ZP4

Summary

Gene Symbol: ZP4
Description: zona pellucida glycoprotein 4
Alias: ZBP, ZP1, ZPB, Zp-4, zona pellucida sperm-binding protein 4, zona pellucida protein B
Species: human
Products:     ZP4

Top Publications

  1. Kim Y, Kang B, Yun J, Ahn J, Kim Y, Kim H, et al. Expression of Transcripts in Marmoset Oocytes Retrieved during Follicle Isolation Without Gonadotropin Induction. Int J Mol Sci. 2019;20: pubmed publisher
    ..The expression of BMP15 and ZP1 was highest when the oocytes were matured using 100 IU/L of hCG without pre-treatment with gonadotropins, and ..
  2. Zou Y, Zhou J, Guo J, Zhang Z, Luo Y, Liu F, et al. Mutation analysis of ZP1, ZP2, ZP3 and ZP4 genes in 152 Han Chinese samples with ovarian endometriosis. Mutat Res. 2019;813:46-50 pubmed publisher
    ..We analyzed a total of 152 Han Chinese samples with ovarian endometriosis for the presence of mutations in the ZP1, ZP2, ZP3 and ZP4 genes. Two novel nonsynonymous ZP4 mutations were identified in three out of 152 (2...
  3. Zhou Z, Ni C, Wu L, Chen B, Xu Y, Zhang Z, et al. Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation. Hum Genet. 2019;138:327-337 pubmed publisher
    The human zona pellucida (ZP) is an extracellular glycoprotein matrix composed of ZP1, ZP2, ZP3, and ZP4 surrounding the oocyte, and it plays an important role in sperm-egg interactions during fertilization...
  4. Yan S, Wu H, He F, Hu X, Zhang Z, Huang M, et al. High expression of zinc-binding protein-89 predicts decreased survival in esophageal squamous cell cancer. Ann Thorac Surg. 2014;97:1966-73 pubmed publisher
    Zinc-binding protein-89 (ZBP-89), a Krüppel-type four-zinc finger transcription factor, is associated with many cellular functions, including cell growth, differentiation, and apoptosis...
  5. Bu Y, Su F, Wang X, Gao H, Lei L, Chang N, et al. Protein tyrosine phosphatase PTPN9 regulates erythroid cell development through STAT3 dephosphorylation in zebrafish. J Cell Sci. 2014;127:2761-70 pubmed publisher
    ..STAT3, and the hyper-phosphorylated STAT3 entrapped and prevented the transcription factors GATA1 and ZBP-89 (also known as ZNF148) from regulating erythroid gene expression...
  6. Yuan P, Li R, Li D, Zheng L, Ou S, Zhao H, et al. Novel mutation in the ZP1 gene and clinical implications. J Assist Reprod Genet. 2019;: pubmed publisher
    ..We performed Sanger sequencing of the LHCGR and ZP1~ZP4 genes in the patients, and further bioinformatics analysis was performed to identify pathogenic elements in the ..
  7. Hara S, Kawasaki S, Yoshihara M, Winegarner A, Busch C, Tsujikawa M, et al. Transcription factor TFAP2B up-regulates human corneal endothelial cell-specific genes during corneal development and maintenance. J Biol Chem. 2019;294:2460-2469 pubmed publisher
    ..of the corneal endothelium-specific proteins type VIII collagen α2 (COL8A2) and zona pellucida glycoprotein 4 (ZP4) and suppressed cell proliferation...
  8. Lee A, Kim N, Seo Y, Choi S, Lee J. Thermodynamic Model for B-Z Transition of DNA Induced by Z-DNA Binding Proteins. Molecules. 2018;23: pubmed publisher
    ..In the ZBP-Z-DNA complexes, three identical, conserved residues (N173, Y177, and W195 in the Zα domain of human ADAR1) play ..
  9. Izumikawa K, Ishikawa H, Simpson R, Takahashi N. Modulating the expression of Chtop, a versatile regulator of gene-specific transcription and mRNA export. RNA Biol. 2018;15:849-855 pubmed publisher
    ..genes in breast cancer cells, the 5-hydroxymethylcytosine-modified genes involved in glioblastomagenesis, or the Zbp-89-dependent genes in erythroleukemia cells. Chtop also represses expression of the fetal γ-globin gene...

More Information

Publications93

  1. Costa J, Pereira R, Oliveira J, Alves A, Marques Magalhães Â, Frutuoso A, et al. Structural and molecular analysis of the cancer prostate cell line PC3: Oocyte zona pellucida glycoproteins. Tissue Cell. 2018;55:91-106 pubmed publisher
    The human oocyte zona pellucida (ZP) is made of four glycoproteins, ZP1-ZP4. Recently, the prostate adenocarcinoma and prostate cancer PC3 cell-line were shown to express the human oocyte ZP3 glycoprotein, which was evaluated in a single ..
  2. Wassarman P, Litscher E. The Mouse Egg's Zona Pellucida. Curr Top Dev Biol. 2018;130:331-356 pubmed publisher
    ..Unlike somatic cell ECM the mouse ZP is composed of three different proteins, ZP1-3, that are synthesized and secreted by growing oocytes and assembled into long interconnected fibrils...
