ZnT 7


Gene Symbol: ZnT 7
Description: solute carrier family 30 member 7
Alias: ZNT7, ZnT-7, ZnTL2, zinc transporter 7, solute carrier family 30 (zinc transporter), member 7, zinc transporter ZnT-7, zinc transporter like 2, znt-like transporter 2
Species: human
Products:     ZnT 7

Top Publications

  1. Kirschke C, Huang L. ZnT7, a novel mammalian zinc transporter, accumulates zinc in the Golgi apparatus. J Biol Chem. 2003;278:4096-102 pubmed
    b>ZnT7, a novel member of the zinc transporter (ZnT) family, was identified by searching the expressed sequence tag (EST) databases with the amino acid sequence of ZnT1...
  2. Huang L, Tepaamorndech S, Kirschke C, Cai Y, Zhao J, Cao X, et al. Subcongenic analysis of a quantitative trait locus affecting body weight and glucose metabolism in zinc transporter 7 (znt7)-knockout mice. BMC Genet. 2019;20:19 pubmed publisher
    A genome-wide mapping study using male F2 zinc transporter 7-knockout mice (znt7-KO) and their wild type littermates in a mixed 129P1/ReJ (129P1) and C57BL/6J (B6) background identified a quantitative trait locus (QTL) on ..
  3. Olgar Y, Turan B. A SGLT2 inhibitor dapagliflozin comparison with insulin exerts important effects on Zn2+-transporters in cardiomyocytes from insulin-resistant metabolic syndrome rats through inhibition of oxidative stress. Can J Physiol Pharmacol. 2018;: pubmed publisher
    ..with no change in ZIP8 of MetS-rat cardiomyoctes, while Zn2+-transporters, responsible from cytosolic Zn2+-efflux, ZnT7 was decreased. Both treatments induced significant beneficial effects on altered ZIP14, ZIP8 and ZnT7 levels...
  4. Huang L, Yan M, Kirschke C. Over-expression of ZnT7 increases insulin synthesis and secretion in pancreatic beta-cells by promoting insulin gene transcription. Exp Cell Res. 2010;316:2630-43 pubmed publisher
    ..In this study, we demonstrated that zinc transporter 7 (ZnT7, Slc30a7) was co-expressed with insulin in the islet of Langerhans in the mouse pancreas...
  5. Foster M, Chu A, Petocz P, Samman S. Zinc transporter gene expression and glycemic control in post-menopausal women with Type 2 diabetes mellitus. J Trace Elem Med Biol. 2014;28:448-52 pubmed publisher
    ..with zinc (40mg/d) and flaxseed oil (FSO; 2g/d) on the gene expression of zinc transporters (ZnT1, ZnT5, ZnT6, ZnT7, ZnT8, Zip1, Zip3, Zip7, and Zip10) and metallothionein (MT-1A, and MT-2A), and markers of glycemic control (..
  6. Byström S, Ayoglu B, Häggmark A, Mitsios N, Hong M, Drobin K, et al. Affinity proteomic profiling of plasma, cerebrospinal fluid, and brain tissue within multiple sclerosis. J Proteome Res. 2014;13:4607-19 pubmed publisher
    ..The affinity proteomic translation of profiles discovered by profiling human body fluids and tissue provides a powerful strategy to suggest additional candidates to studies of neurological disorders. ..
  7. Hoppmann N, Graetz C, Paterka M, Poisa Beiro L, Larochelle C, Hasan M, et al. New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis. Brain. 2015;138:902-17 pubmed publisher
    ..Thus, our study confirms the involvement of multiple sclerosis risk genes in the pathophysiology of the animal model and sheds light on additional disease-relevant inflammatory networks. ..
  8. Giacconi R, Malavolta M, Chiodi L, Boccoli G, Costarelli L, Bonfigli A, et al. ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes. Diabetes Res Clin Pract. 2018;144:102-110 pubmed publisher
    ..intracellular free Zn, higher gene expression of Metallothioneins, Znt1, Znt8, Zip2 genes, and reduced Znt4 and Znt7. Higher release of IL-1α, IL-1β, IFN-γ, IL-12p70 and TNF-α and a reduced IL-10 secretion after ..
  9. Chen G, Luo Z, Wei C, Li D, Pan Y. Six indicator genes for zinc (Zn) homeostasis in freshwater teleost yellow catfish Pelteobagrus fulvidraco: molecular characterization, mRNA tissue expression and transcriptional changes to Zn exposure. Biometals. 2018;31:527-537 pubmed publisher
    ..This study cloned and characterized the full-length cDNA sequences of six Zn transport-relevant genes (ZnT1, ZnT5, ZnT7, ZIP4, ZIP5 and MTF-1) from yellow catfish Pelteobagrus fulvidraco...

