ZBTB46

Summary

Gene Symbol: ZBTB46
Description: zinc finger and BTB domain containing 46
Alias: BTBD4, BZEL, RINZF, ZNF340, dJ583P15.7, dJ583P15.8, zinc finger and BTB domain-containing protein 46, BTB (POZ) domain containing 4, BTB-ZF protein expressed in effector lymphocytes, BTB/POZ domain-containing protein 4, zinc finger protein 340
Species: human
Products:     ZBTB46

Top Publications

  1. Liu Y, Niu S, Chen W, Zhang Q, Tao Y, Chen W, et al. Leukemia inhibitory factor promotes castration-resistant prostate cancer and neuroendocrine differentiation by activated ZBTB46. Clin Cancer Res. 2019;: pubmed publisher
    ..that leukemia inhibitory factor (LIF) was induced by androgen deprivation therapy (ADT) and was upregulated by ZBTB46 in prostate cancer to promote CRPC and NE differentiation...
  2. Cai Y, Yang C, Yu X, Qian J, Dai M, Wang Y, et al. Deficiency of β-Arrestin 2 in Dendritic Cells Contributes to Autoimmune Diseases. J Immunol. 2019;202:407-420 pubmed publisher
    ..We further found that β-arrestin 2 directly interacted with Zbtb46, a DC-specific transcription factor...
  3. Chen W, Zeng T, Wen Y, Yeh H, Jiang K, Chen W, et al. Androgen deprivation-induced ZBTB46-PTGS1 signaling promotes neuroendocrine differentiation of prostate cancer. Cancer Lett. 2018;440-441:35-46 pubmed publisher
    ..Herein, we show that an immunocyte expression protein, ZBTB46, induces inflammatory response gene expression and contributes to NE differentiation of prostate cancer cells...
  4. Sparber F, Dolowschiak T, Mertens S, Lauener L, Clausen B, Joller N, et al. Langerin+ DCs regulate innate IL-17 production in the oral mucosa during Candida albicans-mediated infection. PLoS Pathog. 2018;14:e1007069 pubmed publisher
    ..and found a heterogeneous and dynamic mononuclear phagocyte (MNP) network in the infected tongue that consists of Zbtb46-Langerin- macrophages, Zbtb46+Langerin+ dendritic cells (DCs) and Ly6C+ inflammatory monocytes...
  5. Satpathy A, Brown R, Gomulia E, Briseño C, Mumbach M, Pan Z, et al. Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. Mod Pathol. 2018;31:1479-1486 pubmed publisher
    ..b>ZBTB46 is a zinc finger and BTB domain-containing transcription factor, which is expressed by dendritic cells and ..
  6. Broz M, Binnewies M, Boldajipour B, Nelson A, Pollack J, Erle D, et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell. 2014;26:638-52 pubmed publisher
    ..These are uniquely dependent on IRF8, Zbtb46, and Batf3 transcription factors and are generated by GM-CSF and FLT3L cytokines...
  7. Chistiakov D, Sobenin I, Orekhov A, Bobryshev Y. Myeloid dendritic cells: Development, functions, and role in atherosclerotic inflammation. Immunobiology. 2015;220:833-44 pubmed publisher
    ..and commitment of mDCs is regulated by several transcription and hematopoietic growth factors of which CCr7, Zbtb46, and Flt3 represent 'core' genes responsible for development and functional and phenotypic maintenance of mDCs...
  8. Xu N, Wang F, Lv M, Cheng L. Microarray expression profile analysis of long non-coding RNAs in human breast cancer: a study of Chinese women. Biomed Pharmacother. 2015;69:221-7 pubmed publisher
    ..RP4-583P15.10, an up-regulated lncRNA, was found to be located downstream of the natural antisense of the ZBTB46 gene, which may regulated breast cancer through influence immune system...
  9. Diao J, Gu H, Tang M, Zhao J, Cattral M. Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses. J Immunol. 2018;201:1306-1314 pubmed publisher
    ..To address this issue, we used the Zbtb46-DTR-transgenic mouse model to selectively deplete DC1 and DC2 from tumors and lymphoid tissues...

