XRCC1

Summary

Gene Symbol: XRCC1
Description: X-ray repair complementing defective repair in Chinese hamster cells 1
Alias: RCC, X-ray repair cross-complementing protein 1
Species: human

Top Publications

  1. pmc XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
    M Masson
    UPR 9003 du Centre National de la Recherche Scientifique, Cancerogenese et Mutagenese Moleculaire et Structurale, Ecole Superieure de Biotechnologie de Strasbourg, 67400 Illkirch Graffenstaden, France
    Mol Cell Biol 18:3563-71. 1998
  2. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
  3. ncbi The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks
    Joanna I Loizou
    Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, United Kingdom
    Cell 117:17-28. 2004
  4. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
  5. ncbi Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
    M R Shen
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Res 58:604-8. 1998
  6. pmc X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis
    Ya Li
    Division of Reproductive Medical Center, West China Second University Hospital of Sichuan University, Chengdu, Sichuan Province, People s Republic of China
    PLoS ONE 7:e44441. 2012
  7. pmc X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis
    Libing Wang
    Department of Hematology, Second Military Medical University, Changhai Hospital, Shanghai, China
    PLoS ONE 7:e34897. 2012
  8. doi XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis
    B Wei
    Department of Urology, Affiliated Wuxi People s Hospital of Nanjing Medical University, Wuxi, China
    Prostate Cancer Prostatic Dis 14:225-31. 2011
  9. ncbi DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
  10. ncbi Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma
    Bingtao Hao
    Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Cancer Res 64:4378-84. 2004

Detail Information

Publications343 found, 100 shown here

  1. pmc XRCC1 is specifically associated with poly(ADP-ribose) polymerase and negatively regulates its activity following DNA damage
    M Masson
    UPR 9003 du Centre National de la Recherche Scientifique, Cancerogenese et Mutagenese Moleculaire et Structurale, Ecole Superieure de Biotechnologie de Strasbourg, 67400 Illkirch Graffenstaden, France
    Mol Cell Biol 18:3563-71. 1998
    ..We have identified a physical association between PARP and the base excision repair (BER) protein XRCC1 (X-ray repair cross-complementing 1) in the Saccharomyces cerevisiae system, which was further confirmed to exist ..
  2. ncbi Genetic polymorphisms in the base excision repair pathway and cancer risk: a HuGE review
    Rayjean J Hung
    Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 162:925-42. 2005
    ..glycosylase (OGG1), apurinic/apyrimidinic endonuclease (APE1/APEX1), and x-ray repair cross-complementing group 1 (XRCC1). They found increased lung cancer risk among subjects carrying the OGG1 Cys/Cys genotype (odds ratio (OR) = 1...
  3. ncbi The protein kinase CK2 facilitates repair of chromosomal DNA single-strand breaks
    Joanna I Loizou
    Genome Damage and Stability Centre, University of Sussex, Science Park Road, Falmer, Brighton BN1 9RQ, United Kingdom
    Cell 117:17-28. 2004
    ..We show that this essential protein kinase phosphorylates the scaffold protein XRCC1 and thereby enables the assembly and activity of DNA single-strand break repair protein complexes in vitro and at ..
  4. ncbi Polymorphisms of DNA repair genes and risk of non-small cell lung cancer
    Shanbeh Zienolddiny
    Department of Toxicology, National Institute of Occupational Health, Oslo, Norway
    Carcinogenesis 27:560-7. 2006
    ..NER) genes XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG; base excision repair (BER) genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, POLB, POLiota, LIG3 and EXO1; double-strand break repair (DSB-R) genes XRCC2, XRCC3, XRCC9, NBS1 and ATR; ..
  5. ncbi Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans
    M R Shen
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94550, USA
    Cancer Res 58:604-8. 1998
    ....
  6. pmc X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis
    Ya Li
    Division of Reproductive Medical Center, West China Second University Hospital of Sichuan University, Chengdu, Sichuan Province, People s Republic of China
    PLoS ONE 7:e44441. 2012
    Previous studies investigating the association between X-ray repair cross-complementation group 1(XRCC1) polymorphisms and cervical cancer (CC) risk has provided inconsistent results...
  7. pmc X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis
    Libing Wang
    Department of Hematology, Second Military Medical University, Changhai Hospital, Shanghai, China
    PLoS ONE 7:e34897. 2012
    Recently, there have been a number of studies on the association between XRCC1 polymorphisms and childhood acute lymphoblastic leukemia (ALL) risk. However, the results of previous reports are inconsistent...
  8. doi XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis
    B Wei
    Department of Urology, Affiliated Wuxi People s Hospital of Nanjing Medical University, Wuxi, China
    Prostate Cancer Prostatic Dis 14:225-31. 2011
    Epidemiological studies have evaluated the association between X-ray repair cross-complementing group 1 gene (XRCC1) Arg399Gln and Arg194Trp polymorphisms and risk of prostate cancer (PCa)...
  9. ncbi DNA repair polymorphisms and cancer risk in non-smokers in a cohort study
    G Matullo
    ISI Foundation and Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy
    Carcinogenesis 27:997-1007. 2006
    ..Among the many comparisons, few polymorphisms were associated with the diseases at the univariate analysis: XRCC1-399 Gln/Gln variant homozygotes [odds ratios (OR) = 2.20, 95% confidence intervals (CI) = 1.16-4...
  10. ncbi Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma
    Bingtao Hao
    Laboratory of Systems Biology, Beijing Institute of Radiation Medicine, Beijing, People s Republic of China
    Cancer Res 64:4378-84. 2004
    ..2 in the coding regions (ADPRT Val762Ala and MBD4 Glu346Lys) and others in noncoding regions (LIG3 A3704G and XRCC1 T-77C), remained as significant predictors for the risk of ESCC. The adjusted odd ratios were 1...
  11. ncbi Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand
    Suparp Kietthubthew
    Department of Stomatology, Faculty of Dentistry, Prince of Songkla University, Hatyai, Songkhla 90110, Thailand
    Int J Hyg Environ Health 209:21-9. 2006
    ..Nine known single nucleotide polymorphisms (SNPs) in five common DNA repair genes were investigated: XRCC1 (Arg194Trp and Arg399Gln); XRCC3 (Thr241Met); XPC (PAT and Lys939Gln); XPD (exon 6, and Lys751Gln); and MGMT (..
