YY1

Summary

Gene Symbol: YY1
Description: YY1 transcription factor
Alias: DELTA, GADEVS, INO80S, NF-E1, UCRBP, YIN-YANG-1, transcriptional repressor protein YY1, INO80 complex subunit S, YY-1, Yin and Yang 1 protein, delta transcription factor
Species: human
Products:     YY1

Top Publications

  1. Baritaki S, Chatzinikola A, Vakis A, Soulitzis N, Karabetsos D, Neonakis I, et al. YY1 Over-expression in human brain gliomas and meningiomas correlates with TGF-beta1, IGF-1 and FGF-2 mRNA levels. Cancer Invest. 2009;27:184-92 pubmed publisher
    In this study we examined by QRT-PCR the mRNA expression of TGF-beta 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors...
  2. Liao W, Hsieh R, Hsu K, Wu M, Tseng M, Mai R, et al. The CBF1-independent Notch1 signal pathway activates human c-myc expression partially via transcription factor YY1. Carcinogenesis. 2007;28:1867-76 pubmed
    Transcription factor Ying Yang 1 (YY1) indirectly regulates the C promoter-binding factor 1 (CBF1)-dependent Notch1 signaling via direct interaction with the Notch1 receptor intracellular domain (N1IC) on CBF1-response elements...
  3. Riman S, Rizkallah R, Kassardjian A, Alexander K, Luscher B, Hurt M. Phosphorylation of the transcription factor YY1 by CK2? prevents cleavage by caspase 7 during apoptosis. Mol Cell Biol. 2012;32:797-807 pubmed publisher
    In this report, we describe the phosphorylation of Yin Yang 1 (YY1) in vitro and in vivo by CK2? (casein kinase II), a multifunctional serine/threonine protein kinase...
  4. Wan M, Huang W, Kute T, Miller L, Zhang Q, Hatcher H, et al. Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27. Am J Pathol. 2012;180:2120-33 pubmed publisher
    b>Yin Yang 1 (YY1) is highly expressed in various types of cancers and regulates tumorigenesis through multiple pathways...
  5. Castellano G, Torrisi E, Ligresti G, Nicoletti F, Malaponte G, Traval S, et al. Yin Yang 1 overexpression in diffuse large B-cell lymphoma is associated with B-cell transformation and tumor progression. Cell Cycle. 2010;9:557-63 pubmed
    b>Yin Yang 1 (YY1), a multifunctional transcription factor, has been shown to be involved in the pathogenesis of several cancer types. However, its role in hematological malignancies has not yet been fully investigated...
  6. Zhang Q, Stovall D, Inoue K, Sui G. The oncogenic role of Yin Yang 1. Crit Rev Oncog. 2011;16:163-97 pubmed
    b>Yin Yang 1 (YY1) is a transcription factor with diverse and complex biological functions. YY1 either activates or represses gene transcription, depending on the stimuli received by the cells and its association with other cellular factors...
  7. Galvin K, Shi Y. Multiple mechanisms of transcriptional repression by YY1. Mol Cell Biol. 1997;17:3723-32 pubmed
    The four C-terminal GLI-Krüppel type zinc fingers of YY1 have been identified as a transcriptional repression domain. Previous reports have proposed DNA-bending and activator-quenching mechanisms for this zinc finger-mediated repression...
  8. Ko C, Hsu H, Shen M, Chang W, Wang J. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. J Biol Chem. 2008;283:30919-32 pubmed publisher
    Human CCAAT/enhancer-binding protein delta (CEBPD) has been reported as a tumor suppressor because it both induces growth arrest involved in differentiation and plays a crucial role as a regulator of pro-apoptotic gene expression...
  9. Zhang J, Zhu Y, Zhang X, Liang W, Xie K, Tao J, et al. Transcriptional regulation of human MUC4 gene: identification of a novel inhibitory element and its nuclear binding protein. Mol Biol Rep. 2013;40:4913-20 pubmed publisher
    ..The proteins binding to this element were purified and identified as Yin Yang 1 (YY1) by mass spectrometry...