  3. Nolan M, Bertschinger H, Roth R, Crampton M, Martins I, Fosgate G, et al. Ovarian function following immunocontraceptive vaccination of mares using native porcine and recombinant zona pellucida vaccines formulated with a non-Freund's adjuvant and anti-GnRH vaccines. Theriogenology. 2018;120:111-116 pubmed publisher
    ..following vaccine formulations; native porcine zona pellucida (pZP), recombinant zona pellucida proteins ZP3 and ZP4 (reZP), pZP and reZP combined or a commercially available anti-GnRH vaccine...
  4. Tan Y, Zhang D, Gong B, Zhang X, Jiang L, Lin Y. [Association of ZP4 gene polymorphism with primary open-angle glaucoma in an ethnic Chinese population from Sichuan province]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2018;35:737-740 pubmed publisher
    ..single nucleotide polymorphisms (SNP) rs547984, rs540782, rs693421 and rs2499601 of Zona Pellucida Glycoprotein 4 (ZP4) gene with primary open-angle glaucoma (POAG) among ethnic Han Chinese from Sichuan Province...
  5. Xuan B, Li Z, Wang Q, Xu M, Chen X, Jin Y. Inhibition of PSMD4 alters ZP1 ubiquitination state and sperm-oocyte-binding ability in pigs. Reprod Domest Anim. 2018;53:688-694 pubmed publisher
    ..this study was to determine how the duration of culture affects the ubiquitination of zona pellucida (ZP) proteins (ZP1, ZP2 and ZP3) during porcine oocyte maturation in vitro...
  6. Kong X, Xu P, Cai W, Wang H, Li B, Huang G, et al. ZBP-89 and Sp1 contribute to Bak expression in hepatocellular carcinoma cells. BMC Cancer. 2018;18:419 pubmed publisher
    Kruppel family member zinc binding protein 89 (ZBP-89), also known as ZNF148, regulates Bak expression via binding to GC-rich promoter domain...
  7. Rahmatpanah F, Agrawal S, Jaiswal N, Nguyen H, McClelland M, Agrawal A. Airway epithelial cells prime plasmacytoid dendritic cells to respond to pathogens via secretion of growth factors. Mucosal Immunol. 2019;12:77-84 pubmed publisher
    ..Upregulated transcripts included those encoding cytosolic sensors of DNA, ZBP-1,IRF-3, and NFkB as well as genes involved in amplification of the IFN response, such as IFNAR1, JAK/STAT, ISG15...
  8. Litscher E, Wassarman P. The Fish Egg's Zona Pellucida. Curr Top Dev Biol. 2018;130:275-305 pubmed publisher
    ..The fish egg ZP consists of only a few proteins that are homologs of mammalian ZP proteins ZP1, ZP3, and ZP4...
  9. Tabibnejad N, Soleimani M, Aflatoonian A. Zona pellucida birefringence and meiotic spindle visualization are not related to the time-lapse detected embryo morphokinetics in women with polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol. 2018;230:96-102 pubmed publisher
    ..Time-lapse morphokinetic events in conjunction with zona pellucida birefringence (ZPB) and meiotic spindle visualization (MSV) have been evaluated for predicting pregnancy outcome...
  10. Yoshihara M, Ohmiya H, Hara S, Kawasaki S, Hayashizaki Y, Itoh M, et al. Discovery of molecular markers to discriminate corneal endothelial cells in the human body. PLoS ONE. 2015;10:e0117581 pubmed publisher
    ..We identified five genes, CLRN1, MRGPRX3, HTR1D, GRIP1 and ZP4 as novel markers of CECs, and the specificities of these genes were successfully confirmed by independent ..
  11. Gahlay G, Gauthier L, Baibakov B, Epifano O, Dean J. Gamete recognition in mice depends on the cleavage status of an egg's zona pellucida protein. Science. 2010;329:216-9 pubmed publisher
    At fertilization, mouse sperm bind to the zona pellucida (which consists of glycoproteins ZP1, ZP2, and ZP3) that surrounds eggs...
  12. Moros Nicolás C, Leza A, Chevret P, Guillén Martínez A, González Brusi L, Boue F, et al. Analysis of ZP1 gene reveals differences in zona pellucida composition in carnivores. Reprod Fertil Dev. 2018;30:272-285 pubmed publisher
    ..Previous studies suggested that carnivore ZP was formed by three glycoproteins (ZP2, ZP3 and ZP4), with ZP1 being a pseudogene. However, a recent study in the cat found that all four proteins were expressed...
  13. Gupta S. The Human Egg's Zona Pellucida. Curr Top Dev Biol. 2018;130:379-411 pubmed publisher
    ..network of thin interconnected filaments, is primarily composed of four glycoproteins, namely, ZP1, ZP2, ZP3, and ZP4. All four zona proteins share common structural elements such as signal peptide, "ZP domain," consensus furin ..
