ZFPM2

Summary

Gene Symbol: ZFPM2
Description: zinc finger protein, FOG family member 2
Alias: DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2, zinc finger protein ZFPM2, FOG-2, Friend of GATA2, friend of GATA 2, friend of GATA protein 2, transcription factor GATA4, modulator of, zinc finger protein 89B, zinc finger protein, multitype 2
Species: human
Products:     ZFPM2

Top Publications

  1. De Luca A, Sarkozy A, Ferese R, Consoli F, Lepri F, Dentici M, et al. New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle. Clin Genet. 2011;80:184-90 pubmed publisher
    ..We investigated the occurrence and the prevalence of GATA4, NKX2.5, ZFPM2/FOG2, GDF1, and ISLET1 gene mutations in a large cohort of individuals with CTD, including tetralogy of Fallot ..
  2. Holmes M, Turner J, Fox A, Chisholm O, Crossley M, Chong B. hFOG-2, a novel zinc finger protein, binds the co-repressor mCtBP2 and modulates GATA-mediated activation. J Biol Chem. 1999;274:23491-8 pubmed
    ..Finally, we have identified a repression domain in hFOG-2 and show that repression is dependent upon the integrity of the mCtBP2 interaction motif Pro-Ile-Asp-Leu-Ser. ..
  3. Tan Z, Huang C, Xu Z, Yang J, Yang Y. Novel ZFPM2/FOG2 variants in patients with double outlet right ventricle. Clin Genet. 2012;82:466-71 pubmed publisher
    ..We described a boy with chromosomal translocation: 46, XY t (8; 18) (q22; q21) that may disrupts the ZFPM2/FOG2 locus...
  4. Pizzuti A, Sarkozy A, Newton A, Conti E, Flex E, Digilio M, et al. Mutations of ZFPM2/FOG2 gene in sporadic cases of tetralogy of Fallot. Hum Mutat. 2003;22:372-7 pubmed
    ..TOF), the most common cyanotic conotruncal heart defect (CTD), showed heterozygous missense mutations of the ZFPM2/FOG2 gene. Knockout mice carrying mutations in the ZFPM2/FOG2 gene have similarly been found to exhibit TOF...
  5. Finelli P, Pincelli A, Russo S, Bonati M, Recalcati M, Masciadri M, et al. Disruption of friend of GATA 2 gene (FOG-2) by a de novo t(8;10) chromosomal translocation is associated with heart defects and gonadal dysgenesis. Clin Genet. 2007;71:195-204 pubmed
    FOG-2 (Friend of GATA 2) is a transcriptional cofactor able to differentially regulate the expression of GATA-target genes in different promoter contexts...
  6. Svensson E, Tufts R, Polk C, Leiden J. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc Natl Acad Sci U S A. 1999;96:956-61 pubmed
  7. Crispino J, Lodish M, Thurberg B, Litovsky S, Collins T, Molkentin J, et al. Proper coronary vascular development and heart morphogenesis depend on interaction of GATA-4 with FOG cofactors. Genes Dev. 2001;15:839-44 pubmed
    ..Gata4(ki/ki) mice die just after embryonic day (E) 12.5 exhibiting features in common with Fog2(-/-) embryos as well as additional semilunar cardiac valve defects and a double-outlet right ventricle...
  8. Hirai M, Ono K, Morimoto T, Kawamura T, Wada H, Kita T, et al. FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. J Biol Chem. 2004;279:37640-50 pubmed
    ..These findings demonstrate that FOG-2 represses hypertrophic responses in cardiac myocytes and that p300 is involved in these repressive effects. ..
  9. Yang Y, Ahn Y, Chen Y, Tan X, Guo L, Gibbons D, et al. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014;124:2696-708 pubmed publisher
    ..Additionally, ZEB1-dependent derepression of the miR-200 and miR-183 target friend of GATA 2 (FOG2) enhanced GATA3-induced expression of the p110α catalytic subunit of PI3K...

