Gene Symbol: ZRANB3
Description: zinc finger RANBP2-type containing 3
Alias: 4933425L19Rik, AH2, DNA annealing helicase and endonuclease ZRANB3, annealing helicase 2, zinc finger Ran-binding domain-containing protein 3, zinc finger, RAN-binding domain containing 3
Species: human
Products:     ZRANB3

Top Publications

  1. Sotiriou S, Halazonetis T. Remodeling Collapsed DNA Replication Forks for Cancer Development. Cancer Res. 2019;79:1297-1298 pubmed publisher
    ..SMARCAL1 and ZRANB3 are annealing helicases that mediate the repair of collapsed DNA replication forks...
  2. Puccetti M, Adams C, Kushinsky S, Eischen C. Smarcal1 and Zranb3 Protect Replication Forks from Myc-Induced DNA Replication Stress. Cancer Res. 2019;79:1612-1623 pubmed publisher
    ..Here we report that Smarcal1 and Zranb3, closely related replication fork-remodeling proteins, have nonredundant functions in resolving Myc-induced DNA ..
  3. Mutreja K, Krietsch J, Hess J, Ursich S, Berti M, Roessler F, et al. ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links. Cell Rep. 2018;24:2629-2642.e5 pubmed publisher
    ..Active fork slowing is linked to rapid recruitment of RAD51 to replicating chromatin and to RAD51/ZRANB3-mediated fork reversal...
  4. Fu Y, Long M, Wisitpitthaya S, Inayat H, Pierpont T, Elsaid I, et al. Nuclear RNR-α antagonizes cell proliferation by directly inhibiting ZRANB3. Nat Chem Biol. 2018;14:943-954 pubmed publisher
    ..This underappreciated biological activity functions in the nucleus, where RNR-α interacts with ZRANB3. This process suppresses ZRANB3's function in unstressed cells, which we show to promote DNA synthesis...
  5. Yao Q, Zhang L, Wan X, Chen J, Hu L, Ding X, et al. Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway. PLoS Pathog. 2014;10:e1004522 pubmed publisher
    ..We further identify a new NleE substrate, ZRANB3, that functions in PCNA binding and remodeling of stalled replication forks at the DNA damage sites...
  6. Chavez D, Greer B, Eichman B. The HIRAN domain of helicase-like transcription factor positions the DNA translocase motor to drive efficient DNA fork regression. J Biol Chem. 2018;293:8484-8494 pubmed publisher
    ..SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A-like 1 (SMARCAL1) and zinc finger RANBP2 type-containing 3 (ZRANB3) to provide insight into their nonredundant roles in DNA damage tolerance.
  7. Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher
    ..factor (HLTF), and the SWI/SNF catalytic subunit (SNF2) translocase zinc finger ran-binding domain containing 3 (ZRANB3). This novel p53 activity is lost in the exonuclease-deficient but transcriptionally active p53(H115N) mutant...
  8. Margalef P, Kotsantis P, Borel V, Bellelli R, Panier S, Boulton S. Stabilization of Reversed Replication Forks by Telomerase Drives Telomere Catastrophe. Cell. 2018;172:439-453.e14 pubmed publisher
    ..but not its activity, or blocking replication fork reversal through PARP1 inhibition or depleting UBC13 or ZRANB3 prevents the rapid accumulation of dysfunctional telomeres in RTEL1-deficient cells...
  9. Poole L, Zhao R, Glick G, Lovejoy C, Eischen C, Cortez D. SMARCAL1 maintains telomere integrity during DNA replication. Proc Natl Acad Sci U S A. 2015;112:14864-9 pubmed publisher
    ..regulator of chromatin, subfamily A-like 1) DNA translocase is one of several related enzymes, including ZRANB3 (zinc finger, RAN-binding domain containing 3) and HLTF (helicase-like transcription factor), that are recruited ..