  12. pmc XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study
    Jennifer Zipprich
    Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
    J Carcinog 9:4. 2010
    b>XRCC1 is a scaffold protein involved in the early and late stages of Base Excision Repair (BER)...
  13. doi The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: a meta-analysis
    Jin Huang
    West China Hospital West China Medical School, Sichuan University, Chengdu, Sichuan, China
    Mol Biol Rep 38:4565-73. 2011
    The Arg194Trp polymorphism in the X-ray repair cross-complementing group 1 (XRCC1) gene has been proved to be in association with cancer risk in Chinese Mainland population, but a large number of studies have reported inconclusive ..
  14. doi Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis
    Bo Chen
    Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Chengdu 610041, Sichuan Province, China
    Mol Biol Rep 39:1305-13. 2012
    Studies investigating the association between X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and gastric cancer (GC) risk have reported conflicting results...
  15. doi Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures
    Mostafa Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran
    Breast Cancer Res Treat 115:137-44. 2009
    The X-ray repair cross-complementation group 1 (XRCC1) protein plays an important role in base excision repair. Several polymorphisms in the XRCC1 gene have been described, including Arg399Gln...
  16. ncbi Polymorphisms in XRCC1 and glutathione S-transferase genes and hepatitis B-related hepatocellular carcinoma
    Ming Whei Yu
    Graduate Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan
    J Natl Cancer Inst 95:1485-8. 2003
    ..An arginine (Arg)-to-glutamine (Gln) polymorphism at codon 399 in the XRCC1 gene is putatively associated with DNA damage...
  17. ncbi Polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population
    H Shen
    Department of Epidemiology and Statistics, School of Public Health, Nanjing Medical University, Nanjing, China
    Int J Cancer 88:601-6. 2000
    ..In the present study, we described an association between 2 polymorphisms of the DNA repair gene XRCC1 and risk of gastric cancer in a Chinese population...
  18. ncbi Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk
    Kim De Ruyck
    Department of Anatomy, Embryology, Histology and Medical Physics, Ghent University, Proeftuinstraat 86, B 9000 Gent, Belgium
    Mutat Res 631:101-10. 2007
    ..We investigated the association of 10 base-excision and nucleotide-excision repair gene polymorphisms (XRCC1 -77 T/C, Arg194Trp, Arg280His and Arg399Gln; APE1 Asp148Glu; OGG1 Ser326Cys; XPA -4 G/A; XPC PAT; XPD Asp312Asn ..
  19. ncbi The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
    Ivan Ahel
    Cancer Research UK, London Research Institute, Clare Hall Laboratories, South Mimms, Herts EN6 3LD, UK
    Nature 443:713-6. 2006
    ..Aprataxin associates with the DNA repair proteins XRCC1 and XRCC4, which are partners of DNA ligase III and ligase IV, respectively, suggestive of a role in DNA repair...
  20. pmc XRCC1 coordinates the initial and late stages of DNA abasic site repair through protein-protein interactions
    A E Vidal
    Departement de Radiobiologie et Radiopathologie, Commissariat a l Energie Atomique, UMR217 CNRS CEA, BP6, F 92265 Fontenay aux Roses, France
    EMBO J 20:6530-9. 2001
    ..APE1 therefore plays a central role in the base excision repair (BER) pathway. We report here that XRCC1, another essential protein involved in the maintenance of genome stability, physically interacts with APE1 and ..
  21. ncbi Polymorphisms in DNA base excision repair genes ADPRT and XRCC1 and risk of lung cancer
    Xuemei Zhang
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100 021, China
    Cancer Res 65:722-6. 2005
    Adenosine diphosphate ribosyl transferase (ADPRT) and X-ray repair cross-complementing 1 (XRCC1) are two major DNA base excision repair (BER) proteins and act interactively in stimulating and executing BER processes...
  22. ncbi Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells
    E J Duell
    Department of Cancer Cell Biology and Occupational Health Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Carcinogenesis 21:965-71. 2000
    ..variation in DNA repair genes is related to host DNA damage, we studied the association between polymorphisms in XRCC1 (codon 399) and ERCC2 (codon 751) and two markers of DNA damage, sister chromatid exchange (SCE) frequencies (n = ..
  23. doi Polymorphisms in XRCC1 and XPG and response to platinum-based chemotherapy in advanced non-small cell lung cancer patients
    Xinchen Sun
    Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China
    Lung Cancer 65:230-6. 2009
    ..polymorphisms (SNPs) in Xeroderma pigmentosum group G (XPG) and X-ray repair cross complementing group 1 (XRCC1) were associated with the tumor response in non-small cell lung cancer (NSCLC) patients treated with platinum-..
  24. ncbi XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair
    Anna Campalans
    Departement de Radiobiologie et Radiopathologie, CEA, UMR217 CNRS CEA, 18 route du Panorama, F 92265 Fontenay aux Roses, France
    DNA Repair (Amst) 4:826-35. 2005
    ..In mammalian cells, the XRCC1 protein, essential for the maintenance of genomic stability, is involved in both base excision and single-strand ..
  25. ncbi Association between polymorphisms in the DNA repair genes, XRCC1, APE1, and XPD and acute side effects of radiotherapy in breast cancer patients
    Jenny Chang-Claude
    Division of Clinical Epidemiology and Toxicology, German Cancer Research Center, Heidelberg, Germany
    Clin Cancer Res 11:4802-9. 2005
    ..We evaluated the association of six polymorphisms in the DNA repair genes: XRCC1 (Arg194Trp, Arg280His, and Arg399Gln), APE1 (Asp148Glu), and XPD (Lys751Gln and Asp312Asn), with the risk of acute ..
  26. ncbi XRCC1 polymorphisms and cancer risk: a meta-analysis of 38 case-control studies
    Zhibin Hu
    Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, 140 Hanzhong Road, 210029 Nanjing, China
    Cancer Epidemiol Biomarkers Prev 14:1810-8. 2005
    ..Arg194Trp, Arg280His, Arg399Gln) in the DNA base excision repair gene X-ray repair cross-complementing group 1 (XRCC1) have been implicated in cancer risk...