More Information

Publications74

  1. Erkeland S, Valkhof M, Heijmans Antonissen C, Delwel R, Valk P, Hermans M, et al. The gene encoding the transcriptional regulator Yin Yang 1 (YY1) is a myeloid transforming gene interfering with neutrophilic differentiation. Blood. 2003;101:1111-7 pubmed
    ..4-induced AML frequently harbors virus integrations in the gene encoding the transcription factor Yin Yang 1 (YY1)...
  2. Wu S, Shi Y, Mulligan P, Gay F, Landry J, Liu H, et al. A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair. Nat Struct Mol Biol. 2007;14:1165-72 pubmed
    ..We found that loss of the mouse transcription factor YY1 resulted in polyploidy and chromatid aberrations, which are signatures of defects in homologous recombination...
  3. Burgess S, Shen C, Ferguson L, O Neill G, Docherty K, Hunter N, et al. Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the ovine PrP (Prion) gene promoter. J Biol Chem. 2009;284:6716-24 pubmed publisher
    ..Two proteins bound to these motifs were identified as the Yin Yang 1 (YY1) (motif 1) and E4BP4 (motif 2) transcription factors...
  4. Luke M, Sui G, Liu H, Shi Y. Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription. J Biol Chem. 2006;281:33226-32 pubmed
    b>Yin Yang 1 (YY1) plays an indispensable role in embryonic development...
  5. Rizkallah R, Hurt M. Regulation of the transcription factor YY1 in mitosis through phosphorylation of its DNA-binding domain. Mol Biol Cell. 2009;20:4766-76 pubmed publisher
    Yin-Yang 1 (YY1) is a ubiquitously expressed zinc finger transcription factor. It regulates a vast array of genes playing critical roles in development, differentiation, and cell cycle...
  6. He Y, Kim J, Dupree J, Tewari A, MELENDEZ VASQUEZ C, Svaren J, et al. Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination. Nat Neurosci. 2010;13:1472-80 pubmed publisher
    ..We found that the transcription factor Yin Yang 1 (YY1) is crucial for peripheral myelination...
  7. Hu H, Kanda K, Zhang L, Boxer L. Activation of the c-myc p1 promoter in Burkitt's lymphoma by the hs3 immunoglobulin heavy-chain gene enhancer. Leukemia. 2007;21:747-53 pubmed
    ..We identified a YY1 site in the immunoglobulin heavy-chain gene HS3 enhancer, which increased c-myc P1 promoter activity, and a MARE ..
  8. Baritaki S, Sifakis S, Huerta Yepez S, Neonakis I, Soufla G, Bonavida B, et al. Overexpression of VEGF and TGF-beta1 mRNA in Pap smears correlates with progression of cervical intraepithelial neoplasia to cancer: implication of YY1 in cervical tumorigenesis and HPV infection. Int J Oncol. 2007;31:69-79 pubmed
    ..VEGF, TGF-beta1 and YY1 mRNA expression levels were assessed by QRT-PCR...
  9. Klar M, Bode J. Enhanceosome formation over the beta interferon promoter underlies a remote-control mechanism mediated by YY1 and YY2. Mol Cell Biol. 2005;25:10159-70 pubmed
    ..5, -2, and -3 kb. Our present study delineates the interplay of factors YY1 and YY2 as it occurs at the sites at -3 kb and -2 kb (otherwise called HS1 and HS2), consistent with the idea that ..
  10. Begon D, Delacroix L, Vernimmen D, Jackers P, Winkler R. Yin Yang 1 cooperates with activator protein 2 to stimulate ERBB2 gene expression in mammary cancer cells. J Biol Chem. 2005;280:24428-34 pubmed
    ..In this report, we examined the cooperative effect of Yin Yang 1 (YY1) on AP-2-induced activation of ERBB2 promoter activity...
