Gene Symbol: zyxin
Description: zyxin
Alias: ESP-2, HED-2, zyxin, zyxin-2
Species: human
Products:     zyxin

Top Publications

  1. Reinhard M, Jouvenal K, Tripier D, Walter U. Identification, purification, and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator-stimulated phosphoprotein). Proc Natl Acad Sci U S A. 1995;92:7956-60 pubmed
    ..properties, as well as microsequencing data revealed that porcine platelet p83 is related to chicken gizzard zyxin and most likely represents the mammalian equivalent of the chicken protein...
  2. Yi J, Kloeker S, Jensen C, Bockholt S, Honda H, Hirai H, et al. Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers. J Biol Chem. 2002;277:9580-9 pubmed
    Integrin binding to extracellular matrix proteins induces formation of signaling complexes at focal adhesions. Zyxin co-localizes with integrins at sites of cell-substratum adhesion and is postulated to serve as a docking site for the ..
  3. Hirota T, Morisaki T, Nishiyama Y, Marumoto T, Tada K, Hara T, et al. Zyxin, a regulator of actin filament assembly, targets the mitotic apparatus by interacting with h-warts/LATS1 tumor suppressor. J Cell Biol. 2000;149:1073-86 pubmed
    ..We have identified an interaction of h-warts/LATS1 with zyxin, a regulator of actin filament assembly...
  4. Macalma T, Otte J, Hensler M, Bockholt S, Louis H, Kalff Suske M, et al. Molecular characterization of human zyxin. J Biol Chem. 1996;271:31470-8 pubmed
    b>Zyxin is a component of adhesion plaques that has been suggested to perform regulatory functions at these specialized regions of the plasma membrane...
  5. Degenhardt Y, Silverstein S. Interaction of zyxin, a focal adhesion protein, with the e6 protein from human papillomavirus type 6 results in its nuclear translocation. J Virol. 2001;75:11791-802 pubmed
    b>Zyxin, a focal adhesion molecule, interacts specifically with the E6 protein from human papillomavirus (HPV) type 6 in a yeast two-hybrid screen of a cDNA library prepared from human keratinocytes...
  6. Hobert O, Schilling J, Beckerle M, Ullrich A, Jallal B. SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin. Oncogene. 1996;12:1577-81 pubmed
    ..that the product of the vav proto-oncogene, p95vav, interacts specifically with the focal adhesion protein zyxin both in vitro and in yeast two hybrid system...
  7. Nikiforaki K, Manikis G, Kontopodis E, Lagoudaki E, Bree E, Marias K, et al. T2, T2* and spin coupling ratio as biomarkers for the study of lipomatous tumors. Phys Med. 2019;60:76-82 pubmed publisher
    ..We concluded that T2, T2* and SCr can be used for the classification of fat containing tumors, which may be important for biopsy guidance in heterogeneous masses and treatment planning. ..
  8. Joyce C, Burnett A, Ball K. Methodological considerations for the 3D measurement of the X-factor and lower trunk movement in golf. Sports Biomech. 2010;9:206-21 pubmed publisher
    ..The findings of this study have relevance for further research examining the X-factor its relationship to club head speed and lower trunk movement and low back pain in golf. ..
  9. Yang F, Wang M, Zhang B, Xiang W, Zhang K, Chu M, et al. Identification of new progestogen-associated networks in mammalian ovulation using bioinformatics. BMC Syst Biol. 2018;12:36 pubmed publisher
    ..These networks provide important regulatory genes and signaling pathways which are involved in ovulation. This study provides a fundamental basis for subsequent functional studies to investigate the regulation of mammalian ovulation. ..

More Information


  1. Gaspar P, Holder M, Aerne B, Janody F, Tapon N. Zyxin antagonizes the FERM protein expanded to couple F-actin and Yorkie-dependent organ growth. Curr Biol. 2015;25:679-689 pubmed publisher
    ..The actin-associated LIM proteins Zyxin (Zyx) and Ajuba (Jub) have been linked to the control of tissue growth via regulation of Hpo signaling, but the ..
