ZNF268

Summary

Gene Symbol: ZNF268
Description: zinc finger protein 268
Alias: HZF3, zinc finger protein 3, zinc finger protein HZF3
Species: human

Top Publications

  1. ncbi Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy
    Zhouzhou Zhao
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, P R China
    Oncol Rep 20:1243-8. 2008
  2. ncbi KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains
    Huanjie Shao
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China
    Int J Mol Med 18:457-63. 2006
  3. ncbi Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element
    Ming Xiong Guo
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 281:24623-36. 2006
  4. ncbi [Cloning and characterization of two novel alternatively spliced transcripts of ZNF268]
    Chong Sun
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Yi Chuan 28:513-7. 2006
  5. ncbi ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development
    Yan Sun
    College of Life Sciences, Wuhan University, Wuhan 430072, P R China
    Int J Mol Med 14:971-5. 2004
  6. ncbi Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo
    D M Gou
    College of Life Science, Wuhan University, Wuhan 430072, China
    Biochim Biophys Acta 1518:306-10. 2001
  7. pmc Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway
    Di Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 283:16299-308. 2008
  8. ncbi Cloning and functional analysis of the promoter of ZNF268 gene
    Xiao Peng
    Department of Biotechnology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Yi Chuan Xue Bao 31:221-6. 2004
  9. pmc The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
    Wei Wang
    State Key Laboratory of Virology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China
    J Biol Chem 287:42856-66. 2012
  10. doi Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1
    Wei Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People s Republic of China
    Cell Mol Life Sci 70:3947-58. 2013

Research Grants

  1. ENKEPHALIN AND LEARNING
    Joseph Martinez; Fiscal Year: 1999

Scientific Experts

  • Wenxin Li
  • Mingxiong Guo
  • Wei Wang
  • Di Wang
  • Joseph Martinez
  • Lu Xue
  • Yan Sun
  • Huanjie Shao
  • Wen Xin Li
  • Zhouzhou Zhao
  • Chengang Zhu
  • Chong Sun
  • Yan Zeng
  • Xiao Peng
  • Hongling Qiu
  • Huan Jie Shao
  • Ming Xiong Guo
  • Zhou Zhou Zhao
  • Li Gao
  • Li Hu
  • Jinyang Cai
  • Zan Huang
  • Hui Liu
  • In Sung Song
  • Jung Nyeo Chun
  • Junhua Xu
  • Nayoung Kim
  • Yun Bo Shi
  • Chen Gang Zhu
  • Hong Ling Qiu
  • De ming Gou
  • Ze Chen
  • Yingliang Wu
  • Zongyun Chen
  • Jun Hu
  • Xianguo Wang
  • D M Gou
  • Zhiqiang Shu
  • Jian Ma
  • Jun Luo
  • Dong Hoon Kang
  • Hai Ming Hu
  • Hye In Kim
  • Ja Won Suh
  • Joo Sung Kim
  • Jawon Seo
  • Sang Won Kang
  • Hyun Chae Jung
  • Kong Ju Lee
  • Jung Mogg Kim
  • Kong Joo Lee
  • Hye Jin Song
  • Ji Hyun Park
  • Woong Yang Park
  • Jaesang Kim
  • Jun Liu
  • Yunlian Meng
  • Zhi Li
  • J Huang
  • L Gao
  • Y Sun
  • Y D Feng
  • L M Chow
  • D H Jiang
  • W X Li
  • M Abrink
  • L Hellman
  • M Aveskogh

