ZFHX3

Summary

Gene Symbol: ZFHX3
Description: zinc finger homeobox 3
Alias: ATBF1, ATBT, ZNF927, zinc finger homeobox protein 3, AT motif-binding factor 1, AT-binding transcription factor 1, ZFH-3, alpha-fetoprotein enhancer binding protein, zinc finger homeodomain protein 3
Species: human
Products:     ZFHX3

Top Publications

  1. Miura Y, Tam T, Ido A, Morinaga T, Miki T, Hashimoto T, et al. Cloning and characterization of an ATBF1 isoform that expresses in a neuronal differentiation-dependent manner. J Biol Chem. 1995;270:26840-8 pubmed
    The human ATBF1 cDNA reported previously, now termed ATBF1-B, encodes a 306-kDa protein containing 4 homeodomains and 18 zinc fingers including one pseudo zinc finger motif...
  2. Kaspar P, Dvorakova M, Kralova J, Pajer P, Kozmik Z, Dvorak M. Myb-interacting protein, ATBF1, represses transcriptional activity of Myb oncoprotein. J Biol Chem. 1999;274:14422-8 pubmed
    Using the yeast two-hybrid system, the transcription factor ATBF1 was identified as v-Myb- and c-Myb-binding protein...
  3. Kim T, Kawaguchi M, Suzuki M, Jung C, Asai K, Shibamoto Y, et al. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech. 2010;3:752-62 pubmed publisher
    ..signaling pathway that links ATM via cAMP-responsive-element-binding protein (CREB) to the transcription factor ZFHX3 (also known as ATBF1), which in turn promotes survival of neurons by inducing expression of platelet-derived ..
  4. Mabuchi M, Kataoka H, Miura Y, Kim T, Kawaguchi M, Ebi M, et al. Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-beta signal transduction. Biochem Biophys Res Commun. 2010;398:321-5 pubmed publisher
    b>AT motif binding factor 1 (ATBF1), a homeotic transcription factor, was identified as a tumor suppressor, and loss of heterozygosity at ATBF1 locus occurs frequently in gastric cancers...
  5. Benjamin E, Rice K, Arking D, Pfeufer A, van Noord C, Smith A, et al. Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry. Nat Genet. 2009;41:879-81 pubmed publisher
    ..of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) AF cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7))...
  6. Gudbjartsson D, Holm H, Gretarsdottir S, Thorleifsson G, Walters G, Thorgeirsson G, et al. A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke. Nat Genet. 2009;41:876-8 pubmed publisher
    ..A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with AF (odds ratio OR = 1.21, P = 1.4 x 10(-10))...
  7. Kim C, Song J, Cho Y, Cao Z, Lee Y, Nam S, et al. Down-regulation of ATBF1 is a major inactivating mechanism in hepatocellular carcinoma. Histopathology. 2008;52:552-9 pubmed publisher
    alpha-Fetoprotein (AFP) is frequently detected in hepatocellular carcinomas (HCCs) and AT motif binding factor 1 (ATBF1) down-regulates AFP gene expression in hepatic cells...
  8. Cho Y, Song J, Kim C, Lee Y, Kim S, Nam S, et al. Genetic alterations of the ATBF1 gene in gastric cancer. Clin Cancer Res. 2007;13:4355-9 pubmed
    ..present study was to investigate whether somatic changes of the AFP-negative regulator AT motif binding factor-1 (ATBF1) gene are involved in the development or progression of gastric cancers and the production of AFP in gastric ..
  9. Sun X, Li J, Sica G, Fan S, Wang Y, Chen Z, et al. Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma. Head Neck. 2013;35:1007-14 pubmed publisher
    The AT-motif binding factor 1 (ATBF1) gene is frequently altered at the genetic level in several types of cancer, but its protein expression and subcellular localization have not been well studied in human cancers, including head and ..

More Information

Publications83

  1. Ellinor P, Lunetta K, Albert C, Glazer N, Ritchie M, Smith A, et al. Meta-analysis identifies six new susceptibility loci for atrial fibrillation. Nat Genet. 2012;44:670-5 pubmed publisher
    ..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules. ..