  2. Luo S, Schaefer A, Dour S, Nonet M. The conserved LIM domain-containing focal adhesion protein ZYX-1 regulates synapse maintenance in Caenorhabditis elegans. Development. 2014;141:3922-33 pubmed publisher
    We describe the identification of zyxin as a regulator of synapse maintenance in mechanosensory neurons in C. elegans. zyx-1 mutants lacked PLM mechanosensory synapses as adult animals...
  3. Fukumoto M, Kurisu S, Yamada T, Takenawa T. α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation. PLoS ONE. 2015;10:e0120616 pubmed publisher
    ..Interestingly, zyxin (ZYX) assembly to focal adhesions was markedly decreased in ACTN4-expressing DLD-1 cells, while the recruitment of ..
  4. Wang Y, Kuang Y, Wang Y. Rh2(esp)2-catalyzed allylic and benzylic oxidations. Chem Commun (Camb). 2015;51:5852-5 pubmed publisher
    ..The high catalyst stability in these reactions may be attributed to a dirhodium(II,II) catalyst resting state, which is less prone to decomposition. ..
  5. Shen Z, Xia Z, Zhao H, Hu J, Wan X, Lai Y, et al. Synthesis of naked amino-pyrroloindoline via direct aminocyclization of tryptamine. Org Biomol Chem. 2015;13:5381-4 pubmed publisher
    ..A variety of structurally diverse amino-pyrroloindolines are furnished by the use of O-(2,4-dinitrophenyl)hydroxylamine (DPH) as the nitrogen source in the presence of catalytic Rh2(esp)2. ..
  6. Pakula R, Berry J. Cobalt complexes of the chelating dicarboxylate ligand "esp": a paddlewheel-type dimer and a heptanuclear coordination cluster. Dalton Trans. 2018;47:13887-13893 pubmed publisher
    ..Crystal structures of both complexes are reported as well as their magnetic properties, which indicate antiferromagnetic interactions among the Co(ii) ions. ..
  7. Sunderland T, Berry J. Expanding the family of heterobimetallic Bi-Rh paddlewheel carboxylate complexes via equatorial carboxylate exchange. Dalton Trans. 2016;45:50-5 pubmed publisher
    ..4 to -1.5 V for [BiRh](3+/4+) couples and 1.3 to 1.5 V vs. Fc/Fc(+) for [BiRh](4+/5+) couples for complexes indicating a wide range of stability for the compounds. The X-ray crystal structure of reveals a Bi-Rh distance of 2.53 Ã…. ..
  8. Arosh J, Banu S, McCracken J. Novel concepts on the role of prostaglandins on luteal maintenance and maternal recognition and establishment of pregnancy in ruminants. J Dairy Sci. 2016;99:5926-5940 pubmed publisher
    ..Targeting PGE2 biosynthesis and signaling selectively in the endometrium or CL may provide luteoprotective therapy to improve reproductive efficiency in ruminants. ..
  9. Zanton G, Heinrichs A. Efficiency and rumen responses in younger and older Holstein heifers limit-fed diets of differing energy density. J Dairy Sci. 2016;99:2825-2836 pubmed publisher
    ..Results also support the concept of limit feeding HED diets as a potential means to reduce manure excretion and increase nitrogen efficiency. ..
  10. Wu Y, Luo L, Chen L, Tao X, Huang M, Wang H, et al. Chromosome mapping, molecular cloning and expression analysis of a novel gene response for leaf width in rice. Biochem Biophys Res Commun. 2016;480:394-401 pubmed publisher
  11. Lei P, Zhang H, Shan B, Lv S, Tang W. Heavy metals in estuarine surface sediments of the Hai River Basin, variation characteristics, chemical speciation and ecological risk. Environ Sci Pollut Res Int. 2016;23:7869-79 pubmed publisher
  12. Gregory Call S, Brereton D, Bullard J, Chung J, Meacham K, Morrell D, et al. A zyxin-nectin interaction facilitates zyxin localization to cell-cell adhesions. Biochem Biophys Res Commun. 2011;415:485-9 pubmed publisher
    ..have been implicated in actin remodeling events as cell-cell contacts are assembled and disassembled, including zyxin/LPP-VASP complexes. These complexes facilitate strong cell-cell adhesion by maintaining actin-membrane connections...