More Information

Publications29

  1. Wang Y, Sun H, Kumar S, Puerta M, Jo H, Rezvan A. ZBTB46 is a shear-sensitive transcription factor inhibiting endothelial cell proliferation via gene expression regulation of cell cycle proteins. Lab Invest. 2019;99:305-318 pubmed publisher
    b>ZBTB46 is a transcription factor identified in classical dendritic cells and keeps dendritic cells in a quiescent state...
  2. Viehmann S, Böhner A, Kurts C, Brähler S. The multifaceted role of the renal mononuclear phagocyte system. Cell Immunol. 2018;330:97-104 pubmed publisher
    ..Recent studies have used newly identified transcription factors such as ZBTB46 and lineage tracing techniques for classifying mononuclear phagocytes...
  3. Tesone A, Rutkowski M, Brencicova E, Svoronos N, Perales Puchalt A, Stephen T, et al. Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. Cell Rep. 2016;14:1774-1786 pubmed publisher
    ..However, tumor-driven, unremitting expression of Satb1 in activated Zbtb46(+) inflammatory DCs that infiltrate ovarian tumors results in an immunosuppressive phenotype characterized by ..
  4. Briseño C, Haldar M, Kretzer N, Wu X, Theisen D, Kc W, et al. Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells. Cell Rep. 2016;15:2462-74 pubmed publisher
    ..We found that Ly-6C(hi)TREML4(-) monocytes can differentiate into Zbtb46(+) Mo-DCs in response to granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4) but ..
  5. Rombouts M, Cools N, Grootaert M, de Bakker F, Van Brussel I, Wouters A, et al. Long-Term Depletion of Conventional Dendritic Cells Cannot Be Maintained in an Atherosclerotic Zbtb46-DTR Mouse Model. PLoS ONE. 2017;12:e0169608 pubmed publisher
    ..Recently, a unique transcription factor was described for cDC, namely Zbtb46, enabling us to selectively target this cell type in mice...
  6. Klementowicz J, Mahne A, Spence A, Nguyen V, Satpathy A, Murphy K, et al. Cutting Edge: Origins, Recruitment, and Regulation of CD11c+ Cells in Inflamed Islets of Autoimmune Diabetes Mice. J Immunol. 2017;199:27-32 pubmed publisher
    ..However, the majority of these cells were not from the Zbtb46-dependent dendritic-cell lineage...
  7. Sun T, Rojas O, Li C, Ward L, Philpott D, Gommerman J. Intestinal Batf3-dependent dendritic cells are required for optimal antiviral T-cell responses in adult and neonatal mice. Mucosal Immunol. 2017;10:775-788 pubmed publisher
    ..Here we report that conventional Zbtb46-dependent DCs were critically required for antiviral CD8+ T-cell responses against rotavirus (RV), the ..
  8. Loschko J, Rieke G, Schreiber H, Meredith M, Yao K, Guermonprez P, et al. Inducible targeting of cDCs and their subsets in vivo. J Immunol Methods. 2016;434:32-8 pubmed publisher
    ..of a loxP flanked Stop signal enables expression of the human diphtheria toxin receptor (DTR) under the control of Zbtb46 (zDC(lSlDTR)). cDCs can be specifically depleted by combining zDC(lSlDTR) mice with a Csf1r(Cre) driver line...
  9. Grajales Reyes G, Iwata A, Albring J, Wu X, Tussiwand R, Kc W, et al. Batf3 maintains autoactivation of Irf8 for commitment of a CD8α(+) conventional DC clonogenic progenitor. Nat Immunol. 2015;16:708-17 pubmed publisher
    ..Here we identified two progenitor cells positive for the transcription factor Zbtb46 that separately generated CD8α(+) cDCs and CD4(+) cDCs and arose directly from the common DC progenitor (CDP)...
  10. Wu X, Briseño C, Durai V, Albring J, Haldar M, Bagadia P, et al. Mafb lineage tracing to distinguish macrophages from other immune lineages reveals dual identity of Langerhans cells. J Exp Med. 2016;213:2553-2565 pubmed
