ZBTB17

Summary

Gene Symbol: ZBTB17
Description: zinc finger and BTB domain containing 17
Alias: MIZ-1, ZNF151, ZNF60, pHZ-67, zinc finger and BTB domain-containing protein 17, Myc-interacting Zn finger protein-1, zinc finger protein 151 (pHZ-67), zinc finger protein 60
Species: human

Top Publications

  1. ncbi Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase
    D Sui
    Department of Biochemistry, Michigan State University, East Lansing 48824, USA
    Arch Biochem Biophys 382:262-74. 2000
  2. ncbi c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter
    Holly Bowen
    Biochemistry and Molecular Biology, University of Southampton, Bassett Crescent East, United Kingdom
    J Biol Chem 277:34997-5006. 2002
  3. ncbi Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    Joan Seoane
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nature 419:729-34. 2002
  4. pmc Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region
    Lan Liu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 398:257-67. 2006
  5. pmc A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A
    Q Liu
    Department of Biological Sciences, University of Toledo, Toledo, OH, USA
    Oncogene 29:2843-52. 2010
  6. ncbi A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells
    Toshiharu Sakurai
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:15505-14. 2004
  7. doi A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF
    Nunzio Iraci
    University of Bologna, Department of Biology, Bologna, Italy
    Cancer Res 71:404-12. 2011
  8. pmc Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1
    Suchitra Basu
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    Proc Natl Acad Sci U S A 106:1433-8. 2009
  9. doi ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation
    L Miao
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
    Oncogene 29:711-22. 2010
  10. pmc Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression
    Junling Si
    Department of Veterinary Biosciences, Ohio State University College of Veterinary Medicine, Columbus, Ohio 43210, USA
    Mol Cancer 9:92. 2010

Research Grants

  1. Daitoku Sakamuro; Fiscal Year: 2015
  2. ROBERT NEIL EISENMAN; Fiscal Year: 2016
  3. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
  4. Growth regulatory targets of the Tuberous Sclerosis Complex
    ROBERT NEIL EISENMAN; Fiscal Year: 2010

Scientific Experts

  • E Villard
  • Reidun Aesoy
  • Xiaoping Li
  • Werner Zwerschke
  • Sandy Courapied
  • Sergio Nasi
  • Tarik Moroy
  • Yutaka Miyazawa
  • J D F Licchesi
  • Jing Liu
  • Paul S Knoepfler
  • Kathryn P Burdon
  • Matthias Frisch
  • Andrei Gartel
  • ROBERT NEIL EISENMAN
  • Branko Braam
  • Martin Eilers
  • Steffi Herold
  • Ingrid Saba
  • Daitoku Sakamuro
  • Susanne Walz
  • Michael Wanzel
  • Christian Kosan
  • Barbara Herkert
  • Michal Alter-Koltunoff
  • Elmar Wolf
  • Katrin E Wiese
  • Jian Zhang
  • Jagruti H Patel
  • Holly Bowen
  • Xao X Tang
  • David Bernard
  • Naohiko Ikegaki
  • Yingjie Zhang
  • Masumichi Saito
  • Baohan T Vo
  • C K Lee
  • Yongsheng Huang
  • Pedro Humberto Castro
  • Bonnie L Barrilleaux
  • Quentin Bazot
  • Stephanie S Wang
  • Bu Nam Jeon
  • Björn von Eyss
  • Owen Sansom
  • Javier Leon
  • Ben Zion Levi
  • Iris Uribesalgo
  • Takashi Ishida
  • Dieter Morandell
  • K M Lee
  • Natalia Varlakhanova
  • Richard Marcotte
  • Mauro Savino
  • Jesmin Akter
  • Nunzio Iraci
  • Lothar Vassen
  • Paul L Regan
  • Peter J Stogios
  • Q Liu
  • L Miao
  • Junling Si
  • Peng Guo
  • C Howard Barton
  • Suchitra Basu
  • Luciano Di Croce
  • Laura Kerosuo
  • Jose P Vaque
  • Ludger Klein-Hitpass
  • Axel Weber
  • John D Gordan
  • Wei Zhang
  • Fuyang Li
  • Xinping Liu
  • Libo Yao
  • Katia Basso
  • Adeline F Deyrieux
  • Jing Zhang
  • Yvonne Wollmann
  • Mark A Stead
  • Riccardo Dalla-Favera
  • Steven B McMahon
  • Andreas Hock
  • Nuria Camarero
  • Kang Liu
  • Oliver Walisko
  • Lan Liu
  • K Peukert
  • Aviva Azriel
  • Keiko Ozato

Detail Information

Publications99

  1. ncbi Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase
    D Sui
    Department of Biochemistry, Michigan State University, East Lansing 48824, USA
    Arch Biochem Biophys 382:262-74. 2000
    ..Cotransfection with leptin or Miz-1 resulted in distinctly different localization of the HKIII-GFP fusion protein, at intracellular sites coincident with localization of leptin-GFP or Miz-1-GFP reporter constructs...
  2. ncbi c-Myc represses and Miz-1 activates the murine natural resistance-associated protein 1 promoter
    Holly Bowen
    Biochemistry and Molecular Biology, University of Southampton, Bassett Crescent East, United Kingdom
    J Biol Chem 277:34997-5006. 2002
    ..The results provide further support for a divalent cation antiporter function for Nramp1...