  13. Yang J, Miao S, Wu Y, Zhang Z, Zong S, Wang L, et al. Gene encoding a human testis Sertoli cell component related to LIM domain protein. Biochem Mol Biol Int. 1998;46:11-9 pubmed
    ..Mol. Biol. Int. 34, 1131-1136, 1994). HED-2 has 99% identity with the zyxin gene in amino acid sequence, a component of cell junction matrix and a member of the LIM domain protein family...
  14. Tani K, Sato S, Sukezane T, Kojima H, Hirose H, Hanafusa H, et al. Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase. J Biol Chem. 2003;278:21685-92 pubmed
    ..Mutational analysis demonstrated that the phosphorylation site of Mena is Tyr-296. Our results suggest that Abi-1 regulates c-Abl-mediated phosphorylation of Mena by interacting with both proteins. ..
  15. Li B, Zhuang L, Trueb B. Zyxin interacts with the SH3 domains of the cytoskeletal proteins LIM-nebulette and Lasp-1. J Biol Chem. 2004;279:20401-10 pubmed
    b>Zyxin is a versatile component of focal adhesions in eukaryotic cells. Here we describe a novel binding partner of zyxin, which we have named LIM-nebulette...
  16. Ghosh S, Kollar B, Nahar T, Suresh Babu S, Wójtowicz A, Sticht C, et al. Loss of the mechanotransducer zyxin promotes a synthetic phenotype of vascular smooth muscle cells. J Am Heart Assoc. 2015;4:e001712 pubmed publisher
    ..The focal adhesion protein zyxin can transduce such biomechanical stimuli to the nucleus of both endothelial cells and VSMCs, albeit with different ..
  17. van der Gaag E, Leccia M, Dekker S, Jalbert N, Amodeo D, Byers H. Role of zyxin in differential cell spreading and proliferation of melanoma cells and melanocytes. J Invest Dermatol. 2002;118:246-54 pubmed
    ..b>Zyxin is a focal-adhesion-associated phosphoprotein with one domain involved in the control of actin assembly and three ..
  18. Bianchi Smiraglia A, Kunnev D, Limoge M, Lee A, Beckerle M, Bakin A. Integrin-?5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor ?. Cell Cycle. 2013;12:3377-89 pubmed publisher
    ..TGF-?-Smad signaling upregulates actin-regulatory proteins, such as caldesmon, zyxin, and zyxin-binding protein Csrp1 in mouse and human epithelial cells...
  19. Mise N, Savai R, Yu H, Schwarz J, Kaminski N, Eickelberg O. Zyxin is a transforming growth factor-? (TGF-?)/Smad3 target gene that regulates lung cancer cell motility via integrin ?5?1. J Biol Chem. 2012;287:31393-405 pubmed publisher
    ..Here, we sought to identify novel direct targets of TGF-? signaling in lung cancer cells and have indentified the zyxin gene as a target of Smad3-mediated TGF-?1 signaling...
  20. Wójtowicz A, Babu S, Li L, Gretz N, Hecker M, Cattaruzza M. Zyxin mediation of stretch-induced gene expression in human endothelial cells. Circ Res. 2010;107:898-902 pubmed publisher
    ..Using human primary endothelial cells, we observed that the protein zyxin translocates from focal adhesions to the nucleus solely in response to stretch...
  21. Foxler D, Bridge K, James V, Webb T, Mee M, Wong S, et al. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity. Nat Cell Biol. 2012;14:201-8 pubmed publisher
    ..LIMD1 family member proteins Ajuba and WTIP also bind to VHL and PHDs 1 and 3, indicating that these LIM domain-containing proteins represent a previously unrecognized group of hypoxic regulators. ..
  22. Zhou Z, Gao M, Liu Q, Tao M. Comprehensive transcriptome analysis of mesenchymal stem cells in elderly patients with osteoporosis. Aging Clin Exp Res. 2015;27:595-601 pubmed publisher
    ..A number of DEGs and altered pathways were screened in osteoporosis. Our study provided insights into the role of aging in the pathogenesis of osteoporosis and some DEGs might be potential biomarkers for osteoporosis. ..
