Gene Symbol: ZNF473
Description: zinc finger protein 473
Alias: ZFP100, ZN473, zinc finger protein 473, zinc finger protein 100 homolog
Dominski Z, Erkmann J, Yang X, Sanchez R, Marzluff W. A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing. Genes Dev. 2002;16:58-71 pubmed
..Antibodies to hZFP100 precipitate U7 snRNA, and expression of hZFP100 in Xenopus oocytes stimulates processing of histone pre-mRNA, showing that hZFP100 is a component of the processing machinery. ..
Pillai R, Grimmler M, Meister G, Will C, Luhrmann R, Fischer U, et al
. Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing. Genes Dev. 2003;17:2321-33 pubmed
..Thus, the U7-specific Lsm11 protein not only specifies the assembly of the U7 Sm core but also fulfills an important role in U7 snRNP-mediated histone mRNA processing. ..
Zhang J, Tan L, Xu C, He H, Tian Q, Zhou Y, et al
. Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation. PLoS ONE. 2015;10:e0138524 pubmed publisher
..Through integrating the transcriptomic and epigenomic data, firstly we identified 3 genes (FAM50A, ZNF473 and TMEM55B) and one miRNA (hsa-mir-4291) which showed the consistent association evidence from both gene ..
de Filippo C, Key F, Ghirotto S, Benazzo A, Meneu J, Weihmann A, et al
. Recent Selection Changes in Human Genes under Long-Term Balancing Selection. Mol Biol Evol. 2016;33:1435-47 pubmed publisher
..models with an approximate Bayesian computation approach and show that the patterns in PKDREJ, SDR39U1, and ZNF473 are best explained by recent changes in selective pressure in certain populations...
Wagner E, Ospina J, Hu Y, Dundr M, Matera A, Marzluff W. Conserved zinc fingers mediate multiple functions of ZFP100, a U7snRNP associated protein. RNA. 2006;12:1206-18 pubmed
..We previously identified a 100-kDa zinc finger protein (ZFP100) as a component of U7 snRNP that interacts with the SLBP/pre-mRNA complex...
Wagner E, Marzluff W. ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase. Mol Cell Biol. 2006;26:6702-12 pubmed
..U7 snRNP contains three novel proteins, Lsm10 and Lsm11, which are part of the core U7 Sm complex, and ZFP100, a Zn finger protein that helps stabilize binding of the U7 snRNP to the histone pre-mRNA by interacting with the ..