  2. Dong X, Fu X, Fan S, Guo P, Su D, Dong J. Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. Biochem J. 2012;444:581-90 pubmed publisher
    We reported previously that the tumour suppressor ATBF1 (AT motif-binding factor 1) formed an autoregulatory feedback loop with oestrogen-ER? (oestrogen receptor ?) signalling to regulate oestrogen-dependent cell proliferation in breast ..
  3. Li C, Wang F, Yang Y, Fu F, Xu C, Shi L, et al. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. Hum Genet. 2011;129:239-46 pubmed publisher
    ..association studies (GWAS) identified two single nucleotide polymorphisms (SNPs), rs2106261 and rs7193343 in ZFHX3 (zinc finger homeobox 3 gene) and rs13376333 in KCNN3 (encoding a potassium intermediate/small conductance calcium-..
  4. Burgner D, Davila S, Breunis W, Ng S, Li Y, Bonnard C, et al. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. PLoS Genet. 2009;5:e1000319 pubmed publisher
    ..13 x 10(-6)) and ZFHX3 (rs7199343, p(combined) = 2.37 x 10(-6)) most significantly associated...
  5. Cleton Jansen A, van Eijk R, Lombaerts M, Schmidt M, van T Veer L, Philippo K, et al. ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism. BMC Cancer. 2008;8:105 pubmed publisher
    ..The genes for NAD(P)H dehydrogenase quinone (NQO1) and AT-binding transcription factor 1 (ATBF1) were further investigated given their functions as potential TSGs...
  6. Mori Y, Kataoka H, Miura Y, Kawaguchi M, Kubota E, Ogasawara N, et al. Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer. Int J Cancer. 2007;121:241-7 pubmed
    ..AT motif-binding factor 1 (ATBF1) is a homeotic transcriptional regulatory factor recently identified as a tumor suppressor gene, and its ..
  7. Yasuda H, Mizuno A, Tamaoki T, Morinaga T. ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene. Mol Cell Biol. 1994;14:1395-401 pubmed
    b>ATBF1 is a 306-kDa protein containing four homeodomains, 17 zinc finger motifs, and several segments potentially involved in transcriptional regulation (T. Morinaga, H. Yasuda, T. Hashimoto, K. Higashio, and T. Tamaoki, Mol. Cell. Biol...
  8. Sun X, Zhou Y, Otto K, Wang M, Chen C, Zhou W, et al. Infrequent mutation of ATBF1 in human breast cancer. J Cancer Res Clin Oncol. 2007;133:103-5 pubmed
    ..Recently, the transcription factor ATBF1 at 16q22 was identified as a strong candidate tumor suppressor gene in prostate cancer, and loss of ATBF1 ..
  9. Li M, Zhao D, Ma G, Zhang B, Fu X, Zhu Z, et al. Upregulation of ATBF1 by progesterone-PR signaling and its functional implication in mammary epithelial cells. Biochem Biophys Res Commun. 2013;430:358-63 pubmed publisher
    ..In this study, we have identified the ATBF1 transcription factor as a transcriptional target of Pg-PR signaling in mammary epithelial cells...
  10. Yamada K, Miura Y, Scheidl T, Yoshida M, Tamaoki T. Assignment of the human ATBF1 transcription factor gene to chromosome 16q22.3-q23.1. Genomics. 1995;29:552-3 pubmed
  11. Morinaga T, Yasuda H, Hashimoto T, Higashio K, Tamaoki T. A human alpha-fetoprotein enhancer-binding protein, ATBF1, contains four homeodomains and seventeen zinc fingers. Mol Cell Biol. 1991;11:6041-9 pubmed
    We have isolated a full-length cDNA encoding a protein (ATBF1) that binds to an AT-rich motif in the human alpha-fetoprotein gene enhancer...
  12. Dong X, Guo P, Sun X, Li Q, Dong J. Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells. J Biol Chem. 2011;286:13879-90 pubmed publisher
    ..In a previous study we demonstrated that ATBF1, which has been suggested as a tumor suppressor in breast cancer, inhibited estrogen-mediated cell proliferation ..
  13. Berry F, Miura Y, Mihara K, Kaspar P, Sakata N, Hashimoto Tamaoki T, et al. Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1. J Biol Chem. 2001;276:25057-65 pubmed
    The ATBF1 gene encodes two protein isoforms, the 404-kDa ATBF1-A, possessing four homeodomains and 23 zinc fingers, and the 306-kDa ATBF1-B, lacking a 920-amino acid N-terminal region of ATBF1-A which contains 5 zinc fingers...