  23. Oldenburg J, van der Krogt G, Twiss F, Bongaarts A, Habani Y, Slotman J, et al. VASP, zyxin and TES are tension-dependent members of Focal Adherens Junctions independent of the α-catenin-vinculin module. Sci Rep. 2015;5:17225 pubmed publisher
    ..Here we identify the actin-regulators VASP, zyxin and TES as members of punctate, tensile cadherin-based junctions called Focal Adherens Junctions (FAJ) and show ..
  24. Youn H, Kim E, Um S. Zyxin cooperates with PTOV1 to confer retinoic acid resistance by repressing RAR activity. Cancer Lett. 2013;331:192-9 pubmed publisher
    ..Here, we first identified Zyxin that cooperates with PTOV1 for the negative regulation of RA signaling...
  25. Suresh Babu S, Wójtowicz A, Freichel M, Birnbaumer L, Hecker M, Cattaruzza M. Mechanism of stretch-induced activation of the mechanotransducer zyxin in vascular cells. Sci Signal. 2012;5:ra91 pubmed publisher
    ..We focused on the mechanotransducer zyxin, which translocates to the nucleus to drive gene expression in response to stretch...
  26. Fraley S, Feng Y, Giri A, Longmore G, Wirtz D. Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners. Nat Commun. 2012;3:719 pubmed publisher
    ..Short hairpin RNA depletion shows that these one-dimensional oscillations are uniquely controlled by zyxin and binding partners ?-actinin and p130Cas, but not vasodilator-stimulated phosphoprotein and cysteine-rich ..
  27. Wang L, Miao S, Zong S, Bai Y, Koide S. Gene encoding a mammalian epididymal protein. Biochem Mol Biol Int. 1994;34:1131-6 pubmed
    ..The amino acid sequence of the deduced polypeptide showed no homology with reported polypeptides. The epididymal protein may be involved in sperm maturation and/or capacitation. ..
  28. Fujita Y, Yamaguchi A, Hata K, Endo M, Yamaguchi N, Yamashita T. Zyxin is a novel interacting partner for SIRT1. BMC Cell Biol. 2009;10:6 pubmed publisher
    ..central nervous system, we performed yeast two-hybrid screening on human fetal brain cDNA library and found that zyxin is a possible binding partner...
  29. Conley B, Koleva R, Smith J, Kacer D, Zhang D, Bernabeu C, et al. Endoglin controls cell migration and composition of focal adhesions: function of the cytosolic domain. J Biol Chem. 2004;279:27440-9 pubmed
    ..of studies to address the relationship of the conserved cytosolic domain to endoglin function, we identified zyxin, a LIM domain protein that is concentrated at focal adhesions, as an interactor with endoglin in human umbilical ..
  30. Reinhard M, Zumbrunn J, Jaquemar D, Kuhn M, Walter U, Trueb B. An alpha-actinin binding site of zyxin is essential for subcellular zyxin localization and alpha-actinin recruitment. J Biol Chem. 1999;274:13410-8 pubmed
    The LIM domain protein zyxin is a component of adherens type junctions, stress fibers, and highly dynamic membrane areas and appears to be involved in microfilament organization...
  31. Drees B, Friederich E, Fradelizi J, Louvard D, Beckerle M, Golsteyn R. Characterization of the interaction between zyxin and members of the Ena/vasodilator-stimulated phosphoprotein family of proteins. J Biol Chem. 2000;275:22503-11 pubmed
    b>Zyxin contains a proline-rich N-terminal domain that is similar to the C-terminal domain in the ActA protein of the bacteria, Listeria monocytogenes...
  32. Mihlan S, Reis C, Thalheimer P, Herterich S, Gaetzner S, Kremerskothen J, et al. Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions. Oncogene. 2013;32:2107-13 pubmed publisher
    ..Finally, dephosphorylation of LASP-1 by phosphatase PP2B is suggested to relocalize the protein back to focal contacts. In summary, we define a new pathway for LASP-1 in tumor progression. ..