More Information

Publications89

  1. Wu H, Cohn B, Cirillo P, Santella R, Terry M. DDT exposure during pregnancy and DNA methylation alterations in female offspring in the Child Health and Development Study. Reprod Toxicol. 2019;: pubmed publisher
    ..We observed DDT DMRs in three genes, CCDC85A, CYP1A1 and ZFPM2, each of which has been previously implicated in pubertal development and breast cancer susceptibility...
  2. Liu H, Hu Y, Yin J, Yan X, Chen W, Wang X, et al. Effects of long non-coding RNA uc.245 on cardiomyocyte-like differentiation in P19 cells via FOG2. Gene. 2019;694:83-92 pubmed publisher
    ..245 would influence cardiomyocytes differentiation via FOG2. Lentiviral vectors of pGPU6/GFP/Neo-uc.245 and pGPU6/GFP/Neo-shRNA-uc...
  3. Guo L, Wang J, Yang P, Lu Q, Zhang T, Yang Y. MicroRNA-200 promotes lung cancer cell growth through FOG2-independent AKT activation. IUBMB Life. 2015;67:720-5 pubmed publisher
    ..It was reported that miR-200 can activate PI3K/AKT by targeting FOG2 (friend of GATA 2), which directly binds to the p85α regulatory subunit of PI3K...
  4. Kong F, Deng X, Kong X, Du Y, Li L, Zhu H, et al. ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF. Oncogene. 2018;37:5982-5996 pubmed publisher
    ..Herein we report on our discovery of a novel lncRNA, ZFPM2 antisense RNA 1 (ZFPM2-AS1), and its critical role in gastric carcinogenesis...
  5. Sorrentino A, Federico A, Rienzo M, Gazzerro P, Bifulco M, Ciccodicola A, et al. PR/SET Domain Family and Cancer: Novel Insights from the Cancer Genome Atlas. Int J Mol Sci. 2018;19: pubmed publisher
    ..Overall, PRDM2, PRDM3/MECOM, PRDM9, PRDM16 and ZFPM2/FOG2 were the most mutated genes with pan-cancer frequencies of protein-affecting mutations higher than 1%...
  6. Santra M, Chopp M, Santra S, Nallani A, Vyas S, Zhang Z, et al. Thymosin beta 4 up-regulates miR-200a expression and induces differentiation and survival of rat brain progenitor cells. J Neurochem. 2016;136:118-32 pubmed publisher
    ..an endogenous potent kinase inhibitor of EGFR, which resulted in activation/phosphorylation of EGFR; (iii) friend of GATA 2, and phosphatase and tensin homolog deleted in chromosome 10 (PTEN), which are potent inhibitors of the ..
  7. Panossian A, Seo E, Efferth T. Novel molecular mechanisms for the adaptogenic effects of herbal extracts on isolated brain cells using systems biology. Phytomedicine. 2018;50:257-284 pubmed publisher
    ..ligand-dependent nuclear receptor RORA, transmembrane channels, transcription regulators FOS, FOXO6, SCX, STAT5A, ZFPM2, ZNF396, ZNF467, protein kinases MAPK10, MAPK13, MERTK, FLT1, PRKCH, ROS1, TTN), phosphatases PTPRD, PTPRR, ..
  8. Kim Y, Jin H, Heo J, Ju H, Lee H, Kim S, et al. Small hypoxia-primed mesenchymal stem cells attenuate graft-versus-host disease. Leukemia. 2018;32:2672-2684 pubmed publisher
    ..Collectively, our findings suggest that SHC-MSCs can improve the clinical treatment of allogeneic conflicts, including GVHD. ..
  9. Manuylov N, Tevosian S. Cardiac expression of Tnnt1 requires the GATA4-FOG2 transcription complex. ScientificWorldJournal. 2009;9:575-87 pubmed publisher
    Previous work by us and others has shown that the loss of interaction between GATA4 and FOG2 protein partners is embryonic lethal due to heart failure at embryonic day (E) 13...
  10. Gadelha A, Coleman J, Breen G, Mazzoti D, Yonamine C, Pellegrino R, et al. Genome-wide investigation of schizophrenia associated plasma Ndel1 enzyme activity. Schizophr Res. 2016;172:60-7 pubmed publisher
    ..2 SNPs at region 1p22.2 reached the p<10(-7) level. ZFPM2 and MAD1L1 were the only two genes with more than one hit at 10(-6) order of p value...
  11. Gallagher J, Yamak A, Kirilenko P, Black S, Bochtler M, Lefebvre C, et al. Carboxy terminus of GATA4 transcription factor is required for its cardiogenic activity and interaction with CDK4. Mech Dev. 2014;134:31-41 pubmed publisher
    ..heart, here we have focused on the carboxy-terminal domain and the residues required for interaction with cofactors FOG2 and Tbx5...
  12. Panagopoulos I, Gorunova L, Davidson B, Heim S. Novel TNS3-MAP3K3 and ZFPM2-ELF5 fusion genes identified by RNA sequencing in multicystic mesothelioma with t(7;17)(p12;q23) and t(8;11)(q23;p13). Cancer Lett. 2015;357:502-9 pubmed publisher
    ..The other translocation, t(8;11)(q23;p13), generated a chimeric ZFPM2-ELF5 gene which codes for a chimeric transcription factor in which the first 40 amino acids of ELF5 are replaced ..
  13. Becker L, Takwi A, Lu Z, Li Y. The role of miR-200a in mammalian epithelial cell transformation. Carcinogenesis. 2015;36:2-12 pubmed publisher
    ..This transformative ability is in accordance with miR-200a targeting Fog2 and p53 to activate Akt and directly repress p53 protein levels, respectively...
  14. Galazo M, Emsley J, Macklis J. Corticothalamic Projection Neuron Development beyond Subtype Specification: Fog2 and Intersectional Controls Regulate Intraclass Neuronal Diversity. Neuron. 2016;91:90-106 pubmed publisher
    ..We selected the CThPN-specific transcriptional coregulator Fog2 for functional analysis...
  15. Huang J, Peng J, Cao G, Lu S, Liu L, Li Z, et al. Hypoxia-Induced MicroRNA-429 Promotes Differentiation of MC3T3-E1 Osteoblastic Cells by Mediating ZFPM2 Expression. Cell Physiol Biochem. 2016;39:1177-86 pubmed publisher
    ..To test whether miR-429 directly regulate the expression level of ZFPM2 at transcription level, dual-luciferase reporter gene assay was performed...
  16. Liu W, Zhang T, Guo L, Wang Y, Yang Y. Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis. Sci Rep. 2018;8:11905 pubmed publisher
    ..Here we report that the transcription factor GATA3 and its co-factor FOG2 commonly promote the expression of the lysyl hydroxylase (LH) family members, including LH2 and LH3, which in turn ..
  17. Bashamboo A, McElreavey K. Human sex-determination and disorders of sex-development (DSD). Semin Cell Dev Biol. 2015;45:77-83 pubmed publisher
    ..SOX family gene mutations, as well as mutations involving GATA4, FOG2 and genes involved in MAP kinase signaling have been associated with virilization in 46,XX individuals or with 46,..
  18. Kaur M, Izumi K, Wilkens A, Chatfield K, Spinner N, Conlin L, et al. Genome-wide expression analysis in fibroblast cell lines from probands with Pallister Killian syndrome. PLoS ONE. 2014;9:e108853 pubmed publisher
    ..differentially expressed genes, we identified several genes whose misexpression may be associated with the clinical phenotype of Pallister Killian syndrome such as downregulation of ZFPM2, GATA6 and SOX9, and overexpression of IGFBP2.
  19. Pulignani S, Vecoli C, Borghini A, Foffa I, Ait Ali L, Andreassi M. Targeted Next-Generation Sequencing in Patients with Non-syndromic Congenital Heart Disease. Pediatr Cardiol. 2018;39:682-689 pubmed publisher
    ..Arg25Cys in NKX2-5, p.Val763Ile in ZFPM2, p.Arg1398Gln and Gly1826Asp in MYH6) have been previously linked to CHD or cardiomyopathy...
  20. Bastian C, Muller J, Lortat Jacob S, Nihoul Fékété C, Bignon Topalovic J, McElreavey K, et al. Genetic mutations and somatic anomalies in association with 46,XY gonadal dysgenesis. Fertil Steril. 2015;103:1297-304 pubmed publisher
    ..The mutations were FOG2/ZFPM2 (1 patient), SRY (2 patients), WT1 (1 patient), or deletions of distal chromosome 9p (3 patients)...
  21. Guo Y, Yu J, Deng J, Liu B, Xiao Y, Li K, et al. A Novel Function of Hepatic FOG2 in Insulin Sensitivity and Lipid Metabolism Through PPAR?. Diabetes. 2016;65:2151-63 pubmed publisher
    b>Friend of GATA 2 (FOG2) is a transcriptional cofactor involved mostly in cardiac function. The aim of this study was to investigate the role of hepatic FOG2 in insulin sensitivity and lipid accumulation...
  22. Wang Y, Yang Q, Liu W, Yu M, Zhang Z, Cui X. Di(2-Ethylhexyl) Phthalate Exposure In Utero Damages Sertoli Cell Differentiation Via Disturbance of Sex Determination Pathway in Fetal and Postnatal Mice. Toxicol Sci. 2016;152:53-61 pubmed publisher
    ..2 mg/kg/d and above during the critical time window of sex determination, involving Gadd45g → Gata4/Fog2 → Sry → Sox9 → Fgf9 The results suggest that in utero DEHP exposure damaged Sertoli cells in ..
  23. Priest J, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, et al. De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects. PLoS Genet. 2016;12:e1005963 pubmed publisher
    ..Finally, we apply a rare-disease inheritance model to identify variation in genes previously associated with CHD (ZFPM2, NSD1, NOTCH1, VCAN, and MYH6), cardiac malformations in mouse models (ADAM17, CHRD, IFT140, PTPRJ, RYR1 and ATE1),..
  24. Choi S, Ruggiero D, Sorice R, Song C, Nutile T, Vernon Smith A, et al. Six Novel Loci Associated with Circulating VEGF Levels Identified by a Meta-analysis of Genome-Wide Association Studies. PLoS Genet. 2016;12:e1005874 pubmed publisher
    ..39 x 10(-1467); rs1740073, C6orf223, P = 2.34 x 10(-17); rs6993770, ZFPM2, P = 2.44 x 10(-60); rs2375981, KCNV2, P = 1.48 x 10(-100))...
  25. Giddaluru S, Espeseth T, Salami A, Westlye L, Lundquist A, Christoforou A, et al. Genetics of structural connectivity and information processing in the brain. Brain Struct Funct. 2016;221:4643-4661 pubmed
    ..Meta P value <1 × 10-06) were observed for 12 loci, including one containing ZFPM2 (lowest meta P value = 7.44 × 10-08)...
  26. Mei S, Xin J, Liu Y, Zhang Y, Liang X, Su X, et al. MicroRNA-200c Promotes Suppressive Potential of Myeloid-Derived Suppressor Cells by Modulating PTEN and FOG2 Expression. PLoS ONE. 2015;10:e0135867 pubmed publisher
    ..expansion and immune suppressive activity of MDSCs via targeting phosphatase and tensin homolog (PTEN) and friend of Gata 2 (FOG2), which can lead to STAT3 and PI3K/Akt activation...
  27. Kumarasamy S, Waghulde H, Gopalakrishnan K, Mell B, Morgan E, Joe B. Mutation within the hinge region of the transcription factor Nr2f2 attenuates salt-sensitive hypertension. Nat Commun. 2015;6:6252 pubmed publisher
    ..Because the hinge region of Nr2f2 is required for interaction with Friend of Gata2 (Fog2), protein-protein interaction is examined...
  28. Brauner R, Picard Dieval F, Lottmann H, Rouget S, Bignon Topalovic J, Bashamboo A, et al. Familial forms of disorders of sex development may be common if infertility is considered a comorbidity. BMC Pediatr. 2016;16:195 pubmed
    ..In four families mutations were identified in the genes SRY, NR5A1, GATA4 and FOG2/ZFPM2. Surgery discovered dysgerminoma or gonadoblastoma in two cases with gonadal dysgenesis...
  29. Chen C, Chang T, Hung F, Chern S, Wu P, Chen S, et al. Prenatal diagnosis of an 8q22.2-q23.3 deletion associated with bilateral cleft lip and palate and intrauterine growth restriction on fetal ultrasound. Taiwan J Obstet Gynecol. 2017;56:843-846 pubmed publisher
    ..3 encompassing 37 Online Mendelian Inheritance of in Man (OMIM) genes including SPAG1, GRHL2, NCALD, RRM2B and ZFPM2. Polymorphic DNA marker analysis determined a paternal origin of the deletion...
  30. Qian Y, Xiao D, Guo X, Chen H, Hao L, Ma X, et al. Multiple gene variations contributed to congenital heart disease via GATA family transcriptional regulation. J Transl Med. 2017;15:69 pubmed publisher
    ..CO-IP) and luciferase reporter gene assays were performed in HEK293T cells, and wild-type and mutant mRNA of ZFPM2 were microinjected into zebrafish embryos...
  31. Alaggio R, Midrio P, Sgrò A, Piovan G, Guzzardo V, Donato R, et al. Congenital diaphragmatic hernia: focus on abnormal muscle formation. J Pediatr Surg. 2015;50:388-93 pubmed publisher
    ..Defects of genes involved in diaphragmatic development, such as friend-of-GATA2 (Fog2), may play an important role in its pathogenesis...
  32. Théron A, Pinard A, Riberi A, Zaffran S. An uncommon cause of tricuspid regurgitation: three-dimensional echocardiographic incremental value, surgical and genetic insights. Eur J Cardiothorac Surg. 2016;50:180-2 pubmed publisher
    ..No sign of endocarditis or rheumatic disease was observed during the intervention. Sequence analysis of GATA4, HEY2 and ZFPM2 genes was performed, but no causative mutation was identified.
  33. Goupille O, Penglong T, Kadri Z, Granger Locatelli M, Denis R, Luquet S, et al. The LXCXE Retinoblastoma Protein-Binding Motif of FOG-2 Regulates Adipogenesis. Cell Rep. 2017;21:3524-3535 pubmed publisher
    ..Unlike GATA-1, which inhibits cell division, FOG-2 promotes proliferation. Mice with a knockin of a Fog2 gene bearing a mutated LXCXE pRb-binding site are resistant to obesity and display higher rates of white-to-brown ..
  34. Zhang Z, Ursin R, Mahapatra S, Gallicano G. CRISPR/CAS9 ablation of individual miRNAs from a miRNA family reveals their individual efficacies for regulating cardiac differentiation. Mech Dev. 2018;150:10-20 pubmed publisher
    ..We show that miRNA106a and to a lesser extent miR17 and 93 target the cardiac suppressor gene Fog2, which specifically suppress Gata-4 and Coup-TF2...
  35. Merhi Z, Polotsky A, Bradford A, Buyuk E, Chosich J, Phang T, et al. Adiposity Alters Genes Important in Inflammation and Cell Cycle Division in Human Cumulus Granulosa Cell. Reprod Sci. 2015;22:1220-8 pubmed publisher
    ..genes: fibroblast growth factor 12 (FGF-12), protein phosphatase 1-like (PPM1L), zinc finger protein multitype 2 (ZFPM2), forkhead box M1 (FOXM1), cell division cycle 20 (CDC20), interleukin 1 receptor-like 1 (IL1RL1), and growth ..
  36. Chen L, Yang T, Wang T, Zheng Z, Zhao L, Ye Z, et al. [Association of single nucleotide polymorphisms of transcription factors with congenital heart diseases in the Chinese population: a Meta analysis]. Zhongguo Dang Dai Er Ke Za Zhi. 2018;20:490-496 pubmed
    ..To study the association of single nucleotide polymorphisms (SNPs) of transcription factors (NKX2.5, GATA4, TBX5, and FOG2) with congenital heart disease (CHD) in the Chinese population...
  37. Wystrychowski W, Patlolla B, Zhuge Y, Neofytou E, Robbins R, Beygui R. Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum. Stem Cell Res Ther. 2016;7:84 pubmed publisher
    ..initiated with exogenous overexpression of seven transcription factors (ESRRG, GATA4, MEF2C, MESP1, MYOCD, TBX5, ZFPM2) previously applied successfully for fibroblast transdifferentiation toward cardiomyocytes...
  38. Bagu E, Layoun A, Calvé A, Santos M. Friend of GATA and GATA-6 modulate the transcriptional up-regulation of hepcidin in hepatocytes during inflammation. Biometals. 2013;26:1051-65 pubmed publisher
    ..Our results indicate that during inflammation GATA-6 is up-regulated in concert with hepcidin while GATA-4 and FOG (1 and 2) are repressed. ..
  39. Chimusa E, Zaitlen N, Daya M, Möller M, van Helden P, Mulder N, et al. Genome-wide association study of ancestry-specific TB risk in the South African Coloured population. Hum Mol Genet. 2014;23:796-809 pubmed publisher
    ..This study provides insights into identifying disease genes and ancestry-specific disease risk in multi-way admixed populations. ..
  40. Longoni M, Russell M, High F, Darvishi K, Maalouf F, Kashani A, et al. Prevalence and penetrance of ZFPM2 mutations and deletions causing congenital diaphragmatic hernia. Clin Genet. 2015;87:362-7 pubmed publisher
    Zinc finger protein, FOG2 family member 2 (ZFPM2) (previously named FOG2) gene defects result in the highly morbid congenital diaphragmatic hernia (CDH) in humans and animal models...
  41. Debette S, Visvikis Siest S, Chen M, Ndiaye N, Song C, DESTEFANO A, et al. Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels. Circ Res. 2011;109:554-63 pubmed publisher
    ..Ingenuity pathway analyses showed found plausible biological links between VEGF and 2 novel genes in these loci (ZFPM2 and VLDLR). Genetic variants explaining up to half the heritability of serum VEGF levels were identified...
  42. Virgone C, Cecchetto G, Ferrari A, Bisogno G, Donofrio V, Boldrini R, et al. GATA-4 and FOG-2 expression in pediatric ovarian sex cord-stromal tumors replicates embryonal gonadal phenotype: results from the TREP project. PLoS ONE. 2012;7:e45914 pubmed publisher
    ..In fibroma/thecoma group GATA-4 and FOG-2 point out the abnormal activation of GATA pathway and might be involved in the onset of these tumors. ..
  43. Kardon G, Ackerman K, McCulley D, Shen Y, Wynn J, Shang L, et al. Congenital diaphragmatic hernias: from genes to mechanisms to therapies. Dis Model Mech. 2017;10:955-970 pubmed publisher
    ..The affected genes identified in CDH patients include transcription factors, such as GATA4, ZFPM2, NR2F2 and WT1, and signaling pathway components, including members of the retinoic acid pathway...
  44. Chan E, Comer E, Brown F, Richkind K, Holmes M, Chong B, et al. AML1-FOG2 fusion protein in myelodysplasia. Blood. 2005;105:4523-6 pubmed
    ..3;q22.1) in a patient with myelodysplasia that fuses AML1 in-frame to the novel partner gene FOG2/ZFPM2. The reciprocal gene fusions AML1-FOG2 and FOG2-AML1 are both expressed...
  45. Wat M, Veenma D, Hogue J, Holder A, Yu Z, Wat J, et al. Genomic alterations that contribute to the development of isolated and non-isolated congenital diaphragmatic hernia. J Med Genet. 2011;48:299-307 pubmed publisher
    ..Congenital diaphragmatic hernia (CDH) is a life threatening birth defect. Most of the genetic factors that contribute to the development of CDH remain unidentified...
  46. Sheng W, Chen L, Wang H, Ma X, Ma D, Huang G. CpG island shore methylation of ZFPM2 is identified in tetralogy of fallot samples. Pediatr Res. 2016;80:151-8 pubmed publisher
    b>ZFPM2 gene plays an important role in heart morphogenesis and development of coronary vessels from epicardium, however, little is known regarding its epigenetic regulation in the pathogenesis of tetralogy of fallot (TOF)...
  47. Ackerman K, Herron B, Vargas S, Huang H, Tevosian S, Kochilas L, et al. Fog2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet. 2005;1:58-65 pubmed
    ..Fog2 (Zfpm2) maps within the recombinant interval carrying the N-ethyl-N-nitrosourea-induced mutation, and DNA sequencing of ..
  48. Vastrad B, Vastrad C, Godavarthi A, Chandrashekar R. Molecular mechanisms underlying gliomas and glioblastoma pathogenesis revealed by bioinformatics analysis of microarray data. Med Oncol. 2017;34:182 pubmed publisher
    ..II core promoter proximal region sequence-specific binding (5) such as MEIS2, MEOX2, NR2E1, PITX2, TFAP2B, ZFPM2 were selected...
  49. Guan D, Tian H. Integrated network analysis to explore the key genes regulated by parathyroid hormone receptor 1 in osteosarcoma. World J Surg Oncol. 2017;15:177 pubmed publisher
    ..There were 871 DEGs in the PTHR1 knockdown OS samples compared with the control OS samples. Besides, upregulated ZFPM2 was involved in the miRNA-DEG regulatory network...
  50. Rouf R, Greytak S, Wooten E, Wu J, Boltax J, Picard M, et al. Increased FOG-2 in failing myocardium disrupts thyroid hormone-dependent SERCA2 gene transcription. Circ Res. 2008;103:493-501 pubmed publisher
    ..These results demonstrate that SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling. ..
  51. Hyun S, Lee J, Jin H, Nam J, Namkoong B, Lee G, et al. Conserved MicroRNA miR-8/miR-200 and its target USH/FOG2 control growth by regulating PI3K. Cell. 2009;139:1096-108 pubmed publisher
    ..Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively...
  52. Greenbaum L, Smith R, Lorberboym M, Alkelai A, Zozulinsky P, Lifschytz T, et al. Association of the ZFPM2 gene with antipsychotic-induced parkinsonism in schizophrenia patients. Psychopharmacology (Berl). 2012;220:519-28 pubmed publisher
    ..confounders, we found nominal association of the intronic SNP, rs12678719, in the Zinc Finger Protein Multitype 2 (ZFPM2) gene with AIP (62 affected/116 unaffected), in the whole sample (p?=?0.009; P?=?5...
  53. Aumsuwan P, Khan S, Khan I, Ali Z, Avula B, Walker L, et al. The anticancer potential of steroidal saponin, dioscin, isolated from wild yam (Dioscorea villosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro. Arch Biochem Biophys. 2016;591:98-110 pubmed publisher
    ..cells exhibited the morphological characteristic of epithelial-like cells; mRNA expression of DNMT3A, TET2, TET3, ZFPM2 and E-cad were increased while TET1, VIM and MMP9 were decreased...
  54. Huang X, Niu W, Zhang Z, Zhou C, Xu Z, Liu J, et al. Identification of novel significant variants of ZFPM2/FOG2 in non-syndromic Tetralogy of Fallot and double outlet right ventricle in a Chinese Han population. Mol Biol Rep. 2014;41:2671-7 pubmed publisher
    ..Recent reports have implicated mutations in the zinc finger protein, FOG family member 2 (ZFPM2/FOG2) as a cause of TOF/DORV, but no current literature focuses on the relationship between ZFPM2/FOG2 gene and ..
  55. Bashamboo A, Brauner R, Bignon Topalovic J, Lortat Jacob S, Karageorgou V, Lourenco D, et al. Mutations in the FOG2/ZFPM2 gene are associated with anomalies of human testis determination. Hum Mol Genet. 2014;23:3657-65 pubmed publisher
    ..Based on mouse models, it has been hypothesized that haploinsufficiency of the Friend of GATA 2 (FOG2) gene could lead to 46,XY gonadal dysgenesis on specific inbred genetic backgrounds...
  56. Nesbit M, Bowl M, Harding B, Ali A, Ayala A, Crowe C, et al. Characterization of GATA3 mutations in the hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome. J Biol Chem. 2004;279:22624-34 pubmed
    ..amino acids resulted in a loss of DNA binding, but those of ZnF1 either lead to a loss of interaction with specific FOG2 ZnFs or altered DNA-binding affinity...
  57. Roche A, Bassett B, Samant S, Hong W, Blobel G, Svensson E. The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. J Mol Cell Cardiol. 2008;44:352-60 pubmed
    ..Together, these results demonstrate the importance of FOG-2/MTA/RbAp interactions for FOG-2-mediated transcriptional repression and further define the molecular interactions between the FOG Repression Motif and the NuRD complex. ..
  58. Tahara N, Akiyama R, Theisen J, Kawakami H, Wong J, Garry D, et al. Gata6 restricts Isl1 to the posterior of nascent hindlimb buds through Isl1 cis-regulatory modules. Dev Biol. 2018;434:74-83 pubmed publisher
    ..GATA6 repressed expression of a luciferase reporter that contains the cis-regulatory modules by synergizing with Zfpm2. Analyses of Gata6 mutant embryos showed that ISL1 levels are higher in the anterior of nascent hindlimb buds than ..
  59. Anttonen M, Ketola I, Parviainen H, Pusa A, Heikinheimo M. FOG-2 and GATA-4 Are coexpressed in the mouse ovary and can modulate mullerian-inhibiting substance expression. Biol Reprod. 2003;68:1333-40 pubmed
    ..In postnatal ovary, granulosa cells of growing follicles express FOG-2, partially overlapping with the expression of MIS. These data suggest an important role for FOG-2 and the GATA transcription factors in the developing ovary. ..
  60. Sarkozy A, Conti E, D Agostino R, Digilio M, Formigari R, Picchio F, et al. ZFPM2/FOG2 and HEY2 genes analysis in nonsyndromic tricuspid atresia. Am J Med Genet A. 2005;133A:68-70 pubmed
    ..However, animal models have suggested a role of cardiogenic Zfpm2/Fog2 and Hey2 genes in the pathogenesis of TriAt...
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    Using exome sequencing we identify a heterozygous nonsense mutation in ZFPM2 as a cause of familial isolated congenital diaphragmatic hernia in 2 affected siblings...
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    ..25. Expressions of GATA4, COUP-TF2, and FOG2 were detected in PPF at the early stage of formation...
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    ..assays demonstrated that the mutant GATA3 resulted in a loss of interaction with ZnF1 and ZnF6 of the cofactor FOG2. The mutant GATA3 significantly reduced luciferase reporter activity by more than 65% (P < 0...
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    ..rs6921438 [LOC100132354], rs7043199 [VLDLR-AS1], rs10761741 [JMJD1C], rs6993770 [ZFPM2], and rs114694170 [MEF2C]), VEGF was unrelated to IHD (odds ratio 0...
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    ..The p.Gly221Arg mutant protein also failed to bind to a known protein partner FOG2 that is essential for gonad formation. Our data demonstrate the key role of GATA4 in human testicular development.
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    ..Together, our data suggest that IL-32α associates with PLZF and PKCɛ, and then inhibits PLZF sumoylation, resulting in suppression of the transcriptional activity of PLZF. ..
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    ..Recent reports have identified mutations in a number of genes associated with CTDs in human and animal models. ZFPM2 plays a role in cardiac development by acting as a transcriptional cofactor that interacts with GATA4...
  75. Ma T, Cai X, Wang Z, Huang L, Wang C, Jiang S, et al. miR-200c Accelerates Hepatic Stellate Cell-Induced Liver Fibrosis via Targeting the FOG2/PI3K Pathway. Biomed Res Int. 2017;2017:2670658 pubmed publisher
    ..As a target of miR-200s and inhibitor of PI3K pathway, FOG2 protein expression was significantly suppressed in LX2-200c cells...
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    ..We identified 1 new locus-ZFPM2 rs4602861-at genome-wide significance (odds ratio, 1.11; 95% confidence interval, 1.07-1.15; P=4...
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    ..causative genes have been identified, and in isolated CDH, only one de novo, nonsense mutation has been reported in FOG2 in a female with posterior diaphragmatic eventration...
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    Conotruncal heart defect (CTD) is a complex form of congenital heart disease and usually has a poor prognosis. ZFPM2/FOG2 encodes a transcription cofactor that interacts with GATA4 to regulate cardiac development...