  27. pmc XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage
    Nicolas Levy
    Département Intégrité du Génome de l UMR 7175, CNRS, Ecole Superieure de Biotechnologie de Strasbourg, Boulevard S Brant, BP 10413, F 67412 Illkirch cedex, France
    Nucleic Acids Res 34:32-41. 2006
    The two BRCT domains (BRCT1 and BRCT2) of XRCC1 mediate a network of protein-protein interactions with several key factors of the DNA single-strand breaks (SSBs) and base damage repair pathways...
  28. ncbi Polymorphisms of the DNA repair genes XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp): relationship to breast cancer risk and familial predisposition to breast cancer
    A M Brewster
    Department of Clinical Cancer Prevention, University of Texas M D Anderson Cancer Center, Houston, TX 77230 1439, USA
    Breast Cancer Res Treat 95:73-80. 2006
    ..This population based case-control study examined the association between polymorphisms in XPD (Lys751Gln) and XRCC1 (Arg399Gln and Arg194Trp) genes, and breast cancer...
  29. doi Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients
    A V Khrunin
    Department of Molecular Bases of Human Genetics, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia
    Pharmacogenomics J 10:54-61. 2010
    ..Severe neutropenia was associated with the TP53 72 Pro/Pro, XPD 312 Asp/Asn and XRCC1 399 Arg/Arg genotypes...
  30. ncbi Genetic polymorphisms in base-excision repair pathway genes and risk of breast cancer
    Yawei Zhang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Rockville, Maryland, USA
    Cancer Epidemiol Biomarkers Prev 15:353-8. 2006
    ..We evaluated whether genetic variation in six BER pathway genes (XRCC1, ADPRT, APEX1, OGG1, LIG3, and MUTYH) is associated with breast cancer risk in two large population-based case-..
  31. doi Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population
    Tao Yuan
    Department of Hepato biliary Surgery, The Third Affiliated Hospital of Third Military Medical University, Chongqing, China
    Cancer Epidemiol 35:170-4. 2011
    ..single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum group D (XPD) and X-ray repair cross complement 1 (XRCC1) genes were genotyped in gastric cancer and control subjects in a population from Southwestern China for their ..
  32. doi XRCC1 genetic polymorphisms and bladder cancer susceptibility: a meta-analysis
    Chunyang Wang
    Tianjin Institute of Urological Surgery, Tianjin Medical University, Tianjin, China
    Urology 72:869-72. 2008
    To examine the association between three x-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms (Arg(194)Trp, Arg(280)His, and Arg(399)Gln) and bladder cancer susceptibility.
  33. doi Gastric cardia carcinoma is associated with the promoter -77T>C gene polymorphism of X-ray cross-complementing group 1 (XRCC1)
    Giovanni Corso
    Department of Human Pathology and Oncology, Section of General Surgery and Surgical Oncology, Translational Research Laboratory, University of Siena, Siena, Italy
    J Gastrointest Surg 13:2233-8. 2009
    X-ray repair cross complementing group 1 (XRCC1) is one of the major DNA repair proteins involved in the bas-excision repair pathway...
  34. doi XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case-control studies
    Liping Dai
    Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, China
    Mol Biol Rep 39:9535-47. 2012
    X-ray repair cross-complementing group 1 gene (XRCC1) has been implicated in risk for lung cancer. However, the results from different studies remain controversial...
  35. ncbi XRCC1 Arg399Gln gene polymorphism and breast cancer risk: a meta-analysis based on case-control studies
    Kusheng Wu
    Faculty of Preventive Medicine, Shantou University Medical College, Shantou, Guangdong, China
    Asian Pac J Cancer Prev 12:2237-43. 2011
    The Arg399Gln polymorphism in the XRCC1 DNA repair gene is likely to be involved with the development of breast cancer (BC). However, there have been inconsistent reports of association...
  36. doi XRCC1 genetic polymorphism Arg399Gln and prostate cancer risk: a meta-analysis
    Jian Geng
    Department of Oncology, Nanjing University School of Medicine, Jinling Hospital, Nanjing, Jiangsu, People s Republic of China
    Urology 74:648-53. 2009
    To evaluate the association between x-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and prostate cancer risk using a meta-analysis.
  37. ncbi Polymorphisms of DNA repair genes are risk factors for prostate cancer
    Hiroshi Hirata
    Department of Urology, Veterans Affairs Medical Center and University of California at San Francisco, 4150 Clement Street, San Francisco, CA 94121, United States
    Eur J Cancer 43:231-7. 2007
    ..and healthy controls were analyzed by PCR-RFLP to determine the genotypic frequency of three DNA repair genes (XRCC1, XPC and XRCC7)...
  38. doi A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk
    Tingjia Lao
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, Peoples Republic of China
    Mutagenesis 23:523-32. 2008
    To elucidate the role of X-ray repair cross-complementing group 1 (XRCC1) R399Q and R194W genotypes in bladder cancer risk, all available studies were considered in the present meta-analysis, with 4152 patients and 5372 controls for ..
  39. pmc An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III
    K W Caldecott
    Biology and Biotechnology Research Program, Lawrence Livermore National Laboratory, Livermore, California 94551 0808
    Mol Cell Biol 14:68-76. 1994
    b>XRCC1, the human gene that fully corrects the Chinese hamster ovary DNA repair mutant EM9, encodes a protein involved in the rejoining of DNA single-strand breaks that arise following treatment with alkylating agents or ionizing ..
  40. ncbi Lack of influence of XRCC1 and XPD gene polymorphisms on outcome of platinum-based chemotherapy for advanced non small cell lung cancers
    Cheng Yun Yao
    Department of Chemotherapy, Jiangsu Cancer Hospital and Research Institute, Nanjing, China
    Asian Pac J Cancer Prev 10:859-64. 2009
    ..This study was conducted to assess relationships between X-ray repair cross complementing group1 (XRCC1) and xeroderma pigmentosum group D (XPD) genetic polymorphisms and outcome in NSCLC patients.
  41. pmc Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage
    Ho Chul Kang
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 108:14103-8. 2011
    ..are either PARsylated or bind PAR including PAR polymerase-1, 2 (PARP1, 2), nucleolin, DNA ligase III, KU70, KU86, XRCC1, and histones...