  11. Krippner Heidenreich A, Walsemann G, Beyrouthy M, Speckgens S, Kraft R, Thole H, et al. Caspase-dependent regulation and subcellular redistribution of the transcriptional modulator YY1 during apoptosis. Mol Cell Biol. 2005;25:3704-14 pubmed
    The transcriptional regulator Yin Yang 1 (YY1) controls many aspects of cell behavior and is essential for development. We analyzed the fate of YY1 during apoptosis and studied the functional consequences...
  12. Cole E, Gaston K. A functional YY1 binding site is necessary and sufficient to activate Surf-1 promoter activity in response to serum growth factors. Nucleic Acids Res. 1997;25:3705-11 pubmed
    ..four factor binding sites; members of the ETS family of transcription factors bind to two of these sites whilst YY1 binds to a third site immediately downstream of the major Surf-1 transcription start point...
  13. Shrivastava A, Saleque S, Kalpana G, Artandi S, Goff S, Calame K. Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science. 1993;262:1889-92 pubmed
    Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator...
  14. Satijn D, Hamer K, den Blaauwen J, Otte A. The polycomb group protein EED interacts with YY1, and both proteins induce neural tissue in Xenopus embryos. Mol Cell Biol. 2001;21:1360-9 pubmed
    ..Here we show that YY1, a homolog of the Drosophila PcG protein pleiohomeotic (Pho), interacts specificially with the human PcG protein ..
  15. Margolis D, Somasundaran M, Green M. Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production. J Virol. 1994;68:905-10 pubmed
    ..Homologies near the HIV-1 initiator region to the DNA-binding sequences of YY1, a multifunctional transcription factor known to regulate diverse viral and cellular promoters, suggested that YY1 ..
  16. Jokela T, Makkonen K, Oikari S, Kärnä R, Koli E, Hart G, et al. Cellular content of UDP-N-acetylhexosamines controls hyaluronan synthase 2 expression and correlates with O-linked N-acetylglucosamine modification of transcription factors YY1 and SP1. J Biol Chem. 2011;286:33632-40 pubmed publisher
    ..Instead, altered binding of SP1 and YY1 to the promoter correlated with cellular UDP-HexNAc content and inhibition of HAS2 expression...
  17. Ratajewski M, Pulaski L. YY1-dependent transcriptional regulation of the human GDAP1 gene. Genomics. 2009;94:407-13 pubmed publisher
    ..the first time a functional analysis of the GDAP1 gene promoter which we found to be transcriptionally regulated by YY1, a broadly studied factor that seems to be involved in regulating many of the same cellular phenomena as GDAP1...
  18. Thomas M, Seto E. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?. Gene. 1999;236:197-208 pubmed
    The transcription factor YY1 is a complex protein that is involved in repressing and activating a diverse number of promoters...
  19. Zaravinos A, Spandidos D. Yin yang 1 expression in human tumors. Cell Cycle. 2010;9:512-22 pubmed
    The Yin Yang 1 (YY1) transcription factor has been identified to target a plethora of potential target genes, the products of which are important for proliferation and differentiation...
  20. René C, Lopez E, Claustres M, Taulan M, Romey Chatelain M. NF-E2-related factor 2, a key inducer of antioxidant defenses, negatively regulates the CFTR transcription. Cell Mol Life Sci. 2010;67:2297-309 pubmed publisher
    ..To decipher the molecular mechanisms involved, we evaluated the role of YY1 in the Nrf2-mediated transcriptional activity and showed cooperation between these two factors...
  21. Yang W, Inouye C, Zeng Y, Bearss D, Seto E. Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A. 1996;93:12845-50 pubmed
    b>YY1 is a mammalian zinc-finger transcription factor with unusual structural and functional features...
  22. Wang X, Feng Y, Xu L, Chen Y, Zhang Y, Su D, et al. YY1 restrained cell senescence through repressing the transcription of p16. Biochim Biophys Acta. 2008;1783:1876-83 pubmed publisher
    The transcription factor YY1 has been implicated to play a role in cell growth control...
  23. He Y, Casaccia Bonnefil P. The Yin and Yang of YY1 in the nervous system. J Neurochem. 2008;106:1493-502 pubmed publisher
    The transcription factor Yin Yang 1 (YY1) is a multifunctional protein that can activate or repress gene expression depending on the cellular context. YY1 is ubiquitously expressed and highly conserved between species...
  24. de Nigris F, Rossiello R, Schiano C, Arra C, Williams Ignarro S, Barbieri A, et al. Deletion of Yin Yang 1 protein in osteosarcoma cells on cell invasion and CXCR4/angiogenesis and metastasis. Cancer Res. 2008;68:1797-808 pubmed publisher
    We know that the Yin Yang 1 protein (YY1) overexpression is positively and strongly correlated with the degree of malignancy of bone tumors...
  25. Chen Q, Yu L, Tsang P, Wei J, Song Y, Cheuk A, et al. Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a. J Proteome Res. 2011;10:479-87 pubmed publisher
    ..among the differentially expressed proteins demonstrated that the expression of the ubiquitous transcription factor YY1, as well as its downstream proteins, is significantly reduced by miR-34a...
  26. Rizkallah R, Alexander K, Kassardjian A, Luscher B, Hurt M. The transcription factor YY1 is a substrate for Polo-like kinase 1 at the G2/M transition of the cell cycle. PLoS ONE. 2011;6:e15928 pubmed publisher
    Yin-Yang 1 (YY1) is an essential multifunctional zinc-finger protein...
  27. Lee M, Lahusen T, Wang R, Xiao C, Xu X, Hwang Y, et al. Yin Yang 1 positively regulates BRCA1 and inhibits mammary cancer formation. Oncogene. 2012;31:116-27 pubmed publisher
    ..Among several potential regulators, the Gli-Krueppel-related transcription factor Yin Yang 1 (YY1) showed the most dramatic transactivation of the BRCA1 promoter...
  28. Yao Y, Yang W, Seto E. Regulation of transcription factor YY1 by acetylation and deacetylation. Mol Cell Biol. 2001;21:5979-91 pubmed
    b>YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles...
  29. Donohoe M, Zhang L, Xu N, Shi Y, Lee J. Identification of a Ctcf cofactor, Yy1, for the X chromosome binary switch. Mol Cell. 2007;25:43-56 pubmed
    ..Here, we search for trans-factors and identify Yy1 as a required cofactor for Ctcf...
  30. Schlisio S, Halperin T, Vidal M, Nevins J. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function. EMBO J. 2002;21:5775-86 pubmed
    ..A two-hybrid screen identified RYBP (Ring1- and YY1-binding protein) as a protein that interacts specifically with the E2F2 and E2F3 family members, dependent on the ..
  31. Nicholson S, Whitehouse H, Naidoo K, Byers R. Yin Yang 1 in human cancer. Crit Rev Oncog. 2011;16:245-60 pubmed
    ..This is probably because of the many different roles YY1 plays in control of proliferation and apoptosis, one or the other of which may be more prominent in any given tumor...
  32. Hongo F, Garban H, Huerta Yepez S, Vega M, Jazirehi A, Mizutani Y, et al. Inhibition of the transcription factor Yin Yang 1 activity by S-nitrosation. Biochem Biophys Res Commun. 2005;336:692-701 pubmed
    ..Previous findings demonstrated that the transcription repressor Yin Yang 1 (YY1), which is inhibited by NO, negatively regulates Fas transcription [H.J. Garban, B...
  33. Seligson D, Horvath S, Huerta Yepez S, Hanna S, Garban H, Roberts A, et al. Expression of transcription factor Yin Yang 1 in prostate cancer. Int J Oncol. 2005;27:131-41 pubmed
    The transcription repressor Yin Yang 1 (YY1) is expressed in several human cancer cell lines and its expression correlates with resistance to immune-mediated apoptosis...