  14. Traylor M, Farrall M, Holliday E, Sudlow C, Hopewell J, Cheng Y, et al. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol. 2012;11:951-62 pubmed publisher
    ..We verified previous associations for cardioembolic stroke near PITX2 (p=2·8×10(-16)) and ZFHX3 (p=2·28×10(-8)), and for large-vessel stroke at a 9p21 locus (p=3·32×10(-5)) and HDAC9 (p=2·03Ã..
  15. Kataoka H, Miura Y, Joh T, Seno K, Tada T, Tamaoki T, et al. Alpha-fetoprotein producing gastric cancer lacks transcription factor ATBF1. Oncogene. 2001;20:869-73 pubmed
    ..transcription factor, HNF1 (hepatocyte nuclear factor 1) and a repressive transcription factor, ATBF1 (AT motif binding factor 1)...
  16. Nojiri S, Joh T, Miura Y, Sakata N, Nomura T, Nakao H, et al. ATBF1 enhances the suppression of STAT3 signaling by interaction with PIAS3. Biochem Biophys Res Commun. 2004;314:97-103 pubmed
    b>ATBF1 was first discovered as a suppressor of AFP expression in hepatocytes. It is present in brain, adult liver, lung, and gastro-intestinal tract...
  17. Zhang Z, Yamashita H, Toyama T, Sugiura H, Ando Y, Mita K, et al. ATBF1-a messenger RNA expression is correlated with better prognosis in breast cancer. Clin Cancer Res. 2005;11:193-8 pubmed
    The AT motif-binding factor 1 (ATBF1) gene was first identified as a suppressor of the alpha-fetoprotein (AFP) gene through its binding to an AT-rich enhancer element of this gene. The gene is located at chromosome 16q22.3-q23...
  18. Li M, Fu X, Ma G, Sun X, Dong X, Nagy T, et al. Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling. PLoS ONE. 2012;7:e51283 pubmed publisher
    b>ATBF1 is a candidate tumor suppressor that interacts with estrogen receptor (ER) to inhibit the function of estrogen-ER signaling in gene regulation and cell proliferation control in human breast cancer cells...
  19. Kai K, Zhang Z, Yamashita H, Yamamoto Y, Miura Y, Iwase H. Loss of heterozygosity at the ATBF1-A locus located in the 16q22 minimal region in breast cancer. BMC Cancer. 2008;8:262 pubmed publisher
    ..Recently, the AT-motif binding factor 1 (ATBF1)-A gene, which has been assigned to chromosome 16q22.3-23...
  20. Sun X, Frierson H, Chen C, Li C, Ran Q, Otto K, et al. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Nat Genet. 2005;37:407-12 pubmed
    ..Here we report that ATBF1, which encodes a transcription factor that negatively regulates AFP and MYB but transactivates CDKN1A, is a good ..
  21. Xu J, Sauvageot J, Ewing C, Sun J, Liu W, Isaacs S, et al. Germline ATBF1 mutations and prostate cancer risk. Prostate. 2006;66:1082-5 pubmed
    b>ATBF1 has been recently identified as a candidate prostate tumor suppressor gene...
  22. Yang X, Tang F, Shin J, Cunningham J. Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma. BMC Syst Biol. 2017;11:92 pubmed publisher
    ..Finally, we performed in vitro validation on ZFHX3, a cell differentiation marker silenced by PRC2, and compared cell morphology changes before and after blocking ..
  23. Petrovičová A, Kurča E, Brozman M, Hasilla J, Vahala P, Blaško P, et al. Detection of occult paroxysmal atrial fibrilation by implantable long-term electrocardiographic monitoring in cryptogenic stroke and transient ischemic attack population: a study protocol for prospective matched cohort study. BMC Cardiovasc Disord. 2015;15:160 pubmed publisher
    ..long-term (12 months) ECG monitoring (implantable loop recorder) and testing for PITX2 (chromosome 4q25) and ZFHX3 (chromosome 16q22) gene mutations...
