YARS

Summary

Gene Symbol: YARS
Description: tyrosyl-tRNA synthetase
Alias: CMTDIC, TYRRS, YRS, YTS, tyrosine--tRNA ligase, cytoplasmic, tyrosine tRNA ligase 1, cytoplasmic, tyrosyl--tRNA ligase, tyrosyl-tRNA synthetase, cytoplasmic
Species: human
Products:     YARS

Top Publications

  1. Tsukahara T, Yamagishi S, Neyama H, Ueda H. Tyrosyl-tRNA synthetase: A potential kyotorphin synthetase in mammals. Peptides. 2018;101:60-68 pubmed publisher
    ..However, the latter has never been identified. We aimed to test the hypothesis that tyrosyl-tRNA synthetase (TyrRS) is also KTP synthetase...
  2. Hu J, Tian J, Li F, Xue B, Hu J, Cheng X, et al. Clone and functional analysis of Seryl-tRNA synthetase and Tyrosyl-tRNA synthetase from silkworm, Bombyx mori. Sci Rep. 2017;7:41563 pubmed publisher
    ..In this study, the seryl-tRNA synthetase (SerRS) and tyrosyl-tRNA synthetase (TyrRS) genes from silkworm were cloned...
  3. Mukai T, Reynolds N, Crnkovic A, Soll D. Bioinformatic Analysis Reveals Archaeal tRNATyr and tRNATrp Identities in Bacteria. Life (Basel). 2017;7: pubmed publisher
    ..These bacteria possess genes for tyrosyl-tRNA synthetase (TyrRS) and tryptophanyl-tRNA synthetase (TrpRS) predicted to be derived from DPANN superphylum archaea, while the ..
  4. Shridhar K, Satija A, Dhillon P, Agrawal S, Gupta R, Bowen L, et al. Association between empirically derived dietary patterns with blood lipids, fasting blood glucose and blood pressure in adults - the India migration study. Nutr J. 2018;17:15 pubmed publisher
    ..8 yrs)...
  5. Wei P, Zhuang B, Yu D, Sharipova A, Cai J, Huang L, et al. Cell-Free Expression of Unnatural Amino Acid Incorporated Aquaporin SS9 with Improved Separation Performance in Biomimetic Membranes. Biomed Res Int. 2018;2018:3560894 pubmed publisher
    ..P-AQP SS9) in vitro using a mutated Methanocaldococcus jannaschii tyrosyl-tRNA synthetase (TyrRS) and the cell-free expression system...
  6. Paukstelis P, Chari N, Lambowitz A, Hoffman D. NMR Structure of the C-terminal domain of a tyrosyl-tRNA synthetase that functions in group I intron splicing. Biochemistry. 2011;50:3816-26 pubmed publisher
    ..Here, we determined an NMR structure of the isolated C-terminal domain of the Aspergillus nidulans mt TyrRS, which is closely related to but smaller than CYT-18's...
  7. Kanaji T, Vo M, Kanaji S, Zarpellon A, Shapiro R, Morodomi Y, et al. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia. Proc Natl Acad Sci U S A. 2018;115:E8228-E8235 pubmed publisher
    ..We show an activated form of tyrosyl-tRNA synthetase (YRSACT), prepared either by rationally designed mutagenesis or alternative splicing, induces expansion of a ..
  8. Tracewska Siemiątkowska A, Haer Wigman L, Bosch D, Nickerson D, Bamshad M, van de Vorst M, et al. An Expanded Multi-Organ Disease Phenotype Associated with Mutations in YARS. Genes (Basel). 2017;8: pubmed publisher
    ..A homozygous variant c.806T > C, p.(F269S) in the tyrosyl-tRNA synthetase gene (YARS) was the only identified candidate variant consistent with autosomal recessive inheritance...
  9. Richardson C, First E. Altering the Enantioselectivity of Tyrosyl-tRNA Synthetase by Insertion of a Stereospecific Editing Domain. Biochemistry. 2016;55:1541-53 pubmed publisher
    ..polypeptide 1 (CP1) domain of Geobacillus stearothermophilus tyrosyl-tRNA synthetase (henceforth designated TyrRS-FRSed)...

More Information

Publications158 found, 100 shown here

  1. Guo Z, Yin Y, Wang C, Wang P, Zhang X, Wang Z, et al. Design, synthesis and molecular docking of salicylic acid derivatives containing metronidazole as a new class of antimicrobial agents. Bioorg Med Chem. 2015;23:6148-56 pubmed publisher
    ..of novel salicylic acid derivatives containing metronidazole as Staphylococcus aureus Tyrosyl-tRNA synthetase (TyrRS) inhibitors have been synthesized and evaluated their biology activities as potential antibacterial agents...
  2. Son H, Seo M, Ham S, Hwang W, Lee D, An S, et al. RNA surveillance via nonsense-mediated mRNA decay is crucial for longevity in daf-2/insulin/IGF-1 mutant C. elegans. Nat Commun. 2017;8:14749 pubmed publisher
    ..Furthermore, we find that downregulation of yars-2/tyrosyl-tRNA synthetase, an NMD target transcript, by daf-2 mutations contributes to longevity...
  3. Rybak M, Kovalenko O, Tukalo M. The Dual Role of the 2'-OH Group of A76 tRNATyr in the Prevention of d-tyrosine Mistranslation. J Mol Biol. 2018;430:2670-2676 pubmed publisher
    ..Tyrosyl-tRNA synthetase (TyrRS) does not have such editing properties, but it shares weak stereospecificity in recognition of d-/l-tyrosine (Tyr)...
  4. Xiao Z, Wei W, Wang P, Shi W, Zhu N, Xie M, et al. Synthesis and evaluation of new tyrosyl-tRNA synthetase inhibitors as antibacterial agents based on a N2-(arylacetyl)glycinanilide scaffold. Eur J Med Chem. 2015;102:631-8 pubmed publisher
    Tyrosyl-tRNA synthetase (TyrRS), an essential enzyme in bacterial protein biosynthesis, is an attractive therapeutic target for finding novel antibacterial agents, and a series of N2-(arylacetyl)glycinanilides has been herein synthesized ..
  5. Kunjapur A, Stork D, Kuru E, Vargas Rodriguez O, Landon M, Soll D, et al. Engineering posttranslational proofreading to discriminate nonstandard amino acids. Proc Natl Acad Sci U S A. 2018;115:619-624 pubmed publisher
    ..proofreading system to further evolve a Methanocaldococcus jannaschii tyrosyl-tRNA synthetase (TyrRS) variant and a tRNATyr species for improved specificity of the nsAA biphenylalanine in vitro and in ..
  6. Thomas F, Guergueltcheva V, Gondim F, Tournev I, Rao C, Ishpekova B, et al. Clinical, neurophysiological and morphological study of dominant intermediate Charcot-Marie-Tooth type C neuropathy. J Neurol. 2016;263:467-76 pubmed publisher
    Dominant intermediate Charcot-Marie-Tooth neuropathy subtype C (DI-CMTC) was associated with mutations in the YARS gene, encoding tyrosyl-tRNA synthetase, in two large unrelated Bulgarian and US pedigrees and one sporadic case...
  7. Italia J, Latour C, Wrobel C, Chatterjee A. Resurrecting the Bacterial Tyrosyl-tRNA Synthetase/tRNA Pair for Expanding the Genetic Code of Both E. coli and Eukaryotes. Cell Chem Biol. 2018;25:1304-1312.e5 pubmed publisher
    The bacteria-derived tyrosyl-tRNA synthetase (TyrRS)/tRNA pair was first used for unnatural amino acid (Uaa) mutagenesis in eukaryotic cells over 15 years ago...
  8. Roccatello D, Sciascia S, Baldovino S, Rossi D, Alpa M, Naretto C, et al. A 4-year observation in lupus nephritis patients treated with an intensified B-lymphocyte depletion without immunosuppressive maintenance treatment-Clinical response compared to literature and immunological re-assessment. Autoimmun Rev. 2015;14:1123-30 pubmed publisher
    ..Twelve patients with SLE [3 males, mean age 43.8 yrs (25-55)] with severe multiorgan involvement all including kidney (3 patients with Class IV, 4 with Class III/V and ..
  9. Wei W, Liu Q, Li Z, Shi W, Fu X, Liu J, et al. Synthesis and evaluation of adenosine containing 3-arylfuran-2(5H)-ones as tyrosyl-tRNA synthetase inhibitors. Eur J Med Chem. 2017;133:62-68 pubmed publisher
    Tyrosyl-tRNA synthetase (TyrRS) is an aminoacyl-tRNA synthetase family protein that possesses an essential role in bacterial protein synthesis...
  10. Chen L, Wang P, Tang D, Tao X, Man R, Qiu H, et al. Metronidazole containing pyrazole derivatives potently inhibit tyrosyl-tRNA synthetase: design, synthesis, and biological evaluation. Chem Biol Drug Des. 2016;88:592-8 pubmed publisher
    As an important enzyme in bacterial protein biosynthesis, tyrosyl-tRNA synthetase (TyrRS) has been an absorbing therapeutic target for exploring novel antibacterial agents...
  11. Wolffenbuttel B, Wouters H, Slagter S, van Waateringe R, Muller Kobold A, van Vliet Ostaptchouk J, et al. Thyroid function and metabolic syndrome in the population-based LifeLines cohort study. BMC Endocr Disord. 2017;17:65 pubmed publisher
    ..At similar TSH levels and age (mean 45 yrs), men had significantly higher levels of FT4, FT3, blood pressure (BP), heart rate, total and LDL-cholesterol, ..
  12. Laird E, Casey M, Ward M, Hoey L, Hughes C, McCarroll K, et al. Dairy Intakes in Older Irish Adults and Effects on Vitamin Micronutrient Status: Data from the TUDA Study. J Nutr Health Aging. 2017;21:954-961 pubmed publisher
    ..from the Trinity Ulster Department of Agriculture (TUDA) Study, a large study of older Irish adults (aged >60 yrs) designed to investigate gene-nutrient interactions in the development of chronic diseases of aging...
  13. Marrodán M, Correale J, Alessandro L, Amaya M, Fracaro M, Köhler A, et al. Susac Syndrome: A differential diagnosis of white matter lesions. Mult Scler Relat Disord. 2017;15:42-46 pubmed publisher
    ..The majority of patients were males, and average age at diagnosis was 37.5 years (range: 22-52 yrs)...
  14. Barcza Stockler Pinto M, Carrero J, De Carvalho Cardoso Weide L, Franciscato Cozzolino S, Mafra D. EFFECT OF SELENIUM SUPPLEMENTATION VIA BRAZIL NUT (BERTHOLLETIA EXCELSA, HBK) ON THYROID HORMONES LEVELS IN HEMODIALYSIS PATIENTS: A PILOT STUDY. Nutr Hosp. 2015;32:1808-12 pubmed publisher
    ..we performed an uncontrolled intervention with 40 HD patients (53.3 ± 16.1 yrs, dialysis vintage 62.0 (8.0 - 207.0) months) that received one nut (≈5g, average 58...
  15. Casas Tintó S, Lolo F, Moreno E. Active JNK-dependent secretion of Drosophila Tyrosyl-tRNA synthetase by loser cells recruits haemocytes during cell competition. Nat Commun. 2015;6:10022 pubmed publisher
    ..Here we show that apoptotic loser cells secrete Tyrosyl-tRNA synthetase (TyrRS), which is best known as a core component of the translational machinery...
  16. Anderst W, Gale T, LeVasseur C, Raj S, Gongaware K, Schneider M. Intervertebral kinematics of the cervical spine before, during, and after high-velocity low-amplitude manipulation. Spine J. 2018;18:2333-2342 pubmed publisher
    ..This provides a basis for future clinical trials to identify the mechanisms behind manipulation and to optimize the mechanical factors that reliably and sufficiently impact the key mechanisms behind manipulation. ..
  17. López Sánchez G, Radzimiński Ł, Skalska M, Jastrzębska J, Smith L, Wakuluk D, et al. Body Composition, Physical Fitness, Physical Activity and Nutrition in Polish and Spanish Male Students of Sports Sciences: Differences and Correlations. Int J Environ Res Public Health. 2019;16: pubmed publisher
    ..Polish males were on average 21.5 ± 1.9 yrs old and Spanish males 21.5 ± 2.5...
  18. Allister Price C, Craig C, Spielman D, Cushman S, McLaughlin T. Metabolic markers, regional adiposity, and adipose cell size: relationship to insulin resistance in African-American as compared with Caucasian women. Int J Obes (Lond). 2018;: pubmed publisher
    ..0 yrs) and body mass index (BMI) (mean = 30 kg/m2), underwent a steady-state plasma glucose test to ..
  19. Kaida A, Dietrich J, Laher F, Beksinska M, Jaggernath M, Bardsley M, et al. A high burden of asymptomatic genital tract infections undermines the syndromic management approach among adolescents and young adults in South Africa: implications for HIV prevention efforts. BMC Infect Dis. 2018;18:499 pubmed publisher
    ..Interviewer-administered surveys assessed socio-demographics, behaviors, and GTI symptoms among 352 youth (16-24 yrs., HIV-negative or unknown HIV status at enrollment) enrolled in community-based cohorts in Durban and Soweto (2014-..
  20. Valsamakis G, Papatheodorou D, Chalarakis N, Vrachnis N, Sidiropoulou E, Manolikaki M, et al. In pregnancy increased maternal STAI trait stress score shows decreased insulin sensitivity and increased stress hormones. Psychoneuroendocrinology. 2017;84:11-16 pubmed publisher
    ..Eighty-two pregnant women [aged 27.1±2.5 (mean±SD) yrs; BMI=25±2...
  21. Kloth S, Baur X, Göen T, Budnik L. Accidental exposure to gas emissions from transit goods treated for pest control. Environ Health. 2014;13:110 pubmed publisher
    ..Patients (n=6, aged from 32-54 yrs.) and control group (n=30, mean 40 yrs.) donated blood and urine samples...
  22. Toro C, Hori R, Malicdan M, Tifft C, Goldstein A, Gahl W, et al. A recurrent de novo missense mutation in UBTF causes developmental neuroregression. Hum Mol Genet. 2018;27:691-705 pubmed publisher
    ..Our data underscore the importance of including UBTF E210K in the differential diagnosis of neuroregression and suggest that mainly gain-of-function mechanisms contribute to the pathogenesis of the UBTF E210K neuroregression syndrome. ..
  23. Jagoda L, Giroud N, Neff P, Kegel A, Kleinjung T, Meyer M. Speech perception in tinnitus is related to individual distress level - A neurophysiological study. Hear Res. 2018;367:48-58 pubmed publisher
    ..We examined a sample of individuals with chronic, subjective tinnitus (n?=?30, age range 30-50?yrs.), who underwent behavioural screening (standard tinnitus questionnaires) and comprehensive audiometric testing ..
  24. Yağmur G, Albayrak N, Daş T, Yıldırım M, Ozgün A, Büyük Y. [Comparison of two different real-time PCR systems in postmortem diagnosis of tuberculosis in paraffin-embedded tissues]. Mikrobiyol Bul. 2014;48:577-84 pubmed
    ..caseous pneumonia, necrotic fibrous nodul) obtained from 37 autopsy cases (31 male, 6 female; age range: 25-85 yrs) were included in the study...
  25. Kimando M, Otieno F, Ogola E, Mutai K. Adequacy of control of cardiovascular risk factors in ambulatory patients with type 2 diabetes attending diabetes out-patients clinic at a county hospital, Kenya. BMC Endocr Disord. 2017;17:73 pubmed publisher
    ..However, old age above 50 yrs., longer duration with diabetes above 5 yrs...
  26. Pang H, Han B, Fu Q, Zong Z. Association of High Homocysteine Levels With the Risk Stratification in Hypertensive Patients at Risk of Stroke. Clin Ther. 2016;38:1184-92 pubmed publisher
    ..After the stratification of risk factors, a statistical difference was noted in age (range, 45-74 yrs), glucose ranges (<6.1 and ?7...
  27. Sreckovic B, Sreckovic V, Soldatovic I, Colak E, Sumarac Dumanovic M, Janeski H, et al. Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes Metab Syndr. 2017;11:179-182 pubmed publisher
    ..The study included obese and overweight individuals, aged of 30-75 yrs. classified into two groups: with MS (n=35) and without MS (n=41)...
  28. Haun C, Mobley C, Vann C, Romero M, Roberson P, Mumford P, et al. Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training. Sci Rep. 2018;8:11151 pubmed publisher
    ..signaling markers in subcutaneous (SQ) adipose tissue of previously untrained, college-aged men (n?=?47, 20?±?1?yrs) that resistance trained for 12 weeks...
  29. Shridhar K, Dhillon P, Bowen L, Kinra S, Bharathi A, Prabhakaran D, et al. Nutritional profile of Indian vegetarian diets--the Indian Migration Study (IMS). Nutr J. 2014;13:55 pubmed publisher
    ..Study participants included urban migrants, their rural siblings and urban residents (n = 6555, mean age - 40.9 yrs) of the Indian Migration Study from Lucknow, Nagpur, Hyderabad and Bangalore...
  30. Sexty R, Hamadneh J, Rösner S, Strowitzki T, Ditzen B, Toth B, et al. Cross-cultural comparison of fertility specific quality of life in German, Hungarian and Jordanian couples attending a fertility center. Health Qual Life Outcomes. 2016;14:27 pubmed publisher
    ..Jordanian couples had the shortest relationship (5.8 ± 4.3 yrs.), though they reported the longest duration of child wish (4.2 ± 3.6 yrs.) and fertility treatments (3.0 ± 3...
  31. Hennis P, Mitchell K, Gilbert Kawai E, Bountziouka V, Wade A, Feelisch M, et al. Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp. Nitric Oxide. 2016;60:24-31 pubmed publisher
    ..Forty healthy male students (mean age (SD): 16 (1) yrs) trekked to EBC over 11 days...
  32. Sims D, Onambele Pearson G, Burden A, Payton C, Morse C. Specific force of the vastus lateralis in adults with Achondroplasia. J Appl Physiol (1985). 2017;:jap.00638.2017 pubmed publisher
    ..of this study was to assess specific force of the vastus lateralis (VL) in 10 adults with Achondroplasia (22 ±3 yrs) and 18 gender matched controls (22 ±2 yrs)...
  33. Li F, Liu B, Yin G, Zhang D, Zhai X, Chen M, et al. Young onset type 2 diabetic patients might be more sensitive to metformin compared to late onset type 2 diabetic patients. Sci Rep. 2017;7:16382 pubmed publisher
    ..We included 36 YOD (age?<?40 yrs) and 152 LOD (age?>?40 yrs) patients...
  34. Sutton Traina K, Smith J, Jarvis D, Lee S, Kulig K. Exploring Active and Passive Contributors to Turnout in Dancers and Non-Dancers. Med Probl Perform Art. 2015;30:78-83 pubmed publisher
    ..Cross-sectional cohort study. Twenty-three female dancers and 13 female non-dancers aged 18 to 30 yrs were recruited...
  35. Pilling L, Joehanes R, Melzer D, Harries L, Henley W, Dupuis J, et al. Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol. 2015;70:37-45 pubmed publisher
    ..Blood derived in-vivo RNA from the Framingham Heart Study (FHS, n=2422, ages 40-92 yrs) and InCHIANTI study (n=694, ages 30-104 yrs), with Affymetrix and Illumina expression arrays respectively (>17,..
  36. Elshafie A, Elkhalifa A, Elbagir S, Aledrissy M, Elagib E, Nur M, et al. Active Rheumatoid Arthritis in Central Africa: A Comparative Study Between Sudan and Sweden. J Rheumatol. 2016;43:1777-1786 pubmed
    ..Sudanese patients had lower inclusion age (median 49 vs 68 yrs), disease duration (48 vs 107 mos), and disease onset age (43 vs 56 yrs) as compared with Swedish patients (p < ..
  37. He M, Driehuys B, Que L, Huang Y. Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution. Acad Radiol. 2016;23:1521-1531 pubmed publisher
    ..2 years) and 10 older (62.2 ± 7.2 years) healthy individuals, as well as in 9 younger (25.9 ± 6.4 yrs) and 10 older (63.2 ± 6.1 years) asthmatics...
  38. Genton L, Herrmann F, Spörri A, Graf C. Association of mortality and phase angle measured by different bioelectrical impedance analysis (BIA) devices. Clin Nutr. 2018;37:1066-1069 pubmed publisher
    ..This study encompasses all people 65 yrs and older who underwent a phase angle measurement between 1990 and 2011 at the Geneva University Hospitals, with ..