  3. ncbi Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    Joan Seoane
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Nature 419:729-34. 2002
    ..By inhibiting p21(Cip1) expression Myc favours the initiation of apoptosis, thereby influencing the outcome of a p53 response in favour of cell death...
  4. pmc Polyamine-modulated c-Myc expression in normal intestinal epithelial cells regulates p21Cip1 transcription through a proximal promoter region
    Lan Liu
    Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Biochem J 398:257-67. 2006
    ..These findings confirm that p21Cip1 is one of the direct mediators of induced c-Myc following increased polyamines and that p21Cip1 repression by c-Myc is implicated in stimulation of normal IEC proliferation...
  5. pmc A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A
    Q Liu
    Department of Biological Sciences, University of Toledo, Toledo, OH, USA
    Oncogene 29:2843-52. 2010
    ..Our data reveal an important mechanism by which Gfi-1 regulates cell proliferation and may also have implications for understanding the role of Gfi-1 in lymphomagenesis...
  6. ncbi A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells
    Toshiharu Sakurai
    Department of Clinical Molecular Biology, Faculty of Medicine, Kyoto University, 54 Shogoin Kawaharacho, Sakyo ku, Kyoto 606 8507, Japan
    J Biol Chem 279:15505-14. 2004
    ..Furthermore, the finding that a C-terminal fragment with pro-apoptotic activity is generated from full-length MAGE-A4 after genotoxic stress in human cells suggests a novel function for MAGE-A4...
  7. doi A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF
    Nunzio Iraci
    University of Bologna, Department of Biology, Bologna, Italy
    Cancer Res 71:404-12. 2011
    ..By directly connecting MYCN to the repression of TRKA and p75NTR, our findings establish a key pathway of clinical pathogenicity and aggressiveness in neuroblastoma...
  8. pmc Gfi-1 represses CDKN2B encoding p15INK4B through interaction with Miz-1
    Suchitra Basu
    Department of Biological Sciences, University of Toledo, Toledo, OH 43606, USA
    Proc Natl Acad Sci U S A 106:1433-8. 2009
    ..Our data reveal a mechanism of transcriptional repression by Gfi-1 and may have important implications for understanding the roles of Gfi-1 in normal development and tumorigenesis...
  9. doi ARF antagonizes the ability of Miz-1 to inhibit p53-mediated transactivation
    L Miao
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, People s Republic of China
    Oncogene 29:711-22. 2010
    ....
  10. pmc Myc interacts with Max and Miz1 to repress C/EBPdelta promoter activity and gene expression
    Junling Si
    Department of Veterinary Biosciences, Ohio State University College of Veterinary Medicine, Columbus, Ohio 43210, USA
    Mol Cancer 9:92. 2010
    ..A number of tumor suppressor genes are targets of Myc transcriptional repression including C/EBPalpha, p15INK4, p21CIP1, p27KIP1 and p57KIP2. This study investigated the mechanisms underlying Myc repression of C/EBPdelta expression...
  11. ncbi De novo identification of MIZ-1 (ZBTB17) encoding a MYC-interacting zinc-finger protein as a new favorable neuroblastoma gene
    Naohiko Ikegaki
    Department of Anatomy and Cell Biology, College of Medicine, The University of Illinois at Chicago, Chicago, Illinois, USA
    Clin Cancer Res 13:6001-9. 2007
    ..This study was undertaken to design an experimental strategy to identify additional favorable neuroblastoma genes...
  12. ncbi BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
    Ryan T Phan
    Institute for Cancer Genetics, Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nat Immunol 6:1054-60. 2005
    ..Through this mechanism, BCL6 may facilitate the proliferative expansion of germinal centers during the normal immune response and, when deregulated, the pathological expansion of B cell lymphomas...
  13. ncbi Induction of G1 cell cycle arrest and P15INK4b expression by ECRG1 through interaction with Miz-1
    Nianxi Zhao
    Department of Etiology and Carcinogenesis, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, P R China
    J Cell Biochem 92:65-76. 2004
    ..The physical interaction of ECRG1 and Miz-1 may play an important role in carcinogenesis of EC...
  14. pmc HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity
    John D Gordan
    Abramson Family Cancer Research Institute, School of Medicine, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Cell 11:335-47. 2007
    ..Enhanced c-Myc activity likely contributes to HIF-2alpha-mediated neoplastic progression following loss of the VHL tumor suppressor and influences the behavior of hypoxic tumor cells...
  15. ncbi A beta-sheet interaction interface directs the tetramerisation of the Miz-1 POZ domain
    Mark A Stead
    Molecular Cell Biology Research Group, Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Garstang Astbury Buildings, Leeds LS2 9JT, UK
    J Mol Biol 373:820-6. 2007
    ....
  16. ncbi A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth
    Michael Wanzel
    Institute for Molecular Biology and Tumor Research IMT, Emil Mannkopff Str 2, 35033 Marburg, Germany
    Nat Cell Biol 10:1051-61. 2008
    ..As L23 is encoded by a direct target gene of Myc, this regulatory circuit may provide a feedback mechanism that links translation of Myc target genes and cell growth to Miz1-dependent cell-cycle arrest...
  17. pmc Myc represses transcription through recruitment of DNA methyltransferase corepressor
    Carmen Brenner
    Free University of Brussels, Faculty of Medicine, Laboratory of Molecular Virology, Brussels, Belgium
    EMBO J 24:336-46. 2005
    ..Furthermore, these findings suggest that targeting of DNA methyltransferases by transcription factors is a wide and general mechanism for the generation of specific DNA methylation patterns within a cell...
  18. pmc Zbtb4 represses transcription of P21CIP1 and controls the cellular response to p53 activation
    Axel Weber
    Institute of Molecular Biology and Tumour Research IMT, Marburg, Germany
    EMBO J 27:1563-74. 2008
    ..Our data suggest that Zbtb4 is a critical determinant of the cellular response to p53 activation and reinforce the notion that p21Cip1 can provide an essential survival signal in cells with activated p53...
  19. pmc Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1
    Steffi Herold
    Institute of Molecular Biology and Tumor Research, Philipps University Marburg, Marburg, Germany
    EMBO J 27:2851-61. 2008
    ..Our data show that Miz1 and Myc affect the activity of the Atr checkpoint through their effect on TopBP1 chromatin association and stability...
  20. ncbi BCL2 is a downstream effector of MIZ-1 essential for blocking c-MYC-induced apoptosis
    Jagruti H Patel
    Biomedical Graduate Studies, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 282:5-13. 2007
    ..These data define a genetic pathway that helps to explain historical observations documenting cooperation between c-MYC and BCL2 overexpression in human cancer...
  21. ncbi Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter
    Siqin Wu
    Upsala Genetic Center, Department of Plant Biology, Swedish University of Agricultural Sciences
    Oncogene 22:351-60. 2003
    ..In conclusion, repression of differentiation-induced p21 expression through Miz-1 may be an important mechanism by which Myc blocks differentiation...
  22. ncbi The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation
    Sovana Adhikary
    Institute for Molecular Biology and Tumor Research, University of Marburg, Emil Mannkopff Str 2, 35033 Marburg, Germany
    Cell 123:409-21. 2005
    ..Our results suggest that site-specific ubiquitination regulates the switch between an activating and a repressive state of the Myc protein, and they suggest a strategy to interfere with Myc function in vivo...
  23. ncbi Negative regulation of the mammalian UV response by Myc through association with Miz-1
    Steffi Herold
    Institute for Molecular Biology and Tumor Research, 35033 Marburg, Germany
    Mol Cell 10:509-21. 2002
    ..Our data implicate Miz-1 in a pathway that regulates cell proliferation in response to UV irradiation...
  24. pmc The Arf tumor suppressor protein inhibits Miz1 to suppress cell adhesion and induce apoptosis
    Barbara Herkert
    Theodor Boveri Institute and 2 Rudolf Virchow Center, University of Wurzburg, D 97070 Wurzburg, Germany
    J Cell Biol 188:905-18. 2010
    ..Our data point to a tumor-suppressive pathway that weakens cell-cell and cell-matrix interactions in response to expression of Arf and that may thereby facilitate the elimination of cells harboring an oncogenic mutation...
  25. doi Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1
    Peter J Stogios
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Mol Biol 400:983-97. 2010
    ..The differences in the N-termini seen in the FAZF and Miz1 BTB domains appear to be more recent developments in the structural evolution of the domain...
  26. ncbi Transcription factor MIZ-1 is regulated via microtubule association
    J Ziegelbauer
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA
    Mol Cell 8:339-49. 2001
    ..Thus, MIZ-1 appears to be regulated by association with microtubules and may activate gene transcription in response to changes in the cytoskeleton...
  27. ncbi Repression of p15INK4b expression by Myc through association with Miz-1
    P Staller
    Institute of Molecular Biology and Tumour Research, Emil Mannkopff Strabetae 2, 35033 Marburg, Germany
    Nat Cell Biol 3:392-9. 2001
    ..Alleles of c-myc that are unable to bind to Miz-1 fail to inhibit accumulation of p15INK4b messenger RNA in primary cells and are, as a consequence, deficient in immortalization...
  28. pmc A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
    Eric Villard
    INSERM U956, Paris 75013, France
    Eur Heart J 32:1065-76. 2011
    ..So far, the genetics of DCM remains largely unresolved. We conducted the first genome-wide association study (GWAS) to identify loci contributing to sporadic DCM...
  29. doi Expression of NLRR3 orphan receptor gene is negatively regulated by MYCN and Miz-1, and its downregulation is associated with unfavorable outcome in neuroblastoma
    Jesmin Akter
    Division of Biochemistry and Innovative Cancer Therapeutics, Chiba Cancer Center, Chiba, Japan
    Clin Cancer Res 17:6681-92. 2011
    ..However, the molecular mechanism of transcriptional regulation of NLRR3 remains elusive. This study was undertaken to clarify the transcriptional regulation of NLRR3 and its association with the prognosis of NBL...
  30. ncbi Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes
    Eva Ceballos
    Departamento de Biología Molecular y Unidad de Biomedicina CSIC, Grupo de Biología Molecular del Cáncer, Facultad de Medicina, University of Cantabria, Santander 39011, Spain
    Oncogene 24:4559-71. 2005
    ..Our data suggest that elevated levels of Myc counteract p53 activity in human tumor cells that lack ARF. This mechanism could contribute to explain the c-Myc deregulation frequently found in cancer...
  31. pmc An alternative pathway for gene regulation by Myc
    K Peukert
    Hans Knöll Institut für Naturstoff Forschung, Department of Cell and Molecular Biology, Beutenbergstrasse 11, 07745 Jena, Germany
    EMBO J 16:5672-86. 1997
    ..Our data suggest a model for how gene repression by Myc may occur in vivo...
  32. ncbi Targeting of Miz-1 is essential for Myc-mediated apoptosis
    Jagruti H Patel
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:3283-9. 2006
    ....
  33. pmc Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells
    Peng Guo
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:18184-93. 2009
    ..Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription...
  34. pmc Sumoylation dynamics during keratinocyte differentiation
    Adeline F Deyrieux
    Department of Molecular and Microbial Pathogenesis, College of Medicine, Texas A and M Health Science Center, College Station, TX 77843 1114, USA
    J Cell Sci 120:125-36. 2007
    ..Abrogation of sumoylation by Gam1 expression severely disrupted normal HaCaT differentiation, consistent with an important role for sumoylation in the proper progression of this biological process...
  35. ncbi Nitric oxide-dependent and nitric oxide-independent transcriptional responses to high shear stress in endothelial cells
    Branko Braam
    Department of Nephrology and Hypertension, University Medical Center, F03 226, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Hypertension 45:672-80. 2005
    ..Several transcriptional modulators were found (up: SOX5, SOX25, ZNF151, HOXD10; down: SOX11); a number of genes were regulated by shear and by shear with ODQ, but not regulated during L-..
  36. doi SIZ1-Dependent Post-Translational Modification by SUMO Modulates Sugar Signaling and Metabolism in Arabidopsis thaliana
    Pedro Humberto Castro
    BioSystems and Integrative Sciences Institute BioISI, Plant Functional Biology Center, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal These authors contributed equally to this work
    Plant Cell Physiol 56:2297-311. 2015
    ..The Arabidopsis SUMO E3 ligase SAP and Miz 1 (SIZ1) is the major SUMO conjugation enhancer in response to stress, and is implicated in several aspects of plant ..
  37. pmc The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity
    Baohan T Vo
    Department of Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, 262 Danny Thomas Place, Memphis, TN 38105, USA
    Cancer Cell 29:5-16. 2016
    ..Target genes of Myc/Miz1 are repressed in human G3 MBs but not in other subgroups. Therefore, the Myc/Miz1 interaction is a defining hallmark of G3 MB development. ..
  38. pmc Syk-mediated tyrosine phosphorylation of mule promotes TNF-induced JNK activation and cell death
    C K Lee
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA
    Oncogene 35:1988-95. 2016
    ..Our data provides a missing link in TNF signaling pathway that leads to JNK activation and cell death. ..
  39. doi Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation
    Yongsheng Huang
    The State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Biochem J 466:499-509. 2015
    ..Together, our findings establish a novel layer of Wnt signalling regulation via the MIZ1-Dpr1-Dvl axis. ..
  40. pmc Two ZNF509 (ZBTB49) isoforms induce cell-cycle arrest by activating transcription of p21/CDKN1A and RB upon exposure to genotoxic stress
    Bu Nam Jeon
    Department of Biochemistry and Molecular Biology, Brain Korea 21 PLUS Project for Medical Science, Severance Biomedical Research Institute, Yonsei University School of Medicine, 50 1, Yonsei ro, Seodaemun gu, Seoul 120 752, Korea
    Nucleic Acids Res 42:11447-61. 2014
    ..Immunohistochemical analysis revealed that ZNF509 is highly expressed in normal epithelial cells, but was completely repressed in tumor tissues of the colon, lung and skin, indicating a possible role as a tumor suppressor. ..
  41. pmc Miz-1 activates gene expression via a novel consensus DNA binding motif
    Bonnie L Barrilleaux
    Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, California, United States of America Genome Center, University of California Davis, Davis, California, United States of America Comprehensive Cancer Center, University of California Davis, Sacramento, California, United States of America Institute of Pediatric Regenerative Medicine, Shriners Hospital for Children Northern California, Sacramento, California, United States of America
    PLoS ONE 9:e101151. 2014
    ..Overall, our results indicate that Miz-1 may be directed in vivo to the novel motif sequences we have identified, where it can recruit its specific binding partners to control gene expression and ultimately regulate cell fate...
  42. doi Myc increases self-renewal in neural progenitor cells through Miz-1
    Laura Kerosuo
    Developmental Biology, Institute of Biomedicine, Haartmaninkatu 8, PO Box 63, 00014 University of Helsinki, Finland
    J Cell Sci 121:3941-50. 2008
    ..Our results suggest that Myc, through Miz-1, enhances self-renewal of NPCs and influences the way progenitor cells react to the environmental cues that normally dictate the cellular identity of tissues containing self-renewing cells...
  43. ncbi Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc
    A Schneider
    Zentrum für Molekulare Biologie Heidelberg ZMBH, Germany
    Curr Top Microbiol Immunol 224:137-46. 1997
    ..We have termed this protein Miz-1 (Myc-interacting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo...
  44. pmc Myc-interacting protein 1 target gene profile: a link to microtubules, extracellular signal-regulated kinase, and cell growth
    Joseph Ziegelbauer
    Department of Molecular and Cell Biology, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 101:458-63. 2004
    ..Taken together, our studies suggest that MIZ-1 regulates a specific set of genes that includes LDLR and that the ERK pathway plays a role in the activation of target promoters by MIZ-1...
  45. ncbi Transcriptional repression by Myc
    Michael Wanzel
    Institute for Molecular Biology and Tumour Research IMT, University of Marburg, Marburg 35033, Germany
    Trends Cell Biol 13:146-50. 2003
    ..The findings might explain how Myc interferes with cell-cycle arrest in response to TGF-beta, APC and DNA damage...
  46. pmc The role of MIZ-1 in MYC-dependent tumorigenesis
    Katrin E Wiese
    Comprehensive Cancer Center Mainfranken and Theodor Boveri Institute, Biocenter, University of Wurzburg, 97074 Wurzburg, Germany
    Cold Spring Harb Perspect Med 3:a014290. 2013
    ..The functional interaction of both proteins becomes apparent at oncogenic expression levels of MYC and association with MIZ-1 mediates both oncogenic functions of MYC as well as tumor-suppressive responses to oncogenic levels of MYC. ..
  47. pmc Regulation of CDKN2B expression by interaction of Arnt with Miz-1--a basis for functional integration between the HIF and Myc gene regulatory pathways
    Reidun Aesoy
    Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Mol Cancer 13:54. 2014
    ..Hypoxia- and Myc-dependent transcriptional regulatory pathways are frequently deregulated in cancer cells. These pathways converge in many cellular responses, but the underlying molecular mechanisms are unclear...
  48. pmc Epstein-Barr virus nuclear antigen 3A protein regulates CDKN2B transcription via interaction with MIZ-1
    Quentin Bazot
    Ciri, International Center for Infectiology Research, Oncogenic Herpesviruses team, Universite de Lyon, Lyon 69364, France Université Lyon 1, Centre International de Recherche en Infectiologie, Lyon 69364, France CIRI, International Center for Infectiology Research, Cell Biology of Viral Infections team, Universite de Lyon, Lyon 69364, France INSERM, U1111, Lyon 69364, France CNRS, UMR5308, Lyon 69364, France
    Nucleic Acids Res 42:9700-16. 2014
    ....
  49. doi Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
    Susanne Walz
    1 Theodor Boveri Institute, Biocenter, University of Wurzburg, Am Hubland, 97074 Wurzburg, Germany 2
    Nature 511:483-7. 2014
    ..Third, complex formation with MIZ1 (also known as ZBTB17) mediates repression of multiple target genes by MYC and the ratio of MYC and MIZ1 bound to each promoter ..
  50. doi Structural and dynamical characterization of the Miz-1 zinc fingers 5-8 by solution-state NMR
    David Bernard
    Departement de Biochimie, Faculte de Medecine et des Sciences de la Sante, Institut de Pharmacologie de Sherbrooke, Universite de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, QC, J1H 5N4, Canada
    J Biomol NMR 57:103-16. 2013
    ....
  51. pmc Destabilization of MYC/MYCN by the mitochondrial inhibitors, metaiodobenzylguanidine, metformin and phenformin
    Stephanie S Wang
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Mol Med 33:35-42. 2014
    ..Our data suggest that the destabilization of MYC/MYCN by MIBG, metformin and phenformin and their effects on histone modification are important mechanisms underlying their anticancer effects...
  52. ncbi Nramp1-mediated innate resistance to intraphagosomal pathogens is regulated by IRF-8, PU.1, and Miz-1
    Michal Alter-Koltunoff
    Department of Food Engineering and Biotechnology, Technion, Haifa 32000, Israel
    J Biol Chem 278:44025-32. 2003
    ..Thus, our results explain in molecular terms the role of IRF-8 in conferring innate resistance to intracellular pathogens and point to its possible involvement in autoimmune diseases...
  53. pmc Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc
    S E Salghetti
    Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724, USA
    EMBO J 18:717-26. 1999
    ..Our data reveal a complex network of interactions regulating Myc destruction, and imply that enhanced protein stability contributes to oncogenic transformation by mutant Myc proteins...
  54. pmc MMS21/HPY2 and SIZ1, two Arabidopsis SUMO E3 ligases, have distinct functions in development
    Takashi Ishida
    RIKEN Plant Science Center, Tsurumi, Yokohama, Kanagawa, Japan
    PLoS ONE 7:e46897. 2012
    ..been reported in yeast and animals, but only two types of E3 ligases have been identified in Arabidopsis: SAP and Miz 1 (SIZ1) and Methyl Methanesulfonate-Sensitivity protein 21 (MMS21)/HIGH PLOIDY 2 (HPY2), hereafter referred to as ..
  55. doi From oncogene to tumor suppressor: the dual role of Myc in leukemia
    Iris Uribesalgo
    Centre de Regulació Genòmica CRG and UPF, Barcelona, Spain
    Cell Cycle 11:1757-64. 2012
    ..Here, we discuss the role of c-Myc in balancing proliferation and differentiation and how modulating this previously unidentified c-Myc activity might provide alternative therapies against leukemia and possibly other types of tumors...
  56. pmc Sleeping Beauty transposase modulates cell-cycle progression through interaction with Miz-1
    Oliver Walisko
    Max Delbruck Center for Molecular Medicine, D 13092 Berlin, Germany
    Proc Natl Acad Sci U S A 103:4062-7. 2006
    ..Because nonhomologous end-joining is required for efficient SB transposition, the transposase-induced G(1) slowdown is probably a selfish act on the transposon's part to maximize the chance for a successful transposition event...
  57. ncbi Novel target genes of the Wnt pathway and statistical insights into Wnt target promoter regulation
    Slava Ziegler
    Max Planck Institut fur molekulare Physiologie, Dortmund, Germany
    FEBS J 272:1600-15. 2005
    ..Furthermore, our data indicate that a high proportion of Wnt target genes are regulated by indirect mechanisms...
  58. doi The proto-oncoprotein KR-POK represses transcriptional activation of CDKN1A by MIZ-1 through competitive binding
    K M Lee
    Department of Biochemistry and Molecular Biology, Yonsei University School of Medicine, Seoul, Korea
    Oncogene 31:1442-58. 2012
    ....
  59. ncbi Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1
    David Piluso
    Department of Biochemistry, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 277:46799-808. 2002
    ....
  60. ncbi c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism
    Dalia Barsyte-Lovejoy
    Division of Cellular and Molecular Biology, Ontario Cancer Institute Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Oncogene 23:3481-6. 2004
    ..RNA polymerase II (RNAPII) is recruited to the GADD gene promoters in the presence and absence of c-Myc, which suggests that c-Myc represses these genes through a post-RNAPII recruitment mechanism...
  61. ncbi The repression of human differentiation-related gene NDRG2 expression by Myc via Miz-1-dependent interaction with the NDRG2 core promoter
    Jian Zhang
    Institute of Molecular Biology and the State Key Laboratory of Cancer Biology, Fourth Military Medical University, 710032 Xi an, China
    J Biol Chem 281:39159-68. 2006
    ..The regulatory function of Myc on NDRG2 gene expression implicated the role of the Ndrg2 in regulating cell differentiation...
  62. ncbi Microarray analysis of E-box binding-related gene expression in young and replicatively senescent human fibroblasts
    Alexandre Semov
    Bloomfield Center for Research in Aging, McGill University, Montreal, Quebec, Canada
    Anal Biochem 302:38-51. 2002
    ..Alterations in the expression of E-box-binding transcription factors and c-Myc-binding proteins demonstrate the importance of these genes in establishing the contact-inhibited quiescent or senescent phenotypes...
  63. doi Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation
    Christian Kosan
    Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec H2W 1R7, Canada
    Immunity 33:917-28. 2010
    ..We report that mice lacking the POZ (Poxvirus and zinc finger) domain of the transcription factor Miz-1 (Zbtb17(ΔPOZ/ΔPOZ)) almost entirely lacked follicular B cells, as shown by the fact that their progenitors failed to ..
  64. doi IL-7R-dependent survival and differentiation of early T-lineage progenitors is regulated by the BTB/POZ domain transcription factor Miz-1
    Ingrid Saba
    Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada
    Blood 117:3370-81. 2011
    ....
  65. ncbi c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts
    Richard Marcotte
    The Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, The Sir Mortimer B Davis Jewish General Hospital, and Department of Medicine, McGill University, Montreal, Quebec, Canada
    J Cell Biochem 96:1071-85. 2005
    ....
  66. pmc The action mechanism of the Myc inhibitor termed Omomyc may give clues on how to target Myc for cancer therapy
    Mauro Savino
    Consiglio Nazionale delle Ricerche Istituto di Biologia e Patologia Molecolari CNR IBPM, Dipartimento di Biologia e Biotecnologie, Universita Sapienza, Roma, Italia
    PLoS ONE 6:e22284. 2011
    ....
  67. pmc Hsp90 inhibition increases p53 expression and destabilizes MYCN and MYC in neuroblastoma
    Paul L Regan
    Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Int J Oncol 38:105-12. 2011
    ..Together our data suggest that Hsp90 inhibition suppresses the growth of neuroblastoma through multiple cellular pathways and that MYC/MYCN destabilization is among the important consequences of Hsp90 inhibition...
  68. doi Miz-1 is required to coordinate the expression of TCRbeta and p53 effector genes at the pre-TCR "beta-selection" checkpoint
    Ingrid Saba
    Institut de Recherches Cliniques de Montreal, Montreal, Quebec H2W 1R7, Canada
    J Immunol 187:2982-92. 2011
    ....
  69. ncbi Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN
    D Bannasch
    Division of Cytogenetics H0400, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Oncogene 18:6810-7. 1999
    ..Therefore only a very small amount of MycN and Nmi is likely to be involved in MycN/Nmi interaction in vivo...
  70. doi The role of the transcription factor Miz-1 in lymphocyte development and lymphomagenesis-Binding Myc makes the difference
    Tarik Moroy
    Institut de recherches cliniques de Montreal IRCM, 110 avenue des Pins Ouest, Montreal, QC H2W 1R7, Canada
    Semin Immunol 23:379-87. 2011
    ....
  71. pmc Myc and Miz-1 have coordinate genomic functions including targeting Hox genes in human embryonic stem cells
    Natalia Varlakhanova
    Department of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Sacramento, CA, USA
    Epigenetics Chromatin 4:20. 2011
    ..A proposed role for Myc in maintaining mouse embryonic stem (ES) cell pluripotency is transcriptional repression of key differentiation-promoting genes, but detail of the mechanism has remained an important open topic...
  72. pmc The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1
    Dieter Morandell
    Cell Metabolism and Differentiation Research Group, Institute for Biomedical Aging Research of the Austrian Academy of Sciences, Innsbruck, Austria
    Virology 422:242-53. 2012
    ..E7C24G retained E7-wild-type capability to inhibit Miz-1-dependent transactivation. These findings suggest that HPV-16 E7 can repress Miz-1-induced p21(Cip1) gene expression...
  73. ncbi Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA
    L Wu
    Department of Biochemistry and Molecular Biology, USC Norris Cancer Hospital and Research Institute, University of Southern California School of Medicine, Los Angeles 90033, USA
    Mech Dev 65:3-17. 1997
    ..The p148h mutation in Msx2 augments the Miz1 effect on Msx2 DNA binding, suggesting a reason why this mutation behaves in vivo as a dominant positive, and providing a potential explanation of the craniosynostosis phenotype...
  74. ncbi Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders
    N Tommerup
    Danish Center for Human Genome Research, John F Kennedy Institute, Glostrup
    Genomics 27:259-64. 1995
    ..deleted in solid tumors included ZNF132, 134, 135, 137, 154, and 155, all located on 19q13 (thyroid adenoma), and ZNF151, at 1p36.1-p36.2 (neuroblastoma, colon cancer, and other tumors)...
  75. pmc Characterization and mapping of human genes encoding zinc finger proteins
    P Bray
    Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
    Proc Natl Acad Sci U S A 88:9563-7. 1991
    ..The results of these analyses support the conclusion that the human genome contains many, probably several hundred, zinc finger genes with consensus H/C link regions...
  76. pmc Regulation of the Aurora-A gene following topoisomerase I inhibition: implication of the Myc transcription factor
    Sandy Courapied
    Cancer Center Paul Papin, INSERM U892, Angers, France
    Mol Cancer 9:205. 2010
    ..We therefore propose the hypothesis that the coordinated overexpression of Myc and Aurora-A, together with a downregulation of Mad and Miz-1 should be tested as a prognosis signature of poor responses to topoisomerase I inhibitors...
  77. ncbi Six lysine residues on c-Myc are direct substrates for acetylation by p300
    Kangling Zhang
    Department of Chemistry, University of California at Riverside, Riverside, CA 92521, USA
    Biochem Biophys Res Commun 336:274-80. 2005
    ..Our results further indicate that p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1...
  78. ncbi Pontin and Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1
    Christelle Etard
    Zoologisches Institut II, Universitat Karlsruhe TH, Kaiserstrasse 12, 76131 Karlsruhe, Germany
    Mech Dev 122:545-56. 2005
    ..We propose a novel function of xPontin and xReptin as co-repressors in the c-Myc/Miz-1 pathway...
  79. ncbi Ketogenic HMGCS2 Is a c-Myc target gene expressed in differentiated cells of human colonic epithelium and down-regulated in colon cancer
    Nuria Camarero
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    Mol Cancer Res 4:645-53. 2006
    ..Based on these findings, we propose that ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2...
  80. pmc Regulation of TopBP1 oligomerization by Akt/PKB for cell survival
    Kang Liu
    Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    EMBO J 25:4795-807. 2006
    ..Together, this study defines a novel pathway involving PI3K-Akt-TopBP1 for specific control of E2F1 apoptosis, in parallel with cyclin-Cdk-Rb for general control of E2F activities...
  81. ncbi Identification of novel CBP interacting proteins in embryonic orofacial tissue
    Xiaolong Yin
    Department of Molecular, Cellular and Craniofacial Biology, University of Louisville Birth Defects Center, ULSD Louisville, KY 40292, USA
    Biochem Biophys Res Commun 329:1010-7. 2005
    ..The identification of these proteins as novel CBP-binding partners allows exploration of new mechanisms by which CBP regulates and integrates diverse cell signaling pathways...
  82. ncbi The DNA topoisomerase IIbeta binding protein 1 (TopBP1) interacts with poly (ADP-ribose) polymerase (PARP-1)
    Yvonne Wollmann
    Department of Cell and Molecular Biology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knoell Institute, Beutenbergstrasse 11a, D 07745 Jena, Germany
    J Cell Biochem 102:171-82. 2007
    ..Finally, cellular (ADP-ribosyl)ating activity impairs binding of TopBP1 to Myc-interacting zinc finger protein-1 (Miz-1). The results indicate an influence of post-translational modifications of TopBP1 on its function during DNA repair...
  83. ncbi The mouse C/EBPdelta gene promoter is regulated by STAT3 and Sp1 transcriptional activators, chromatin remodeling and c-Myc repression
    Yingjie Zhang
    Department of Veterinary Biosciences, Ohio State University, Columbus, Ohio 43210, USA
    J Cell Biochem 102:1256-70. 2007
    ..These results provide a molecular model of C/EBPdelta transcriptional regulation under G(0) growth arrest conditions...
  84. ncbi Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1
    Holly Bowen
    Division of Biochemistry and Molecular Biology, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    J Biol Chem 278:36017-26. 2003
    ....
  85. ncbi Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc
    Michal Alter-Koltunoff
    Department of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa 32000, Israel
    J Biol Chem 283:2724-33. 2008
    ..Thus, interplay between repression and activation state of the Nramp1 promoter mediated by IRF-8 provides the molecular basis by which macrophages resist intraphagosomal pathogens at early stage after infection...
  86. doi c-Myc inhibits Ras-mediated differentiation of pheochromocytoma cells by blocking c-Jun up-regulation
    Jose P Vaque
    Grupo de Biología Molecular del Cáncer, Dpto de Biología Molecular and Instituto de Biomedicina y Biotecnología de Cantabria, Universidad de Cantabria CSIC IDICAN, Santander, Spain
    Mol Cancer Res 6:325-39. 2008
    ..In conclusion, we describe a novel interplay between c-Myc and c-Jun that controls the ability of Ras to trigger the differentiation program of pheochromocytoma cells...