  14. Jin Y, Zhang X, Zhang B, Kang H, Du L, Li M. Nanostructures of an amphiphilic zinc phthalocyanine polymer conjugate for photodynamic therapy of psoriasis. Colloids Surf B Biointerfaces. 2015;128:405-409 pubmed publisher
    ..In this study, an amphiphilic zinc phthalocyanine polymer conjugate (ZPB) was synthesized, in which zinc phthalocyanine (ZnPc) was conjugated with the poly(ethylene glycol) (PEG) chain of ..
  15. Bornelöv S, Seroussi E, Yosefi S, Benjamini S, Miyara S, Ruzal M, et al. Comparative omics and feeding manipulations in chicken indicate a shift of the endocrine role of visceral fat towards reproduction. BMC Genomics. 2018;19:295 pubmed publisher
    ..These comparisons revealed expression of new adipokines and secreted proteins (LCAT, LECT2, SERPINE2, SFTP1, ZP1, ZP3, APOV1, VTG1 and VTG2) at the mRNA and/or protein levels, with dynamic gene expression patterns in the ..
  16. Shah S, Saini N, Ashraf S, Singh M, Manik R, Singla S, et al. Cumulus cell-conditioned medium supports embryonic stem cell differentiation to germ cell-like cells. Reprod Fertil Dev. 2017;29:679-693 pubmed publisher
    ..DAZL and VASA), meiotic (SYCP3, MLH1 and PROTAMINE 1), spermatocyte (ACROSIN and HAPRIN) and oocyte (GDF9 and ZP4) markers in both EBs and monolayer differentiation cultures...
  17. Anchan R, Gerami Naini B, Lindsey J, Ho J, Kiezun A, Lipskind S, et al. Efficient differentiation of steroidogenic and germ-like cells from epigenetically-related iPSCs derived from ovarian granulosa cells. PLoS ONE. 2015;10:e0119275 pubmed publisher
    ..markers (AMHR, FSHR, Cyp19a1, ER and Inha) as well as markers of early gametogenesis (Mvh, Dazl, Gdf9, Boule and Zp1) more frequently than EBs of the other cell lines...
  18. Li P, Zhou L, Mou Y, Mao Z. Extraction optimization of polysaccharide from Zanthoxylum bungeanum using RSM and its antioxidant activity. Int J Biol Macromol. 2015;72:19-27 pubmed publisher
    ..In those four antioxidant assay models, Z. bungeanum polysaccharide (ZBP) displayed prominent antioxidant activities with low EC50 values of 0.011, 0.021, 0.056 and 0...
  19. Dalman A, Totonchi M, Rezazadeh Valojerdi M. Human Ovarian Theca-Derived Multipotent Stem Cells Have The Potential to Differentiate into Oocyte-Like Cells In Vitro. Cell J. 2019;20:527-536 pubmed publisher
    ..Gene expressions of PRDM1, PRDM14, VASA, DAZL, OCT4, ZP1, 2, 3 GDF9, SCP3 and DMC1 were evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) ..
  20. Nishio S, Okumura H, Matsuda T. Egg-Coat and Zona Pellucida Proteins of Chicken as a Typical Species of Aves. Curr Top Dev Biol. 2018;130:307-329 pubmed publisher
    ..The egg-coat ZP proteins, ZP1, ZP3, and ZPD as the majors, accumulate and form the matrix by self-assembly around the egg rapidly growing in the ..
  21. Kempisty B, Piotrowska H, Bukowska D, Woźna M, Ciesiółka S, Wojtanowicz Markiewicz K, et al. Expression and cellular distribution of zona pellucida glycoproteins in canine oocytes before and after in vitro maturation. Zygote. 2015;23:863-73 pubmed publisher
    ..This study was aimed at investigating zona pellucida glycoproteins (ZP) ZP2, ZP3 mRNA expression as well as ZP3, ZP4 (ZPB) protein distribution before and after in vitro maturation (IVM) in canine oocytes...
  22. Stetson I, Avilés M, Moros C, García Vázquez F, Gimeno L, Torrecillas A, et al. Four glycoproteins are expressed in the cat zona pellucida. Theriogenology. 2015;83:1162-73 pubmed publisher
    ..In cat (Felis catus), this matrix is composed of at least three glycoproteins called ZP2, ZP3, and ZP4. However, recent studies have pointed to the presence of a fourth protein in several mammals (rat, human, hamster ..
  23. Ye C, Liu L, Chen G, Tang X, He Z, He M, et al. ZBP-89 reduces histone deacetylase 3 by degrading IkappaB in the presence of Pin1. J Transl Med. 2015;13:23 pubmed publisher
    Histone deacetylase 3 (HDAC3) is overexpressed in cancers and its inhibition enhances anti-tumor chemotherapy. ZBP-89, a transcription factor, can induce pro-apoptotic Bak and reduce HDAC3 but the mechanism is unknown...
  24. Nishio S, Kohno Y, Iwata Y, Arai M, Okumura H, Oshima K, et al. Glycosylated chicken ZP2 accumulates in the egg coat of immature oocytes and remains localized to the germinal disc region of mature eggs. Biol Reprod. 2014;91:107 pubmed publisher
    ..RT-PCR analysis indicated marked expression of the ZP2 and ZP4 genes in the granulosa cells of immature white follicles, whereas the ZP3 and ZPD genes showed marked expression in ..