  39. Santos Morales O, Díaz Machado A, Jiménez Rodríguez D, Pomares Iturralde Y, Festary Casanovas T, González Delgado C, et al. Nasal administration of the neuroprotective candidate NeuroEPO to healthy volunteers: a randomized, parallel, open-label safety study. BMC Neurol. 2017;17:129 pubmed publisher
    ..Twenty-five volunteers, 56% women, with a mean age of 27 yrs. were included. Twelve of them received the highest NeuroEPO dose...
  40. Wang X, Jin X, Blizzard L, Antony B, Han W, Zhu Z, et al. Associations Between Knee Effusion-synovitis and Joint Structural Changes in Patients with Knee Osteoarthritis. J Rheumatol. 2017;44:1644-1651 pubmed publisher
    ..A posthoc analysis using data from a randomized controlled trial in 413 patients with symptomatic OA (aged 63 ± 7 yrs, 208 women)...
  41. Corli J, Flipo R, Philippe P, Bera Louville A, Béhal H, Wibaux C, et al. Tumor Necrosis Factor-α Inhibition in Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis: Treatment Response, Drug Survival, and Patient Outcome. J Rheumatol. 2015;42:2376-82 pubmed publisher
    ..02% vs 45.92%, p = 0.001) and had longer symptom duration (11.71 ± 9.52 vs 7.34 ± 9.30 yrs, p < 0.001)...
  42. Rauch B, Porter J, Mehl R, Perona J. Improved Incorporation of Noncanonical Amino Acids by an Engineered tRNA(Tyr) Suppressor. Biochemistry. 2016;55:618-28 pubmed publisher
    The Methanocaldcoccus jannaschii tyrosyl-tRNA synthetase (TyrRS):tRNA(Tyr) cognate pair has been used to incorporate a large number of noncanonical amino acids (ncAAs) into recombinant proteins in Escherichia coli...
  43. Veissi M, Anari R, Amani R, Shahbazian H, Latifi S. Mediterranean diet and metabolic syndrome prevalence in type 2 diabetes patients in Ahvaz, southwest of Iran. Diabetes Metab Syndr. 2016;10:S26-9 pubmed publisher
    ..3±9.6 yrs). Fasting glucose and lipid profile were measured...
  44. Bajaj J, White M, Unser A, Ganapathy D, Fagan A, Gavis E, et al. Cirrhotic patients have good insight into their daily functional impairment despite prior hepatic encephalopathy: comparison with PROMIS norms. Metab Brain Dis. 2016;31:1199-203 pubmed publisher
    ..Comparisons between HE/no-HE were also performed. 203 cirrhotic patients (57 yrs., 62 % men, MELD 12, 83 HE) were included. All HE patients were controlled on therapy...
  45. Hinojosa Azaola A, Romero Díaz J, Vargas Ruiz A, Nuñez Alvarez C, Cicero Casarrubias A, Ocampo Torres M, et al. Venous and Arterial Thrombotic Events in Systemic Lupus Erythematosus. J Rheumatol. 2016;43:576-86 pubmed publisher
    ..03). Patients with ATE were older (median age 44 vs 29 yrs, p = 0...
  46. Furuta S, Chaudhry A, Arimura Y, Dobashi H, Fujimoto S, Homma S, et al. Comparison of the Phenotype and Outcome of Granulomatosis with Polyangiitis Between UK and Japanese Cohorts. J Rheumatol. 2017;44:216-222 pubmed publisher
    ..Median age at onset was higher in Japan than in the UK (62.2 yrs vs 57.5 yrs, p < 0.01)...
  47. Horie S, Takahashi Y, Shishido T, Masaoka T, Tateiwa T, Yamamoto K. The aging micromechanisms of alumina matrix composite (AMC) used in total hip arthroplasty. J Orthop Sci. 2017;22:524-530 pubmed publisher
    ..According to ASTM standard, 1-h aging under these conditions corresponds approximately to 2 yrs in vivo exposure...
  48. Braimah I, Dumpala S, Chhablani J. OUTER RETINAL TUBULATION IN RETINAL DYSTROPHIES. Retina. 2017;37:578-584 pubmed publisher
    ..ORT was detected in 12 eyes of 8 patients (unilateral in 4 eyes). Their mean age was 42.5 ± 13.89 yrs. (range, 21-60 yrs.), the mean baseline best corrected visual acuity was 0.425 ± 0...
  49. Hamer M, Biddle S, Stamatakis E. Weekend warrior physical activity pattern and common mental disorder: a population wide study of 108,011 British adults. Int J Behav Nutr Phys Act. 2017;14:96 pubmed publisher
    ..Adult participants (n = 108,011, age = 47 ± 17 yrs., 46...
  50. Entwistle E, Romanowicz K, Argiroff W, Freedman Z, Morris J, Zak D. Anthropogenic N Deposition Alters the Composition of Expressed Class II Fungal Peroxidases. Appl Environ Microbiol. 2018;84: pubmed publisher
  51. Fernandes R, Ritti Dias R, Balagopal P, Conceição R, Santos R, Cucato G, et al. Self-initiated physical activity is associated with high sensitivity C-reactive protein: A longitudinal study in 5,030 adults. Atherosclerosis. 2018;273:131-135 pubmed publisher
    ..9 years (P25th 1.97 and P75th 4.37?yrs)...
  52. Newman R, Morini G, Ahsan F, Kidd G. Linguistically-based informational masking in preschool children. J Acoust Soc Am. 2015;138:EL93-8 pubmed publisher
    ..The authors tested adults, school-age children (aged 8 yrs), and preschool-age children (aged 4 yrs) on sentence recognition in the presence of normal speech, "jumbled" ..
