Gene Symbol: ZBTB1
Description: zinc finger and BTB domain containing 1
Alias: ZNF909, zinc finger and BTB domain-containing protein 1
Species: human
Products:     ZBTB1

Top Publications

  1. Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, et al. Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer. Oncogene. 2004;23:7734-45 pubmed
  2. Kim H, Dejsuphong D, Adelmant G, Ceccaldi R, Yang K, Marto J, et al. Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Mol Cell. 2014;54:107-118 pubmed publisher
    ..Here, we show that the UBZ4 domain-containing transcriptional repressor ZBTB1 is a critical upstream regulator of TLS...
  3. Du J, Cao X, Liu H, Zeng Y, Yang X, Wan X, et al. Function of the PLZF gene in early development and self-renewal of T cells in mice. Biochem Biophys Res Commun. 2019;511:935-940 pubmed publisher
    The expression of transcription factor Zbtb1 is essential for the maintenance and development of various blood cells in the hematopoietic system...
  4. Cao X, Lu Y, Zhang X, Kovalovsky D. Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors. J Immunol. 2016;197:1199-211 pubmed publisher
    Expression of the transcription factor Zbtb1 is required for normal lymphoid development...
  5. Zhang X, Lu Y, Cao X, Zhen T, Kovalovsky D. Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors. Oncotarget. 2016;7:58768-58778 pubmed publisher
    b>Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid development when hematopoietic progenitors are in competition in mixed bone ..
  6. Matic I, Schimmel J, Hendriks I, van Santen M, van de Rijke F, van Dam H, et al. Site-specific identification of SUMO-2 targets in cells reveals an inverted SUMOylation motif and a hydrophobic cluster SUMOylation motif. Mol Cell. 2010;39:641-52 pubmed publisher
    ..In 16 proteins we identified a hydrophobic cluster SUMOylation motif (HCSM). SUMO conjugation of RanGAP1 and ZBTB1 via HCSMs is remarkably efficient.
  7. Punwani D, Simon K, Choi Y, Dutra A, González Espinosa D, Pak E, et al. Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development. J Immunol. 2012;189:1253-64 pubmed publisher
    ..using bacterial artificial chromosome transgenesis implicated zinc finger BTB-POZ domain protein 1 (Zbtb1) in the immunodeficiency, confirming its role in T cell development and suggesting involvement in B and NK cell ..
  8. Zheng W, Dong X, Yin R, Xu F, Ning H, Zhang M, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014;32:2278-89 pubmed publisher
    ..Microarray analysis suggested that EDAG knockdown selectively inhibits GATA1-activated target genes. These data provide novel insights into EDAG in regulation of erythroid differentiation. ..
  9. Vertegaal A, Ogg S, Jaffray E, Rodriguez M, Hay R, Andersen J, et al. A proteomic study of SUMO-2 target proteins. J Biol Chem. 2004;279:33791-8 pubmed
    ..SART1 and heterogeneous nuclear RNP M were both shown to be genuine SUMO targets, confirming the validity of the approach. ..

More Information


  1. van de Wijngaart D, Dubbink H, Molier M, de Vos C, Trapman J, Jenster G. Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression. Mol Endocrinol. 2009;23:1776-86 pubmed publisher
    ..In summary, our data demonstrate that BAF60a directly interacts with the coactivator groove in the AR ligand-binding domain via its FxxFF motif, thereby selectively activating specific AR-driven promoters. ..
  2. Liu Q, Yao F, Wang M, Zhou B, Cheng H, Wang W, et al. Novel human BTB/POZ domain-containing zinc finger protein ZBTB1 inhibits transcriptional activities of CRE. Mol Cell Biochem. 2011;357:405-14 pubmed publisher
    ..Here, we characterized the member of C(2)H(2) type zinc finger gene, Zinc finger and BTB domain containing 1 (ZBTB1)...