  25. Gupta S. Role of zona pellucida glycoproteins during fertilization in humans. J Reprod Immunol. 2015;108:90-7 pubmed publisher
    ..ZP glycoprotein-1 (ZP1), ZP3, and ZP glycoprotein-4 (ZP4) have been shown to bind to the capacitated human sperm. ZP2 binds to the acrosome-reacted human spermatozoa...
  26. Ha N, Shin H, Sharma P, Cho H, Min C, Kim H, et al. Generation of protective immunity against Orientia tsutsugamushi infection by immunization with a zinc oxide nanoparticle combined with ScaA antigen. J Nanobiotechnology. 2016;14:76 pubmed
    ..A novel zinc oxide-binding peptide (ZBP), FPYPGGDA, with high affinity to ZNP (K a  = 2...
  27. Wu T, Cheng Y, Liu Z, Tao W, Zheng S, Wang D. Bioinformatic analyses of zona pellucida genes in vertebrates and their expression in Nile tilapia. Fish Physiol Biochem. 2018;44:435-449 pubmed publisher
    ..9, 17, 27, 21, 20, 26, 19, 14,11, 24, 17, 9, 18, 8, 11, 9, 8, 5, and 4 ZP genes belonging to 5 subfamilies (ZPA, ZPB, ZPC, ZPD, and ZPAX) were found in the sea lamprey, elephant shark, coelacanth, spotted gar, zebrafish, medaka, ..
  28. Kim M, Lee H, Park J, Hong J, Yang W. Zanthoxylum piperitum reversed alveolar bone loss of periodontitis via regulation of bone remodeling-related factors. J Ethnopharmacol. 2017;195:137-142 pubmed publisher
    ..were assigned into 4 groups; non-ligated (NOR), ligated and treated vehicle (CTR), ligated and treated 1mg/mL ZP (ZP1), and ligated and treated 100mg/mL ZP (ZP100)...
  29. Ben Bassat T, Avnieli S. The effect of a road safety educational program for kindergarten children on their parents' behavior and knowledge. Accid Anal Prev. 2016;95:78-85 pubmed publisher
    ..The program, named the "Zahav Bagan" program (ZBP), is presented at kindergartens once a week during the entire academic year...
  30. Louros N, Iconomidou V, Giannelou P, Hamodrakas S. Structural analysis of peptide-analogues of human Zona Pellucida ZP1 protein with amyloidogenic properties: insights into mammalian Zona Pellucida formation. PLoS ONE. 2013;8:e73258 pubmed publisher
    ..Mammalian ZP consists of three to four glycoproteins, called ZP1, ZP2, ZP3, ZP4...
  31. Suzuki K, Tatebe N, Kojima S, Hamano A, Orita M, Yonezawa N. The Hinge Region of Bovine Zona Pellucida Glycoprotein ZP3 Is Involved in the Formation of the Sperm-Binding Active ZP3/ZP4 Complex. Biomolecules. 2015;5:3339-53 pubmed publisher
    ..Bovine ZP consists of glycoproteins ZP2, ZP3, and ZP4. Neither ZP3 nor ZP4 alone shows inhibitory activity for the binding of sperm to the ZP; however, this activity is ..
  32. Feng Y, Wang X, Xu L, Pan H, Zhu S, Liang Q, et al. The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. FEBS J. 2009;276:4197-206 pubmed publisher
    The transcription factor ZBP-89 has been implicated in the induction of growth arrest and apoptosis...
  33. Borghaei R, Gorski G, Seutter S, Chun J, Khaselov N, Scianni S. Zinc-binding protein-89 (ZBP-89) cooperates with NF-κB to regulate expression of matrix metalloproteinases (MMPs) in response to inflammatory cytokines. Biochem Biophys Res Commun. 2016;471:503-9 pubmed publisher
    ..Zinc-binding protein-89 (ZBP-89) is a transcription factor with roles in regulating vital cellular processes, acting through complex ..
  34. Shah S, Saini N, Singh M, Manik R, Singla S, Palta P, et al. Testicular cell-conditioned medium supports embryonic stem cell differentiation toward germ lineage and to spermatocyte- and oocyte-like cells. Theriogenology. 2016;86:715-29 pubmed publisher
    ..markers (SYCP3, MLH1 and PROTAMINE1), spermatocyte markers (ACROSIN and HAPRIN), and oocyte markers (GDF9 and ZP4), indicating progression into post-meiotic gametogenesis...
  35. Wahadat M, Bodewes I, Maria N, van Helden Meeuwsen C, van Dijk Hummelman A, Steenwijk E, et al. Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?. Arthritis Res Ther. 2018;20:4 pubmed publisher
    ..Upregulated gene expression of TLR7, RLRs (IFIH1, DDX58, DDX60, DHX58) and DBRs (ZBP-1, IFI16) was observed in CD14+ monocytes of the IFN-I-positive cSLE patients...
