HA

Summary

Gene Symbol: HA
Description: HA
Alias: hemagglutinin
Species: Influenza B virus (B/Lee/1940)
Products:     HA

Top Publications

  1. Ni F, Mbawuike I, Kondrashkina E, Wang Q. The roles of hemagglutinin Phe-95 in receptor binding and pathogenicity of influenza B virus. Virology. 2014;450-451:71-83 pubmed publisher
    ..our prior structural studies, we hypothesized that a single-residue difference in the receptor-binding site of hemagglutinin (HA), Phe-95 in influenza B virus versus Tyr-98 in influenza A/H1-H15, is possibly a key determinant for the ..
  2. Oong X, Ng K, Tan J, Chan K, Kamarulzaman A, Chan Y, et al. Whole-Genome Phylogenetic Analysis of Influenza B/Phuket/3073/2013-Like Viruses and Unique Reassortants Detected in Malaysia between 2012 and 2014. PLoS ONE. 2017;12:e0170610 pubmed publisher
    ..Based on hemagglutinin (HA) and neuraminidase (NA) genes, recent surveillance study has identified reassortment properties in B/..
  3. Krystal M, Young J, Palese P, Wilson I, Skehel J, Wiley D. Sequential mutations in hemagglutinins of influenza B virus isolates: definition of antigenic domains. Proc Natl Acad Sci U S A. 1983;80:4527-31 pubmed
    ..B viruses proceeds mostly through the accumulation of amino acid substitutions within the HA1 portion of the HA molecule...
  4. Ujike M, Nakajima K, Nobusawa E. A point mutation at the C terminus of the cytoplasmic domain of influenza B virus haemagglutinin inhibits syncytium formation. J Gen Virol. 2006;87:1669-76 pubmed publisher
    ..bound to red blood cells, were cleaved properly into two subunits and could be acylated like the wild-type (wt) HA. The membrane-fusion ability of these mutants was examined with a lipid (R18) and aqueous (calcein) dye-transfer ..
  5. Imai M, Watanabe S, Kawaoka Y. The cytoplasmic tail domain of influenza B virus hemagglutinin is important for its incorporation into virions but is not essential for virus replication in cell culture in the presence of compensatory mutations. J Virol. 2012;86:11633-44 pubmed publisher
    Influenza B virus hemagglutinin (BHA) contains a predicted cytoplasmic tail of 10 amino acids that are highly conserved among influenza B viruses...
  6. Ni F, Kondrashkina E, Wang Q. Structural basis for the divergent evolution of influenza B virus hemagglutinin. Virology. 2013;446:112-22 pubmed publisher
    ..Here we report the crystal structures of influenza B/Yamanashi/166/1998 hemagglutinin (HA) belonging to B/Yamagata lineage and its complex with the avian-like receptor analogue...
  7. Dudas G, Bedford T, Lycett S, Rambaut A. Reassortment between influenza B lineages and the emergence of a coadapted PB1-PB2-HA gene complex. Mol Biol Evol. 2015;32:162-72 pubmed publisher
    ..the eight segments of influenza B viruses only segments coding for polymerase basic 1 and 2 (PB1 and PB2) and hemagglutinin (HA) proteins have maintained separate Victoria and Yamagata lineages and that currently circulating strains ..
  8. Gatherer D. Passage in egg culture is a major cause of apparent positive selection in influenza B hemagglutinin. J Med Virol. 2010;82:123-7 pubmed publisher
    Several studies have identified residues apparently under positive selection in influenza B virus hemagglutinin. Host immune evasion is the main mechanism proposed to exert this selection pressure...