  34. Rezai Zadeh N, Zhang X, Namour F, Fejer G, Wen Y, Yao Y, et al. Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1. Genes Dev. 2003;17:1019-29 pubmed
    ..Here we report that the sequence-specific DNA-binding transcription factor Yin Yang 1 (YY1) binds to and recruits the histone H4 (Arg 3)-specific methyltransferase, PRMT1, to a YY1-activated ..
  35. Zhang S, Jiang T, Feng L, Sun J, Lu H, Wang Q, et al. Yin Yang-1 suppresses differentiation of hepatocellular carcinoma cells through the downregulation of CCAAT/enhancer-binding protein alpha. J Mol Med (Berl). 2012;90:1069-77 pubmed publisher
    As a member of the GLI-Kruppel family of transcriptional factors, Yin Yang-1 (YY1) functions as an oncogene in various types of cancers. However, the role of YY1 in hepatocellular carcinogenesis remains unknown...
  36. Grönroos E, Terentiev A, Punga T, Ericsson J. YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress. Proc Natl Acad Sci U S A. 2004;101:12165-70 pubmed
    ..Here, we demonstrate that the transcription factor Yin Yang 1 (YY1) interacts with p53 and inhibits its transcriptional activity...
  37. Wu S, Kasim V, Kano M, Tanaka S, Ohba S, Miura Y, et al. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1? in a p53-independent manner. Cancer Res. 2013;73:1787-99 pubmed publisher
    ..The transcription factor Yin Yang 1 (YY1) is an important negative regulator of the tumor suppressor factor p53...
  38. Lee J, Galvin K, See R, Eckner R, Livingston D, Moran E, et al. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 1995;9:1188-98 pubmed
    b>YY1 represses transcription when bound upstream of transcriptional initiation sites. This repression can be relieved by adenovirus E1A...
  39. Becker K, Swergold G, Ozato K, Thayer R. Binding of the ubiquitous nuclear transcription factor YY1 to a cis regulatory sequence in the human LINE-1 transposable element. Hum Mol Genet. 1993;2:1697-702 pubmed
    ..form a specific complex with a nuclear protein extracted from NTera2D1 and Jurkat cells, and with recombinant YY1 produced in E. coli...
  40. de Nigris F, Crudele V, Giovane A, Casamassimi A, Giordano A, Garban H, et al. CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy. Proc Natl Acad Sci U S A. 2010;107:14484-9 pubmed publisher
    ..The multifunctional Yin Yang 1 (YY1) protein is highly expressed in different types of cancers and may regulate some cancer-related genes...
  41. Tang S, Mishra M, Frazier D, Moore M, Inoue K, Deora R, et al. Positive and negative regulation of prostate stem cell antigen expression by Yin Yang 1 in prostate epithelial cell lines. PLoS ONE. 2012;7:e35570 pubmed publisher
    ..In the present study, we identified the multi-functional transcription factor Yin Yang 1 (YY1) as a modulator of PSCA expression in prostate epithelial cell lines...
  42. Romerio F, Gabriel M, Margolis D. Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF. J Virol. 1997;71:9375-82 pubmed
    ..b>YY1, a widely distributed human transcription factor, is known to inhibit HIV-1 long terminal repeat (LTR) ..
  43. Cai Y, Jin J, Yao T, Gottschalk A, Swanson S, Wu S, et al. YY1 functions with INO80 to activate transcription. Nat Struct Mol Biol. 2007;14:872-4 pubmed
    Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80)...
  44. Wang C, Tsai M, Hong T, Chang G, Chen C, Yang W, et al. The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion. Oncogene. 2005;24:4081-93 pubmed
    ..of the HLJ1 gene promoter region showed absence of a TATA box, but identified an inverted CCAAT box and four YY1 transcriptional factor-binding sites, which may be important in the regulation of HLJ1 expression...