  42. ncbi DNA-repair genetic polymorphisms and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003
    ..breast cancer risk is associated with four amino acid substitution variants in three DNA repair genes, including XRCC1 Arg194Trp and XRCC1 Arg399Gln in base excision repair, XRCC3 Thr241Met in homologous recombination repair, and ..
  43. ncbi Single nucleotide polymorphisms of DNA repair genes XRCC1 and XPD and its molecular mapping in Indian oral cancer
    Surya Ramachandran
    Department of Molecular Medicine, Regional Cancer Centre, Thiruvananthapuram 695 011, India
    Oral Oncol 42:350-62. 2006
    ..The distribution of single nucleotide polymorphisms (SNPs) in DNA repair genes XRCC1 and XPD in 110 oral carcinoma cases, 84 leukoplakia and 110 controls belonging to the Travancore South Indian ..
  44. pmc Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study
    Michelle R Roberts
    Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY 14214, USA
    Carcinogenesis 32:1223-30. 2011
    ..polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000, OGG1 rs1052133 and XRCC1 rs25487 and rs25486) and breast cancer risk, examining modification by smoking and alcohol consumption, using data ..
  45. ncbi Polymorphisms in three base excision repair genes and breast cancer risk in Thai women
    Suleeporn Sangrajrang
    Research Division, National Cancer Institute, Bangkok, 10400, Thailand
    Breast Cancer Res Treat 111:279-88. 2008
    ..possible associations between polymorphisms in three important BER genes (OGG1 Ser326Cys, APEX1 Asp148Glu, XRCC1 Arg194Trp, XRCC1 Arg280His, XRCC1 Arg399Gln) and breast cancer incidence in Thai women...
  46. pmc Functional capacity of XRCC1 protein variants identified in DNA repair-deficient Chinese hamster ovary cell lines and the human population
    Brian R Berquist
    Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA
    Nucleic Acids Res 38:5023-35. 2010
    b>XRCC1 operates as a scaffold protein in base excision repair, a pathway that copes with base and sugar damage in DNA...
  47. ncbi Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma
    Chun Chieh Chen
    Department of Family Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan
    Int J Epidemiol 34:1310-8. 2005
    ..We investigated the mechanisms underlying the inflammatory hepatocarcinogenesis by examining whether genetic variations in cytokines, antioxidant enzymes, and DNA repair genes affect the HCC risk...
  48. doi DNA repair gene hOGG1 codon 326 and XRCC1 codon 399 polymorphisms and bladder cancer risk in a Japanese population
    Katsuyuki Arizono
    Department of Public Health, Faculty of Medicine, University of Miyazaki, 5200 Kihara Kiyotake, Miyazaki, 889 1692 Japan
    Jpn J Clin Oncol 38:186-91. 2008
    ..Human oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing 1 (XRCC1) are enzyme genes of BER...
  49. ncbi From genotype to phenotype: correlating XRCC1 polymorphisms with mutagen sensitivity
    Yunfei Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    DNA Repair (Amst) 2:901-8. 2003
    ..damage, assessed by the mutagen sensitivity assay, with genotypes of the X-ray repair cross complementing group 1 (XRCC1) gene, which encodes for a base excision repair protein...
  50. pmc Association and interactions between DNA repair gene polymorphisms and adult glioma
    Yanhong Liu
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Epidemiol Biomarkers Prev 18:204-14. 2009
    ..In the single-locus analysis, six single-nucleotide polymorphisms [ERCC1 3' untranslated region (UTR), XRCC1 R399Q, APEX1 E148D, PARP1 A762V, MGMT F84L, and LIG1 5'UTR] showed a significant association with glioma risk...
  51. doi XRCC1 gene polymorphisms and breast cancer risk in different populations: a meta-analysis
    Huihua Li
    Clinical Trials and Epidemiological Sciences, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Republic of Singapore
    Breast 18:183-91. 2009
    We performed a meta-analysis to investigate the role of XRCC1 polymorphisms Arg194Trp, Arg280His and Arg399Gln in breast cancer...
  52. doi XRCC1 and XRCC3 variants and risk of glioma and meningioma
    Anne Kiuru
    Department of Research and Environmental Surveillance, STUK Radiation and Nuclear Safety Authority, Box 14, 00881 Helsinki, Finland
    J Neurooncol 88:135-42. 2008
    ..We evaluated the association of SNPs Arg194Trp, Arg280His, and Arg399Gln in the X-ray cross-complementing group 1 (XRCC1) and Thr241Met in the X-ray cross-complementing group 3 (XRCC3) DNA repair genes with the risk of brain tumors...
  53. ncbi Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer
    Sambasivarao Damaraju
    Cross Cancer Institute, Department of Oncology, University of Alberta, Edmonton, Alberta, Canada
    Clin Cancer Res 12:2545-54. 2006
    ....
  54. ncbi Risk of radiation-induced subcutaneous fibrosis in relation to single nucleotide polymorphisms in TGFB1, SOD2, XRCC1, XRCC3, APEX and ATM--a study based on DNA from formalin fixed paraffin embedded tissue samples
    C N Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, Denmark
    Int J Radiat Biol 82:577-86. 2006
    ..fibrosis were found for single nucleotide polymorphisms (SNP) in TGFB1 (transforming growth factor beta 1 gene), XRCC1 (X-ray repair cross-complementing 1 gene), XRCC3 (X-ray repair cross-complementing 3 gene), SOD2 (manganese ..
  55. ncbi Genetic variation in the base excision repair pathway and bladder cancer risk
    Jonine D Figueroa
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, Bethesda, MD, USA
    Hum Genet 121:233-42. 2007
    ..we analyzed 43 single nucleotide polymorphisms (SNPs) in 12 BER genes (OGG1, MUTYH, APEX1, PARP1, PARP3, PARP4, XRCC1, POLB, POLD1, PCNA, LIG1, and LIG3)...
  56. ncbi Polymorphisms of DNA repair genes and risk of glioma
    Li E Wang
    Department of Epidemiology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 64:5560-3. 2004
    ..chromosomal breaks, which may be influenced by genetic variation in genes involved in DNA strand breaks, such as XRCC1 in single-strand break repair, XRCC3 and RAD51 in homologous recombination repair, and XRCC7 in nonhomologous end ..
  57. ncbi Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer
    Victor Moreno
    Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
    Clin Cancer Res 12:2101-8. 2006
    ..We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients...