  24. Xiang S, Huang Z, Wang T, Han Z, Yu C, Ni D, et al. Condition-specific gene co-expression network mining identifies key pathways and regulators in the brain tissue of Alzheimer's disease patients. BMC Med Genomics. 2018;11:115 pubmed publisher
    ..upstream transcription factor analysis identified differentially expressed upstream regulators such as ZFHX3 for several modules, which can be potential driver genes for AD etiology and pathology...
  25. Rollo J, Knight S, May H, Anderson J, Muhlestein J, Bunch T, et al. Incidence of dementia in relation to genetic variants at PITX2, ZFHX3, and ApoE ε4 in atrial fibrillation patients. Pacing Clin Electrophysiol. 2015;38:171-7 pubmed publisher
    ..There were no significant interactions between ApoE ε4 allele and both the PITX2 loci and ZFHX3. These findings support prior studies of ApoE risk of noncerebral vascular accident-related dementia/Alzheimer's ..
  26. Gęgotek A, Domingues P, Wroński A, Wojcik P, Skrzydlewska E. Proteomic plasma profile of psoriatic patients. J Pharm Biomed Anal. 2018;155:185-193 pubmed publisher
    ..This was particularly evident by the level of transcriptional factors, including AT motif binding factor 1, which regulates excessive cellular proliferation and differentiation...
  27. Chauhan G, Debette S. Genetic Risk Factors for Ischemic and Hemorrhagic Stroke. Curr Cardiol Rep. 2016;18:124 pubmed
    ..Risk loci for ischemic stroke and its subtypes have been implicated in atrial fibrillation (PITX2 and ZFHX3), coronary artery disease (ABO, chr9p21, HDAC9, and ALDH2), blood pressure (ALDH2 and HDAC9), pericyte and smooth ..
  28. Shoemaker M, Bollmann A, Lubitz S, Ueberham L, SAINI H, Montgomery J, et al. Common genetic variants and response to atrial fibrillation ablation. Circ Arrhythm Electrophysiol. 2015;8:296-302 pubmed publisher
    ..SNPs) at chromosomes 4q25 (rs2200733, rs10033464 near PITX2), 1q21 (rs13376333 in KCNN3), and 16q22 (rs7193343 in ZFHX3) have consistently been associated with the risk of atrial fibrillation (AF)...
  29. Park J, Lee J, Yang P, Kim T, Shin E, Park J, et al. Good responders to catheter ablation for long-standing persistent atrial fibrillation: Clinical and genetic characteristics. J Cardiol. 2017;69:584-590 pubmed publisher
    ..010), and smaller left atrial (LA) size (p=0.033) than others. The rs2106216 (16q22/ZFHX3) genetic polymorphism was independently associated with being a good responder in multivariate analysis (adjusted ..
  30. Lin H, Sinner M, Brody J, Arking D, Lunetta K, Rienstra M, et al. Targeted sequencing in candidate genes for atrial fibrillation: the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study. Heart Rhythm. 2014;11:452-7 pubmed publisher
    ..loci of complex diseases or traits, including 4 genes hypothesized to be related to AF (PRRX1, CAV1, CAV2, and ZFHX3)...
  31. Huang Y, Wang C, Yao Y, Zuo X, Chen S, Xu C, et al. Molecular Basis of Gene-Gene Interaction: Cyclic Cross-Regulation of Gene Expression and Post-GWAS Gene-Gene Interaction Involved in Atrial Fibrillation. PLoS Genet. 2015;11:e1005393 pubmed publisher
    ..for AF, only three were replicated in the Chinese Han population, including SNP rs2106261 (G/A substitution) in ZFHX3, rs2200733 (C/T substitution) near PITX2c, and rs3807989 (A/G substitution) in CAV1...
  32. Husser D, Buttner P, Ueberham L, Dinov B, Sommer P, Arya A, et al. Association of atrial fibrillation susceptibility genes, atrial fibrillation phenotypes and response to catheter ablation: a gene-based analysis of GWAS data. J Transl Med. 2017;15:71 pubmed publisher
    Previous studies have suggested PITX2, KCNN3 and ZFHX3 as atrial fibrillation (AF) susceptibility genes...
  33. Turcot V, Lu Y, Highland H, Schurmann C, Justice A, Fine R, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nat Genet. 2018;50:26-41 pubmed publisher
    ..We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously ..