  45. Caretti G, Di Padova M, Micales B, Lyons G, Sartorelli V. The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 2004;18:2627-38 pubmed
    ..In undifferentiated myoblasts, endogenous Ezh2 was associated with the transcriptional regulator YY1. Both Ezh2 and YY1 were detected, with the deacetylase HDAC1, at genomic regions of silent muscle-specific genes...
  46. Deng Z, Wan M, Sui G. PIASy-mediated sumoylation of Yin Yang 1 depends on their interaction but not the RING finger. Mol Cell Biol. 2007;27:3780-92 pubmed
    As a multifunctional protein, Yin Yang 1 (YY1) has been demonstrated to regulate both gene expression and protein posttranslational modifications...
  47. Adams D, van der Weyden L, Mayeda A, Stamm S, Morris B, Rasko J. ZNF265--a novel spliceosomal protein able to induce alternative splicing. J Cell Biol. 2001;154:25-32 pubmed
    ..gene product SMN, the snRNP protein U1-70K, the SR protein SC35, and with the transcriptosomal components p300 and YY1. Transfection of HT-1080 cells with ZNF265-EGFP fusion constructs showed that nuclear localization of ZNF265 ..
  48. Foti D, Reichardt J. YY1 binding within the human HSD3B2 gene intron 1 is required for maximal basal promoter activity: identification of YY1 as the 3beta1-A factor. J Mol Endocrinol. 2004;33:99-119 pubmed
    ..By competition analysis and use of anti-YY1 antibody in both gel shift and Western blot experiments, we identified the 3beta1-A protein as the ubiquitous ..
  49. Wang C, Tsai M, Dai T, Hong T, Chan W, Chen J, et al. Synergistic activation of the tumor suppressor, HLJ1, by the transcription factors YY1 and activator protein 1. Cancer Res. 2007;67:4816-26 pubmed
    ..Overexpression of either YY1 at promoter or AP-1 at enhancer results in a 3-fold increase in the transcriptional activity of HLJ1...
  50. Lieberthal J, Kaminsky M, Parkhurst C, Tanese N. The role of YY1 in reduced HP1alpha gene expression in invasive human breast cancer cells. Breast Cancer Res. 2009;11:R42 pubmed publisher
    ..The transcription factor yin yang 1 (YY1) was found to play a role in differential transcriptional activity of the HP1alpha gene...
  51. Coull J, Romerio F, Sun J, Volker J, Galvin K, Davie J, et al. The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1. J Virol. 2000;74:6790-9 pubmed
    ..We detail a mechanism whereby cellular factors could establish virological latency. The transcription factors YY1 and LSF cooperate in repression of transcription from the HIV-1 long terminal repeat (LTR)...
  52. Rylski M, Amborska R, Zybura K, Mioduszewska B, Michaluk P, Jaworski J, et al. Yin Yang 1 is a critical repressor of matrix metalloproteinase-9 expression in brain neurons. J Biol Chem. 2008;283:35140-53 pubmed publisher
    ..in vivo, as well as in the nondepolarized brain neurons in primary culture, the transcriptional regulator Yin Yang 1 (YY1) is bound to the proximal Mmp-9 promoter and strongly represses Mmp-9 transcription...
  53. Kim J, Kim J. YY1's longer DNA-binding motifs. Genomics. 2009;93:152-8 pubmed publisher
    The DNA-binding sites of YY1 located within two newly identified downstream genes of YY1, Peg3 (GGCGCCATnTT) and Xist (CCGCCATnTT), are longer than the known motif of YY1 (CGCCATnTT)...
  54. Ren G, Zhang G, Dong Z, Liu Z, Li L, Feng Y, et al. Recruitment of HDAC4 by transcription factor YY1 represses HOXB13 to affect cell growth in AR-negative prostate cancers. Int J Biochem Cell Biol. 2009;41:1094-101 pubmed publisher
    ..We also show that both HDAC4 and YY1 participated in the repression of HOXB13 expression through an epigenetic mechanism involving histone acetylation ..
  55. Yao Y, DuPont B, Ghosh S, Fang Y, Leach R, Seto E. Cloning, chromosomal localization and promoter analysis of the human transcription factor YY1. Nucleic Acids Res. 1998;26:3776-83 pubmed
    b>Yin Yang 1 (YY1) is a protein that activates and represses transcription of a large number of cellular and viral genes. In addition, studies suggest that YY1 may play an important role in development and differentiation...
  56. Chinnappan D, Xiao D, Ratnasari A, Andry C, King T, Weber H. Transcription factor YY1 expression in human gastrointestinal cancer cells. Int J Oncol. 2009;34:1417-23 pubmed
    Over-expression of the multifunctional zinc-finger transcription factor Yin Yang 1 (YY1) has been associated with cellular proliferation and resistance to apoptotic stimuli...
  57. Petrella B, Brinckerhoff C. PTEN suppression of YY1 induces HIF-2 activity in von-Hippel-Lindau-null renal-cell carcinoma. Cancer Biol Ther. 2009;8:1389-401 pubmed
    ..Our data show that PTEN induces HIF-2alpha transcriptional activity by inhibiting expression of Yin Yang 1 (YY1), which acts as a novel corepressor of HIF-2alpha...
  58. Sui G, Affar E, Shi Y, Brignone C, Wall N, Yin P, et al. Yin Yang 1 is a negative regulator of p53. Cell. 2004;117:859-72 pubmed
    b>Yin Yang 1 (YY1) is a transcription factor that plays an essential role in development. However, the full spectrum of YY1's functions and mechanism of action remains unclear...
  59. Zhang N, Li X, Wu C, Dong Y, Cai M, Mok M, et al. microRNA-7 is a novel inhibitor of YY1 contributing to colorectal tumorigenesis. Oncogene. 2013;32:5078-88 pubmed publisher
    ..05). The 3'-untranslated region (3'UTR) of Yin Yang 1 (YY1) mRNA contains an evolutionarily conserved miR-7 binding site using in silico searches, luciferase reporter ..
  60. Yeh T, Lin Y, Hsieh R, Tseng M. Association of transcription factor YY1 with the high molecular weight Notch complex suppresses the transactivation activity of Notch. J Biol Chem. 2003;278:41963-9 pubmed
    ..In this study, we found that endogenous transcription factor Ying Yang 1 (YY1) was associated with exogenous N1IC in human K562 erythroleukemic cells...
  61. Hiromura M, Choi C, Sabourin N, Jones H, Bachvarov D, Usheva A. YY1 is regulated by O-linked N-acetylglucosaminylation (O-glcNAcylation). J Biol Chem. 2003;278:14046-52 pubmed
    b>YY1 is a zinc finger DNA-binding transcription factor that influences expression of a wide variety of cellular and viral genes. YY1 is essential for the development of mammalian embryos...
  62. Lorente M, Perez C, Sanchez C, Donohoe M, Shi Y, Vidal M. Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A. Mech Dev. 2006;123:312-20 pubmed
    ..Here, we show anterior homeotic transformations of the axial skeleton of YY1(+/-) mice...
  63. He G, Wang Q, Zhou Y, Wu X, Wang L, Duru N, et al. YY1 is a novel potential therapeutic target for the treatment of HPV infection-induced cervical cancer by arsenic trioxide. Int J Gynecol Cancer. 2011;21:1097-104 pubmed publisher
    b>YY1 is a zinc finger transcription factor involved in the regulation of cell growth, development, and differentiation...
  64. Jeon Y, Lee J. YY1 tethers Xist RNA to the inactive X nucleation center. Cell. 2011;146:119-33 pubmed publisher
    ..Here, we define the nucleation center for Xist RNA and show that YY1 docks Xist particles onto the X chromosome...
  65. Shi Y, Seto E, Chang L, Shenk T. Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell. 1991;67:377-88 pubmed
    ..One of these proteins, YY1, is responsible for the repression...