More Information


  1. Poole L, Cortez D. SMARCAL1 and telomeres: Replicating the troublesome ends. Nucleus. 2016;7:270-4 pubmed publisher
    ..Furthermore, cells lacking the highly related proteins ZRANB3 and HLTF do not exhibit similar problems suggesting a unique function for SMARCAL1...
  2. Taglialatela A, Alvarez S, Leuzzi G, Sannino V, Ranjha L, Huang J, et al. Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers. Mol Cell. 2017;68:414-430.e8 pubmed publisher
    ..In addition to SMARCAL1, other SNF2-family fork remodelers, including ZRANB3 and HLTF, cause nascent DNA degradation and genomic instability in BRCA1/2-deficient cells upon replication stress...
  3. Vujanovic M, Krietsch J, Raso M, Terraneo N, Zellweger R, Schmid J, et al. Replication Fork Slowing and Reversal upon DNA Damage Require PCNA Polyubiquitination and ZRANB3 DNA Translocase Activity. Mol Cell. 2017;67:882-890.e5 pubmed publisher
    ..Fork reversal is driven in vitro by multiple enzymes, including the DNA translocase ZRANB3, shown to bind polyubiquitinated PCNA...
  4. Yusufzai T, Kadonaga J. Annealing helicase 2 (AH2), a DNA-rewinding motor with an HNH motif. Proc Natl Acad Sci U S A. 2010;107:20970-3 pubmed publisher
    ..Here we report the identification of a second annealing helicase, which we term AH2, for annealing helicase 2. Like HARP, AH2 catalyzes the ATP-dependent rewinding of replication protein A (RPA)-bound complementary ..
  5. Badu Nkansah A, Mason A, Eichman B, Cortez D. Identification of a Substrate Recognition Domain in the Replication Stress Response Protein Zinc Finger Ran-binding Domain-containing Protein 3 (ZRANB3). J Biol Chem. 2016;291:8251-7 pubmed publisher
    ..Several enzymes including SMARCAL1, HLTF, and ZRANB3 catalyze these reactions...
  6. Han J, Liu T, Huen M, Hu L, Chen Z, Huang J. SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination. J Cell Biol. 2014;205:811-27 pubmed publisher
    ..Collectively, our results provide evidence that the RAD18 E3 ligase requires an accessory protein for binding to its substrate PCNA. ..
  7. Weston R, Peeters H, Ahel D. ZRANB3 is a structure-specific ATP-dependent endonuclease involved in replication stress response. Genes Dev. 2012;26:1558-72 pubmed publisher
    ..Here we identify a new replication-associated factor, ZRANB3 (zinc finger, RAN-binding domain containing 3), and propose its role in the repair of replication-blocking lesions...
  8. Ciccia A, Nimonkar A, Hu Y, Hajdu I, Achar Y, Izhar L, et al. Polyubiquitinated PCNA recruits the ZRANB3 translocase to maintain genomic integrity after replication stress. Mol Cell. 2012;47:396-409 pubmed publisher
    ..Here we report that the ZRANB3 translocase, a SNF2 family member related to the SIOD disorder SMARCAL1 protein, is recruited by polyubiquitinated ..
  9. Poole L, Cortez D. Functions of SMARCAL1, ZRANB3, and HLTF in maintaining genome stability. Crit Rev Biochem Mol Biol. 2017;52:696-714 pubmed publisher
    ..SMARCAL1, ZRANB3, and HLTF are three related members of this family with specialized functions that maintain genome stability ..
  10. Zhang Y, Mühlen S, Oates C, Pearson J, Hartland E. Identification of a Distinct Substrate-binding Domain in the Bacterial Cysteine Methyltransferase Effectors NleE and OspZ. J Biol Chem. 2016;291:20149-62 pubmed publisher
    ..Another NleE target, ZRANB3, also associated with NleE through the (49)GITR(52) motif...
  11. Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell. 2012;47:410-21 pubmed publisher
    ..AH2 (annealing helicase 2, also named as ZRANB3) is the second protein with annealing activity, the function of which is still ..