  58. doi Genetic variants of XRCC1, APE1, and ADPRT genes and risk of bladder cancer
    Meilin Wang
    Department of Molecular and Genetic Toxicology, Cancer Center of Nanjing Medical University, Nanjing, China
    DNA Cell Biol 29:303-11. 2010
    ..and endogenous carcinogens could be removed effectively by the base excision repair pathway, in which the XRCC1, APE1, and ADPRT genes play a key role...
  59. doi Association of single nucleotide polymorphisms in ATM, GSTP1, SOD2, TGFB1, XPD and XRCC1 with clinical and cellular radiosensitivity
    Oliver Zschenker
    Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Radiother Oncol 97:26-32. 2010
    To examine the association of polymorphisms in ATM (codon 158), GSTP1 (codon 105), SOD2 (codon 16), TGFB1 (position -509), XPD (codon 751), and XRCC1 (codon 399) with fibrosis and also individual radiosensitivity.
  60. ncbi Synergistic effects of polymorphisms in DNA repair genes and endogenous estrogen exposure on female breast cancer risk
    Hsu Ming-Shiean
    Division of General Surgery, Yuanli Lee s General Hospital, Lee s Medical Corporation, Miaoli, Taiwan
    Ann Surg Oncol 17:760-71. 2010
    ..Genotypic variants of DNA damage repair genes, participating in base excision repair (BER) and nucleotide excision repair (NER) pathways, may act as modifiers that affect the association between estrogen exposure and breast cancer...
  61. ncbi Adenosine diphosphate ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer
    Xiaoping Miao
    Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Gastroenterology 131:420-7. 2006
    Adenosine diphosphate ribosyl transferase (ADPRT) and x-ray repair cross-complementing 1 (XRCC1) are major DNA base excision repair proteins acting interactively in repair processes...
  62. ncbi DNA repair polymorphisms might contribute differentially on familial and sporadic breast cancer susceptibility: a study on a Portuguese population
    Sandra Costa
    ICVS, Life and Health Sciences Research Institute, Health Science School, Minho University, Braga, 4710 057, Portugal
    Breast Cancer Res Treat 103:209-17. 2007
    ..We analysed DNA samples from 285 breast cancer patients and 442 control subjects, for XRCC1 Arg399Gln, XPD Lys751Gln, RAD51 G135C and XRCC3 Thr241Met polymorphisms using PCR-RFLP...
  63. doi Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia
    Iraj Saadat
    Department of Biology, College of Sciences, Shiraz University, Shiraz, 71454, Iran
    Arch Gynecol Obstet 286:1459-62. 2012
    ..b>XRCC1 (MIM: 194360) and XRCC7 (MIM: 600899) play a crucial role in the DNA repair pathways...
  64. ncbi XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects
    G Matullo
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, 10126, Torino, ISI Foundation, Institute for Scientific Interchange, Villa Gualino, 10133, Torino, Italy
    Carcinogenesis 22:1437-45. 2001
    ..DNA damage, as measured by (32)P-DNA adduct levels, and three genetic polymorphisms in different repair genes: XRCC1-Arg399Gln (exon 10), XRCC3-Thr241Met (exon 7) and XPD-Lys751Gln (exon 23)...
  65. ncbi A prospective study of XRCC1 haplotypes and their interaction with plasma carotenoids on breast cancer risk
    Jiali Han
    Department of Nutrition, Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Cancer Res 63:8536-41. 2003
    The XRCC1 protein is involved in the base excision repair pathway through interactions with other proteins. Polymorphisms in the XRCC1 gene may lead to variation in repair proficiency and confer inherited predisposition to cancer...
  66. pmc Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair
    Wen Cheng Chou
    Institute of Public Health, National Yang Ming University, Taipei, Taiwan
    EMBO J 27:3140-50. 2008
    ..Furthermore, Chk2 formed a complex with XRCC1, the BER scaffold protein, and phosphorylated XRCC1 in vivo and in vitro at Thr(284)...
  67. doi Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair
    K Kudo
    Mitchell Cancer Institute, University of South Alabama, Mobile, AL, USA
    Oncogene 31:4718-24. 2012
    ..We therefore studied the possible relationships between Gli1, c-jun, and the upregulation of ERCC1, XPD and XRCC1 in cisplatin-resistant human ovarian cancer cells...
  68. ncbi Single nucleotide polymorphisms in breast cancer
    Asta Forsti
    Division of Molecular Genetic Epidemiology, German Cancer Research Center DKFZ, 69120 Heidelberg, Germany
    Oncol Rep 11:917-22. 2004
    ..The frequencies for single nucleotide polymorphisms (SNPs) were measured in the following genes: NBS1, XPC, XPD, XRCC1, XRCC3, MTHFR, and cyclin D1. Odds ratios (ORs) were calculated to the wild-type genotype...
  69. doi Functional polymorphisms in XRCC-1 and APE-1 contribute to increased apoptosis and risk of ulcerative colitis
    Avinash Bardia
    Centre for Liver Research and Diagnostics, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad 500 058, Andhra Pradesh, India
    Inflamm Res 61:359-65. 2012
    The present study was designed to investigate the role of X-ray cross-complementing group 1 (XRCC1) and apurinic/apyrimidinic endonuclease 1 (APE1) polymorphisms in apoptosis and the risk of ulcerative colitis (UC).
  70. ncbi Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair
    Jason T Heale
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, 92697, USA
    Mol Cell 21:837-48. 2006
    ..We show that the association between condensin I, PARP-1, and the base excision repair (BER) factor XRCC1 increases dramatically upon single-strand break damage (SSB) induction...
  71. pmc Polymorphisms of the XRCC1, XRCC3 and XPD genes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study
    Camilla Furu Skjelbred
    Department of Laboratory Medicine, Telemark Hospital, N 3710 Skien, Norway
    BMC Cancer 6:67. 2006
    ..Less is known about other DNA repair pathways in colorectal carcinogenesis. In this study we have focused on the XRCC1, XRCC3 and XPD genes, involved in base excision repair, homologous recombinational repair and nucleotide excision ..
  72. pmc XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample
    Ri A Ryu
    Department of Otolaryngology Head and Neck Surgery, Hanyang University School of Medicine, Seoul, Korea
    J Korean Med Sci 26:991-5. 2011
    Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers...