More Information


  1. Huang L, Tepaamorndech S, Kirschke C, Newman J, Keyes W, Pedersen T, et al. Aberrant fatty acid metabolism in skeletal muscle contributes to insulin resistance in zinc transporter 7 (znt7)-knockout mice. J Biol Chem. 2018;293:7549-7563 pubmed publisher
    b>ZnT7 (Slc30a7) is a widely expressed zinc transporter involved in sequestration of zinc into the Golgi apparatus and vesicular compartments. znt7-knockout (KO) mice are mildly zinc-deficient and lean...
  2. Tepaamorndech S, Kirschke C, Pedersen T, Keyes W, Newman J, Huang L. Zinc transporter 7 deficiency affects lipid synthesis in adipocytes by inhibiting insulin-dependent Akt activation and glucose uptake. FEBS J. 2016;283:378-94 pubmed publisher
    Mice deficient for zinc transporter 7 protein (ZnT7) are mildly zinc deficient with low body weight gain and body fat accumulation...
  3. Hennigar S, Kelley A, McClung J. Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review. Adv Nutr. 2016;7:735-46 pubmed publisher
    ..SLC39A14), zinc transporter (ZnT)1 (SLC30A1), ZnT2 (SLC30A2), ZnT4 (SLC30A4), ZnT5 (SLC30A5), ZnT6 (SLC30A6), ZnT7 (SLC30A7), ZnT9 (SLC30A9), and/or metallothionein in various blood cells isolated from healthy adult men and women ..
  4. Tian T, Li L, Zhang S, Ni H. Long-Term Effects of Ketogenic Diet on Subsequent Seizure-Induced Brain Injury During Early Adulthood: Relationship of Seizure Thresholds to Zinc Transporter-Related Gene Expressions. Biol Trace Elem Res. 2016;174:369-376 pubmed
  5. Tuncay E, Bitirim C, Olgar Y, Durak A, Rutter G, Turan B. Zn2+-transporters ZIP7 and ZnT7 play important role in progression of cardiac dysfunction via affecting sarco(endo)plasmic reticulum-mitochondria coupling in hyperglycemic cardiomyocytes. Mitochondrion. 2019;44:41-52 pubmed publisher
    ..Since we recently have shown how hyperglycemia (HG)-induced changes in ZIP7 and ZnT7 contribute to Zn2+-transport across S(E)R and contribute to S(E)R-stress in the heart, herein, we ..
  6. Sun Q, Li Q, Zhong W, Zhang J, Sun X, Tan X, et al. Dysregulation of hepatic zinc transporters in a mouse model of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2014;307:G313-22 pubmed publisher
    ..ZIP5 and ZIP14 proteins were downregulated, while ZIP7 and ZnT7 proteins were upregulated, by ethanol exposure at all time points...
  7. Chu Q, Chi Z, Zhang X, Liang D, Wang X, Zhao Y, et al. A potential role for zinc transporter 7 in testosterone synthesis in mouse Leydig tumor cells. Int J Mol Med. 2016;37:1619-26 pubmed publisher
    ..Thus, in the present study, we aimed to determine the effect of Zn transporter 7 (ZnT7) on testosterone synthesis in male CD-1 mice and mouse Leydig cells...
  8. Tuncay E, Bitirim V, Durak A, Carrat G, Taylor K, Rutter G, et al. Hyperglycemia-Induced Changes in ZIP7 and ZnT7 Expression Cause Zn2+ Release From the Sarco(endo)plasmic Reticulum and Mediate ER Stress in the Heart. Diabetes. 2017;66:1346-1358 pubmed publisher
    ..We hypothesized that ZIP7 and ZnT7 transport Zn2+ in opposing directions across the S(E)R membrane in cardiomyocytes and that changes in ..
  9. Florea D, Molina López J, Hogstrand C, Lengyel I, de la Cruz A, Rodríguez Elvira M, et al. Changes in zinc status and zinc transporters expression in whole blood of patients with Systemic Inflammatory Response Syndrome (SIRS). J Trace Elem Med Biol. 2018;49:202-209 pubmed publisher
    ..0% of critical ill after 7?days of ICU stay. ZnT7, ZIP4 and ZIP9 were the zinc transporters with highest expression in whole blood...
  10. Ni H, Zhang L, Ren S, Sun B. Long-term expression of zinc transporters in hippocampus following penicillin-induced developmental seizures and its regulation by E-64d. Exp Ther Med. 2016;12:208-214 pubmed
    ..Thus, E-64d may offer a novel strategy for the development of therapeutic interventions for developmental seizure-induced brain damage. ..
  11. Tepaamorndech S, Oort P, Kirschke C, Cai Y, Huang L. ZNT7 binds to CD40 and influences CD154-triggered p38 MAPK activity in B lymphocytes-a possible regulatory mechanism for zinc in immune function. FEBS Open Bio. 2017;7:675-690 pubmed publisher
    ..Most importantly, we demonstrated that the zinc transporter protein zinc transporter 7 (ZNT7) interacted with CD40 using immunoprecipitation analyses...