    ..In this study, we generated a Mafb-driven Cre strain to determine whether any dendritic cells (DCs) identified by Zbtb46-GFP expression originate from a Mafb-expressing population...
  11. Kutsenko A, Gizatullin R, Al Amin A, Wang F, Kvasha S, Podowski R, et al. NotI flanking sequences: a tool for gene discovery and verification of the human genome. Nucleic Acids Res. 2002;30:3163-70 pubmed
  12. Pandey V, Amin P, Shankar B. COX-2 inhibitor prevents tumor induced down regulation of classical DC lineage specific transcription factor Zbtb46 resulting in immunocompetent DC and decreased tumor burden. Immunol Lett. 2017;184:23-33 pubmed publisher
    ..tumor derived prostanoids down regulated classical dendritic cells DC (cDC) lineage specific transcription factor Zbtb46 in the progenitor cells which affects its differentiation...
  13. Chen W, Tsai Y, Siu M, Yeh H, Chen C, Yin J, et al. Inhibition of the androgen receptor induces a novel tumor promoter, ZBTB46, for prostate cancer metastasis. Oncogene. 2017;36:6213-6224 pubmed publisher
    ..Herein, we report a novel tumor promoter, ZBTB46, which is negatively regulated by AR signaling via microRNA (miR)-1-mediated downregulation...
  14. Smebye M, Agostini A, Johannessen B, Thorsen J, Davidson B, Tropé C, et al. Involvement of DPP9 in gene fusions in serous ovarian carcinoma. BMC Cancer. 2017;17:642 pubmed publisher
    ..Several fusion candidates were identified, among them TMEM123-MMP27, ZBTB46-WFDC13, and PLXNB1-PRKAR2A, all of which led to stronger expression of the 3' genes...
  15. Brähler S, Zinselmeyer B, Raju S, Nitschké M, Suleiman H, Saunders B, et al. Opposing Roles of Dendritic Cell Subsets in Experimental GN. J Am Soc Nephrol. 2018;29:138-154 pubmed publisher
    ..of DCs in renal inflammation using a CD11c reporter mouse line and two mouse lines with DC-specific reporters, Zbtb46-GFP and Snx22-GFP...
  16. Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, et al. The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells. Immunity. 2016;45:1205-1218 pubmed publisher
    ..GM-CSF-dependent moDCs but was distal from the DC lineage, as shown by fate-mapping experiments using Zbtb46. By contrast, Flt3-CD11c-MHCII-PU...
  17. Wang J, Wang T, Benedicenti O, Collins C, Wang K, Secombes C, et al. Characterisation of ZBTB46 and DC-SCRIPT/ZNF366 in rainbow trout, transcription factors potentially involved in dendritic cell maturation and activation in fish. Dev Comp Immunol. 2018;80:2-14 pubmed publisher
    b>ZBTB46 and DC-SCRIPT/ZNF366 are two zinc finger transcription factors that play important roles in regulating differentiation of dendritic cells in mammals...
  18. Lill C, Schjeide B, Graetz C, Ban M, Alcina A, Ortiz M, et al. MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis. Brain. 2013;136:1778-82 pubmed publisher
    ..nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), rs180515 (RPS6KB1), and rs6062314 (ZBTB46) for association with multiple sclerosis risk in a total of 8499 cases with multiple sclerosis, 8765 unrelated ..
  19. Shin E, Shin H, Nam E, Kim W, Kim J, Oh B, et al. DeSUMOylating isopeptidase: a second class of SUMO protease. EMBO Rep. 2012;13:339-46 pubmed publisher
    ..We describe BZEL—a new transcriptional repressor—as substrate of DeSI-1...
  20. Anderson D, Grajales Reyes G, Satpathy A, Vasquez Hueichucura C, Murphy T, Murphy K. Revisiting the specificity of the MHC class?II transactivator CIITA in classical murine dendritic cells in vivo. Eur J Immunol. 2017;47:1317-1323 pubmed publisher
    ..However, recent identification of the cDC-specific transcription factor Zbtb46 allows the identification of cDCs independently of MHCII expression...