  73. doi DNA repair gene XRCC1 polymorphisms and non-Hodgkin lymphoma risk in a Chinese population
    Jie Liu
    Department of Oncology, Shandong Cancer Hospital and Institute, 440 Jiyan Road, Jinan 250117, Shandong, P R China
    Cancer Genet Cytogenet 191:67-72. 2009
    ..case-control study examined whether polymorphism in the DNA repair gene x-ray repair cross-complementing groups 1 (XRCC1 Arg194Trp [C-->T], Arg280His [G-->A], and Arg399Gln [G-->A]) played a role in susceptibility to non-..
  74. ncbi Association of DNA repair polymorphisms with DNA repair functional outcomes in healthy human subjects
    Pavel Vodicka
    Institute of Experimental Medicine, Videnska 1083, 14200, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Carcinogenesis 28:657-64. 2007
    ..Irradiation-specific DNA repair rates were significantly decreased in individuals with XRCC1 Arg399Gln homozygous variant genotype (0.45 +/- 0.47 SSB/10(9) Da) than in those with wild-type genotype (1...
  75. pmc XRCC1 Arg194Trp and Arg280His polymorphisms increase bladder cancer risk in Asian population: evidence from a meta-analysis
    Zhenqiang Fang
    Department of Urology, Center of Nephrology, the Second Affiliated Hospital of the Third Military Medical University, Chongqing, China
    PLoS ONE 8:e64001. 2013
    A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive...
  76. doi The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia
    Amani Sorour
    Department of Clinical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt
    Genet Test Mol Biomarkers 17:195-201. 2013
    ....
  77. doi Association of the Arg194Trp and the Arg399Gln polymorphisms of the XRCC1 gene with risk occurrence and the response to adjuvant therapy among Polish women with breast cancer
    Karolina Przybylowska-Sygut
    Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Lodz, Poland
    Clin Breast Cancer 13:61-8. 2013
    The XRCC1 gene encoding the X-ray cross-complementing group 1 protein (XRCC1) is involved in the base excision repair (BER) pathway.
  78. doi Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case-control study
    Loredana Covolo
    Department of Experimental and Applied Medicine, Institute of Hygiene, Epidemiology and Public Health, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
    Eur J Epidemiol 23:355-62. 2008
    The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case-control study...
  79. ncbi [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population]
    Na Wang
    School of Public Health, Zhengzhou University, Zhengzhou 450001, China
    Wei Sheng Yan Jiu 41:251-6. 2012
    ..To investigate the association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of pulmonary cancer in Henan population...
  80. doi The cAMP signaling system inhibits the repair of γ-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells
    Eun Ah Cho
    Department of Biochemistry and Molecular Biology, Cancer Research Center, Seoul National University College of Medicine, Seoul 110 799, Republic of Korea
    Biochem Biophys Res Commun 422:256-62. 2012
    ..of GαsQL or treatment with forskolin or isoproterenol inhibited the radiation-induced expression of the XRCC1 protein, and exogenous expression of XRCC1 abolished the DNA repair-inhibiting effect of forskolin...
  81. ncbi Association of XRCC1 gene polymorphisms with breast cancer susceptibility in Saudi patients
    Fatima Masoud Al Mutairi
    Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia
    Asian Pac J Cancer Prev 14:3809-13. 2013
    X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex...
  82. ncbi Polymorphisms of DNA repair genes XRCC1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population
    Deyin Xing
    Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Int J Cancer 100:600-5. 2002
    ..We therefore investigated the associations between genetic polymorphisms in the DNA repair genes XRCC1 (Arg194Trp and Arg399Gln) and XPD (Asp312Asn and Lys751Gln) and risk of ESCC in an at-risk Chinese population...
  83. ncbi DNA repair single-nucleotide polymorphisms in colorectal cancer and their role as modifiers of the effect of cigarette smoking and alcohol in the Singapore Chinese Health Study
    Mariana C Stern
    Department of Preventive Medicine, Keck School of Medicine, Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Room 5421A, Los Angeles, CA 90089, USA
    Cancer Epidemiol Biomarkers Prev 16:2363-72. 2007
    ..study, we investigated the role in colorectal cancer of single-nucleotide polymorphisms in five DNA repair genes: XRCC1 (Arg(194)Trp and Arg(399)Gln), PARP (Val(762)Ala, Lys(940)Arg), XPD (Asp(312)Asn, Lys(751)Gln), OGG1 (Ser(326)Cys),..
  84. ncbi Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to glioma
    Xue bin Hu
    Department of Neurosurgery, Union Hospital, Tongji Medical College, Wuhan, China
    Asian Pac J Cancer Prev 12:2981-4. 2011
    The XRCC1 gene encodes the XRCC1 protein, which complexes with three other DNA repair enzymes involved in the base-excision repair (BER) pathways...
  85. pmc Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis
    Zhigang Cui
    China Medical University, Shenyang 110001, PR China
    BMC Cancer 12:71. 2012
    X-ray repair cross-complementing group 1 (XRCC1) protein plays an important role in the repair of DNA damage and adducts...
  86. ncbi Polymorphisms in DNA repair gene XRCC1 and skin cancer risk: a meta-analysis
    Haijun Zhang
    Department of Cell and Developmental Biology, Weill Medical College of Cornell University, New York, NY, USA
    Anticancer Res 31:3945-52. 2011
    Published data on the association between polymorphisms of the X-ray repair cross-complementing group 1 (XRCC1) gene and skin cancer risk are inconsistent...
  87. ncbi Polymorphisms of DNA repair gene XRCC1 and risk of glioma: a case-control study in Southern China
    Lu Qiu Zhou
    1Department of Neurosurgery, 2Department of Respiratory Diseases, Shenzhen Longgang Central Hospital, Shenzhen, China
    Asian Pac J Cancer Prev 12:2547-50. 2011
    ..This study aimed to examine associations between polymorphisms in the X-ray cross- complementing group 1 (XRCC 1) gene and risk of glioma in a Chinese population...
  88. ncbi Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk
    Qiu wen Li
    Oncology Department, No 1 Hospital Affiliated to General Hospital of Chinese People s Liberation Army, Beijing, China
    Asian Pac J Cancer Prev 13:191-4. 2012
    We conducted a case-control study in China to clarify the association between XRCC1-Arg399Gln polymorphism and HCC risk...