  33. Yamamura M, Noguchi K, Nakano Y, Segawa E, Zushi Y, Takaoka K, et al. Functional analysis of Zyxin in cell migration and invasive potential of oral squamous cell carcinoma cells. Int J Oncol. 2013;42:873-80 pubmed publisher
    b>Zyxin is an evolutionarily conserved protein that has been implicated in the regulation of actin assembly and is mainly located at focal adhesions. However, the biological roles of Zyxin in cancer cells are incompletely understood...
  34. Hirata H, Tatsumi H, Sokabe M. Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner. J Cell Sci. 2008;121:2795-804 pubmed publisher
    ..the molecular mechanism underlying the force-induced actin polymerization at FAs, we examined the distribution of zyxin, a postulated actin-regulatory protein. Actin-polymerizing activity was strong at zyxin-rich FAs...
  35. Martynova N, Eroshkin F, Ermolina L, Ermakova G, Korotaeva A, Smurova K, et al. The LIM-domain protein Zyxin binds the homeodomain factor Xanf1/Hesx1 and modulates its activity in the anterior neural plate of Xenopus laevis embryo. Dev Dyn. 2008;237:736-49 pubmed publisher
    ..neural plate patterning, the homeodomain transcriptional repressor Xanf1/Hesx1, can bind to the LIM-domain protein Zyxin, which is known to regulate cell morphogenetic movements via influence on actin cytoskeleton dynamics...
  36. Schenker T, Trueb B. BSPRY, a novel protein of the Ro-Ret family. Biochim Biophys Acta. 2000;1493:255-8 pubmed
    ..It comprises six exons and five introns and possesses a GC rich promoter forming a typical CpG island. The function of BSPRY is not known, but several related proteins of the RBCC family have been implicated in cell transformation. ..
  37. Crone J, Glas C, Schultheiss K, Moehlenbrink J, Krieghoff Henning E, Hofmann T. Zyxin is a critical regulator of the apoptotic HIPK2-p53 signaling axis. Cancer Res. 2011;71:2350-9 pubmed publisher
    ..Here we identify the LIM domain protein Zyxin as a novel regulator of the HIPK2-p53 signaling axis in response to DNA damage...
  38. Sun N, Huiatt T, Paulin D, Li Z, Robson R. Synemin interacts with the LIM domain protein zyxin and is essential for cell adhesion and migration. Exp Cell Res. 2010;316:491-505 pubmed publisher
    ..as the bait in a yeast two-hybrid screen of a human skeletal muscle cDNA library, the LIM domain protein zyxin was identified as an interaction partner for human synemin...
  39. Tan R, Patni H, Tandon P, Luan L, Sharma B, Salhan D, et al. Nef interaction with actin compromises human podocyte actin cytoskeletal integrity. Exp Mol Pathol. 2013;94:51-7 pubmed publisher
    ..the following Nef-interacting proteins: syntrophin, filamin B, syntaxin, translational elongation factor 1, and zyxin. The Nef-actin and Nef-zyxin interactions were confirmed by co-localization studies on Nef/CIHP stable cell lines...
  40. Martynova N, Ermolina L, Eroshkin F, Zarayskiy A. [The Cytoskelrtal Protein Zvxin Interacts with the Hedgehog Receptor Patched]. Bioorg Khim. 2015;41:744-8 pubmed
    Earlier, we demonstrated Zyxin influence upon Hedgehog (Hh)-signaling pathway during early patterning of the central neural system (CNS) anlage of the Xenopus laevis embryo...
  41. Lanni C, Necchi D, Pinto A, Buoso E, Buizza L, Memo M, et al. Zyxin is a novel target for ?-amyloid peptide: characterization of its role in Alzheimer's pathogenesis. J Neurochem. 2013;125:790-9 pubmed publisher
    b>Zyxin is an adaptor protein recently identified as a novel regulator of the homeodomain-interacting protein kinase 2 (HIPK2)-p53 signaling in response to DNA damage...
  42. Zumbrunn J, Trueb B. A zyxin-related protein whose synthesis is reduced in virally transformed fibroblasts. Eur J Biochem. 1996;241:657-63 pubmed
    ..It is therefore possible that the novel protein represents the human equivalent of the chicken protein zyxin as the two proteins display a very similar overall structure, although their amino acid sequences diverge markedly ..