  36. Nilton A, Sayin V, Zou Z, Sayin S, Bondjers C, Gul N, et al. Targeting Zfp148 activates p53 and reduces tumor initiation in the gut. Oncotarget. 2016;7:56183-56192 pubmed publisher
    The transcription factor Zinc finger protein 148 (Zfp148, ZBP-89, BFCOL, BERF1, ht?) interacts physically with the tumor suppressor p53, but the significance of this interaction is not known...
  37. Egge N, Muthusubramanian A, Cornwall G. Amyloid properties of the mouse egg zona pellucida. PLoS ONE. 2015;10:e0129907 pubmed publisher
    ..The mouse ZP is composed of three proteins, ZP1, ZP2, and ZP3, all of which have a ZP polymerization domain that directs protein fibril formation and assembly into ..
  38. Zhao X, Wu J, Zhang Y, Zhu L, Lu X. Alterations of Intestinal Labile Zinc and Cytokine Production Following Subarachnoid Hemorrhage in Rats. Ann Clin Lab Sci. 2016;46:622-626 pubmed
    ..SAH caused a gradual increase of intestinal labile zinc as demonstrated by fluorescence staining with Zinpyr-4 (ZP4)...
  39. Wang D, An S, Liu L, Bai S, Wu K, Zhu R, et al. Hepatitis B virus X protein influences enrichment profiles of H3K9me3 on promoter regions in human hepatoma cell lines. Oncotarget. 2016;7:84883-84892 pubmed publisher
    ..Most of these genes have not been previously reported in HCC, and BTBD17, MIR6089, ZNF205-AS1 and ZP1 have not previously been linked to cancer; only two genes (DAB2IP and ZNF185) have been reported in HCC...
  40. Xiong B, Zhao Y, Beall S, Sadusky A, Dean J. A Unique Egg Cortical Granule Localization Motif Is Required for Ovastacin Sequestration to Prevent Premature ZP2 Cleavage and Ensure Female Fertility in Mice. PLoS Genet. 2017;13:e1006580 pubmed publisher
    Monospermic fertilization is mediated by the extracellular zona pellucida composed of ZP1, ZP2 and ZP3...
  41. Watanabe A, Takayama Watanabe E. In silico identification of the genes for sperm-egg interaction in the internal fertilization of the newt Cynops pyrrhogaster. Int J Dev Biol. 2014;58:873-9 pubmed publisher
    ..In the ovary, ZP homologues of all six subgroups were found, including a ZP1 homologue that was newly found in amphibians, a ZP4 homologue, and six ZPC homologues...
  42. Wang S, Fu Y, Luo Y. Comparisons of biophysical properties and bioactivities of mono-PEGylated endostatin and an endostatin analog. Chin J Cancer. 2016;35:14 pubmed publisher
    ..An ES variant, called zinc-binding protein-ES (ZBP-ES), is clinically available; however, its use is limited by rapid renal clearance and short residence time...
  43. Dyce P, Tenn N, Kidder G. Retinoic acid enhances germ cell differentiation of mouse skin-derived stem cells. J Ovarian Res. 2018;11:19 pubmed publisher
    ..the structural integrity of the OLCs produced by initiating the expression of all three zona pellucida transcripts (Zp1-3) and improving ZP3 expression levels and localization...
  44. Zhang X, Zhou H, Zhang Y, Cai L, Jiang G, Li A, et al. ZNF452 facilitates tumor proliferation and invasion via activating AKT-GSK3β signaling pathway and predicts poor prognosis of non-small cell lung cancer patients. Oncotarget. 2017;8:38863-38875 pubmed publisher
    ZNF452 is a zinc-finger protein family member which contains an isolated SCAN (SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) zinc-finger domain...
  45. Kondkar A, Edward N, Kalantan H, Al Kharashi A, Altuwaijri S, Mohamed G, et al. Lack of association between polymorphism rs540782 and primary open angle glaucoma in Saudi patients. J Negat Results Biomed. 2017;16:3 pubmed publisher
    ..To investigate whether polymorphism rs540782 on chromsome 1, in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene, is a risk factor for primary open angle glaucoma (POAG)...
  46. Lee A, Park C, Cheong H, Ryu K, Park J, Kwon M, et al. Solution structure of the Z-DNA binding domain of PKR-like protein kinase from Carassius auratus and quantitative analyses of the intermediate complex during B-Z transition. Nucleic Acids Res. 2016;44:2936-48 pubmed publisher
    ..Here, we report the solution structure of the Zα domain of the ZBP-containing protein kinase from Carassius auratus(caZαPKZ)...
  47. Shah S, Singla S, Palta P, Manik R, Chauhan M. Retinoic acid induces differentiation of buffalo (Bubalus bubalis) embryonic stem cells into germ cells. Gene. 2017;626:358-366 pubmed publisher
    ..SYCP3, MLH1 and PROTAMINE1 (Meiotic-markers); ACROSIN and HAPRIN (Spermatocyte-markers); and GDF9 and ZP4 (Oocyte-markers) in optimally differentiated embryoid bodies (EBs) and adherent cultures...