  87. doi Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region
    Jian Zhang
    The Department of Biochemistry and Molecular Biology and The State Key Laboratory of Cancer Biology, The Fourth Military Medical University, Xi an, 710032, People s Republic of China
    Gene 417:5-12. 2008
    ..Taken together, our results demonstrate that, in common with NDRG2, human NDRG1 can be indirectly transcriptionally down-regulated by Myc via interaction with the NDRG1 core promoter...
  88. pmc Investigation of eight candidate genes on chromosome 1p36 for autosomal dominant total congenital cataract
    Kathryn P Burdon
    Department of Ophthalmology, Flinders University, Adelaide, Australia
    Mol Vis 14:1799-804. 2008
    ..To identify the causative gene for autosomal dominant total congenital cataract in a six-generation Australian family displaying linkage to chromosome 1p36...
  89. ncbi Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes
    Andrei L Gartel
    Department of Molecular Genetics, M C 669, 900 S Ashland Avenue, University of Illinois at Chicago, Chicago, IL 60607, USA
    Exp Cell Res 283:17-21. 2003
    ..The ability of c-Myc to repress transcription of growth arrest genes may contribute to its potential to promote proliferation and oncogenesis...
  90. pmc Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc
    Louise Kime
    School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, U K
    Biochem J 370:291-8. 2003
    ....
  91. pmc LitInspector: literature and signal transduction pathway mining in PubMed abstracts
    Matthias Frisch
    Genomatix Software, 80335 Munich, Germany
    Nucleic Acids Res 37:W135-40. 2009
    ..g. signaling cascade). The performance was checked for 10 randomly selected genes. Eighty-two per cent of the 38 predicted pathway associations were correct. LitInspector is freely available at http://www.litinspector.org/...
  92. pmc BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma
    Masumichi Saito
    Institute for Cancer Genetics, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 106:11294-9. 2009
    ..These results identify an important function for BCL6 in facilitating apoptosis of GC B cells via suppression of BCL2, and suggest that blocking this pathway is critical for lymphomagenesis...
  93. pmc Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation
    Jing Liu
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:18279-84. 2009
    ..Thus, our results show that in addition to being a transcription factor Miz1 acts as a signal- and pathway-specific modulator or regulator that specifically regulates TNF-alpha-induced JNK1 activation and cell death...
  94. ncbi TGF-beta flips the Myc switch
    A Orian
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue North, Seattle, WA 98109, USA
    Sci STKE 2001:pe1. 2001
    ..Orian and Eisenman discuss how Myc interacts with Miz-1 to block the expression of a cell cycle inhibitory protein, p15(INK4b), and how TGF-beta is able to unblock Myc-dependent repression of Miz-1...
  95. pmc Transcriptional regulation of Wnt inhibitory factor-1 by Miz-1/c-Myc
    J D F Licchesi
    Cancer Biology Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA
    Oncogene 29:5923-34. 2010
    ..Our data reveal novel insights into c-Myc-mediated DNA methylation-dependent transcriptional silencing, a mechanism that might contribute to the dysregulation of Wnt signaling in cancer...
  96. pmc P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration
    Hongquan Zhang
    Karolinska Institutet, Department of Microbiology, Pathology, and Immunology, SE 141 86 Huddinge, Sweden
    J Cell Biol 158:1287-97. 2002
    ..In conclusion, our results demonstrate that PAK4 interacts with integrin alpha v beta 5 and selectively promotes integrin alpha v beta 5-mediated cell migration...
  97. ncbi The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I
    Maria Isabel Tussie-Luna
    Department of Pathology, Programs in Immunology and Genetics, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    J Biol Chem 277:43185-93. 2002
    ..Finally, ectopically expressed Miz1/mPIASxbeta augments the transcriptional activity of TFII-I and relieves the repression exerted by a mutant hMusTRD1/BEN that co-localized with TFII-I in the nucleus...
  98. ncbi ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation
    N Kotaja
    Department of Physiology, Institute of Biomedicine, University of Helsinki, Finland
    Mol Endocrinol 14:1986-2000. 2000
    ..It remains to be established whether the PIAS proteins play a more significant physiological role in steroid receptor than in cytokine signaling...
  99. ncbi Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes
    P Lichter
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510
    Genomics 13:999-1007. 1992
    ..Zinc finger loci were found to reside predominantly either in telomeric regions or in chromosomal bands known to exhibit chromosome fragility. Chromosome 19 carries a disproportionate fraction (10 of 23) of the mapped zinc finger loci...

Research Grants4

  1. Daitoku Sakamuro; Fiscal Year: 2015
    ..This knowledge will be significant, as it may guide the development of therapeutic strategies for the treatment of cisplatin-resistant human cancers that overexpress c-Myc. ..
  2. ROBERT NEIL EISENMAN; Fiscal Year: 2016
    ..We will also identify downstream target genes for dMyc-dMax and dMad-dMax. Information gained from these studies will lead to an understanding of a transcription factor network that regulates cell behavior. ..
  3. P21 transcriptional inhibitors as proapoptotic compounds
    Andrei Gartel; Fiscal Year: 2003
    ..This study may improve treatment of cancer by leading to the identification of new compounds that will increase the efficiency of cell death promoting anticancer drugs for cancer treatment. ..
  4. Growth regulatory targets of the Tuberous Sclerosis Complex
    ROBERT NEIL EISENMAN; Fiscal Year: 2010
    ..Such genes are expected to be effectors of deregulated cell growth in tuberous sclerosis, and as such constitute potential targets for diagnosis and treatment of the disease. ..