  12. Tsuji T, Kurokawa Y, Chiche J, Pouysségur J, Sato H, Fukuzawa H, et al. Dissecting the Process of Activation of Cancer-promoting Zinc-requiring Ectoenzymes by Zinc Metalation Mediated by ZNT Transporters. J Biol Chem. 2017;292:2159-2173 pubmed publisher
    ..which is elaborately activated by means of a two-step mechanism by zinc transporter 5 (ZNT5)-ZNT6 heterodimers and ZNT7 homodimers, through protein stabilization followed by enzyme activation with zinc in the early secretory pathway...
  13. Fujimoto S, Tsuji T, Fujiwara T, Takeda T, Merriman C, Fukunaka A, et al. The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation. Biochem J. 2016;473:2611-21 pubmed publisher
    ..via protein stabilization and subsequent enzyme activation through metalation, by ZnT5-ZnT6 heterodimers or ZnT7 homodimers. However, little is known about the molecular basis underlying the activation process...
  14. Zhang X, Liang D, Guo B, Deng W, Chi Z, Cai Y, et al. Zinc transporter 5 and zinc transporter 7 induced by high glucose protects peritoneal mesothelial cells from undergoing apoptosis. Cell Signal. 2013;25:999-1010 pubmed publisher
    ..While many zinc transporters were constitutively expressed, ZnT5 mRNA and ZnT7 mRNA were strongly induced by HG...
  15. Seve M, Chimienti F, Devergnas S, Favier A. In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression. BMC Genomics. 2004;5:32 pubmed
    ..The method presented herein provides a useful tool to complete gene families from sequencing programs and to produce preliminary expression data to select the proper biological samples for laboratory experimentation. ..
  16. Grau Perez M, Pichler G, Galan Chilet I, Briongos Figuero L, Rentero Garrido P, López Izquierdo R, et al. Urine cadmium levels and albuminuria in a general population from Spain: A gene-environment interaction analysis. Environ Int. 2017;106:27-36 pubmed publisher
    ..Genetic variation in oxidative stress and cadmium metabolism and transport genes may confer differential susceptibility to potential cadmium effects. ..
  17. Olgar Y, Ozdemir S, Turan B. Induction of endoplasmic reticulum stress and changes in expression levels of Zn2+-transporters in hypertrophic rat heart. Mol Cell Biochem. 2018;440:209-219 pubmed publisher
    ..the first time, determined significantly increased ZIP7, ZIP14, and ZnT8 expressions along with decreased ZIP8 and ZnT7 levels in the heart tissue from TAC-group in comparison to SHAM-group...
  18. Cousins R. Gastrointestinal factors influencing zinc absorption and homeostasis. Int J Vitam Nutr Res. 2010;80:243-8 pubmed publisher
    ..Intracellular transporters such as ZnT7, influence the transcellular movement of zinc across the enterocyte...
  19. Overbeck S, Uciechowski P, Ackland M, Ford D, Rink L. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol. 2008;83:368-80 pubmed
    ..These data provide insight into the regulation of intracellular zinc homeostasis in cells of the immune system and may explain the variable effects of zinc deficiency on different leukocyte subsets. ..
  20. Devergnas S, Chimienti F, Naud N, Pennequin A, Coquerel Y, Chantegrel J, et al. Differential regulation of zinc efflux transporters ZnT-1, ZnT-5 and ZnT-7 gene expression by zinc levels: a real-time RT-PCR study. Biochem Pharmacol. 2004;68:699-709 pubmed
  21. Syring K, Boortz K, Oeser J, Ustione A, Platt K, Shadoan M, et al. Combined Deletion of Slc30a7 and Slc30a8 Unmasks a Critical Role for ZnT8 in Glucose-Stimulated Insulin Secretion. Endocrinology. 2016;157:4534-4541 pubmed
    ..We hypothesized that functional compensation by the Slc30a7 isoform, which encodes ZnT7, limits the impact of Slc30a8 deletion on islet function...
  22. Chen G, Hogstrand C, Luo Z, Zhang D, Ling S, Wu K. Dietary zinc addition influenced zinc and lipid deposition in the fore- and mid-intestine of juvenile yellow catfish Pelteobagrus fulvidraco. Br J Nutr. 2017;118:570-579 pubmed publisher
    ..In the fore-intestine, dietary Zn up-regulated mRNA levels of ZnT1, ZnT5, ZnT7, metallothionein (MT) and metal response element-binding transcription factor-1 (MTF-1), but down-regulated mRNA ..
  23. Zhang L, Wang X, Stoltenberg M, Danscher G, Huang L, Wang Z. Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. Brain Res Bull. 2008;77:55-60 pubmed publisher
    ..In conclusion, our data provided significant morphological evidence of zinc ions and ZNTs being actively involved in the pathological processes that lead to plaque formation. ..
  24. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed