Gene Symbol: ZFP42
Description: ZFP42 zinc finger protein
Alias: REX-1, REX1, ZNF754, zfp-42, zinc finger protein 42 homolog, REX1 transcription factor, reduced expression protein 1, zinc finger protein 754
Species: human
Products:     ZFP42

Top Publications

  1. Murakami T, Saitoh I, Sato M, Inada E, Soda M, Oda M, et al. Isolation and characterization of lymphoid enhancer factor-1-positive deciduous dental pulp stem-like cells after transfection with a piggyBac vector containing LEF1 promoter-driven selection markers. Arch Oral Biol. 2017;81:110-120 pubmed publisher
    ..RT-PCR analysis confirmed the expression of several stem cell markers, including OCT3/4, SOX2, REX1, and NANOG, in LEF1-positive HDDPCs, which could be differentiated into osteoblasts and neuronal cells...
  2. Ubaidah M, Chua K, Ami M, Zainal A, Saim A, Saim L, et al. Effect of Growth Factor Supplementation on the Hair Cell Specific Markers of Cells Harvested from Basilar Membrane. J Int Adv Otol. 2015;11:23-9 pubmed publisher
    ..the expression of the hair cell-specific genes myosin VIIa and calretinin as well as the stem cell genes nestin, Rex1, and Sox2 was reduced after the cells were passaged in the growth factor-supplemented medium...
  3. Inada E, Saitoh I, Kubota N, Iwase Y, Murakami T, Sawami T, et al. Increased Expression of Cell Surface SSEA-1 is Closely Associated with Naïve-Like Conversion from Human Deciduous Teeth Dental Pulp Cells-Derived iPS Cells. Int J Mol Sci. 2019;20: pubmed publisher
    ..analysis also confirmed increased expression of FUT9 transcripts as well as other stemness-related transcripts such as REX-1 (ZFP42). These results suggest that SSEA-1 can be an excellent marker for human NSCs.
  4. Aguilo F, Zakirova Z, Nolan K, Wagner R, Sharma R, Hogan M, et al. THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem Cell Reports. 2017;9:92-107 pubmed publisher
    ..with a disease-causing mutation results in an enhanced rate of cell death, prolongs Nanog, Prdm14, and/or Rex1 expression upon differentiation, and results in failure to upregulate ectodermal genes...
  5. Yoda K, Ohnuki Y, Kurosawa H. Optimization of the treatment conditions with glycogen synthase kinase-3 inhibitor towards enhancing the proliferation of human induced pluripotent stem cells while maintaining an undifferentiated state under feeder-free conditions. J Biosci Bioeng. 2019;127:381-387 pubmed publisher
    ..g., OCT3/4, NANOG, SOX2, and REX1. Repeated use of 1 μM CHIR in subcultures provided no adverse effect on the proliferation of hiPSCs...
  6. Alimoradi E, Sisakhtnezhad S, Akrami H. Thymoquinone influences the expression of genes involved in self-renewal and immunomodulatory potential of mouse bone marrow-derived mesenchymal stem cells in vitro. Environ Toxicol Pharmacol. 2018;60:216-224 pubmed publisher
    ..05). The gene expression analysis also showed that Tlr3, Tlr4, Ccl2, Ccl3, Sox2, and Rex1 are overexpressed (Fold change ≥1.5) in the TQ-treated BM-MSCs compared with the untreated samples...
  7. Carducci F, Barucca M, Canapa A, Biscotti M. Rex Retroelements and Teleost Genomes: An Overview. Int J Mol Sci. 2018;19: pubmed publisher
    ..In this review, we focus our attention on Rex1, Rex3 and Rex6, three elements specific of teleost genomes...
  8. Habibi R, Hosseini S, Zadegan F, Hajian M, Ostadhosseini S, Vash N, et al. Functional characterization of NANOG in goat pre-implantation embryonic development. Theriogenology. 2018;120:33-39 pubmed publisher
    ..knockdown results in significant increase in expression of SOX2 and OCT4 and among the possible target genes (CDX2, REX1 and GATA4) of this network, only GATA4 showed increased expression...
  9. Hajian M, Hosseini S, Ostadhosseini S, Nasr Esfahani M. Targeting the transforming growth factor-β signaling during pre-implantation development in embryos of cattle, sheep and goats. Growth Factors. 2016;34:141-8 pubmed publisher
    ..Regarding pluripotency triad (OCT4, NANOG, SOX2) and cell lineage commitment (REX1, CDX2, GATA4), SB led to a significant reduction in SOX2 expression in goat and cattle, while Noggin increased at ..

More Information

Publications124 found, 100 shown here

  1. Cannon D, Corrigan A, Miermont A, McDonel P, Chubb J. Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity. Development. 2015;142:2840-9 pubmed publisher
    ..b>Rex1 expression dynamics showed shared and distinct regulatory effects...
  2. Weltner J, Balboa D, Katayama S, Bespalov M, Krjutskov K, Jouhilahti E, et al. Human pluripotent reprogramming with CRISPR activators. Nat Commun. 2018;9:2643 pubmed publisher
    ..This effect is mediated in part by more efficient activation of NANOG and REX1. These data demonstrate that human somatic cells can be reprogrammed into iPSCs using only CRISPRa...
  3. Panina Y, Germond A, Masui S, Watanabe T. Validation of Common Housekeeping Genes as Reference for qPCR Gene Expression Analysis During iPS Reprogramming Process. Sci Rep. 2018;8:8716 pubmed publisher
    ..The results were validated by a proof-of-point qPCR experiment with pluripotent markers Nanog, Rex1 and Oct4 normalized to the best and the worst reference gene identified by the analyses...
  4. Holz G, Chepurny O, Leech C. "A-kinase" regulator runs amok to provide a paradigm shift in cAMP signaling. J Biol Chem. 2019;294:2247-2248 pubmed publisher
    ..PKA-RIα instead binds to and stimulates the catalytic activity of a guanine nucleotide exchange factor (P-REX1) that itself promotes Rac1 GTPase activation...
  5. Moro L, Amin G, Furmento V, Waisman A, Garate X, Neiman G, et al. MicroRNA characterization in equine induced pluripotent stem cells. PLoS ONE. 2018;13:e0207074 pubmed publisher
    ..The pluripotency of both lines was assessed by phosphatase alkaline activity, expression of OCT-4, NANOG and REX1 by RT-PCR, and by immunofluorescence of OCT-4, SOX-2 and c-MYC...
  6. Adame García S, Cervantes Villagrana R, Orduña Castillo L, Del Rio J, Gutkind J, Reyes Cruz G, et al. cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits. J Biol Chem. 2019;294:2232-2246 pubmed publisher
    ..subunits (RIα) interact with phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a chemotactic Rac guanine exchange factor (RacGEF)...
  7. Hosseinnia P, Hajian M, Jafarpour F, Hosseini S, Tahmoorespur M, Nasr Esfahani M. Dynamics of The Expression of Pluripotency and Lineage Specific Genes in The Pre and Peri-Implantation Goat Embryo. Cell J. 2019;21:194-203 pubmed publisher
    ..of three pluripotency markers (Oct4, Nanog and Sox2) and the linage specific markers (Rex1, Gata4 and Cdx2) were quantitatively assessed in in vitro matured (MII) oocytes and ..
  8. Supiwong W, Pinthong K, Seetapan K, Saenjundaeng P, Bertollo L, de Oliveira E, et al. Karyotype diversity and evolutionary trends in the Asian swamp eel Monopterus albus (Synbranchiformes, Synbranchidae): a case of chromosomal speciation?. BMC Evol Biol. 2019;19:73 pubmed publisher
    ..Ag-NO3, and Chromomycin A3), and FISH with repetitive DNA probes (5S rDNA, 18S rDNA, Rex1 element and microsatellite repeats)...
  9. Kazanietz M, Barrio Real L, Casado Medrano V, Baker M, Lopez Haber C. The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses. Small Gtpases. 2018;9:297-303 pubmed publisher
    ..We have previously established that the Rac-GEF P-Rex1 is a mediator of actin cytoskeleton rearrangements and cell motility in breast cancer cells downstream of HER/ErbB ..
  10. Huang Y, Xie Y, Jiang H, Abel P, Panettieri R, Casale T, et al. Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma. J Allergy Clin Immunol. 2018;: pubmed publisher
    P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling ..
  11. Cervantes Villagrana R, Color Aparicio V, Reyes Cruz G, Vazquez Prado J. Protumoral bone marrow-derived cells migrate via Gβγ-dependent signaling pathways and exhibit a complex repertoire of RhoGEFs. J Cell Commun Signal. 2019;: pubmed publisher
    ..BMDC exhibited a higher expression of G protein regulated RhoGEFs including P-Rex1, PDZ-RhoGEF, LARG, Trio and some less well characterized RhoGEFs such as ARHGEF5, ARHGEF17 and PLEKHG6...
  12. Lee J, Lee J, Cho Y. Peroxisome Proliferator-Activated Receptor α Agonist and Its Target Nanog Cooperate to Induce Pluripotency. J Clin Med. 2018;7: pubmed publisher
    ..compound libraries, increase the expression of pluripotency-associated genes, such as Nanog, Nr5A2, Oct4, and Rex1, during the reprogramming process and facilitate iPSC generation by enhancing their reprogramming efficiency...
  13. Li Q, Louden E, Zhou J, Drewlo S, Dai J, Puscheck E, et al. Stress forces first lineage differentiation of mouse Embryonic Stem Cells, validation of a high throughput screen for toxicant stress. Stem Cells Dev. 2018;: pubmed publisher
    ..In agreement with previous reports, Rex1 and Oct4 loss was inversely proportional to increased Pdgfra-GFP mESC after treatment with high hyperosmotic ..
  14. Cervantes Villagrana R, Adame García S, García Jiménez I, Color Aparicio V, Beltrán Navarro Y, König G, et al. Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins. J Biol Chem. 2019;294:531-546 pubmed publisher
    ..investigated whether Gβγ signaling to phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchange factor 1 (P-REX1), a key Gβγ chemotactic effector, is directly controlled by Rho-activating Gα subunits...
  15. de Lázaro I, Yilmazer A, Nam Y, Qubisi S, Razak F, Degens H, et al. Non-viral, Tumor-free Induction of Transient Cell Reprogramming in Mouse Skeletal Muscle to Enhance Tissue Regeneration. Mol Ther. 2019;27:59-75 pubmed publisher
    ..Intramuscular pOKSM administration rapidly upregulated pluripotency (Nanog, Ecat1, and Rex1) and early myogenesis genes (Pax3) in the healthy gastrocnemius of various strains...
  16. Satar N, Fakiruddin K, Lim M, Mok P, Zakaria N, Fakharuzi N, et al. Novel triple‑positive markers identified in human non‑small cell lung cancer cell line with chemotherapy-resistant and putative cancer stem cell characteristics. Oncol Rep. 2018;40:669-681 pubmed publisher
    ..Consistently, elevated levels of the stem cell genes such as REX1 and SSEA4 were also found in the triple‑positive subpopulation indicating that the subpopulation displayed a ..
  17. Chávez Vargas L, Adame García S, Cervantes Villagrana R, Castillo Kauil A, Bruystens J, Fukuhara S, et al. Protein Kinase A (PKA) Type I Interacts with P-Rex1, a Rac Guanine Nucleotide Exchange Factor: EFFECT ON PKA LOCALIZATION AND P-Rex1 SIGNALING. J Biol Chem. 2016;291:6182-99 pubmed publisher
    ..Here we show that the endogenous regulatory (R) subunit of type I PKA interacts with P-Rex1, a Rac guanine nucleotide exchange factor that integrates chemotactic signals...
  18. Gontan C, Mira Bontenbal H, Magaraki A, Dupont C, Barakat T, Rentmeester E, et al. REX1 is the critical target of RNF12 in imprinted X chromosome inactivation in mice. Nat Commun. 2018;9:4752 pubmed publisher
    ..RNF12 is an E3 ubiquitin ligase that plays a key role in XCI. RNF12 targets pluripotency protein REX1 for degradation to initiate rXCI in embryonic stem cells (ESCs) and loss of the maternal copy of Rnf12 leads to ..
  19. Forte A, Schettino M, Finicelli M, Cipollaro M, Colacurci N, Cobellis L, et al. Expression pattern of stemness-related genes in human endometrial and endometriotic tissues. Mol Med. 2009;15:392-401 pubmed publisher
    ..The expression profiles of a panel of 13 genes (SOX2, SOX15, ERAS, SALL4, OCT4, NANOG, UTF1, DPPA2, BMI1, GDF3, ZFP42, KLF4, TCL1) were analyzed by reverse transcription-polymerase chain reaction in human endometriotic (n = 12) and ..
  20. Mata Cantero L, Azkargorta M, Aillet F, Xolalpa W, Lafuente M, Elortza F, et al. New insights into host-parasite ubiquitin proteome dynamics in P. falciparum infected red blood cells using a TUBEs-MS approach. J Proteomics. 2016;139:45-59 pubmed publisher
    ..Ring-exported protein (REX1), a P...
  21. Montero J, Seoane S, García Alonso S, Pandiella A. Multisite phosphorylation of P-Rex1 by protein kinase C. Oncotarget. 2016;7:77937-77949 pubmed publisher
    ..activation of growth factor receptors has been reported to activate a phosphorylation/dephosphorylation cycle of P-Rex1. Such cycle includes dephosphorylation of serines 313 and 319 which negatively regulate the GEF activity of P-Rex1, ..
  22. Marei H, Carpy A, Macek B, Malliri A. Proteomic analysis of Rac1 signaling regulation by guanine nucleotide exchange factors. Cell Cycle. 2016;15:1961-74 pubmed publisher
    ..In a recent study, we demonstrated a role for 2 Rac-specific GEFs, Tiam1 and P-Rex1, in mediating Rac1 anti- versus pro-migratory effects, respectively...
  23. Chen W, Huang L, Liu H, Li X, Xu C. Expressions of HBV X gene regulated by different promoters and their effects on cell apoptosis. Eur Rev Med Pharmacol Sci. 2018;22:5906-5913 pubmed publisher
    ..transfected by different recombinant plasmids, of which the relationships of the expression levels were rCX>rEX1 and rEX2> rPX (p<0.05)...
  24. Leung E, Schneider C, Yan F, Mohi El Din H, Kudla G, Tuck A, et al. Integrity of SRP RNA is ensured by La and the nuclear RNA quality control machinery. Nucleic Acids Res. 2014;42:10698-710 pubmed publisher
    ..In cells lacking the exonuclease Rex1, scR1 terminates in a longer U5-6 tail that presumably represents the primary transcript...
  25. Barrio Real L, Benedetti L, Engel N, Tu Y, Cho S, Sukumar S, et al. Subtype-specific overexpression of the Rac-GEF P-REX1 in breast cancer is associated with promoter hypomethylation. Breast Cancer Res. 2014;16:441 pubmed publisher
    The Rac-GEF P-REX1 is a key mediator of ErbB signaling in breast cancer recently implicated in mammary tumorigenesis and metastatic dissemination...
  26. Katsiani E, Garas A, Skentou C, Tsezou A, Messini C, Dafopoulos K, et al. Chorionic villi derived mesenchymal like stem cells and expression of embryonic stem cells markers during long-term culturing. Cell Tissue Bank. 2016;17:517-29 pubmed publisher
    ..b>ZFP42 and SOX2 expression were not detected. Moreover, CV-cells were found to express GATA4 but not NES (Nestin)...
  27. Russell R, Fu Y, Liu Y, Maye P. Inverse agonism of retinoic acid receptors directs epiblast cells into the paraxial mesoderm lineage. Stem Cell Res. 2018;30:85-95 pubmed publisher
    ..inverse agonist treatment had no impact on the conversion of ESCs into epiblast cells based on the expression of Rex1, Fgf5, and pluripotency marker genes Oct4, Nanog, and Sox2, after three days of differentiation in the presence of ..
  28. Xu X, Zhang L, Xie X. Somatostatin receptor type 2 contributes to the self-renewal of murine embryonic stem cells. Acta Pharmacol Sin. 2014;35:1023-30 pubmed publisher
    ..decreases in expression of somatostatin receptor type 2 (SSTR2), as well as the pluripotency biomarkers Oct4, Sox2, Rex1 and Nanog. Addition of the SSTR2 agonist octreotide or seglitide (0...
  29. Fani N, Ziadlou R, Shahhoseini M, Baghaban Eslaminejad M. Comparative epigenetic influence of autologous versus fetal bovine serum on mesenchymal stem cells through in vitro osteogenic and adipogenic differentiation. Exp Cell Res. 2016;344:176-82 pubmed publisher
    ..and methylation patterns in lysine 9 (Lys9) of histone H3 on the regulatory regions of stemness (Nanog, Sox2, Rex1), osteogenic (Runx2, Oc, Sp7) and adipogenic (Ppar-γ, Lpl, adiponectin) marker genes in undifferentiated MSCs, ..
  30. Lujan E, Zunder E, Ng Y, Goronzy I, Nolan G, Wernig M. Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature. 2015;521:352-6 pubmed publisher
    ..Etv5 in this reprogramming state, preceding activation of key pluripotency regulators such as Rex1 (also known as Zfp42), Dppa2, Nanog and Sox2...
  31. Dillon L, Bean J, Yang W, Shee K, Symonds L, Balko J, et al. P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT and MEK/ERK signaling in breast cancer. Oncogene. 2015;34:3968-76 pubmed publisher
    ..PIP3-regulated proteins in breast cancer cells, levels of the Rac activator PIP3-dependent Rac exchange factor-1 (P-REX1) increased in response to PI3K inhibition, and decreased upon loss of the PI3K antagonist phosphatase and tensin ..
  32. Ebi H, Costa C, Faber A, Nishtala M, Kotani H, Juric D, et al. PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1. Proc Natl Acad Sci U S A. 2013;110:21124-9 pubmed publisher
    ..Finally, we identified phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 (P-Rex1) as the PI(3,4,5)P3-dependent guanine exchange factor for Rac1 responsible for regulation of the Rac1/C-RAF/MEK/ERK ..
  33. Wang H, Zhou Y, Yu D, Zhu H. Klf2 contributes to the stemness and self-renewal of human bone marrow stromal cells. Cytotechnology. 2016;68:839-48 pubmed publisher
    ..The expression of pluripotency-associated genes, including Oct4, Nanog, and Rex1, was also upregulated by Klf2 overexpression...
  34. Joo J, Choi H, Kim M, Zaehres H, Tapia N, Stehling M, et al. Establishment of a primed pluripotent epiblast stem cell in FGF4-based conditions. Sci Rep. 2014;4:7477 pubmed publisher
    ..The expression levels of Rex1 and Nanog was very low although Oct4 level is comparable to ESCs...
  35. Farshchian M, Matin M, Bahrami M, Geerts D, Dastpak M, Shahriyari M, et al. Pluripotency induction in HEK293T cells by concurrent expression of STELLA, OCT4 and NANOS2. Biochem Biophys Res Commun. 2016;480:635-640 pubmed publisher
    ..protein level showed the potential of SON factors and serum starvation in the induction of ESRRB, NANOG, OCT4 and REX1 expression...
  36. Jamaladdin S, Kelly R, O Regan L, Dovey O, Hodson G, Millard C, et al. Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells. Proc Natl Acad Sci U S A. 2014;111:9840-5 pubmed publisher
    ..we detected a reduction in the expression of the pluripotent transcription factors, Oct4, Nanog, Esrrb, and Rex1. HDAC1/2 activity is regulated through binding of an inositol tetraphosphate molecule (IP4) sandwiched between the ..
  37. Slater J, Zhou S, Puscheck E, Rappolee D. Stress-induced enzyme activation primes murine embryonic stem cells to differentiate toward the first extraembryonic lineage. Stem Cells Dev. 2014;23:3049-64 pubmed publisher
    ..kinase (JNK), and PI3K enzymatic signaling, which led to proteasomal degradation of Oct4, Nanog, Sox2, and Rex1 TF proteins...
  38. Srijakotre N, Man J, Ooms L, Lucato C, Ellisdon A, Mitchell C. P-Rex1 and P-Rex2 RacGEFs and cancer. Biochem Soc Trans. 2017;45:963-77 pubmed publisher
    ..P-Rex1 and P-Rex2 share similar amino acid sequence homology, domain structure, and catalytic function...
  39. Sisakhtnezhad S, Heidari M, Bidmeshkipour A. Eugenol enhances proliferation and migration of mouse bone marrow-derived mesenchymal stem cells in vitro. Environ Toxicol Pharmacol. 2018;57:166-174 pubmed publisher
    ..of MSCs using wound healing assay in vitro and quantitative gene expression analysis for Oct4, Sox2, Cyclin-D1, Rex1, Tex10, Cxcr4, Vla4 and c-Met...
  40. El Sayed A, Zhang Z, Zhang L, Liu Z, Abbott L, Zhang Y, et al. Pluripotent state induction in mouse embryonic fibroblast using mRNAs of reprogramming factors. Int J Mol Sci. 2014;15:21840-64 pubmed publisher
  41. Heo J, Choi Y, Kim H, Kim H. Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med. 2016;37:115-25 pubmed publisher
    ..factor 4 (OCT4), sex determining region Y-box (SOX)2, MYC, Krüppel-like factor 4 (KLF4), NANOG, LIN28 and REX1] and lineage‑related and differentiation stage-related genes [B4GALNT1 (GM2/GS2 synthase), inhibin, beta A (..
  42. Gurunathan S, Kim J. Biocompatible Gold Nanoparticles Ameliorate Retinoic Acid-Induced Cell Death and Induce Differentiation in F9 Teratocarcinoma Stem Cells. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..and Gata 6 and decreasing the expressions of markers of stem cell pluripotency including Nanog, Rex1, octamer-binding transcription factor 4, and Sox-2...
  43. Esteves C, Sharma R, Dawson L, Taylor S, Pearson G, Keen J, et al. Expression of putative markers of pluripotency in equine embryonic and adult tissues. Vet J. 2014;202:533-5 pubmed publisher
    Expression of several putative markers of pluripotency (OCT4, SOX2, NANOG, LIN28A, REX1, DNMT3B and TERT) was examined in a range of equine tissues, including early embryos, induced pluripotent stem cells (iPSCs), testis, adipose- and ..
  44. Dirat B, Ader I, Golzio M, Massa F, Mettouchi A, Laurent K, et al. Inhibition of the GTPase Rac1 mediates the antimigratory effects of metformin in prostate cancer cells. Mol Cancer Ther. 2015;14:586-96 pubmed publisher
    ..inhibition of Rac1 GTPase activity by interfering with some of its multiple upstream signaling pathways, namely P-Rex1 (a Guanine nucleotide exchange factor and activator of Rac1), cAMP, and CXCL12/CXCR4, resulting in decreased ..
  45. Pan D, Amison R, Riffo Vasquez Y, Spina D, Cleary S, Wakelam M, et al. P-Rex and Vav Rac-GEFs in platelets control leukocyte recruitment to sites of inflammation. Blood. 2015;125:1146-58 pubmed publisher
    ..Thioglycollate-induced neutrophil recruitment into the peritoneum was more severely impaired in P-Rex1(-/-) Vav1(-/-) (P1V1) or P-Rex1(-/-) Vav3(-/-) (P1V3) mice than in P-Rex null or Vav null mice, suggesting ..
  46. Speakman C, Domke T, Wongpaiboonwattana W, Sanders K, Mudaliar M, van Aalten D, et al. Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ESC differentiation without affecting naïve to primed cell transition. Stem Cells. 2014;32:2605-15 pubmed publisher
    ..However, the transition of naïve cells to primed pluripotency indicated by Rex1 (Zfp42), Nanog, Esrrb, and Dppa3 downregulation and Fgf5 upregulation remains unchanged...
  47. Tyagi D, Pérez J, Nand A, Zhiqiang C, Wang P, Na J, et al. Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption. Anal Biochem. 2015;471:29-37 pubmed publisher
    ..We detect the expression of Oct4, Sox2, Nanog, Rex1, and Lin28 biomarkers present in mouse embryonic stem cell (mESC) lysate against their corresponding antibodies ..
  48. McHugh E, Batinovic S, Hanssen E, McMillan P, Kenny S, Griffin M, et al. A repeat sequence domain of the ring-exported protein-1 of Plasmodium falciparum controls export machinery architecture and virulence protein trafficking. Mol Microbiol. 2015;98:1101-14 pubmed publisher
    ..The Ring-EXported Protein-1 (REX1) is a Maurer's cleft resident protein...
  49. Liu S, Bou G, Sun R, Guo S, Xue B, Wei R, et al. Sox2 is the faithful marker for pluripotency in pig: evidence from embryonic studies. Dev Dyn. 2015;244:619-27 pubmed publisher
    ..and pluripotent regulatory networks, we examined expression pattern of pluripotency factors, including SOX2, REX1, SALL4, ESG1, NANOG, TBX3, LIN28, KLF2, and KLF5, in porcine blastocysts...
  50. Welch H. Regulation and function of P-Rex family Rac-GEFs. Small Gtpases. 2015;6:49-70 pubmed publisher
    ..Work in genetically-modified mice has shown that P-Rex1 has physiological importance in the inflammatory response and the migration of melanoblasts during development, ..
  51. Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, et al. Selection and dynamics of embryonic stem cell integration into early mouse embryos. Development. 2016;143:24-34 pubmed publisher
    ..Using a fluorescent reporter for naive pluripotency (Rex1-GFP), we established that the acutely eliminated serum/LIF ESCs had started to differentiate...
  52. Quintero C, Laursen K, Mongan N, Luo M, Gudas L. CARM1 (PRMT4) Acts as a Transcriptional Coactivator during Retinoic Acid-Induced Embryonic Stem Cell Differentiation. J Mol Biol. 2018;430:4168-4182 pubmed publisher
    ..We identify CARM1 as a novel transcriptional coactivator required for the RA-associated decrease in Rex1 (Zfp42) and for the RA induction of a subset of RA-regulated genes, including CRABP2 and NR2F1 (Coup-TF1)...
  53. Daniel S, Penitente M, Silva D, Hashimoto D, Ferreira D, Foresti F, et al. Organization and Chromosomal Distribution of Histone Genes and Transposable Rex Elements in the Genome of Astyanax bockmanni (Teleostei, Characiformes). Cytogenet Genome Res. 2015;146:311-8 pubmed publisher
    ..The sixth population revealed 7 chromosomes marked with this probe. Probes for the transposable elements Rex1 and Rex6 showed small sites dispersed on most chromosomes of the 6 populations, and the Rex3 element is located in ..
  54. Costa G, Cioffi M, Bertollo L, Molina W. The Evolutionary Dynamics of Ribosomal Genes, Histone H3, and Transposable Rex Elements in the Genome of Atlantic Snappers. J Hered. 2016;107:173-80 pubmed publisher
    ..chrysurus showed a noteworthy dispersion of this gene in almost all chromosomes of the karyotype. Retrotransposons Rex1 and Rex3 do not exhibit any association with the explosive distribution of H3 sequences in O. chrysurus...
  55. Hou D, Jin Y, Nie X, Zhang M, Ta N, Zhao L, et al. Derivation of Porcine Embryonic Stem-Like Cells from In Vitro-Produced Blastocyst-Stage Embryos. Sci Rep. 2016;6:25838 pubmed publisher
    ..Microarray analysis showed the expression of the pluripotency markers, PODXL, REX1, SOX2, KLF5 and NR6A1, was significantly higher compared with porcine embryonic fibroblasts (PEF), but expression ..
  56. Secher J, Ceylan A, Mazzoni G, Mashayekhi K, Li T, Muenthaisong S, et al. Systematic in vitro and in vivo characterization of Leukemia-inhibiting factor- and Fibroblast growth factor-derived porcine induced pluripotent stem cells. Mol Reprod Dev. 2017;84:229-245 pubmed publisher
    ..analysis of the pluripotency-related gene network of the LIF- versus FGF-derived piPSCs revealed that ZFP42 (REX1) expression was absent in both piPSC-like cells, whereas it was expressed in the porcine inner cell mass at ..
  57. Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, et al. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS ONE. 2017;12:e0173047 pubmed publisher
    ..was reduced with increasing passages by teratoma formation test, and correlated with declined expression levels of Rex1, an important marker for naïve state...
  58. Mulas C, Kalkan T, Smith A. NODAL Secures Pluripotency upon Embryonic Stem Cell Progression from the Ground State. Stem Cell Reports. 2017;9:77-91 pubmed publisher
    ..Here, we investigated progression from the ESC ground state in defined culture. We utilized downregulation of Rex1::GFPd2 to track the loss of ESC identity...
  59. Kawaguchi T, Tsukiyama T, Kimura K, Matsuyama S, Minami N, Yamada M, et al. Generation of Naïve Bovine Induced Pluripotent Stem Cells Using PiggyBac Transposition of Doxycycline-Inducible Transcription Factors. PLoS ONE. 2015;10:e0135403 pubmed publisher
    ..Both types of biPSCs had strong alkaline phosphatase activity, expressed pluripotent markers (OCT3/4, NANOG, REX1, ESRRβ, STELLA, and SOCS3), and formed embryoid bodies that gave rise to differentiated cells from all three ..
  60. Kim E, Hwang S, Yoo H, Yoon J, Jeon Y, Kim H, et al. Putative embryonic stem cells derived from porcine cloned blastocysts using induced pluripotent stem cells as donors. Theriogenology. 2016;85:601-16 pubmed publisher
    ..Based on quantitative polymerase chain reaction, the expression levels of REX1 and FGFR2 in iPS-NT lines were higher than those of cells of other origins...
  61. Nakai Futatsugi Y, Niwa H. Zscan4 Is Activated after Telomere Shortening in Mouse Embryonic Stem Cells. Stem Cell Reports. 2016;6:483-495 pubmed publisher
    ..Using live cell imaging, we monitored the activity of Zscan4 together with the pluripotency marker Rex1. The lengths of the cell cycles in ESCs were diverse...
  62. Lopez Haber C, Barrio Real L, Casado Medrano V, Kazanietz M. Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α. Mol Cell Biol. 2016;36:2011-26 pubmed publisher
    ..enhanced Rac1 activation and migratory activity in response to the CXCR4 ligand SDF-1/CXCL12, effects mediated by P-Rex1, a Rac-guanine nucleotide exchange factor (GEF) aberrantly expressed in breast cancer...
  63. Pérez Palacios R, Macías Redondo S, Climent M, Contreras Moreira B, Muniesa P, Schoorlemmer J. In Vivo Chromatin Targets of the Transcription Factor Yin Yang 2 in Trophoblast Stem Cells. PLoS ONE. 2016;11:e0154268 pubmed publisher
    ..Following up on our previous report on ERV binding by YY2 in TS cells, we investigated the tissue-specificity of REX1 and YY2 binding and confirm binding to RE/ERV targets in both ES cells and TS cells...
  64. Hulbert A, Jusue Torres I, Stark A, Chen C, Rodgers K, Lee B, et al. Early Detection of Lung Cancer Using DNA Promoter Hypermethylation in Plasma and Sputum. Clin Cancer Res. 2017;23:1998-2005 pubmed publisher
    ..real-time PCR and methylation-on-beads for cancer-specific genes (SOX17, TAC1, HOXA7, CDO1, HOXA9, and ZFP42)...
  65. Wang H, Zhang K, Liu Y, Fu Y, Gao S, Gong P, et al. Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017;15:114 pubmed publisher
    ..Compared to those with long telomere, hESCs with short telomeres exhibit the lowest expressions of TERF1/TRF1, and ZFP42/REX1, PRDM14 and NANOG markers for pluripotency, suggesting that these hESCs are prone to exit from the ..
  66. Lucato C, Halls M, Ooms L, Liu H, Mitchell C, Whisstock J, et al. The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J Biol Chem. 2015;290:20827-40 pubmed publisher
    The P-Rex (phosphatidylinositol (3,4,5)-trisphosphate (PIP3)-dependent Rac exchanger) family (P-Rex1 and P-Rex2) of the Rho guanine nucleotide exchange factors (Rho GEFs) activate Rac GTPases to regulate cell migration, invasion, and ..
  67. Shah S, Saini N, Ashraf S, Zandi M, Manik R, Singla S, et al. Development, Characterization, and Pluripotency Analysis of Buffalo (Bubalus bubalis) Embryonic Stem Cell Lines Derived from In Vitro-Fertilized, Hand-Guided Cloned, and Parthenogenetic Embryos. Cell Reprogram. 2015;17:306-22 pubmed publisher
    ..expressed stem cell markers, such as Alkaline Phosphatase, OCT4, NANOG, SSEA1, SSEA4, TRA-1-60, TRA-1-81, SOX2, REX1, CD-90, STAT3, and TELOMERASE...
  68. García Castro I, Garcia Lopez G, Avila González D, Flores Herrera H, Molina Hernández A, Portillo W, et al. Markers of Pluripotency in Human Amniotic Epithelial Cells and Their Differentiation to Progenitor of Cortical Neurons. PLoS ONE. 2015;10:e0146082 pubmed publisher
    ..and quantitatively the expression of the transcription factors of pluripotency (OCT4, SOX2, NANOG, KLF4 and REX1) by RT-PCR and RT-qPCR in hAEC...
  69. Pan D, Barber M, Hornigold K, Baker M, Toth J, Oxley D, et al. Norbin Stimulates the Catalytic Activity and Plasma Membrane Localization of the Guanine-Nucleotide Exchange Factor P-Rex1. J Biol Chem. 2016;291:6359-75 pubmed publisher
    P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates the small G protein (GTPase) Rac1 to control Rac1-dependent cytoskeletal dynamics, and thus cell morphology...
  70. Cash J, Davis E, Tesmer J. Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3. Structure. 2016;24:730-740 pubmed publisher
    Phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger 1 (P-Rex1) is a Rho guanine nucleotide exchange factor synergistically activated by PIP3 and G?? that plays an important role in the metastasis of breast, prostate, ..
  71. Vazquez Prado J, Bracho Valdés I, Cervantes Villagrana R, Reyes Cruz G. G?? Pathways in Cell Polarity and Migration Linked to Oncogenic GPCR Signaling: Potential Relevance in Tumor Microenvironment. Mol Pharmacol. 2016;90:573-586 pubmed
    ..Specifically, phosphoinositide-3 kinases (class I PI3Ks, ? and ?) and P-Rex1, a Rac-specific guanine nucleotide exchange factor, are fundamental G?? effectors in the pathways controlling ..
  72. Tobias I, Brooks C, Teichroeb J, Villagómez D, Hess D, Séguin C, et al. Small-Molecule Induction of Canine Embryonic Stem Cells Toward Naïve Pluripotency. Stem Cells Dev. 2016;25:1208-22 pubmed publisher
    ..cESCs propagated in 2iL exhibited significant induction of genes associated with the naïve pluripotent state (eg, REX1, TBX3) and downregulation of primed pluripotency markers (eg, OTX2, FGF5) (P?<?0.05)...
  73. Liu D, Peng H, Sun Q, Zhao Z, Yu X, Ge S, et al. The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis. Int J Environ Res Public Health. 2017;14: pubmed publisher
    ..84, specificity: 0.88), CDO1 (sensitivity: 0.78, specificity: 0.67), ZFP42 (sensitivity: 0.87, specificity: 0.63) and TAC1 (sensitivity: 0.86, specificity: 0.75)...
  74. Sun Y, Cooper M, Finch S, Lin H, Chen Z, Williams B, et al. Rest-mediated regulation of extracellular matrix is crucial for neural development. PLoS ONE. 2008;3:e3656 pubmed publisher
    ..by intricate transcriptional programmes that initiate the down-regulation of pluripotent genes, Oct4, Nanog and Rex1 in blastocysts followed by up-regulation of lineage-specific genes as neural development proceeds...
  75. Hernández García R, Iruela Arispe M, Reyes Cruz G, Vázquez Prado J. Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells. Vascul Pharmacol. 2015;74:60-72 pubmed publisher
    ..Among them, we found that the most abundant endothelial RhoGEFs were: Tuba, FGD5, Farp1, ARHGEF17, TRIO, P-Rex1, ARHGEF15, ARHGEF11, ABR, Farp2, ARHGEF40, ALS, DOCK1, DOCK7 and DOCK6...
  76. Pinheiro V, Carvalho N, Carmo E, Schneider C, Feldberg E, Gross M. Karyoevolution in Potamorhina (Cope, 1878) (Ostariophysi, Curimatidae): Using Repetitive DNA for the Elucidation of Genome Organization. Zebrafish. 2016;13:118-31 pubmed publisher
    ..physical chromosome mapping using probes targeting 5S and 18S ribosomal DNA (rDNA), retroelement of Xiphophorus 1 (Rex1), Rex3, telomeres, and tropomyosin 1 (TPM1), we attempted to understand the evolutionary mechanisms involved in the ..
  77. Li J, Chai A, Wang L, Ma Y, Wu Z, Yu H, et al. Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. Proc Natl Acad Sci U S A. 2015;112:E6964-72 pubmed publisher
    ..we report that autism in Chinese Han population is associated with genetic variations and copy number deletion of P-Rex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1)...
  78. Liang Q, Cheng N, Zhang G, Liang Y, Qian F, Wu D, et al. Identification of P-Rex1 as an anti-inflammatory and anti-fibrogenic target for pulmonary fibrosis. Sci Rep. 2016;6:25785 pubmed publisher
    ..We examined P-Rex1, a PI3K- and G protein βγ-regulated guanine nucleotide exchange factor (GEF) of the Rac small GTPase, for its ..
  79. Bolnick A, Abdulhasan M, Kilburn B, Xie Y, Howard M, Andresen P, et al. Commonly used fertility drugs, a diet supplement, and stress force AMPK-dependent block of stemness and development in cultured mammalian embryos. J Assist Reprod Genet. 2016;33:1027-39 pubmed publisher
    ..g., Met, Asa, BR-DIM, control hyperosmotic stress) exposure on AMPK-dependent loss of Oct4 and/or Rex1 nuclear potency factors, confirm AMPK dependence by reversing potency loss in two-cell-stage embryos with AMPK ..
  80. Rungsiwiwut R, Pavarajarn W, Numchaisrika P, Virutamasen P, Pruksananonda K. Transgene-free human induced pluripotent stem cell line (HS5-SV.hiPS) generated from cesarean scar-derived fibroblasts. Stem Cell Res. 2016;16:10-3 pubmed publisher
    ..Transgene-free HS5-SV.hiPS cells expressed pluripotent associated transcription factors Oct4, Nanog, Sox2, Rex1 and surface markers SSEA-4, TRA-1-60 and OCT4. HS5-SV...
  81. Barrio Real L, Wertheimer E, Garg R, Abba M, Kazanietz M. Characterization of a P-Rex1 gene signature in breast cancer cells. Oncotarget. 2016;7:51335-51348 pubmed publisher
    The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ..
  82. Laksana K, Sooampon S, Pavasant P, Sriarj W. Cobalt Chloride Enhances the Stemness of Human Dental Pulp Cells. J Endod. 2017;43:760-765 pubmed publisher
    ..The messenger RNA expression of the stem cell markers REX1, OCT4, SOX2, and NANOG and the osteogenic-associated genes ALP, COLI, and RUNX2 were evaluated using reverse ..
  83. Schartl M, Schories S, Wakamatsu Y, Nagao Y, Hashimoto H, Bertin C, et al. Sox5 is involved in germ-cell regulation and sex determination in medaka following co-option of nested transposable elements. BMC Biol. 2018;16:16 pubmed publisher
    ..We now show that a second TE, Rex1, has been incorporated into Izanagi...
  84. Jin S, Lee H, Kim E, Ha J, Kim Y, Bae S. Reactive oxygen species and PI3K/Akt signaling in cancer. Free Radic Biol Med. 2014;75 Suppl 1:S34-5 pubmed publisher
    ..Expression of PIP3-dependent Rac exchanger1 (P-Rex1), a Rac guanosine exchange factor and a component of the mTOR complex...
  85. Malaver Ortega L, Sumer H, Liu J, Verma P. Inhibition of JAK-STAT ERK/MAPK and Glycogen Synthase Kinase-3 Induces a Change in Gene Expression Profile of Bovine Induced Pluripotent Stem Cells. Stem Cells Int. 2016;2016:5127984 pubmed publisher
    ..Sc1 inhibitors alone or in combination with 5-AzaC induced significantly higher levels of expression of endogenous REX1, OCT4, NANOG, and SOX2...
  86. Marei H, Carpy A, Woroniuk A, Vennin C, White G, Timpson P, et al. Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration. Nat Commun. 2016;7:10664 pubmed publisher
    ..Here we show that Tiam1 and P-Rex1, two Rac GEFs, promote Rac1 anti- and pro-migratory signalling cascades, respectively, through regulating the Rac1 ..
  87. Herberg M, Glauche I, Zerjatke T, Winzi M, Buchholz F, Roeder I. Dissecting mechanisms of mouse embryonic stem cells heterogeneity through a model-based analysis of transcription factor dynamics. J R Soc Interface. 2016;13: pubmed publisher
    ..expression levels of transcription factors (TFs) involved in pluripotency regulation, among them Nanog and Rex1. The expression of both TFs can change dynamically between states of high and low activity, correlating with the ..
  88. Graziano B, Gong D, Anderson K, Pipathsouk A, Goldberg A, Weiner O. A module for Rac temporal signal integration revealed with optogenetics. J Cell Biol. 2017;216:2515-2531 pubmed publisher
    ..We further identify the guanine nucleotide exchange factor P-Rex1 as the primary PIP3-stimulated Rac activator, whereas actin polymerization and the GTPase-activating ..
  89. Shi H, Fu Q, Li G, Ren Y, Hu S, Ni W, et al. Roles of p53 and ASF1A in the Reprogramming of Sheep Kidney Cells to Pluripotent Cells. Cell Reprogram. 2015;17:441-52 pubmed publisher
    ..stem cells (ESCs) and were positive for alkaline phosphatase and, pluripotent marker genes (Oct4, Nanog, Sox2, Rex1, TRA-1-60, TRA-1-81, and E-cadherin)...
  90. Goel H, Pursell B, Shultz L, Greiner D, Brekken R, Vander Kooi C, et al. P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer. Cell Rep. 2016;14:2193-2208 pubmed publisher
    ..VEGF/neuropilin signaling, which is not inhibited by bevacizumab and sunitinib, and it involves the induction of P-Rex1, a Rac GEF, and consequent Rac1-mediated ERK activation. This induction of P-Rex1 is dependent on Myc...
  91. Sandrasaigaran P, Algraittee S, Ahmad A, Vidyadaran S, Ramasamy R. Characterisation and immunosuppressive activity of human cartilage-derived mesenchymal stem cells. Cytotechnology. 2018;70:1037-1050 pubmed publisher
    ..cells and a defined immunophenotyping, MSCs expressed early embryonic transcriptional markers (SOX2, REX1, OCT4 and NANOG) and differentiated into chondrocytes, adipocytes and osteocytes when induced accordingly...
  92. Kristensen D, Nielsen J, Skakkebaek N, Graem N, Jacobsen G, Rajpert De Meyts E, et al. Presumed pluripotency markers UTF-1 and REX-1 are expressed in human adult testes and germ cell neoplasms. Hum Reprod. 2008;23:775-82 pubmed publisher
    UTF-1 and REX-1/ZFP42 are transcription factors involved in pluripotency...