  34. Balzani E, Lassi G, Maggi S, Sethi S, Parsons M, Simon M, et al. The Zfhx3-Mediated Axis Regulates Sleep and Interval Timing in Mice. Cell Rep. 2016;16:615-21 pubmed publisher
    An AT motif-dependent axis, modulated by the transcription factor Zfhx3, influences the circadian clock in mice...
  35. Kao Y, Hsu J, Chen Y, Lin Y, Lkhagva B, Chen S, et al. ZFHX3 knockdown increases arrhythmogenesis and dysregulates calcium homeostasis in HL-1 atrial myocytes. Int J Cardiol. 2016;210:85-92 pubmed publisher
    b>ZFHX3 plays an important role in the genesis of atrial fibrillation. However, the atrial electrophysiological effects of ZFHX3 are not clear...
  36. Parsons M, Brancaccio M, Sethi S, Maywood E, Satija R, Edwards J, et al. The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis. Cell. 2015;162:607-21 pubmed publisher
    We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3(Sci)), which accelerates circadian locomotor rhythms in mice...
  37. Lozano Velasco E, Hernández Torres F, Daimi H, Serra S, Herraiz A, Hove Madsen L, et al. Pitx2 impairs calcium handling in a dose-dependent manner by modulating Wnt signalling. Cardiovasc Res. 2016;109:55-66 pubmed publisher
    ..appendage in NppaCrePitx2(+/-) and NppaCrePitx2(-/-) adult mice demonstrate that AF GWAS-associated genes such as Zfhx3, Kcnn3, and Wnt8a are severely impaired but not Cav1, Synpo2l, nor Prrx1...
  38. Carty C, Keene K, Cheng Y, Meschia J, Chen W, Nalls M, et al. Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans. Stroke. 2015;46:2063-8 pubmed publisher
    ..03), and 1p31.1 (P=0.018). Four of 7 previously reported ischemic stroke loci (PITX2, HDAC9, CDKN2A/CDKN2B, and ZFHX3) were nominally associated (P<0.05) with stroke in COMPASS...
  39. Chang I, Parrilla M. Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages. Gene Expr Patterns. 2016;21:69-80 pubmed publisher
    ..Pou6f1, Tshz2, Zhx1, Zhx3) that were expressed exclusively in neurons; 4 homeobox genes (Pax6, Six1, Tgif1, Zfhx3) that were expressed in all non-neuronal cell populations, with Pax6, Six1 and Tgif1 also expressed in some ..
  40. Panaccione A, Zhang Y, Mi Y, Mitani Y, Yan G, Prasad M, et al. Chromosomal abnormalities and molecular landscape of metastasizing mucinous salivary adenocarcinoma. Oral Oncol. 2017;66:38-45 pubmed publisher
    ..in KDM6A, KMT2D, and other genes frequently mutated in colorectal and other cancers: FAT1, NBEA, RELN, RLP1B, and ZFHX3. Proteomic analysis of MAC implied epigenetic up-regulation of a genetic program involved in proliferation and ..
  41. Liu L, Ebana Y, Nitta J, Takahashi Y, Miyazaki S, Tanaka T, et al. Genetic Variants Associated With Susceptibility to Atrial Fibrillation in a Japanese Population. Can J Cardiol. 2017;33:443-449 pubmed publisher
    ..PITX2), rs11773845 (7q31 in CAV1), rs6584555 (10q25 in NEURL), rs6490029 (12q24 in CUX2), and rs12932445 (16q22 in ZFHX3) (P < 1.9 × 10-5)-were confirmed as being associated with AF...
  42. Helder C, Schwartz B, Redondo M, Piponov H, Gonzalez M. Blood Transfusion After Primary Total Hip Arthroplasty: National Trends and Perioperative Outcomes. J Surg Orthop Adv. 2017;26:216-222 pubmed
    ..the changes in transfusion rates, both allogeneic blood transfusion (ALBT) and autogenic blood transfusion (ATBT) on a national scale, and determine patient factors associated with transfusions...
  43. Zaw K, Sato N, Ikeda S, Thu K, Mieno M, Arai T, et al. Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study. J Cardiol. 2017;70:180-184 pubmed publisher
    We aimed to study a single nucleotide polymorphism (SNP), rs2106261, in the transcription factor gene, ZFHX3, in atrial fibrillation (AF) and other related phenotypes by phenome scanning in a Japanese population...
  44. Gupta S, Li J, Kemeny G, Bitting R, Beaver J, Somarelli J, et al. Whole Genomic Copy Number Alterations in Circulating Tumor Cells from Men with Abiraterone or Enzalutamide-Resistant Metastatic Castration-Resistant Prostate Cancer. Clin Cancer Res. 2017;23:1346-1357 pubmed publisher
    ..Genomic gains in >25% of CTCs were observed in AR, FOXA1, ABL1, MET, ERG, CDK12, BRD4, and ZFHX3, while common genomic losses involved PTEN, ZFHX3, PDE4DIP, RAF1, and GATA2 Analysis of aCGH in ..
  45. Sun X, Li J, Dong F, Dong J. Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells. PLoS ONE. 2014;9:e92746 pubmed publisher
    b>ATBF1/ZFHX3 is a large transcription factor that functions in development, tumorigenesis and other biological processes. ATBF1 is normally localized in the nucleus, but is often mislocalized in the cytoplasm in cancer cells...
  46. Bedford M, Chan D, Leder P. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. EMBO J. 1997;16:2376-83 pubmed
  47. Li M, Zhang C, Zhong Y, Zhao J. Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells. Biochem Biophys Res Commun. 2017;490:492-498 pubmed publisher
    b>ATBF1, a large transcription factor, was normally localized in nuclei, and its mislocalization to cytoplasm was reported in multiple cancers...
  48. Hauer A, Pulit S, van den Berg L, de Bakker P, Veldink J, Ruigrok Y. A replication study of genetic risk loci for ischemic stroke in a Dutch population: a case-control study. Sci Rep. 2017;7:12175 pubmed publisher
    ..We confirmed the association at 4q25 (PITX2) (OR 1.43; 95% CI, 1.13-1.81, p = 0.029) and 16q22 (ZFHX3) (OR 1.62; 95% CI, 1.26-2.07, p = 0.001) as risk loci for CE...
  49. Kawaguchi M, Hara N, Bilim V, Koike H, Suzuki M, Kim T, et al. A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. BMC Cancer. 2016;16:805 pubmed
    ..AT-motif binding factor 1 (ATBF1) is a tumor suppressive transcription factor that is normally localized to the nucleus but has been detected in ..
  50. Zhang Z, Li Q, Diao M, Liu N, Cheng W, Xiao P, et al. Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing. Sci Rep. 2017;7:14796 pubmed publisher
    ..In addition, 6 genes (PTPN13, PHKB, AGL, ZFHX3, LAMA1, and AP3B2) were prioritized for follow-up studies: both their time-space expression patterns in mouse and ..
  51. Yang S. Association study between ZFHX3 gene polymorphisms and obesity in Korean population. J Exerc Rehabil. 2017;13:491-494 pubmed publisher
    ..The aim of this study is to investigate whether single nucleotide polymorphisms (SNPs) of zinc finger homeobox 3 (ZFHX3 ) gene are susceptibility to obesity...
  52. Mao L, Huang W, Zou P, Dang X, Zeng X. The unrecognized role of tumor suppressor genes in atrial fibrillation. Gene. 2018;642:26-31 pubmed publisher
  53. Sun X, Xing C, Fu X, Li J, Zhang B, Frierson H, et al. Additive Effect of Zfhx3/Atbf1 and Pten Deletion on Mouse Prostatic Tumorigenesis. J Genet Genomics. 2015;42:373-82 pubmed publisher
    The phosphatase and tensin homolog (PTEN) and the zinc finger homeobox 3 (ZFHX3)/AT-motif binding factor 1 (ATBF1) genes have been established as tumor suppressor genes in prostate cancer by their frequent deletions and mutations in ..
  54. Minamiya Y, Saito H, Ito M, Imai K, Konno H, Takahashi N, et al. Suppression of Zinc Finger Homeobox 3 expression in tumor cells decreases the survival rate among non-small cell lung cancer patients. Cancer Biomark. 2012;11:139-46 pubmed publisher
    Zinc Finger Homeobox 3 (ZFHX3) was first identified as a suppressor of alpha-fetoprotein gene and is a good candidate for the 16q22 tumor suppressor...
  55. Sun S, Zhang W, Chen X, Song H. The CAA repeat polymorphism in the ZFHX3 gene is associated with risk of coronary heart disease in a Chinese population. Tohoku J Exp Med. 2015;235:261-6 pubmed publisher
    ..Zinc finger homeobox 3 (ZFHX3) is a transcription factor and contains a poly-glutamine tract in a compositionally biased region that is encoded ..
  56. Elmas E, Bugert P, Popp T, Lang S, Weiss C, Behnes M, et al. The P-selectin gene polymorphism Val168Met: a novel risk marker for the occurrence of primary ventricular fibrillation during acute myocardial infarction. J Cardiovasc Electrophysiol. 2010;21:1260-5 pubmed publisher
    ..CD40LG (-3459A>G, -122A>C, -123A>C, 148T>C, intr4-13T>C), the H558R SNP in SCN5A, and rs2106261 in ZFHX3. In addition, length polymorphisms in SELPLG (36bp-tandem repeat) and CD40LG (CA-repeat) were genotyped by PCR ..
  57. Lange E, Beebe Dimmer J, Ray A, Zuhlke K, Ellis J, Wang Y, et al. Genome-wide linkage scan for prostate cancer susceptibility from the University of Michigan Prostate Cancer Genetics Project: suggestive evidence for linkage at 16q23. Prostate. 2009;69:385-91 pubmed publisher
    ..and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX...
  58. Uhm K, Kim M, Kawaguchi M, Akatsu H, Miura Y, Misumi S, et al. ATBF1 is a novel amyloid-? protein precursor (A?PP) binding protein that affects A?PP expression. J Alzheimers Dis. 2015;43:243-57 pubmed publisher
    ..We previously reported that levels of AT-motif binding factor 1 (ATBF1) are increased in the brains of 17-month-old Tg2576 mice compared with wild-type controls, and that A?42 increases ..
  59. Nishio E, Miura Y, Kawaguchi M, Morita A. Nuclear translocation of ATBF1 is a potential prognostic marker for skin cancer. Acta Dermatovenerol Croat. 2012;20:239-45 pubmed
    The AT motif binding factor 1 (ATBF1) is expressed in various tissues, such as brain, liver, lung, and gastrointestinal tract, and has an important role in cell differentiation in organs...
  60. Liu Y, Ni B, Lin Y, Chen X, Fang Z, Zhao L, et al. Genetic polymorphisms in ZFHX3 are associated with atrial fibrillation in a Chinese Han population. PLoS ONE. 2014;9:e101318 pubmed publisher
    The gene zinc finger homeobox 3 (ZFHX3) encodes a transcription factor with cardiac expression and its genetic variants are associated with atrial fibrillation (AF)...
  61. Wilcox A, Vizor L, Parsons M, Banks G, Nolan P. Inducible Knockout of Mouse Zfhx3 Emphasizes Its Key Role in Setting the Pace and Amplitude of the Adult Circadian Clock. J Biol Rhythms. 2017;32:433-443 pubmed publisher
    The transcription factor zinc finger homeobox 3 (ZFHX3) plays a key role in coupling intracellular transcriptional-translational oscillations with intercellular synchrony in mouse suprachiasmatic nucleus (SCN)...
  62. An C, Kim S, Kang M, Kim Y, Kim H, Yoo N, et al. Frameshift mutations of ATBF1, WNT9A, CYLD and PARK2 in gastric and colorectal carcinomas with high microsatellite instability. Pathology. 2010;42:583-5 pubmed publisher
  63. Bevan S, Traylor M, Adib Samii P, Malik R, Paul N, Jackson C, et al. Genetic heritability of ischemic stroke and the contribution of previously reported candidate gene and genomewide associations. Stroke. 2012;43:3161-7 pubmed publisher
    ..63e(-6)), PITX2 in cardioembolic stroke (P=4.78e(-8)), and ZFHX3 in cardioembolic stroke (P=5.50e(-7))...
  64. Lozano Velasco E, Wangensteen R, Quesada A, García Padilla C, Osorio J, Ruiz Torres M, et al. Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling. PLoS ONE. 2017;12:e0188473 pubmed publisher
    ..In vitro cell culture analyses using gain- and loss-of-function strategies demonstrate that Pitx2, Zfhx3 and Wnt signaling influence redox homeostasis in cardiomyocytes...
