ZC3HAV1

Summary

Gene Symbol: ZC3HAV1
Description: zinc finger CCCH-type containing, antiviral 1
Alias: ARTD13, FLB6421, PARP13, ZAP, ZC3H2, ZC3HDC2, zinc finger CCCH-type antiviral protein 1, ADP-ribosyltransferase diphtheria toxin-like 13, zinc finger CCCH domain-containing protein 2, zinc finger CCCH-type, antiviral 1
Species: human
Products:     ZC3HAV1

Top Publications

  1. Bick M, Carroll J, Gao G, Goff S, Rice C, Macdonald M. Expression of the zinc-finger antiviral protein inhibits alphavirus replication. J Virol. 2003;77:11555-62 pubmed
    The rat zinc-finger antiviral protein (ZAP) was recently identified as a host protein conferring resistance to retroviral infection...
  2. Jeong M, Kim E, Jang S. Expression and RNA-binding of human zinc-finger antiviral protein. Biochem Biophys Res Commun. 2010;396:696-702 pubmed publisher
    Zinc-finger antiviral protein (ZAP) is a recently isolated host antiviral factor that inhibits the replication of many viruses such as Moloney murine leukemia virus (MLV) and Sindbis virus (SIN) by preventing the accumulation of viral ..
  3. Hayakawa S, Shiratori S, Yamato H, Kameyama T, Kitatsuji C, Kashigi F, et al. ZAPS is a potent stimulator of signaling mediated by the RNA helicase RIG-I during antiviral responses. Nat Immunol. 2011;12:37-44 pubmed publisher
    ..Here we report that the PARP-13 shorter isoform (ZAPS), rather than the full-length protein (ZAP), was selectively induced by 5'-triphosphate-modified RNA (3pRNA) and functioned as a potent stimulator of ..
  4. Ye P, Liu S, Zhu Y, Chen G, Gao G. DEXH-Box protein DHX30 is required for optimal function of the zinc-finger antiviral protein. Protein Cell. 2010;1:956-64 pubmed publisher
    The zinc-finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by eliminating viral mRNAs in the cytoplasm...
  5. Zhu Y, Chen G, Lv F, Wang X, Ji X, Xu Y, et al. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. Proc Natl Acad Sci U S A. 2011;108:15834-9 pubmed publisher
    The zinc-finger antiviral protein (ZAP) was originally identified as a host factor that inhibits the replication of Moloney murine leukemia virus...
  6. Xuan Y, Liu L, Shen S, Deng H, Gao G. Zinc finger antiviral protein inhibits murine gammaherpesvirus 68 M2 expression and regulates viral latency in cultured cells. J Virol. 2012;86:12431-4 pubmed publisher
    Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to specific viral mRNAs and repressing mRNA expression...
  7. Gao G, Guo X, Goff S. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. Science. 2002;297:1703-6 pubmed
    ..The gene encodes a CCCH-type zinc finger protein designated ZAP. Expression of the gene caused a profound and specific loss of viral messenger RNAs (mRNAs) from the cytoplasm ..
  8. Katoh M, Katoh M. Identification and characterization of human TIPARP gene within the CCNL amplicon at human chromosome 3q25.31. Int J Oncol. 2003;23:541-7 pubmed
    ..Human TIPARP showed 27.5% and 26.0% total-amino-acid identity with human FLJ22693 and ZAP, respectively...
  9. Macdonald M, Machlin E, Albin O, Levy D. The zinc finger antiviral protein acts synergistically with an interferon-induced factor for maximal activity against alphaviruses. J Virol. 2007;81:13509-18 pubmed
    ..Overexpression of the zinc finger antiviral protein (ZAP) imparts a cellular antiviral state against Retroviridae, Togaviridae, and Filoviridae virus family members...

More Information

Publications111 found, 100 shown here

  1. Kerns J, Emerman M, Malik H. Positive selection and increased antiviral activity associated with the PARP-containing isoform of human zinc-finger antiviral protein. PLoS Genet. 2008;4:e21 pubmed publisher
    ..Zinc-finger antiviral protein (ZAP) from rats was discovered to be an intrinsic immunity gene that can restrict murine leukemia virus, and certain ..
  2. Wang N, Dong Q, Li J, Jangra R, Fan M, Brasier A, et al. Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent. J Biol Chem. 2010;285:6080-90 pubmed publisher
    The zinc finger antiviral protein (ZAP) is an interferon-stimulated gene that restricts the replication of retroviruses, alphaviruses, and filoviruses...
  3. Cockayne A, Hill P, Powell N, Bishop K, Sims C, Williams P. Molecular cloning of a 32-kilodalton lipoprotein component of a novel iron-regulated Staphylococcus epidermidis ABC transporter. Infect Immun. 1998;66:3767-74 pubmed
    ..The gene encoding the 32-kDa lipoprotein from S. epidermidis has been isolated from a Lambda Zap II genomic DNA library and found to be a component of an iron-regulated operon encoding a novel ABC-type ..
  4. Ruiz Díaz P, Mucci J, Meira M, Bogliotti Y, Musikant D, Leguizamón M, et al. Trypanosoma cruzi trans-sialidase prevents elicitation of Th1 cell response via interleukin 10 and downregulates Th1 effector cells. Infect Immun. 2015;83:2099-108 pubmed publisher
    ..TSs also reduced the T cell receptor signaling as assayed by Zap-70 phosphorylation...
  5. Galvão C, Fragoso S, de Oliveira C, Forner O, Pereira R, Soares C, et al. Identification of new Corynebacterium pseudotuberculosis antigens by immunoscreening of gene expression library. BMC Microbiol. 2017;17:202 pubmed publisher
    ..pairs (bp) were excised from the gel, purified, and the digested DNA fragments were joined to bacteriophage vector ZAP Express, packaged into phage and transfected into Escherichia coli...
  6. Lusková P, Draber P. Modulation of the Fcepsilon receptor I signaling by tyrosine kinase inhibitors: search for therapeutic targets of inflammatory and allergy diseases. Curr Pharm Des. 2004;10:1727-37 pubmed
    ..phosphorylation of FcepsilonRI subunits by Src family kinase Lyn, which is followed by an activation of Syk/Zap family kinase Syk...
  7. Brisslert M, Bian L, Svensson M, Santos R, Jonsson I, Barsukov I, et al. S100A4 regulates the Src-tyrosine kinase dependent differentiation of Th17 cells in rheumatoid arthritis. Biochim Biophys Acta. 2014;1842:2049-59 pubmed publisher
    ..CD5 and low (pTyr705)STAT3 (signal transducer and activator of transcription 3), which led to increased (pTyr352)ZAP-70 (theta-chain associated protein kinase of 70kDa), lymphocyte proliferation and production of IL2...
  8. Zhang Y, Zhou X, Li Y, Xu Y, Lu K, Li P, et al. Inhibition of maternal embryonic leucine zipper kinase with OTSSP167 displays potent anti-leukemic effects in chronic lymphocytic leukemia. Oncogene. 2018;37:5520-5533 pubmed publisher
    ..correlated with higher WBC count, advanced stage, elevated LDH, increased β2-MG level, unmutated IGHV, positive ZAP-70, deletion of 17p13 and inferior prognosis of CLL patients...
  9. Gomes L, Ferrão A, Evangelista F, de Almeida T, Barbosa R, Carvalho M, et al. Advances in chronic lymphocytic leukemia pharmacotherapy. Biomed Pharmacother. 2018;97:349-358 pubmed publisher
    ..CLL may be indolent or aggressive and has a range of prognostic factors such as expression of CD38 and ZAP-70, immunophenotypic and cytogenetic changes, imbalanced apoptosis proteins, and others...
  10. Nakagawa R, Vukovic M, Tarafdar A, Cosimo E, Dunn K, McCaig A, et al. Generation of a poor prognostic chronic lymphocytic leukemia-like disease model: PKCα subversion induces up-regulation of PKCβII expression in B lymphocytes. Haematologica. 2015;100:499-510 pubmed publisher
    ..leukemia, expressing predominantly unmutated immunoglobulin heavy chain genes, with upregulated tyrosine kinase ZAP-70 expression and elevated ERK-MAPK-mTor signaling, resulting in enhanced proliferation and increased tumor load in ..
  11. Zhang Y, Yu S, Li X, Yang B, Wu C. The ligands of translocator protein inhibit human Th1 responses and the rejection of murine skin allografts. Clin Sci (Lond). 2017;131:297-308 pubmed publisher
    ..and activation of CD4+ T-cells by the inhibition of TCR signal transduction including membrane proteins: Zap, Lck, Src; cytoplasm proteins: Plcγ1, Slp-76, ERK, JNK and the nucleoproteins: c-Jun and c-Fos...
  12. Carvalho Alves Silva J, do Amaral Rabello D, Oliveira Bravo M, Lucena Araujo A, Madureira de Oliveira D, Morato de Oliveira F, et al. Aberrant levels of SUV39H1 and SUV39H2 methyltransferase are associated with genomic instability in chronic lymphocytic leukemia. Environ Mol Mutagen. 2017;58:654-661 pubmed publisher
    ..SUV39H (1/2), SUV420H (1/2), and hTERT expression was determined in 59 CLL samples by real time PCR. In addition, ZAP-70 protein expression was evaluated by Flow Cytometry and patients' karyotype was defined by Cytogenetic Analysis...
  13. Chu C, Zhang L, Dhayalan A, Agagnina B, Magli A, Fraher G, et al. Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera. Mol Med. 2011;17:1338-48 pubmed publisher
    ..immunoglobulin heavy chain variable region [IGHV ] mutation, CD38 or zeta-chain associated protein kinase 70 kDa [ZAP-70]) did not correlate with BIS8-17 infection...
  14. Kwon J, Shatynski K, Chen H, Morand S, De Deken X, Miot F, et al. The nonphagocytic NADPH oxidase Duox1 mediates a positive feedback loop during T cell receptor signaling. Sci Signal. 2010;3:ra59 pubmed publisher
    ..signaling, especially phosphorylation of tyrosine-319 of zeta chain-associated protein kinase of 70 kilodaltons (ZAP-70), store-operated entry of calcium ions (Ca(2+)), and activation of extracellular signal-regulated kinase...
  15. Pauker M, Reicher B, Joseph N, Wortzel I, Jakubowicz S, Noy E, et al. WASp family verprolin-homologous protein-2 (WAVE2) and Wiskott-Aldrich syndrome protein (WASp) engage in distinct downstream signaling interactions at the T cell antigen receptor site. J Biol Chem. 2014;289:34503-19 pubmed publisher
    ..We show that, similar to WASp, WAVE2 recruitment to the TCR site depends on protein-tyrosine kinase, ZAP-70, and the adaptors LAT, SLP-76, and Nck...
  16. Min H, Choi J, Lee S, Seo H, Jung K, Na H, et al. Protein inhibitor of activated STAT3 reduces peripheral arthritis and gut inflammation and regulates the Th17/Treg cell imbalance via STAT3 signaling in a mouse model of spondyloarthritis. J Transl Med. 2019;17:18 pubmed publisher
    ..Curdlan was injected into SKG ZAP-70W163C mice for SpA induction. The PIAS3 or Mock vector was inserted into mice for 10 weeks...
  17. Alves Silva J, de Carvalho J, Rabello D, Serejo T, Rego E, Neves F, et al. GLP overexpression is associated with poor prognosis in Chronic Lymphocytic Leukemia and its inhibition induces leukemic cell death. Invest New Drugs. 2018;36:955-960 pubmed publisher
    ..In addition, patient samples were classified according to ZAP-70 protein expression by flow cytometry and according to karyotype integrity by cytogenetics analysis...
  18. Feng G, Wang X. Role of spleen tyrosine kinase in the pathogenesis of chronic lymphocytic leukemia. Leuk Lymphoma. 2014;55:2699-705 pubmed publisher
    ..Studies of the correlation between Syk and ZAP-70 expression in CLL cells have brought a new perspective to determining the value of Syk in evaluating the effect ..
  19. Tauber S, Hauschild S, Paulsen K, Gutewort A, Raig C, Hürlimann E, et al. Signal transduction in primary human T lymphocytes in altered gravity during parabolic flight and clinostat experiments. Cell Physiol Biochem. 2015;35:1034-51 pubmed publisher
    ..Furthermore, we observed decreased CD3 surface expression, reduced ZAP-70 abundance and increased histone H3-acetylation in activated T lymphocytes after 5 minutes of clinorotation and a ..
  20. Huang C, Ho K. Isolation and characterization of the ATP-binding cassette (ABC) transporter system genes from loofah witches' broom phytoplasma. DNA Seq. 2007;18:347-56 pubmed
    A clone containing a 3903 bp EcoRI-restriction fragment was obtained from a lambda(ZAP) genomic library of loofah witches' broom (LfWB) phytoplasma by plaque hybridization using a PCR fragment as a probe...
  21. Mirzaei H, Fathullahzadeh S, Khanmohammadi R, Darijani M, Momeni F, Masoudifar A, et al. State of the art in microRNA as diagnostic and therapeutic biomarkers in chronic lymphocytic leukemia. J Cell Physiol. 2018;233:888-900 pubmed publisher
    ..Among different biomarkers (e.g., CD38, chromosomes abnormalities, ZAP-70, TP53, and microRNA [miRNA]), miRNAs have appeared as new diagnostic and therapeutic biomarkers in patients with ..
  22. Wang X, Ao H, Song M, Bai L, He W, Wang C, et al. Identification of DNA methylation regulated novel host genes relevant to inhibition of virus replication in porcine PK15 cell using double stranded RNA mimics and DNA methyltransferase inhibitor. Genomics. 2018;: pubmed publisher
    ..GO analysis revealed hypo-methylated genes (BNIP3L and CDK9) and a hyper-methylated gene (ZC3HAV1) involved in the host response to viral replication...
  23. Amaya Chanaga C, Rassenti L. Biomarkers in chronic lymphocytic leukemia: Clinical applications and prognostic markers. Best Pract Res Clin Haematol. 2016;29:79-89 pubmed publisher
    ..abnormalities (trisomy 12, 11q deletions and 17p deletions), β2 microglobulin, thymidine kinase, CD38 and ZAP-70 expression, IGHV mutation status, and mutations in genes such as NOTCH1, MYD88, SF3B1, and ATM are also ..
  24. Li Z, Li F, Yi S, Gu Z, Yu Z, Xu Y, et al. Superior efficacy of rituximab-based chemoimmunotherapy as an initial therapy in newly diagnosed patients with B cell indolent lymphomas: long-term results from a single center in China. BMC Cancer. 2015;15:555 pubmed publisher
    ..5 mg/L, lactate dehydrogenase (LDH) < 220 U/L, zeta-chain-associated protein kinase 70 (ZAP-70) negative, and non high-risk genetic abnormality could achieve more benefits from R-based regimens with higher ..
  25. Kumar Singh P, Kashyap A, Silakari O. Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions. Biomed Pharmacother. 2018;108:1565-1571 pubmed publisher
    ..As a 56 KDa protein, Lck phosphorylates tyrosine residues of various proteins such as ZAP-70, ITK and protein kinase C...
  26. Dong H, Miao K, Qiao C, Zhuang Y, Shen W, Hong M, et al. Polymorphisms and haplotypes in multidrug resistance 1 gene are not associated with chronic lymphocytic leukemia susceptibility and prognostic parameters of chronic lymphocytic leukemia in Chinese population. Leuk Lymphoma. 2011;52:1003-9 pubmed publisher
    ..genotypes and Binet stage, unmutated immunoglobulin heavy-chain variable region (IGHV) status, CD38 expression, ZAP-70 expression, and p53 deletion...
  27. Gimenez N, Martínez Trillos A, Montraveta A, Lopez Guerra M, Rosich L, Nadeu F, et al. Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia. Haematologica. 2019;104:576-586 pubmed publisher
    ..Patients with these mutations more frequently had increased lactate dehydrogenase levels, high expression of ZAP-70, CD49d, CD38, trisomy 12 and unmutated immunoglobulin heavy-chain variable region genes and had a worse 5-year ..
  28. Bonura A, Vizzini A, Vlah S, Gervasi F, Longo A, Melis M, et al. Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis, modulates responses of the human immune system. Immunobiology. 2018;223:210-219 pubmed publisher
    ..The biological activities of this molecule include the activation of 70kDa TCR ? chain Associated Protein kinase (ZAP-70) and T Cell Receptor (TCR) V? oligo clonal selection on CD4+ T lymphocytes as well as increased ..
  29. Kharfan Dabaja M, Bazarbachi A. Hematopoietic stem cell allografting for chronic lymphocytic leukemia: a focus on reduced-intensity conditioning regimens. Cancer Control. 2012;19:68-75 pubmed
    ..capable of overcoming the adverse effect of poor prognostic factors in CLL such as del(17p), unmutated IgVH, or ZAP-70 expression...
  30. Nesmiyanov P, Tolkachev B, Strygin A. ZO-1 expression shows prognostic value in chronic B cell leukemia. Immunobiology. 2016;221:6-11 pubmed publisher
    ..Results indicated that ZO-1 and Cx43 expression was reduced and correlated negatively with CD38 and Zap-70 expression...
  31. Doucette C, Rodgers G, Liwski R, Hoskin D. Piperine from black pepper inhibits activation-induced proliferation and effector function of T lymphocytes. J Cell Biochem. 2015;116:2577-88 pubmed publisher
    ..with hypophosphorylation of Akt, extracellular signal-regulated kinase, and inhibitor of κBα, but not ZAP-70...
  32. Baer A, Colon Moran W, Bhattarai N. Characterization of the effects of immunomodulatory drug fingolimod (FTY720) on human T cell receptor signaling pathways. Sci Rep. 2018;8:10910 pubmed publisher
    ..FTY720 did not affect proximal TCR signaling events as measured by phosphorylation of Lck, ZAP-70 and LAT; however, inhibited PMA/Ionomycin induced distal TCR signaling as measured by IL-2, IFN-? release and ..
  33. Góra Tybor J, Szemraj J, Robak T, Jamroziak K. Clinical relevance of vascular endothelial growth factor type A (VEGFA) and VEGF receptor type 2 (VEGFR2) gene polymorphism in chronic lymphocytic leukemia. Blood Cells Mol Dis. 2015;54:139-43 pubmed publisher
    ..significantly associated with important prognostic factors in CLL including clinical stage, IgVH mutational status, ZAP-70 expression and FISH cytogenetic abnormalities...
  34. Sofi M, Heinrichs J, Dany M, Nguyen H, Dai M, Bastian D, et al. Ceramide synthesis regulates T cell activity and GVHD development. JCI Insight. 2017;2: pubmed publisher
    ..the molecular level, CerS6 was required for efficient TCR signal transduction, including tyrosine phosphorylation, ZAP-70 activation, and PKCθ/TCR colocalization...
  35. Fu C, Gong Y, Shi X, Shi H, Wan Y, Wu Q, et al. Expression and regulation of COP1 in chronic lymphocytic leukemia cells for promotion of cell proliferation and tumorigenicity. Oncol Rep. 2016;35:1493-500 pubmed publisher
    ..The observed upregulated expression of COP1 in CLL patients was positively correlated with CLL clinical stage and ZAP-70 expression, but not del(13q14) and del(17q-)...
  36. Cai G, Sun K, Wang T, Zou H, Gu J, Yuan Y, et al. Mechanism and effects of Zearalenone on mouse T lymphocytes activation in vitro. Ecotoxicol Environ Saf. 2018;162:208-217 pubmed publisher
    ..Additionally, ZEA exposure reduces the expression of initiative regulatory protein, i.e. LAT, Lck, Zap-70 during the activation of T cells...
  37. Colado A, Almejún M, Podaza E, Risnik D, Stanganelli C, Elías E, et al. The kinase inhibitors R406 and GS-9973 impair T cell functions and macrophage-mediated anti-tumor activity of rituximab in chronic lymphocytic leukemia patients. Cancer Immunol Immunother. 2017;66:461-473 pubmed publisher
    ..Interestingly, ?-chain-associated protein kinase (ZAP)-70 phosphorylation was diminished by both inhibitors upon TCR stimulation on T cells...
  38. Autore F, Strati P, Laurenti L, Ferrajoli A. Morphological, immunophenotypic, and genetic features of chronic lymphocytic leukemia with trisomy 12: a comprehensive review. Haematologica. 2018;103:931-938 pubmed publisher
    ..Patients with chronic lymphocytic leukemia and trisomy 12 frequently have unmutated IGHV, ZAP-70 positivity, and closely homologous stereotyped B-cell receptors...
  39. Dillard P, Pi F, Lellouch A, Limozin L, Sengupta K. Nano-clustering of ligands on surrogate antigen presenting cells modulates T cell membrane adhesion and organization. Integr Biol (Camb). 2016;8:287-301 pubmed publisher
    ..local membrane adhesion and topography, as well as the distribution of the T cell receptors (TCRs) and the kinase ZAP-70, are influenced by dot-geometry, whereas the cell spreading area is determined by the overall average density of ..
  40. Collins M, Tremblay M, Chapman N, Curtiss M, Rothman P, Houtman J. The T cell receptor-mediated phosphorylation of Pyk2 tyrosines 402 and 580 occurs via a distinct mechanism than other receptor systems. J Leukoc Biol. 2010;87:691-701 pubmed publisher
    ..Interestingly, the TCR-mediated phosphorylation of Pyk2 tyrosines 402 and 580 did not require Ca(2+) influx, ZAP-70 activation, actin cytoskeleton rearrangement, or PI3K function...
  41. Wang Z, Guo Z, Peng H. A mathematical model verifying potent oncolytic efficacy of M1 virus. Math Biosci. 2016;276:19-27 pubmed publisher
    ..identify a naturally occurring alphavirus (M1) as a novel selective killer targeting zinc-finger antiviral protein (ZAP)-deficient cancer cells, we propose a mathematical model to illustrate the growth of normal cells, tumor cells and ..
  42. Roach E, Wroblewski C, Seidel L, Berezuk A, Brewer D, Kimber M, et al. Structure and Mutational Analyses of Escherichia coli ZapD Reveal Charged Residues Involved in FtsZ Filament Bundling. J Bacteriol. 2016;198:1683-1693 pubmed publisher
    ..Z-ring formation relies on a group of FtsZ-associated proteins (Zap) for stability throughout the process of division...
  43. Mukhopadhyay H, de Wet B, Clemens L, Maini P, Allard J, van der Merwe P, et al. Multisite Phosphorylation Modulates the T Cell Receptor ?-Chain Potency but not the Switchlike Response. Biophys J. 2016;110:1896-1906 pubmed publisher
    ..We further find that the tyrosine kinase ZAP-70 increases receptor potency but does not modulate the switchlike response...
  44. Hu J, Luo T, Xi D, Guo K, Hu L, Zhao J, et al. Silencing ZAP70 prevents HSP65-induced reverse cholesterol transport and NF-κB activation in T cells. Biomed Pharmacother. 2018;102:271-277 pubmed publisher
    ..We also found that silencing ZAP enhanced the expression of ATP-binding cassette transporter A1 (ABCA1), ATP-binding cassette transporter G1 (ABCG1),..
  45. Oliveira Santos W, Rabello D, Lucena Araujo A, de Oliveira F, Rego E, Pittella Silva F, et al. Residual expression of SMYD2 and SMYD3 is associated with the acquisition of complex karyotype in chronic lymphocytic leukemia. Tumour Biol. 2016;37:9473-81 pubmed publisher
    ..The obtained results were associated with white blood cells (WBC) and platelet counts, ZAP-70 protein expression, and cytogenetic analysis...
  46. Min H, Kim J, Lee S, Kim E, Lee S, Lee J, et al. Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis. J Transl Med. 2016;14:190 pubmed publisher
    ..This study examined the effect of rebamipide on SpA development. SKG ZAP-70(W163C) mice were immunized with curdlan to induce SpA features...
  47. Kouzegaran S, Siroosbakht S, Farsad B, Rezakhaniha B, Dormanesh B, Behnod V, et al. Elevated IL-17A and IL-22 regulate expression of inducible CD38 and Zap-70 in chronic lymphocytic leukemia. Cytometry B Clin Cytom. 2016;: pubmed publisher
    ..expression of CD38 and higher median serum levels of IL-17A in patients, but patients with negative expression of ZAP-70 showed a significant association with higher median serum levels of IL-17A compared with healthy subjects. (57...
  48. Sela M, Bogin Y, Beach D, Oellerich T, Lehne J, Smith Garvin J, et al. Sequential phosphorylation of SLP-76 at tyrosine 173 is required for activation of T and mast cells. EMBO J. 2011;30:3160-72 pubmed publisher
    ..In intact cells, Y173 phosphorylation depended on three, ZAP-70-targeted tyrosines at the N-terminus of SLP-76 that recruit and activate Itk, a kinase that selectively ..
  49. Helou Y, Petrashen A, Salomon A. Vav1 Regulates T-Cell Activation through a Feedback Mechanism and Crosstalk between the T-Cell Receptor and CD28. J Proteome Res. 2015;14:2963-75 pubmed publisher
    ..of TCR components, including the ζ chain, the CD3 δ, ε, γ chains, and the associated kinases Lck and ZAP-70, is not well established...
  50. Park S, Cheon S, Park T, Shin B, Oh H, Ghosh S, et al. Intranuclear interactomic inhibition of NF-κB suppresses LPS-induced severe sepsis. Biochem Biophys Res Commun. 2015;464:711-7 pubmed publisher
    ..nt-p65-TMD did not inhibit tyrosine phosphorylation of signaling mediators such as ZAP-70, p38, JNK, or ERK involved in T cell activation, but was capable of suppressing the transcriptional activity of ..
  51. Zhao N, Wu J, Xiong S, Zhang L, Lu X, Chen S, et al. Mannan-binding lectin, a serum collectin, suppresses T-cell proliferation via direct interaction with cell surface calreticulin and inhibition of proximal T-cell receptor signaling. FASEB J. 2017;31:2405-2417 pubmed publisher
    ..MBL during T-cell priming interfered with proximal T-cell receptor signaling by decreasing phosphorylation of Lck, ZAP-70, and LAT...
  52. Chen P, Chu A, Zia H, Koduru P, Collins R, Winick N, et al. CD25 Expression in B Lymphoblastic Leukemia/Lymphoma Predicts t(9;22)(q34;q11)/Philadelphia Chromosome Translocation (Ph) and Is Associated With Residual Disease in Ph-Negative Patients. Am J Clin Pathol. 2016;146:632-638 pubmed publisher
    ..Interestingly, one CD25+/Ph- patient had a Ph-like genotype ( ZC3HAV1-ABL2 rearrangement), and another had dual MYC-IGH and BCL2-IGH rearrangements...
  53. Rusak M, Osada J, Pawlus J, Chociej Stypułkowska J, Dabrowska M, Kłoczko J. Utility of laboratory tests in B-CLL patients in different clinical stages. Int J Hematol. 2011;93:736-744 pubmed publisher
    ..Gumprecht's shadows, low apoptotic activity of peripheral blood lymphocytes, and increased percentage of CD38- and ZAP-70 ± cells markedly correlate with the stage of disease progression...
  54. Ortíz C, Natale P, Cueto L, Vicente M. The keepers of the ring: regulators of FtsZ assembly. FEMS Microbiol Rev. 2016;40:57-67 pubmed publisher
    ..ZipA and FtsA serve to anchor the ring, and together with a set of Zap proteins, they stabilize it...
  55. Schumacher M, Huang K, Zeng W, Janakiraman A. Structure of the Z Ring-associated Protein, ZapD, Bound to the C-terminal Domain of the Tubulin-like Protein, FtsZ, Suggests Mechanism of Z Ring Stabilization through FtsZ Cross-linking. J Biol Chem. 2017;292:3740-3750 pubmed publisher
    ..There are no structures of a Zap protein bound to FtsZ; therefore, how these proteins affect FtsZ polymerization has been unclear...
  56. Schumacher M, Zeng W, Huang K, Tchorzewski L, Janakiraman A. Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. J Biol Chem. 2016;291:2485-98 pubmed publisher
    ..Strikingly, these Zap proteins show no discernable sequence similarity, suggesting that they likely harbor distinct structures and ..
  57. Ohno A, Ochi A, Maita N, Ueji T, Bando A, Nakao R, et al. Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin. Arch Biochem Biophys. 2016;594:1-7 pubmed publisher
    ..this complex, the Cblin structure closely resembles the TKB-bound form of another substrate-derived phosphopeptide, Zap-70-derived phosphopeptide...
  58. Ball K, Johnson J, Lewinski M, Guatelli J, Verschueren E, Krogan N, et al. Non-degradative Ubiquitination of Protein Kinases. PLoS Comput Biol. 2016;12:e1004898 pubmed publisher
    ..We chose one human kinase, ZAP-70, to simulate using molecular dynamics with and without a monoubiquitin modification...
  59. Tang Q, Wang X, Gao G. The Short Form of the Zinc Finger Antiviral Protein Inhibits Influenza A Virus Protein Expression and Is Antagonized by the Virus-Encoded NS1. J Virol. 2017;91: pubmed publisher
    Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses. There are two ZAP isoforms arising from alternative splicing, which differ only at the C termini...
  60. Chen S, Liu M, Wang C. Genetic polymorphism of 3' untranslated region of zeta-chain associated protein kinase 70 kDa in southern Taiwanese patients with rheumatoid arthritis. Clin Rheumatol. 2016;35:747-50 pubmed publisher
    ..pathogenesis of rheumatoid arthritis (RA), and the signaling molecule zeta-chain-associated protein kinase 70 kDa (ZAP-70) plays a crucial role in this process...
  61. Cleret Buhot A, Zhang Y, Planas D, Goulet J, Monteiro P, Gosselin A, et al. Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach. Retrovirology. 2015;12:102 pubmed publisher
    ..significantly enriched in Th17 versus Th1 were previously associated with the regulation of TCR signaling (ZAP-70, Lck, and CD96) and Th17 polarization (RORγt, ARNTL, PTPN13, and RUNX1)...
  62. Kinosada H, Yasunaga J, Shimura K, Miyazato P, Onishi C, Iyoda T, et al. HTLV-1 bZIP Factor Enhances T-Cell Proliferation by Impeding the Suppressive Signaling of Co-inhibitory Receptors. PLoS Pathog. 2017;13:e1006120 pubmed publisher
    ..PD-1 in T cells, thereby leading to impaired inhibition of T-cell proliferation and suppressed dephosphorylation of ZAP-70 and CD3ζ. HBZ does this by interacting with THEMIS, which associates with Grb2 and SHP-2...
  63. Fu C, Wan Y, Shi H, Gong Y, Wu Q, Yao Y, et al. Expression and regulation of CacyBP/SIP in chronic lymphocytic leukemia cell balances of cell proliferation with apoptosis. J Cancer Res Clin Oncol. 2016;142:741-8 pubmed publisher
    ..CacyBP/SIP expression and clinical stage, chromosome abnormalities and zeta-chain-associated protein kinase 70 (ZAP-70) expression...
  64. Choudhury N, Heikel G, Trubitsyna M, Kubik P, Nowak J, Webb S, et al. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. BMC Biol. 2017;15:105 pubmed publisher
    ..We demonstrate that TRIM25 controls the levels of Zinc Finger Antiviral Protein (ZAP)...
  65. Hu C, Liu Y, Lin Y, Liang J, Zhong W, Li K, et al. Intravenous injections of the oncolytic virus M1 as a novel therapy for muscle-invasive bladder cancer. Cell Death Dis. 2018;9:274 pubmed publisher
    ..Knocking down ZC3HAV1 (ZAP), an antiviral factor in ISGs, restores M1 virus reactivity in resistant cells, and overexpressing ZAP ..
  66. Seo D, Choi C. Inhibitory mechanism of five natural flavonoids against murine norovirus. Phytomedicine. 2017;30:59-66 pubmed publisher
    ..the expression of interferon (IFN)-?, IFN-?, tumor necrosis factor-? (TNF-?), Mx, and zinc finger CCCH type antiviral protein 1 (ZAP), 2'-5' oligo (A) synthetase (OAS), and inducible nitric oxide synthase (iNOS) in RAW 264...
  67. Liang W, Mao S, Sun S, Li M, Li Z, Yu R, et al. Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation. Front Immunol. 2018;9:78 pubmed publisher
    ..Moreover, the phosphorylation of ZAP-70 was significantly reduced in Fut8+/+OT-II CD4+ T cells by the treatment of fucosidase...
  68. Vangapandu H, Havranek O, Ayres M, Kaipparettu B, Balakrishnan K, Wierda W, et al. B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia. Mol Cancer Res. 2017;15:1692-1703 pubmed publisher
    ..Higher OCR was associated with poor prognostic factors such as ZAP 70 positivity, unmutated IGHV, high ?2M levels, and higher Rai stage...
  69. Blevins L, Parsonage D, Oliver M, Domzalski E, Swords W, Alexander Miller M. A Novel Function for the Streptococcus pneumoniae Aminopeptidase N: Inhibition of T Cell Effector Function through Regulation of TCR Signaling. Front Immunol. 2017;8:1610 pubmed publisher
    ..Inhibitory activity was associated with reduced activation of ZAP-70, ERK1/2, c-Jun N-terminal kinase, and p38, demonstrating the ability of PepN to negatively regulate TCR ..
  70. Au Yeung B, Shah N, Shen L, Weiss A. ZAP-70 in Signaling, Biology, and Disease. Annu Rev Immunol. 2018;36:127-156 pubmed publisher
    ..One such molecule is the cytoplasmic tyrosine kinase ZAP-70, which associates with the TCR complex and is required for initiating the canonical biochemical signal pathways ..
  71. Miyazawa R, Matsuura Y, Shibasaki Y, Imamura S, Nakanishi T. Cross-reactivity of monoclonal antibodies against CD4-1 and CD8? of ginbuna crucian carp with lymphocytes of zebrafish and other cyprinid species. Dev Comp Immunol. 2018;80:15-23 pubmed publisher
    ..First, mAbs 6D1 and 2C3 recognized 7-11% of zebrafish lymphocytes that were ZAP-70 positive and had the typical morphology of lymphocytes...
  72. Marczynke M, Gröger K, Seitz O. Selective Binders of the Tandem Src Homology 2 Domains in Syk and Zap70 Protein Kinases by DNA-Programmed Spatial Screening. Bioconjug Chem. 2017;28:2384-2392 pubmed publisher
    ..For example, the spleen tyrosine kinase (Syk) and the ?-chain-associated protein kinase (ZAP-70) recognize the consensus sequence pYXXI/L(X)6-8 pYXXI/L with near-identical nanomolar affinity...
  73. Fregoso O. Mind Your Cs and Gs. Cell Host Microbe. 2017;22:575-576 pubmed publisher
    ..2017) determined that the antiviral protein ZAP recognizes CG dinucleotide composition to differentiate self from non-self...
  74. Todorova T, Bock F, Chang P. Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer. Trends Mol Med. 2015;21:373-84 pubmed publisher
    ..Poly(ADP-ribose) polymerase-13 (PARP13), also known as ZC3HAV1 and zinc-finger antiviral protein (ZAP), is an RNA-binding protein that regulates the stability and translation ..
  75. Shah N, Wang Q, Yan Q, Karandur D, Kadlecek T, Fallahee I, et al. An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. elife. 2016;5: pubmed publisher
    ..sorting, and deep sequencing, we have defined the specificities of the first two kinases in this pathway, Lck and ZAP-70, for the T cell receptor ? chain and the scaffold proteins LAT and SLP-76...
  76. Takata M, Gonçalves Carneiro D, Zang T, Soll S, York A, Blanco Melo D, et al. CG dinucleotide suppression enables antiviral defence targeting non-self RNA. Nature. 2017;550:124-127 pubmed publisher
    ..A focused screen using small inhibitory RNAs revealed that zinc-finger antiviral protein (ZAP) inhibited virion production by cells infected with CG-enriched HIV-1...
  77. Huang W, Ditlev J, Chiang H, Rosen M, Groves J. Allosteric Modulation of Grb2 Recruitment to the Intrinsically Disordered Scaffold Protein, LAT, by Remote Site Phosphorylation. J Am Chem Soc. 2017;: pubmed publisher
    ..Using Grb2 as a phosphorylation reporter, we further monitored LAT phosphorylation by TCR ? chain-recruited ZAP-70, which suggests a weakly processive catalysis on membranes...
  78. Charron G, Li M, Macdonald M, Hang H. Prenylome profiling reveals S-farnesylation is crucial for membrane targeting and antiviral activity of ZAP long-isoform. Proc Natl Acad Sci U S A. 2013;110:11085-90 pubmed publisher
    ..Notably, S-farnesylation was crucial for targeting the long-isoform of ZAP (ZAPL/PARP-13.1/zc3hav1) to endolysosomes and enhancing the antiviral activity of this immune effector...
  79. Todorova T, Bock F, Chang P. PARP13 regulates cellular mRNA post-transcriptionally and functions as a pro-apoptotic factor by destabilizing TRAILR4 transcript. Nat Commun. 2014;5:5362 pubmed publisher
    Poly(ADP-ribose) polymerase-13 (PARP13/ZAP/ZC3HAV1) is an antiviral factor, active against specific RNA viruses such as murine leukaemia virus, Sindbis virus and human immunodeficiency virus...
  80. Zhou W, Yin Y, Weinheimer A, Kaur N, Carpino N, French J. Structural and Functional Characterization of the Histidine Phosphatase Domains of Human Sts-1 and Sts-2. Biochemistry. 2017;56:4637-4645 pubmed publisher
    ..05 ± 0.15 ?M). Finally, we demonstrated that human Sts-1 has robust phosphatase activity against the substrate, Zap-70, in a cell-based assay...
  81. Kim E, Lee Y, Park H. Comparison of efficacy of continuous epidural block and pulsed radiofrequency to the dorsal root ganglion for management of pain persisting beyond the acute phase of herpes zoster. PLoS ONE. 2017;12:e0183559 pubmed publisher
    ..There is little evidence regarding the effectiveness of intervention methods in the treatment of zoster-related pain (ZAP) after the acute phase of zoster...
  82. Gläsker S, Töller M, Kümmerer B. The alternate triad motif of the poly(ADP-ribose) polymerase-like domain of the human zinc finger antiviral protein is essential for its antiviral activity. J Gen Virol. 2014;95:816-22 pubmed publisher
    ..Contrary to previous assumptions, these results indicate an essential function of the PARP-like domain in hZAP-L's antiviral activity. ..
  83. Ngoenkam J, Schamel W, Pongcharoen S. Selected signalling proteins recruited to the T-cell receptor-CD3 complex. Immunology. 2018;153:42-50 pubmed publisher
    ..Here, we review knowledge about five of those interaction partners: Lck, ZAP-70, Nck, WASP and Numb...
  84. Su C, Zhang J, Zheng C. Herpes simplex virus 1 UL41 protein abrogates the antiviral activity of hZAP by degrading its mRNA. Virol J. 2015;12:203 pubmed publisher
    The zinc finger antiviral protein (ZAP) is a host restriction factor that inhibits the replication of various viruses by degradation of certain viral mRNA...
  85. Li M, Lau Z, Cheung P, Aguilar E, Schneider W, Bozzacco L, et al. TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). PLoS Pathog. 2017;13:e1006145 pubmed publisher
    The host factor and interferon (IFN)-stimulated gene (ISG) product, zinc-finger antiviral protein (ZAP), inhibits a number of diverse viruses by usurping and intersecting with multiple cellular pathways...
  86. Benon A, Ya C, Martin L, Watrin C, Chounlamountri N, Jaaoini I, et al. The Syk kinases orchestrate cerebellar granule cell tangential migration. Neuroscience. 2017;360:230-239 pubmed publisher
    ..treated with a Syk pharmacological inhibitor together with the quantification of ectopic GC in Syk+/-; ZAP-70-/- mutant mice brought evidence of a requirement of Syk in GC tangential migration...
  87. Gladkikh A, Potashnikova D, Tatarskiy V, Yastrebova M, Khamidullina A, Barteneva N, et al. Comparison of the mRNA expression profile of B-cell receptor components in normal CD5-high B-lymphocytes and chronic lymphocytic leukemia: a key role of ZAP70. Cancer Med. 2017;6:2984-2997 pubmed publisher
    ..05). We also show that ZAP70 is the only gene that is differentially expressed in CD5-high and CD5-low normal B-lymphocytes, confirming the key role of Zap-70 tyrosine kinase in BCR signaling alterations in B-CLL.
  88. Xie L, Lu B, Zheng Z, Miao Y, Liu Y, Zhang Y, et al. The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP). J Gen Virol. 2018;99:73-85 pubmed publisher
    ..The host zinc-finger antiviral protein (ZAP), an IFN-stimulated gene product, has been reported to specifically inhibit the replication of certain viruses...
  89. Mao R, Nie H, Cai D, Zhang J, Liu H, Yan R, et al. Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein. PLoS Pathog. 2013;9:e1003494 pubmed publisher
    The zinc finger antiviral protein (ZAP) is a mammalian host restriction factor that inhibits the replication of a variety of RNA viruses, including retroviruses, alphaviruses and filoviruses, through interaction with the ZAP-responsive ..
  90. Erazo A, Goff S. Nuclear matrix protein Matrin 3 is a regulator of ZAP-mediated retroviral restriction. Retrovirology. 2015;12:57 pubmed publisher
    ..b>ZAP is a potent host restriction factor of multiple viruses including retroviruses HIV-1 and MoMuLV...
  91. Gomes L, Evangelista F, Sousa L, Araújo S, Carvalho M, Sabino A. Prognosis biomarkers evaluation in chronic lymphocytic leukemia. Hematol Oncol Stem Cell Ther. 2017;10:57-62 pubmed publisher
    ..evaluate the potential prognostic value of the apoptotic/survival-controlling proteins and protein tyrosine kinase ZAP-70 gene expression in CLL patients and control individuals, correlating such findings with patients' clinical data...
  92. Zheng X, Wang X, Tu F, Wang Q, Fan Z, Gao G. TRIM25 Is Required for the Antiviral Activity of Zinc Finger Antiviral Protein. J Virol. 2017;91: pubmed publisher
    Zinc finger antiviral protein (ZAP) is a host factor that specifically inhibits the replication of certain viruses by binding to viral mRNAs and repressing the translation and/or promoting the degradation of target mRNA...