  53. Rivière E, Arnaud L, Ebbo M, Allanore Y, Claudepierre P, Dernis E, et al. Takayasu Arteritis and Spondyloarthritis: Coincidence or Association? A Study of 14 Cases. J Rheumatol. 2017;44:1011-1017 pubmed publisher
    ..We included 14 patients (women: 10/14; median age at SpA diagnosis: 43.5 yrs, ranging from 19 to 63)...
  54. Tenorio L, Devine K, Lee J, Kowalewski T, Barocas V. Biomechanics of human parietal pleura in uniaxial extension. J Mech Behav Biomed Mater. 2017;75:330-335 pubmed publisher
    ..5 yrs) and BMI range (31 ± 5...
  55. Jaspers Fayer F, Lin S, Belschner L, Mah J, Chan E, Bleakley C, et al. A case-control study of sleep disturbances in pediatric obsessive-compulsive disorder. J Anxiety Disord. 2018;55:1-7 pubmed publisher
    ..Thirty OCD-affected youth (8-18 yrs, 40% male) and 30 age and gender-matched healthy controls (HCs) completed the Sleep Disturbances Scale for Children ..
  56. Dey S, Senapati A, Pandit A, Biswas A, Guin D, Joardar A, et al. Genetic and Clinical Profile of Patients of Duchenne Muscular Dystrophy: Experience from a Tertiary Care Center in Eastern India. Indian Pediatr. 2015;52:481-4 pubmed
    ..Mean age of onset of clinical symptoms was 3.9 yrs; Valley sign and calf hypertrophy were most consistent features, while about 51% had facial weakness...
  57. Agarwal S, Jawad A, Miller V. A multivariate model exploring the predictive value of demographic, adolescent, and family factors on glycemic control in adolescents with type 1 diabetes. Pediatr Diabetes. 2016;17:500-508 pubmed publisher
    ..Participants included 100 adolescents with T1D ages 10-16 yrs and their parents...
  58. Koenraads Y, Porro G, Braun K, Groenendaal F, de Vries L, van der Aa N. Prediction of visual field defects in newborn infants with perinatal arterial ischemic stroke using early MRI and DTI-based tractography of the optic radiation. Eur J Paediatr Neurol. 2016;20:309-318 pubmed publisher
    ..2 yrs) were included. Conventional T1-weighted MRI was used to assess asymmetry of the optic radiation (OR)...
  59. Chalmers R, Wagner H, Kinoshita B, Sorbara L, Mitchell G, Lam D, et al. Is purchasing lenses from the prescriber associated with better habits among soft contact lens wearers?. Cont Lens Anterior Eye. 2016;39:435-441 pubmed publisher
    ..Purchase sources were: ECP 646 (67%, 44±12 yrs, 17% male), Retail 104 (11%, 45±13 yrs, 28% male), and Internet/telephone 218 (23%, 45±12 yrs, 18% male); age (p=..
  60. Rehmani A, Judkins C, Whelan A, Nguyen M, Schultz C. Comparison of Safety and Efficacy of Unfractionated Heparin Versus Bivalirudin in Patients Undergoing Percutaneous Coronary Intervention. Heart Lung Circ. 2017;26:1277-1281 pubmed publisher
    ..The two groups were similar with respect to age, 62.5 SD 12.1 yrs vs. 62.8 SD 12.2 yrs, (p=0.575) female gender, 24% vs. 26% (p=0.10), current smokers, 66% vs. 70% (p=0...
  61. Nenna R, Midulla F, Lambiase C, De Castro G, Zicari A, Indinnimeo L, et al. Effects of inhaled hypertonic (7%) saline on lung function test in preschool children with cystic fibrosis: results of a crossover, randomized clinical trial. Ital J Pediatr. 2017;43:60 pubmed publisher
    ..Twelve CF children (6M, mean age ± SD: 5.7 ± 0.8 yrs) were enrolled and randomly assigned to receive hypertonic saline (HS-4 ml 7% sodium chloride), or normal saline (..
  62. Costacou T, Orchard T, Moon C, Bae K, Fried L, Evans R. Is MRI Detection of Kidney Iron Deposition Increased in Haptoglobin 2-2 Genotype Carriers with Type 1 Diabetes?. Antioxid Redox Signal. 2018;: pubmed publisher
    ..level in the cortex and medullar of type 1 diabetes adults (15 Hp 1-1 and 15 Hp 2-2 carriers of similar age (53 yrs), duration (45 yrs) and sex). Total kidney iron level was estimated as the sum of the cortex and medullar iron...
  63. Crush E, Frith E, Loprinzi P. Experimental effects of acute exercise duration and exercise recovery on mood state. J Affect Disord. 2018;229:282-287 pubmed publisher
    ..Participants (N = 352; 22 per group; young [Mage = 21 yrs] healthy adults) were randomized into one of 16 experimental groups: 10, 20, 30, 45 or 60min bout of exercise ..
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    ..6 ± 10.7 yrs, mean disease duration 8.9 ± 7.8 yrs) and 72 for extrarenal manifestations (mean age 38.6 ± 11...