  65. Kaushik N, Malaspina A, de Belleroche J. Characterization of trinucleotide- and tandem repeat-containing transcripts obtained from human spinal cord cDNA library by high-density filter hybridization. DNA Cell Biol. 2000;19:265-73 pubmed
    ..Other genes containing extended TNRs of 9 to 21 repeats were calcium-dependent protease, ATBF1-A, ferritin H chain, and the G protein Gsalpha2...
  66. Kataoka H, Miura Y, Kawaguchi M, Suzuki S, Okamoto Y, Ozeki K, et al. Expression and subcellular localization of AT motif binding factor 1 in colon tumours. Mol Med Rep. 2017;16:3095-3102 pubmed publisher
    b>AT motif binding factor 1 (ATBF1) is a transcriptional regulator that functions as a tumour suppressor to negatively affect cancer cell growth...
  67. Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, et al. Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clin Epigenetics. 2017;9:54 pubmed publisher
    ..60?×?10-8, respectively). The DNAm sites cg07786668 and cg17218495 are located in ZFHX3 (zinc finger homeobox 3) and SMARCA4 (SWI/SNF-related, matrix-associated, actin-dependent regulator of ..
  68. Tsai C, Hsieh C, Chang S, Chuang E, Juang J, Lin L, et al. Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. J Med Genet. 2015;52:28-36 pubmed publisher
    ..variants in nine genomic regions associated with AF (KCNN3, PRRX1, PITX2, WNT8A, CAV1, C9orf3, SYNE2, HCN4 and ZFHX3 genes); however, the genetic variability of these risk variants does not explain the entire genetic susceptibility ..
  69. Martin R, Owens W, Cunnington M, Mayosi B, Koref M, Keavney B. Chromosome 16q22 variants in a region associated with cardiovascular phenotypes correlate with ZFHX3 expression in a transcript-specific manner. BMC Genet. 2014;15:136 pubmed publisher
    The ZFHX3 gene, located in Chromosome 16q22.3, codes for a transcription factor which is widely expressed in human tissues...
  70. Zhai C, Cong H, Liu Y, Zhang Y, Liu X, Zhang H, et al. Rs7193343 polymorphism in zinc finger homeobox 3 (ZFHX3) gene and atrial fibrillation: an updated meta-analysis of 10 case-control comparisons. BMC Cardiovasc Disord. 2015;15:58 pubmed publisher
    ..genome-wide studies have shown that rs7193343 single-nucleotide polymorphism (SNP) in zinc finger homeobox 3 (ZFHX3) gene correlate with risk of atrial fibrillation (AF)...
  71. Iida M, Imura J, Furuichi T, Sawada T, Nagawa H, Fujimori T. Alteration of the AT motif binding factor-1 expression in alpha-fetoprotein producing gastric cancer: is it an event for differentiation and proliferation of the tumors?. Oncol Rep. 2004;11:3-7 pubmed
    ..Recently, AT motif binding factor-1 (ATBF1) was identified as a modulator of AFP production by hepatocellular carcinoma, and the decreased expression of the ..
  72. Ji S, Zhong L. [A preliminary functional study of AT motif binding factor 1 in colorectal cancer]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:957-63 pubmed
    To investigate the function of AT motif binding factor 1 (ATBF1) in colorectal cancer. ATBF1 protein expression was detected in 146 pairs of colorectal cancer tissues and the adjacent tissues using immunohistochemistry...
  73. Smith J, Melander O, Sjögren M, Hedblad B, Engstrom G, Newton Cheh C, et al. Genetic polymorphisms confer risk of atrial fibrillation in patients with heart failure: a population-based study. Eur J Heart Fail. 2013;15:250-7 pubmed publisher
    ..A polymorphism in the ZFHX3 gene, encoding a cardiac transcription factor, was associated with increased AF risk in HF patients, and the ..
  74. Walker C, Miranda M, O Hern M, McElroy J, Coombes K, Bundschuh R, et al. Patterns of CTCF and ZFHX3 Mutation and Associated Outcomes in Endometrial Cancer. J Natl Cancer Inst. 2015;107: pubmed publisher
    ..The chromosome 16q22 tumor suppressor genes CTCF and ZFHX3 are both frequently mutated in EEC, but their respective roles in outcome have not been determined...