  48. Yang S, Liu L, Niu L, Sun Y, Yang X, Fan J, et al. Downregulation and pro-apoptotic effect of hypoxia-inducible factor 2 alpha in hepatocellular carcinoma. Oncotarget. 2016;7:34571-81 pubmed publisher
    ..Over-expression of HIF-2? induced apoptosis in HCC cells and increased the levels of pro-apoptotic proteins, Bak, ZBP-89 and PDCD4, whereas the inhibition of HIF-2? expression achieved opposite results...
  49. Canosa S, Adriaenssens T, Coucke W, Dalmasso P, Revelli A, Benedetto C, et al. Zona pellucida gene mRNA expression in human oocytes is related to oocyte maturity, zona inner layer retardance and fertilization competence. Mol Hum Reprod. 2017;23:292-303 pubmed publisher
    Do the mRNA expression levels of zona pellucida (ZP) genes, ZP1, 2, 3 and 4 in oocyte and cumulus cells (CC) reveal relevant information on the oocyte? The ZP mRNA expression in human oocytes is related to oocyte maturity, zona inner ..
  50. Upton J, Kaiser W. DAI Another Way: Necroptotic Control of Viral Infection. Cell Host Microbe. 2017;21:290-293 pubmed publisher
    ..This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.
  51. Yang P, Luan X, Peng Y, Chen T, Su S, Zhang C, et al. Novel zona pellucida gene variants identified in patients with oocyte anomalies. Fertil Steril. 2017;107:1364-1369 pubmed publisher
    To detect ZP (zona pellucida) gene (ZP1-ZP4) mutations in patients with oocyte anomalies. Case-control genetic study. University-based reproductive medicine center...
  52. Azad T, Edward N, Kondkar A, Kalantan H, Altuwaijri S, Sultan T, et al. Polymorphism rs547984 on human chromosome 1q43 is not associated with primary open angle glaucoma in a Saudi cohort. J Negat Results Biomed. 2017;16:12 pubmed publisher
    ..the association between polymorphism rs547984, located in close proximity to the Zona Pellucida Glycoprotein 4 (ZP4) gene on human chromosome 1q43 and primary open angle glaucoma (POAG)...
  53. Papageorgiou D, Karkoulia E, Amaral Psarris A, Burda P, Kolodziej K, Demmers J, et al. Distinct and overlapping DNMT1 interactions with multiple transcription factors in erythroid cells: Evidence for co-repressor functions. Biochim Biophys Acta. 2016;1859:1515-1526 pubmed publisher
    ..specific transcription factors and propose the existence of a "core" DNMT1 complex with the transcription factors ZBP-89 and ZNF143, which is also present in non-hematopoietic cells. Furthermore, we identified the short (17a.a...
  54. Petit F, Serres C, Bourgeon F, Pineau C, Auer J. Identification of sperm head proteins involved in zona pellucida binding. Hum Reprod. 2013;28:852-65 pubmed publisher
    ..Co-precipitation experiments with rhZP-coated beads confirmed the direct interaction of GSTM with ZP4 and of VDAC2 with ZP2 and ZP3. We used recombinant ZP in place of native ZP...
  55. Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, et al. Three susceptible loci associated with primary open-angle glaucoma identified by genome-wide association study in a Japanese population. Proc Natl Acad Sci U S A. 2009;106:12838-42 pubmed publisher
    ..These findings would provide the foundation for future studies to build on, such as for the metaanalysis, to reveal the molecular mechanism of the POAG pathogenesis...
  56. Caballero Campo P, Chirinos M, Fan X, González González M, Galicia Chavarría M, Larrea F, et al. Biological effects of recombinant human zona pellucida proteins on sperm function. Biol Reprod. 2006;74:760-8 pubmed
    ..Recently, human ZP was demonstrated to be composed of four proteins: ZP1, ZP2, ZP3, and ZP4...
  57. José O, Hernandez Hernandez O, Chirinos M, González González M, Larrea F, Almanza A, et al. Recombinant human ZP3-induced sperm acrosome reaction: evidence for the involvement of T- and L-type voltage-gated calcium channels. Biochem Biophys Res Commun. 2010;395:530-4 pubmed publisher
    ..Four glycoproteins (ZP1-ZP4) compose the human ZP, being ZP3 the physiological inductor of the AR...
  58. Tsai T, JOHNSON J, White Y, John J. The molecular characterization of porcine egg precursor cells. Oncotarget. 2017;8:63484-63505 pubmed publisher
    ..The presence of Zp1, Zp2, Zp3 and Nobox were not detected, indicating that porcine EPCs are not indicative of ..
  59. Zhao M, Gold L, Ginsberg A, Liang L, Dean J. Conserved furin cleavage site not essential for secretion and integration of ZP3 into the extracellular egg coat of transgenic mice. Mol Cell Biol. 2002;22:3111-20 pubmed
    The extracellular zona pellucida surrounding mammalian eggs is formed by interactions of the ZP1, ZP2, and ZP3 glycoproteins. Female mice lacking ZP2 or ZP3 do not form a stable zona matrix and are sterile...
