Gene Symbol: ZSCAN10
Description: zinc finger and SCAN domain containing 10
Alias: ZNF206, zinc finger and SCAN domain-containing protein 10, zinc finger protein 206
Species: human
Products:     ZSCAN10

Top Publications

  1. Yanagihara Y, Inoue K, Saeki N, Sawada Y, Yoshida S, Lee J, et al. Zscan10 suppresses osteoclast differentiation by regulating expression of Haptoglobin. Bone. 2019;122:93-100 pubmed publisher
    Zinc finger and SCAN domain containing 10 (Zscan10) was identified as a novel transcription factor that is involved in osteoclast differentiation in our previous report...
  2. Liang Y, Huimei Hong F, Ganesan P, Jiang S, Jauch R, Stanton L, et al. Structural analysis and dimerization profile of the SCAN domain of the pluripotency factor Zfp206. Nucleic Acids Res. 2012;40:8721-32 pubmed
    Zfp206 (also named as Zscan10) belongs to the subfamily of C(2)H(2) zinc finger transcription factors, which is characterized by the N-terminal SCAN domain...
  3. Kraus P, V S, Yu H, Xing X, Lim S, Adler T, et al. Pleiotropic functions for transcription factor zscan10. PLoS ONE. 2014;9:e104568 pubmed publisher
    The transcription factor Zscan10 had been attributed a role as a pluripotency factor in embryonic stem cells based on its interaction with Oct4 and Sox2 in in vitro assays...
  4. Papatsenko D, Darr H, Kulakovskiy I, Waghray A, Makeev V, MacArthur B, et al. Single-Cell Analyses of ESCs Reveal Alternative Pluripotent Cell States and Molecular Mechanisms that Control Self-Renewal. Stem Cell Reports. 2015;5:207-20 pubmed publisher
    ..Certain target genes alternatively regulated by OCT4 and NANOG, such as Sall4 and Zscan10, feed back into the top hierarchical regulator Oct4...
  5. Yamane M, Fujii S, Ohtsuka S, Niwa H. Zscan10 is dispensable for maintenance of pluripotency in mouse embryonic stem cells. Biochem Biophys Res Commun. 2015;468:826-31 pubmed publisher
    Zinc finger and SCAN domain-containing 10 (Zscan10, also known as Zfp206) encodes a transcription factor that has been reported to be involved in the maintenance of pluripotency in mouse embryonic stem (ES) cells...
  6. Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, et al. The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas. Br J Cancer. 2016;115:454-64 pubmed publisher
    ..SOX17 levels unchanged, but resulted in downregulation of pluripotency- and PGC-related genes (LIN28, PRDM14, ZSCAN10), whereas somatic and germ cell differentiation markers were upregulated...
  7. Kawashima H, Sugito K, Yoshizawa S, Uekusa S, Furuya T, Ikeda T, et al. DNA hypomethylation at the ZNF206-exon 5 CpG island associated with neuronal differentiation in mice and development of neuroblastoma in humans. Int J Oncol. 2012;40:31-9 pubmed publisher
    ..regions (DS-DMRs) we reported that the exon 5 CpG island (CpGi) of Zfp206 (human: ZNF206), which was required to maintain embryonic stem cells in a pluripotent state, was one of potent brain ..
  8. Wei D, Gui L, Raza S, Zhang S, Khan R, Wang L, et al. NRF1 and ZSCAN10 bind to the promoter region of the SIX1 gene and their effects body measurements in Qinchuan cattle. Sci Rep. 2017;7:7867 pubmed publisher
    ..mobility shift assays (EMSA) and chromatin immunoprecipitation assay (ChIP) demonstrated that NRF1 and ZSCAN10 binding occurred in the promoter region of diplotypes H1-H2 to regulate SIX1 ..
  9. Skamagki M, Zhang C, Ross C, Ananthanarayanan A, Liu Z, Mu Q, et al. RNA Exosome Complex-Mediated Control of Redox Status in Pluripotent Stem Cells. Stem Cell Reports. 2017;9:1053-1061 pubmed publisher
    ..We identified a transcription factor, ZSCAN10, which binds to the promoters of multiple RNA exosome complex subunits in pluripotent stem cells to maintain ..

More Information


  1. Bernot A, Heilig R, Clepet C, Smaoui N, da Silva C, Petit J, et al. A transcriptional Map of the FMF region. Genomics. 1998;50:147-60 pubmed
    ..Data accumulated in this region were also used in a comparative study of different methods of exon detection. ..
  2. Sugito K, Kawashima H, Uekusa S, Yoshizawa S, Hoshi R, Furuya T, et al. Identification of aberrant methylation regions in neuroblastoma by screening of tissue-specific differentially methylated regions. Pediatr Blood Cancer. 2013;60:383-9 pubmed publisher
    ..Screening of 12 tDMRs revealed 2 genomic regions (SLC16A5 and ZNF206) with frequent aberrant methylation patterns in NB...
  3. Skamagki M, Correia C, Yeung P, Baslan T, Beck S, Zhang C, et al. ZSCAN10 expression corrects the genomic instability of iPSCs from aged donors. Nat Cell Biol. 2017;19:1037-1048 pubmed publisher
    ..We found that the pluripotency factor ZSCAN10 is poorly expressed in A-iPSCs and addition of ZSCAN10 to the four Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) ..