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    ..Experimental. University biomechanics laboratory. Twenty three healthy female runners (Age: 22.17 ± 1.64 yrs; Height: 168.91 ± 5.46 cm; Mass: 64.29 ± 7.11 kg)...
  66. Hamer M, Aggio D, Knock G, Kipps C, Shankar A, Smith L. Effect of major school playground reconstruction on physical activity and sedentary behaviour: Camden active spaces. BMC Public Health. 2017;17:552 pubmed publisher
    ..6, 95% CI, 0.3, 48.9 min/d, p = 0.047) for children aged under 9 yrs. old in the intervention...
  67. Nagamine M, Noguchi H, Takahashi N, Kim Y, Matsuoka Y. Effect of cortisol diurnal rhythm on emotional memory in healthy young adults. Sci Rep. 2017;7:10158 pubmed publisher
    ..Participants included healthy volunteers (44 men and 23 women; mean age 20.60 yrs)...
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    ..A genome-wide association study (GWAS) was performed in a discovery cohort of 4134 persons (58% females; age 46-68 yrs), linking SNPs to fasting hs-GH. Fifteen SNPs were replicated in an independent cohort of 5262 persons (28...
  69. Römkens T, Te Morsche R, Peters W, Burger D, Hoentjen F, Drenth J. Urinalysis of MMX-mesalazine as a tool to monitor 5-ASA adherence in daily IBD practice. Br J Clin Pharmacol. 2017;: pubmed publisher
    ..Twenty-nine patients (51.7% male, mean age 52 ± 11 yrs) were included (median FU 9 months) and collected weekly spot urine samples...
  70. Raymond C, Dengel D, Bosch T. Total And Segmental Body Composition Examination In Collegiate Football Players Using Multifrequency Bia And Dxa. J Strength Cond Res. 2017;: pubmed publisher
    ..Forty-four male collegiate athletes (age=19±1 yrs; height=1.9±1.0 m; weight=106.4±18.8 kg) participated...
  71. Baadjou V, Verbunt J, VAN Eijsden Besseling M, Huysmans S, Smeets R. The Musician as (In)Active Athlete?: Exploring the Association Between Physical Activity and Musculoskeletal Complaints in Music Students. Med Probl Perform Art. 2015;30:231-7 pubmed publisher
    ..Participants were 132 students, 63.6% female, with a median age of 23 yrs (range 21.3-25.0). 67% reported musculoskeletal complaints in the past 7 days...
  72. Wei Z, Xu Z, Liu X, Lo W, Ye F, Lau C, et al. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase. Nucleic Acids Res. 2016;44:1247-55 pubmed publisher
    ..we report analysis of two closely related, internally deleted, SVs of homodimeric human tyrosyl-tRNA synthetase (TyrRS)...
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    ..The age (65.8 ± 9.8 vs. 65.8 ± 12.1 yrs) and mean brachial SBP (141 ± 16 vs. 141 ± 17 mmHg) were similar between the DM and non-DM groups...
  74. Kumar G, Chhabra A, Dewan V, Yadav T. Idiopathic musculoskeletal pain in Indian children-Prevalence and impact on daily routine. Rev Bras Reumatol Engl Ed. 2017;57:8-14 pubmed publisher
    ..1%), headache (47.3%) and abdominal pain (24.8%). Prevalence of IMSP in school children aged 5-16 yrs was found to be 16...
  75. Barillas S, Watkins C, Wong M, Dobbs I, Archer D, Munger C, et al. Repeated Plyometric Exercise Attenuates Blood Glucose in Healthy Adults. Int J Exerc Sci. 2017;10:1076-1084 pubmed
    ..Thirteen subjects (6 females age= 21.8 ± 1.0 yrs.; height= 163.7 ± 7.8 cm; mass= 60.8 ± 6.7 kg and 7 males age= 22.0 ± 2.6 yrs.; height= 182.3 ± 3...
  76. Cho S, Khan A, Jee S, Lee H, Hwang M, Koo Y, et al. High resolution metabolomics to determines the risk associated with bisphenol A exposure in humans. Environ Toxicol Pharmacol. 2018;58:1-10 pubmed publisher
    ..Fatty acid elongation and sphingolipid metabolism were further investigated among age groups consisted of 30-39?yrs old, 40-49?yrs old, and 50-59?yrs old males and females with high or low urinary BPA...
  77. Wakasugi K, Schimmel P. Two distinct cytokines released from a human aminoacyl-tRNA synthetase. Science. 1999;284:147-51 pubmed
    ..Secretion of this tRNA synthetase may contribute to apoptosis both by arresting translation and producing needed cytokines. ..
  78. Foppa I, Cheng P, Reynolds S, Shay D, Carias C, Bresee J, et al. Deaths averted by influenza vaccination in the U.S. during the seasons 2005/06 through 2013/14. Vaccine. 2015;33:3003-9 pubmed publisher
    ..5 to 4, 5 to 19, 20 to 64 and ≥65 yrs.) for the nine influenza seasons from 2005/6 through 2013/14...
  79. Vellers H, Irwin C, Lightfoot J. Heart Rate Response of Professional Musicians When Playing Music. Med Probl Perform Art. 2015;30:100-5 pubmed publisher
    ..HR response was monitored in 27 professional musicians (3 women, 24 men) between the ages of 21 and 67 yrs old during rehearsal and public performances...