  60. Shah S, Singla S, Palta P, Manik R, Chauhan M. Retinoic acid induces differentiation of buffalo (Bubalus bubalis) embryonic stem cells into germ cells. Gene. 2017;631:54-67 pubmed publisher
    ..SYCP3, MLH1 and PROTAMINE1 (Meiotic-markers); ACROSIN and HAPRIN (Spermatocyte-markers); and GDF9 and ZP4 (Oocyte-markers) in optimally differentiated embryoid bodies (EBs) and adherent cultures...
  61. Ocadiz Ruiz R, Photenhauer A, Hayes M, Ding L, Fearon E, Merchant J. ZBP-89 function in colonic stem cells and during butyrate-induced senescence. Oncotarget. 2017;8:94330-94344 pubmed publisher
    b>ZBP-89 (Zfp148, ZNF148) is a Kruppel-type zinc-finger family transcription factor that binds to GC-rich DNA elements...
  62. Chiu P, Wong B, Chung M, Lam K, Pang R, Lee K, et al. Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa. Biol Reprod. 2008;79:869-77 pubmed publisher
    ..Human ZP glycoprotein-3 (ZP3) is believed to initiate acrosome reaction. Recently, human ZP4 was also implicated in inducing acrosome reaction...
  63. Chalasani N, Guo X, Loomba R, Goodarzi M, Haritunians T, Kwon S, et al. Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease. Gastroenterology. 2010;139:1567-76, 1576.e1-6 pubmed publisher
    ..A GWAS significantly associated genetic variants with features of hepatic histology in patients with NAFLD. These findings should be validated in larger and more diverse cohorts. ..
  64. Eberspaecher U, Becker A, Bringmann P, van der Merwe L, Donner P. Immunohistochemical localization of zona pellucida proteins ZPA, ZPB and ZPC in human, cynomolgus monkey and mouse ovaries. Cell Tissue Res. 2001;303:277-87 pubmed
    ..The genes coding for the three zona pellucida glycoproteins ZPA, ZPB, and ZPC of various species including mouse, dog, and human have been cloned and sequenced by several groups...
  65. Harris J, Hibler D, Fontenot G, Hsu K, Yurewicz E, Sacco A. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: the ZPA, ZPB and ZPC gene families. DNA Seq. 1994;4:361-93 pubmed
    ..The members of these gene families are herein referred to as ZPA, ZPB and ZPC genes to avoid the confusion that currently exists in the zona pellucida of nomenclature...
  66. McCauley J, Zuvich R, Bradford Y, Kenealy S, Schnetz Boutaud N, Gregory S, et al. Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis. Genes Immun. 2009;10:624-30 pubmed publisher
    ..We found preliminary evidence to suggest that common variation within the RGS7 locus may be involved in disease susceptibility. ..
  67. Lefievre L, Conner S, Salpekar A, Olufowobi O, Ashton P, Pavlovic B, et al. Four zona pellucida glycoproteins are expressed in the human. Hum Reprod. 2004;19:1580-6 pubmed
    ..Recent data have shown the presence of four human zona genes (ZP1, ZP2, ZP3 and ZPB)...
  68. Lee A, Seo Y, Choi S, Ryu K, Cheong H, Lee S, et al. NMR elucidation of reduced B-Z transition activity of PKZ protein kinase at high NaCl concentration. Biochem Biophys Res Commun. 2017;482:335-340 pubmed publisher
    A Z-DNA binding protein (ZBP)-containing protein kinase (PKZ) in fish species has an important role in the innate immune response...
  69. Essien B, Sundaresan S, Ocadiz Ruiz R, Chavis A, Tsao A, Tessier A, et al. Transcription Factor ZBP-89 Drives a Feedforward Loop of ?-Catenin Expression in Colorectal Cancer. Cancer Res. 2016;76:6877-6887 pubmed
    ..Here, we show in colorectal cancer that increased expression of ZNF148, the gene coding for transcription factor ZBP-89, correlated with reduced patient survival...
  70. Saldívar Hernández A, González González M, Sánchez Tusié A, Maldonado Rosas I, López P, Treviño C, et al. Human sperm degradation of zona pellucida proteins contributes to fertilization. Reprod Biol Endocrinol. 2015;13:99 pubmed publisher
    ..This study suggests that sperm proteasomes could participate in the degradation of ZP, particularly of the ZP4 protein...
  71. Rankin T, Dean J. The zona pellucida: using molecular genetics to study the mammalian egg coat. Rev Reprod. 2000;5:114-21 pubmed
    ..In mice and humans, this matrix is known as the zona pellucida and comprises three glycoproteins: ZP1, ZP2 and ZP3...
  72. Meczekalski B, Nawrot R, Nowak W, Czyzyk A, Kedzia H, Gozdzicka Jozefiak A. Study on the zona pellucida 4 (ZP4) gene sequence and its expression in the ovaries of patients with polycystic ovary syndrome. J Endocrinol Invest. 2015;38:791-7 pubmed publisher
    ..The zona pellucida 4 (ZP4) gene encodes glycoprotein which is a part of the extracellular matrix of oocyte...