  43. Smolenski A, Poller W, Walter U, Lohmann S. Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I. J Biol Chem. 2000;275:25723-32 pubmed
    ..8-pCPT-cGMP) activates transfected cGK I and causes detachment of VASP and its known binding partner (zyxin) from focal adhesions in >60% of cells after 30 min...
  44. Abbey C, Bayless K. Matrix density alters zyxin phosphorylation, which limits peripheral process formation and extension in endothelial cells invading 3D collagen matrices. Matrix Biol. 2014;38:36-47 pubmed publisher
    ..at higher density have been reported to be stiffer, we tested for changes in the mechanosensitive protein, zyxin. Interestingly, zyxin phosphorylation levels inversely correlated with matrix density, while levels of total zyxin ..
  45. Uemura A, Nguyen T, Steele A, Yamada S. The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration. Biophys J. 2011;101:1069-75 pubmed publisher
    ..In particular, migrating cells have been shown to sense substrate stiffness and alter cell morphology and speed. Zyxin is a focal adhesion protein that responds to external mechanical forces; however, the mechanisms of zyxin ..
  46. Wu H, Liu T, Wang R, Tian S, Liu M, Li X, et al. MicroRNA-16 targets zyxin and promotes cell motility in human laryngeal carcinoma cell line HEp-2. IUBMB Life. 2011;63:101-8 pubmed publisher
    ..Subsequently, zyxin, whose expression is negatively regulated by miR-16, is confirmed to be a direct target gene of miR-16...
  47. Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, et al. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-? signalling pathways. Nat Commun. 2016;7:11123 pubmed publisher
    ..In this study, we identify LIM domain protein Zyxin, as a scaffold protein, that in response to hypoxia and TGF-? stimuli, forms a ternary complex with Lats2 and ..
  48. Wolfenson H, Bershadsky A, Henis Y, Geiger B. Actomyosin-generated tension controls the molecular kinetics of focal adhesions. J Cell Sci. 2011;124:1425-32 pubmed publisher
    ..We measured the early changes in k(off) values for three FA proteins (vinculin, paxillin and zyxin) upon inhibition of actomyosin-generated forces using two methods - high temporal resolution FRAP and direct ..
  49. Kotake K, Ozaki N, Mizuta M, Sekiya S, Inagaki N, Seino S. Noc2, a putative zinc finger protein involved in exocytosis in endocrine cells. J Biol Chem. 1997;272:29407-10 pubmed
    ..cDNA library with the yeast two-hybrid system shows that Noc2 interacts with the LIM domain-containing protein zyxin, a component of the cytoskeleton, and this interaction is further confirmed by the coimmunoprecipitation ..
  50. Han J, Liu G, Profirovic J, Niu J, Voyno Yasenetskaya T. Zyxin is involved in thrombin signaling via interaction with PAR-1 receptor. FASEB J. 2009;23:4193-206 pubmed publisher
    ..In this study, we demonstrated that zyxin, a LIM-domain-containing protein, is involved in thrombin-mediated actin cytoskeleton remodeling and serum ..
  51. Harbeck B, Huttelmaier S, Schluter K, Jockusch B, Illenberger S. Phosphorylation of the vasodilator-stimulated phosphoprotein regulates its interaction with actin. J Biol Chem. 2000;275:30817-25 pubmed
    ..no significant effect on VASP oligomerization or its interaction with its known ligands profilin, vinculin, and zyxin. When overexpressing VASP mutants in eukaryotic cells, they all showed targeting to focal contacts and stress ..
  52. Marie H, Pratt S, Betson M, Epple H, Kittler J, Meek L, et al. The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin. J Biol Chem. 2003;278:1220-8 pubmed
  53. Yamada K, Kawata H, Shou Z, Hirano S, Mizutani T, Yazawa T, et al. Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3. Biochem J. 2003;373:167-78 pubmed
    ..Nuclear proteins such as ZHX1, transcriptional co-factors and DNA-binding proteins, zyxin, androgen-induced aldose reductase and eleven-nineteen lysine-rich leukaemia gene, as well as some unknown ..