  80. Beare R, Adamson C, Bellgrove M, Vilgis V, Vance A, Seal M, et al. Altered structural connectivity in ADHD: a network based analysis. Brain Imaging Behav. 2017;11:846-858 pubmed publisher
    ..3 ± 1.9 yrs) and 21 typically developing boys (m 14.8 ± 2.1 yrs)...
  81. Hauschild V, Schuh A, Taylor B, Canham Chervak M, Jones B. Identification of specific activities associated with fall-related injuries, active component, U.S. Army, 2011. MSMR. 2016;23:2-9 pubmed
    ..20 per 1,000 non-deployed person-years [p-yrs], 2.21 per 1,000 deployed p-yrs, respectively)...
  82. Buddhadev H, Martin P. Effects of age and physical activity status on redistribution of joint work during walking. Gait Posture. 2016;50:131-136 pubmed publisher
    ..We recruited 18 young (18-35 yrs) and 17 older (65-80 yrs) physically active and sedentary adults...
  83. Srivatsa U, Swaminathan K, Sithy Athiya Munavarah K, Amsterdam E, Shantaraman K. Sudden cardiac death in South India: Incidence, risk factors and pathology. Indian Pacing Electrophysiol J. 2016;16:121-125 pubmed publisher
    ..During a two year period, 223 patients (mean age 55 + 10 yrs, 78...
  84. Goldstone A, Jensen C, Bilbao M, Woo Y. Autograft Valve-Sparing Root Replacement for Late Ross Failure during Quadruple-Valve Surgery. Ann Thorac Cardiovasc Surg. 2017;23:313-315 pubmed publisher
    Approximately 25% of patients require reoperation within 15 yrs of a Ross procedure. Increasing experience with valve-sparing root replacement (VSRR) has led some surgeons to spare the autograft valve...
  85. Ewing Cobbs L, Prasad M, Cox C, Granger D, Duque G, Swank P. Altered stress system reactivity after pediatric injury: Relation with post-traumatic stress symptoms. Psychoneuroendocrinology. 2017;84:66-75 pubmed publisher
    ..Participants were 8-15 years of age and hospitalized for traumatic brain injury (TBI; n=55; M age=13.9 yrs; 40 males) or extracranial injury (EI; n=29; M age 12.3 yrs, 20 males) following vehicular accidents...
  86. Eraj S, Jomaa M, Rock C, Mohamed A, Smith B, Smith J, et al. Long-term patient reported outcomes following radiation therapy for oropharyngeal cancer: cross-sectional assessment of a prospective symptom survey in patients ?65 years old. Radiat Oncol. 2017;12:150 pubmed publisher
    ..Median age at RT was 71 yrs. (range: 65-85); median time from RT to MDASI-HN was 46 mos. (2/3 > 24 mos.)...
  87. Moryl N, Dave V, Glare P, Bokhari A, Malhotra V, Gulati A, et al. Patient-Reported Outcomes and Opioid Use by Outpatient Cancer Patients. J Pain. 2018;19:278-290 pubmed publisher
    ..Consideration of sex and age as predictors of opioid use is critical in attempting to understand PROs and their relationship to pain management. ..
  88. Ewalt K, Schimmel P. Activation of angiogenic signaling pathways by two human tRNA synthetases. Biochemistry. 2002;41:13344-9 pubmed
    ..Thus, these tRNA synthetases link translation to a major cell-signaling pathway in mammalian cells. The results with animals suggest that therapeutic applications are possible with these tRNA synthetases. ..
  89. Francica G, Meloni M, de Sio I, Terracciano F, Caturelli E, Riccardi L, et al. Biopsy of Liver Target Lesions under Contrast-Enhanced Ultrasound Guidance - A Multi-Center Study. Ultraschall Med. 2017;: pubmed publisher
    ..b>Results?CEUS-guided biopsy of LTLs was carried out in 103 patients (68?M/35 F, median age: 69 yrs) with 103 liver target lesions (median size: 20?mm) using cutting needles (18?-?20?g) in 94 cases (91.2?%)...
  90. Goubert L, Francken G, Crombez G, Vansteenwegen D, Lysens R. Exposure to physical movement in chronic back pain patients: no evidence for generalization across different movements. Behav Res Ther. 2002;40:415-29 pubmed
    ..Thirty-nine patients (11 male, 28 female; mean age=43.49 yrs) were requested to perform two movements twice, i.e. bending forward and straight leg raising...
  91. Schmucker J, Seide S, Wienbergen H, Fiehn E, Stehmeier J, Gunther K, et al. Socially disadvantaged city districts show a higher incidence of acute ST-elevation myocardial infarctions with elevated cardiovascular risk factors and worse prognosis. BMC Cardiovasc Disord. 2017;17:254 pubmed publisher
    ..63, men IRR 1.54) and was most prominent in inhabitants <50 yrs. of age (women IRR 2.18, men IRR 2.17). Smoking (OR 1.7, 95%CI 1.3-2.4) and obesity (1.6, 95%CI 1.1-2...
  92. Yang Q, Xu W, Guo W, Cui W, Li Y, Wang X, et al. [A retrospective analysis of CO(2) laser and microdebrider for the treatment of severe juvenile on-set recurrent respiratory papillomatosis]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2017;52:733-737 pubmed publisher
    ..experience of RRP treatment in a group of patients with relatively short recurrence-free-interval (>4 times/yrs) was reported...