  73. Yauger B, Boggs N, Dean J. Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice. Reproduction. 2011;141:313-9 pubmed publisher
    ..ovulated eggs contains three proteins (ZP1, ZP2, and ZP3) whereas the human zona contains four (ZP1, ZP2, ZP3, and ZP4). Human sperm are fastidious and recognize human but not mouse eggs...
  74. Moros Nicolás C, Chevret P, Izquierdo Rico M, Holt W, Esteban Díaz D, Lopez Bejar M, et al. Composition of marsupial zona pellucida: a molecular and phylogenetic approach. Reprod Fertil Dev. 2017;: pubmed publisher
    ..In eutherians it is formed from three or four proteins (ZP1, ZP2, ZP3, ZP4)...
  75. Nizyaeva N, Kulikova G, Nagovitsyna M, Khlestova G, Yushina M, Baev O, et al. DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia. Bull Exp Biol Med. 2017;164:109-114 pubmed publisher
    DAI-1 receptor (DNA-dependent activator of IFN-regulatory factors; DLM-1/ZBP-1) is an innate immunity cytoplasmic receptor of the DNA-recognition receptor class of antiviral immunity...
  76. Kiefer S, Saling P. Proteolytic processing of human zona pellucida proteins. Biol Reprod. 2002;66:407-14 pubmed
    ..Zona pellucida glycoproteins, ZP1, ZP2, and ZP3, are secreted to form an insoluble extracellular matrix surrounding mammalian eggs...
  77. Avella M, Baibakov B, Jimenez Movilla M, Sadusky A, Dean J. ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception. Sci Transl Med. 2016;8:336ra60 pubmed publisher
    ..The acellular zona matrix is composed of three (mouse) or four (human) proteins (ZP1 to ZP4), and the amino terminus of ZP2 is the primary sperm-binding ligand...
  78. Gonzalez P, Epstein D, Borras T. Characterization of gene expression in human trabecular meshwork using single-pass sequencing of 1060 clones. Invest Ophthalmol Vis Sci. 2000;41:3678-93 pubmed
  79. Choudhury S, Ganguly A, Chakrabarti K, Sharma R, Gupta S. DNA vaccine encoding chimeric protein encompassing epitopes of human ZP3 and ZP4: immunogenicity and characterization of antibodies. J Reprod Immunol. 2009;79:137-47 pubmed publisher
    ..ZP glycoprotein-3 (ZP3) epitope corresponding to amino acid (aa) residues 334-343 and a human ZP glycoprotein-4 (ZP4) epitope corresponding to aa residues 251-273 separated by a triglycine spacer was constructed using the mammalian ..
  80. Furlong L, Harris J, Vazquez Levin M. Binding of recombinant human proacrosin/acrosin to zona pellucida (ZP) glycoproteins. I. Studies with recombinant human ZPA, ZPB, and ZPC. Fertil Steril. 2005;83:1780-90 pubmed
    ..from human proacrosin (Rec-40, Rec-30, Rec-20, Rec-10, and Rec-6) and from human ZP glycoproteins (rec-hZPA, ZPB, and ZPC). In vitro binding assay developed to assess proacrosin/acrosin-ZP interaction...
  81. Qi H, Williams Z, Wassarman P. Secretion and assembly of zona pellucida glycoproteins by growing mouse oocytes microinjected with epitope-tagged cDNAs for mZP2 and mZP3. Mol Biol Cell. 2002;13:530-41 pubmed
    ..These results strongly suggest that nascent mZP2 and mZP3 are incorporated into only the innermost layer of the ZP and that excision of the C-terminal region of the glycoproteins is required for assembly into the oocyte ZP. ..
  82. Chakravarty S, Suraj K, Gupta S. Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C. Mol Hum Reprod. 2005;11:365-72 pubmed
    ..These studies, for the first time, have demonstrated that in humans, ZPB also induces acrosomal exocytosis through a Gi independent pathway.
  83. Mabuchi F, Mabuchi N, Takamoto M, Sakurada Y, Yoneyama S, Kashiwagi K, et al. Genetic Variant Near PLXDC2 Influences the Risk of Primary Open-angle Glaucoma by Increasing Intraocular Pressure in the Japanese Population. J Glaucoma. 2017;26:963-966 pubmed publisher
    ..HTG), n=207] and 244 control subjects without glaucoma were analyzed for 3 genetic variants: rs547984 (near gene: ZP4), rs7081455 (PLXDC2), and rs7961953 (TMTC2)...
  84. Louros N, Chrysina E, Baltatzis G, Patsouris E, Hamodrakas S, Iconomidou V. A common 'aggregation-prone' interface possibly participates in the self-assembly of human zona pellucida proteins. FEBS Lett. 2016;590:619-30 pubmed publisher
    Human zona pellucida (ZP) is composed of four glycoproteins, namely ZP1, ZP2, ZP3 and ZP4. ZP proteins form heterodimers, which are incorporated into filaments through a common bipartite polymerizing component, designated as the ZP ..