  54. Janssen H, Marynen P. Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?. Exp Cell Res. 2006;312:1194-204 pubmed
    ..In contrast to its rat homolog, human ZNF384 does not interact with p130CAS. Zyxin, PCBP1, and vimentin, however, were identified as ZNF384-binding partners...
  55. Miyazaki Y, Yusa T, Matsuo S, Terauchi Y, Miyazaki S. Zyxin modulates the transmigration of Haemophilus influenzae to the central nervous system. Virulence. 2014;5:665-72 pubmed publisher
    ..b>Zyxin, which is thought to be essential for tight cell-to-cell junctions, decreased 1.8-fold in TNF-?-treated HBMECs...
  56. Li B, Trueb B. Analysis of the alpha-actinin/zyxin interaction. J Biol Chem. 2001;276:33328-35 pubmed
    The yeast two-hybrid system was used to search for interaction partners of human zyxin. Screening of two different cDNA libraries, one prepared from human placenta, the other from human heart, yielded several positive clones that ..
  57. Moon H, Even Ram S, Kleinman H, Cha H. Zyxin is upregulated in the nucleus by thymosin beta4 in SiHa cells. Exp Cell Res. 2006;312:3425-31 pubmed
    ..We searched for genes upregulated by thymosin beta4 and identified zyxin as increased in SiHa cells in the presence of exogenously added thymosin beta4 and when thymosin beta4 is ..
  58. Kouwaki T, Okamoto M, Tsukamoto H, Fukushima Y, Matsumoto M, Seya T, et al. Zyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response. Sci Rep. 2017;7:11905 pubmed publisher
    ..the molecular mechanism of MAVS-dependent signaling, we performed a yeast two-hybrid screening and identified zyxin as a protein that binds to MAVS. Zyxin co-immunoprecipitated with MAVS in human cells...
  59. Loveless T, Qadota H, Benian G, Hardin J. Caenorhabditis elegans SORB-1 localizes to integrin adhesion sites and is required for organization of sarcomeres and mitochondria in myocytes. Mol Biol Cell. 2017;28:3621-3633 pubmed publisher
    ..we demonstrate that SORB-1 interacts directly with two other dense body components, DEB-1(vinculin) and ZYX-1(zyxin)...
  60. Ohenoja K, Körkkö M, Wigren V, Österbacka J, Illikainen M. Fly ash classification efficiency of electrostatic precipitators in fluidized bed combustion of peat, wood, and forest residues. J Environ Manage. 2018;206:607-614 pubmed publisher
    ..The separation of the finer fractions (ESP 2 and 3) from ESP 1 field fly ash is recommended.
  61. Zumbrunn J, Trueb B. Assignment of the ZYX gene for the LIM protein zyxin to human chromosome bands 7q34-->q35 by in situ hybridization. Cytogenet Cell Genet. 1998;81:283-4 pubmed
  62. Amsellem V, Kryszke M, Hervy M, Subra F, Athman R, Leh H, et al. The actin cytoskeleton-associated protein zyxin acts as a tumor suppressor in Ewing tumor cells. Exp Cell Res. 2005;304:443-56 pubmed
    ..the involvement of the microfilament network in tumor cell behavior, several actin-binding proteins, including zyxin, a potential regulator of actin polymerization, may play a role in oncogenesis...
  63. Petko J, Justice Bitner S, Jin J, Wong V, Kittanakom S, Ferraro T, et al. MOR is not enough: identification of novel mu-opioid receptor interacting proteins using traditional and modified membrane yeast two-hybrid screens. PLoS ONE. 2013;8:e67608 pubmed publisher
  64. Garvalov B, Higgins T, Sutherland J, Zettl M, Scaplehorn N, Kocher T, et al. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions. J Cell Biol. 2003;161:33-9 pubmed
    The function of the human Tes protein, which has extensive similarity to zyxin in both sequence and domain organization, is currently unknown...
  65. Rosner S, Pascoe C, Blankman E, Jensen C, Krishnan R, James A, et al. The actin regulator zyxin reinforces airway smooth muscle and accumulates in airways of fatal asthmatics. PLoS ONE. 2017;12:e0171728 pubmed publisher
    ..Using cells and tissues from wild type and zyxin-/- mice we report responses to a transient stretch of physiologic magnitude and duration...