  89. doi Haplotypes of microsomal epoxide hydrolase and x-ray cross-complementing group 1 genes in Indian hepatocellular carcinoma patients
    Manjula Kiran
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, India
    DNA Cell Biol 28:573-7. 2009
    ..genetic polymorphism and haplotypes of microsomal epoxide hydrolase (mEPHX) and X-ray cross-complementing group 1 (XRCC1) with altered cancer risk...
  90. pmc DNA repair gene XRCC1 polymorphisms and bladder cancer risk
    Sei Chung Sak
    Molecular Radiobiology Group, Section of Oncology, Leeds Institute of Molecular Medicine, St James s University Hospital, Leeds, UK
    BMC Genet 8:13. 2007
    ..The XRCC1 protein plays a crucial role in BER by acting as a scaffold for other BER enzymes...
  91. doi Polymorphism of DNA repair gene XRCC1 and hepatitis-related hepatocellular carcinoma risk in Indian population
    Manjula Kiran
    Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh 160012, India
    Mol Cell Biochem 327:7-13. 2009
    ..The risk of HCC might also increase because of the hereditary genetic defects in DNA repair genes. In this regard, X-ray cross-complementing group 1 gene (XRCC1) is a major DNA repair gene involved in base excision repair (BER).
  92. doi XRCC1 polymorphisms and lung cancer risk in Chinese populations: a meta-analysis
    Huilie Zheng
    Department of Epidemiology and Statistics, School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China
    Lung Cancer 65:268-73. 2009
    X-ray repair cross-complementing group 1 (XRCC1), one of the >20 genes that participate in the base excision repair (BER) pathway, is thought to account for differences in lung cancer susceptibility...
  93. ncbi Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner
    Jill Moser
    Department of Toxicogenetics, Leiden University Medical Center, Einthovenweg 20, Leiden, The Netherlands
    Mol Cell 27:311-23. 2007
    ..Impaired gap filling and sealing of chromosomal DNA in nucleotide excision repair (NER) leads to genome instability. XRCC1-DNA ligase IIIalpha (XRCC1-Lig3) plays a central role in the repair of DNA single-strand breaks but has never been ..
  94. ncbi XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women
    G Barbisan
    IGEVET Institute of Veterinary Genetics Ingeniero Fernando Noel Dulout Faculty of Veterinary Science, National University of La Plata, Buenos Aires, Argentina
    Eur J Gynaecol Oncol 32:274-9. 2011
    b>XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the DNA base excision repair mechanism...
  95. pmc XRCC1 genetic polymorphism Arg399Gln and gastric cancer risk: A meta-analysis
    Jian Geng
    Department of Oncology, Nanjing University School of Medicine, Jinling Hospital, 305 Zhongshan East Road, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 14:6733-7. 2008
    To evaluate the association between X-ray cross-complementing gene 1 (XRCC1) genetic polymorphism Arg399Gln and gastric cancer risk by means of meta-analysis.
  96. pmc Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans
    Jeffrey S Chang
    Department of Epidemiology and Biostatistics, Division of Neuroepidemiology, University of California San Francisco, San Francisco, CA 94143 1215, USA
    Carcinogenesis 30:78-87. 2009
    ..This study examines the association between 24 single-nucleotide polymorphisms (SNPs) belonging to five BER genes (XRCC1, APEX1, PARP1, MUTYH and OGG1) and lung cancer among Latinos (113 cases and 299 controls) and African-Americans (..
  97. ncbi TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer
    Christian Nicolaj Andreassen
    Department of Experimental Clinical Oncology, Aarhus University Hospital, DK 8000 Aarhus, Denmark
    Radiother Oncol 75:18-21. 2005
    ..findings, this study investigated SNPs in genes TGFB1 (position -509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked ..
  98. ncbi XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival of BRCA2 mutant cells
    Jinshui Fan
    Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, Maryland, USA
    Environ Mol Mutagen 48:491-500. 2007
    Previous studies using rodent cells indicate that a deficiency in XRCC1 results in reduced single-strand break repair, increased sensitivity to DNA-damaging agents, and elevated levels of sister chromatid exchange (SCE)...
  99. pmc Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer
    J Chang-Claude
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Br J Cancer 100:1680-6. 2009
    ..Polymorphisms in genes involved in DNA repair (APEX1, XRCC1, XRCC2, XRCC3, XPD) and damage response (TP53, P21) were determined...
  100. ncbi Polymorphisms/haplotypes in DNA repair genes and smoking: a bladder cancer case-control study
    Giuseppe Matullo
    Department of Epidemiology and Public Health, Imperial College of Science, Technology and Medicine, Norfolk Place, London W2 1PG, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:2569-78. 2005
    ..in seven DNA repair genes belonging to different repair pathways [X-ray repair cross-complementing group 1 (XRCC1): 26304C>T, 26651A>G, 28152A>G; xeroderma pigmentosum-D (XPD): 23591A>G, 35931A>C; excision repair ..
  101. ncbi PAH-DNA adducts in environmentally exposed population in relation to metabolic and DNA repair gene polymorphisms
    Blanka Binkova
    Laboratory of Genetic Ecotoxicology, Institute of Experimental Medicine AS CR and Health Institute of Central Bohemia, Videnska 1083, 14220 Prague, Czech Republic
    Mutat Res 620:49-61. 2007
    ..Polymorphisms of metabolizing (GSTM1, GSTP1, GSTT1, EPHX1, CYP1A1-MspI) and DNA repair (XRCC1, XPD) genes were determined by PCR-based RFLP assays...

Research Grants83

  1. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..newly diagnosed cases of kidney cancer in the United States, the majority of which represent renal cell carcinoma (RCC). The prevalence of cancer of the kidney and renal pelvis is 296,074, with 61.3% localized or 181493 patients...
  2. Novel multivalent/multifunctional agents derived from a humanized anti-insulin-li
    Thomas M Cardillo; Fiscal Year: 2010
    ..One of the most challenging forms of this type of cancer is metastatic renal cell carcinoma (RCC). It has resisted attempts of curative radiotherapy and chemotherapy...