Detail Information

Publications16

  1. ncbi Aberrant alternative splicing of human zinc finger gene ZNF268 in human hematological malignancy
    Zhouzhou Zhao
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, P R China
    Oncol Rep 20:1243-8. 2008
    The human ZNF268 gene was initially described as a gene associated with early human embryogenesis and was later implicated in human leukemia due to the identification of an alternatively splice form in leukemia patients...
  2. ncbi KRAB-containing zinc finger gene ZNF268 encodes multiple alternatively spliced isoforms that contain transcription regulatory domains
    Huanjie Shao
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China
    Int J Mol Med 18:457-63. 2006
    The ZNF268 gene was originally isolated from an early human embryo cDNA library...
  3. ncbi Transcription of human zinc finger ZNF268 gene requires an intragenic promoter element
    Ming Xiong Guo
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 281:24623-36. 2006
    Human ZNF268 gene is a typical Krüppel-associated box/C2H2 zinc finger gene whose homolog has been found only in higher mammals and not in lower mammals such as mouse...
  4. ncbi [Cloning and characterization of two novel alternatively spliced transcripts of ZNF268]
    Chong Sun
    College of Life Sciences, Wuhan University, Wuhan 430072, China
    Yi Chuan 28:513-7. 2006
    b>ZNF268 gene encodes a typical KRAB-containing zinc finger protein, which has an amino-terminal KRAB domain and 24 carboxyl-terminal C2H2 zinc finger motifs...
  5. ncbi ZNF268, a novel kruppel-like zinc finger protein, is implicated in early human liver development
    Yan Sun
    College of Life Sciences, Wuhan University, Wuhan 430072, P R China
    Int J Mol Med 14:971-5. 2004
    ..We have previously isolated a novel zinc finger gene, ZNF268, from a 3-week-old human embryo cDNA library in an effort to identify genes important for human embryonic ..
  6. ncbi Cloning and characterization of a novel Krüppel-like zinc finger gene, ZNF268, expressed in early human embryo
    D M Gou
    College of Life Science, Wuhan University, Wuhan 430072, China
    Biochim Biophys Acta 1518:306-10. 2001
    ..in early human embryonic development, we have isolated a cDNA clone representing a novel human zinc finger gene ZNF268 from 3 week old human embryo cDNA library using a differential hybridization strategy...
  7. pmc Human T-cell leukemia virus type 1 oncoprotein tax represses ZNF268 expression through the cAMP-responsive element-binding protein/activating transcription factor pathway
    Di Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    J Biol Chem 283:16299-308. 2008
    ..In this study, we investigated the role of Tax in the regulation of the ZNF268 gene, which plays a role in the differentiation of blood cells and the pathogenesis of leukemia...
  8. ncbi Cloning and functional analysis of the promoter of ZNF268 gene
    Xiao Peng
    Department of Biotechnology, College of Life Sciences, Wuhan University, Wuhan 430072, China
    Yi Chuan Xue Bao 31:221-6. 2004
    The human ZNF268 gene is a novel C2H2 zinc finger gene restrictively expressed in the liver of human embryo. As an initial study on the regulation of its expression, 2...
  9. pmc The zinc finger protein ZNF268 is overexpressed in human cervical cancer and contributes to tumorigenesis via enhancing NF-κB signaling
    Wei Wang
    State Key Laboratory of Virology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430072, China
    J Biol Chem 287:42856-66. 2012
    ..Here, we demonstrated that ZNF268, a Krüppel-associated box-containing zinc finger protein, might contribute to the development of cervical cancer...
  10. doi Novel activity of KRAB domain that functions to reinforce nuclear localization of KRAB-containing zinc finger proteins by interacting with KAP1
    Wei Wang
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, 430072, Hubei, People s Republic of China
    Cell Mol Life Sci 70:3947-58. 2013
    Previously, we found that two isoforms of the ZNF268 gene (ZNF268a and ZNF268b2, with and without the KRAB domain, respectively) might play distinct roles in normal epithelia and in cervical cancer...
  11. pmc Knockdown of ZNF268, which is transcriptionally downregulated by GATA-1, promotes proliferation of K562 cells
    Yan Zeng
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China
    PLoS ONE 7:e29518. 2012
    The human ZNF268 gene encodes a typical KRAB-C2H2 zinc finger protein that may participate in hematopoiesis and leukemogenesis. A recent microarray study revealed that ZNF268 expression continuously decreases during erythropoiesis...
  12. ncbi The mammalian gene ZNF268 is regulated by hUpf1
    Chengang Zhu
    State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, P R China
    Biochemistry (Mosc) 73:881-5. 2008
    ..Taking advantage of our previous research on ZNF268 transcription control, we studied the relationship between the ZNF268 promoter and the NMD pathway...
  13. ncbi A splice variant of the C(2)H(2)-type zinc finger protein, ZNF268s, regulates NF-kappaB activation by TNF-alpha
    Jung Nyeo Chun
    Division of Life and Pharmaceutical Sciences and Center for Cell Signaling Drug Discovery Research, Ewha Womans University, Seoul 127 750, Korea
    Mol Cells 26:175-80. 2008
    ..the IKK complex, and by MALDI-TOF mass spectrometry identified a splice variant of zinc finger protein 268 (ZNF268) as a novel IKK-interacting protein...
  14. ncbi Gene expression of AGS cells stimulated with released proteins by Helicobacter pylori
    Nayoung Kim
    Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi Do, Korea
    J Gastroenterol Hepatol 23:643-51. 2008
    ..The present study was performed to evaluate the gene expression of AGS gastric cancer cells stimulated with released proteins by H. pylori...
  15. ncbi The KRAB domain of zinc finger gene ZNF268: a potential transcriptional repressor
    Yan Sun
    College of Life Sciences, Wuhan University, Wuhan 430072, P R China
    IUBMB Life 55:127-31. 2003
    ..b>ZNF268, which was novelty isolated from early human embryo, is a typical krupple-type C2H2 zinc finger protein with a ..
  16. ncbi Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937
    M Abrink
    Department of Immunology, University of Uppsala, The Biomedical Centre, Sweden
    DNA Cell Biol 14:125-36. 1995
    ..In addition, several novel KRAB-containing zinc finger genes and a novel conserved sequence element were identified...

Research Grants1

  1. ENKEPHALIN AND LEARNING
    Joseph Martinez; Fiscal Year: 1999
    ..we think important for the acquisition and retrieval of learning in this task including lag (LTP-Associated Gene), hzf3, ngfi-b, proenkephalin, proenkephalin, and prodynorphin and others...