrix protein (M1) of the influenza virus A/WSN/1933(H1N1)...
  6. Liu H, Grantham M, Pekosz A. Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail. J Virol. 2018;92: pubmed publisher
    The influenza A virus M1 and M2 proteins play important roles in virus assembly and in the morphology of virus particles...
  7. Liu T, Ye Z. Attenuating mutations of the matrix gene of influenza A/WSN/33 virus. J Virol. 2005;79:1918-23 pubmed publisher
    The matrix protein (M1) of influenza virus plays an essential role in viral replication. Our previous studies have shown that basic amino acids 101RKLKR105 of M1 are involved in RNP binding and nuclear localization...
  8. Shishkov A, Bogacheva E, Fedorova N, Ksenofontov A, Badun G, Radyukhin V, et al. Spatial structure peculiarities of influenza A virus matrix M1 protein in an acidic solution that simulates the internal lysosomal medium. FEBS J. 2011;278:4905-16 pubmed publisher
    The structure of the C-terminal domain of the influenza virus A matrix M1 protein, for which X-ray diffraction data were still missing, was studied in acidic solution...
  9. Halder U, Bhowmick R, Roy Mukherjee T, Nayak M, Chawla Sarkar M. Phosphorylation drives an apoptotic protein to activate antiapoptotic genes: paradigm of influenza A matrix 1 protein function. J Biol Chem. 2013;288:14554-68 pubmed publisher
    ..We demonstrate that influenza A virus matrix 1 protein (M1), an established proapoptotic protein, activates nuclear factor-?B member RelB-mediated survival genes (cIAP1, cIAP2,..

More Information


  1. Winter G, Fields S. Cloning of influenza cDNA ino M13: the sequence of the RNA segment encoding the A/PR/8/34 matrix protein. Nucleic Acids Res. 1980;8:1965-74 pubmed
    ..In addition, there is a second long reading frame which partly overlaps the reading frame of the matrix protein...
  2. Bourmakina S, Garc a Sastre A. The morphology and composition of influenza A virus particles are not affected by low levels of M1 and M2 proteins in infected cells. J Virol. 2005;79:7926-32 pubmed publisher
    We generated a recombinant influenza A virus (Mmut) that produced low levels of matrix (M1) and M2 proteins in infected cells...
  3. Ksenofontov A, Dobrov E, Fedorova N, Radiukhin V, Badun G, Arutiunian A, et al. [Disordered regions in C-domain structure of influenza virus M1 protein]. Mol Biol (Mosk). 2011;45:689-96 pubmed
    Influenza virus matrix M1 protein is one of the main structural components of the virion performing also many different functions in infected cell. X-ray analysis data with 2...