  3. Identification of Biomarkers for Early Detection of Renal Cell Carcinoma
    Othon Iliopoulos; Fiscal Year: 2012
    The incidence of renal cell carcinoma (RCC) in United States has been projected to reach 56,000 cases/year in 2007 and has been rising since 1970 for both men and women and for whites as well as blacks...
  4. ROLE OF TGF BETA 1 IN RENAL CANCER
    S Karumanchi; Fiscal Year: 2004
    DESCRIPTION (Applicant's Description): Clear-cell renal carcinoma (RCC), the most common cancer of the kidney, occurs in 27,000 individuals in the US each year and is responsible for 11,000 deaths annually...
  5. Genetic Retargeted Human T-cells for RCC Immunotherapy
    Wayne Marasco; Fiscal Year: 2006
    unreadable] DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC) is the most prevalent malignancy within the kidney and the incidence is rising...
  6. Differential Gene Expression in Renal Cancers
    Alexander Parker; Fiscal Year: 2004
    Incidence and mortality rates for renal cell carcinoma (RCC) have increased steadily over the past three decades, and these trends are largely unexplained...
  7. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..Indeed, loss of heterozygosity at the OGG1 allele was found in human renal clear cell carcinoma (RCC) identifying loss of OGG1 function as a possible contributor to tumorigenesis in the kidney...
  8. Genistein, microRNAs and kidney cancer
    Rajvir Dahiya; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Background: Renal cell carcinoma (RCC) is one of the most common malignancies among our Veterans...
  9. Effect of MIP-1 delta on Osteoclast Development and Pathological Bone Resorption
    Scott L Kominsky; Fiscal Year: 2010
    ..In addition, we will determine the clinical correlation between MIP-1d expression in primary RCC and the subsequent development of osteolytic metastasis...
  10. Nanoscale proteomic profiles of hypoxia pathways to develop biomarkers of renal c
    JOHN THOMAS LEPPERT; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC, kidney cancer) is one of the most commonly diagnosed cancers and is associated with significant mortality...
  11. Wnt antagonist genes in kidney tumor progression and metastasis
    Rajvir Dahiya; Fiscal Year: 2012
    ..Renal cell carcinoma (RCC) is the third most common malignancy of the genitourinary system...
  12. Predictive Markers in Metastatic Renal Cancer
    Phillip G Febbo; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Metastatic renal cell carcinoma (RCC) is a dismal disease, with nearly uniform resistance to radiotherapy, chemotherapy and immunotherapy...
  13. Pathway Specific Imaging in VHL Deficient Renal Cancer
    PANKAJ K SETH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): 54,000 new cases of renal cell cancer (RCC) are diagnosed each year in the US and approximately 13,000 patients succumb to the disease annually...
  14. TRAIL-expressing Recombinant Adenovirus Based Immunotherapy for RCC
    Thomas S Griffith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This year in the U.S. ~40,000 new cases of renal cell carcinoma (RCC) will be diagnosed and >13,000 deaths are expected from RCC...
  15. Technology and Endothelial Biology of Kidney Injury Molecule-1
    Vishal S Vaidya; Fiscal Year: 2010
    ..g. acute kidney injury, AKI) or growth of cancer (e.g. renal cell carcinoma, RCC) is adequate supply of oxygen through formation of blood vessels...
  16. REGULATORY PATHWAYS AND ROLE OF VPF/VEGF IN RENAL CANCER
    Debabrata Mukhopadhyay; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Most of the cases, the clear-cell renal cell carcinoma (RCC) express strikingly elevated baseline levels of vascular permeability factor also known as vascular endothelial growth factor (VEGF) ..
  17. 124I-cG250 ImmunoPET Imaging of Sunitinib Treatment Response in Renal Cell Cancer
    STEVEN MARK LARSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC) is the most common malignancy of the kidney, accounting for more than 58,000 new diagnoses of cancer and 13,000 cancer deaths in the United States during 2010...
  18. The Role of KIR and FcR Genotype in the Efficacy of mAb and IL2 Immunotherapy
    Paul M Sondel; Fiscal Year: 2013
    ..data, can identify patients more likely to respond to: a) single agent mAb therapy for lymphoma, b) single agent IL2 treatment for renal cell carcinoma (RCC), and c) mAb + cytokine (IL2 + GM-CSF) therapy for neuroblastoma (NBL).
  19. Expression profiling of renal cell carcinoma utilizing tissue from CALGB 90206
    Hyung L Kim; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): One third of patients newly diagnosed with renal cell carcinoma (RCC) have metastatic disease...
  20. Targeting Novel T Cell Antigens on Renal Cell Carcinoma
    Scott S Tykodi; Fiscal Year: 2010
    Metastatic renal cell carcinoma (RCC) is poorly responsive to most conventional cancer therapy, but regression of metastatic RCC is seen in 10-20% of patients treated with non-specific immunotherapies such as interleukin-2 or interferon-..
  21. Models to predict prognosis and benefit from adjuvant therapy in renal cell carci
    Harriet M Kluger; Fiscal Year: 2013
    ..and develop models to predict clinical benefit from adjuvant sorafenib and sunitinib for renal cell carcinoma (RCC), as well as models to predict prognosis in untreated patients...
  22. High-throughput screen for specific small-molecule inhibitors of HIF-2A activity
    Mei Yee Koh; Fiscal Year: 2013
    ..HIF-2[unreadable] is an important driver of tumor morbidity in renal cell carcinoma (RCC), neuroblastoma, glioblastoma (GBM) and non small cell lung cancer (NSCLC)...
  23. Free-Breathing Perfusion MRI of the Abdomen with Predictive Motion Correction
    H Michael Gach; Fiscal Year: 2013
    ..Diagnostic imaging serves a key role in detecting and monitoring renal diseases including renal cell carcinoma (RCC)...
  24. Enhancing renal cell carcinoma response to IL-2 with the HDAC inhibitor SNDX-275
    Roberto Pili; Fiscal Year: 2010
    ..provided by applicant): High dose interleukin 2 (IL-2) is an approved regimen for metastatic renal cell carcinoma (RCC). Unfortunately, the response rate is modest and only few patients achieve durable remission...
  25. Cadherin-regulated apoptosis and survival signaling in epithelial cells
    STEEN HENNING HANSEN; Fiscal Year: 2013
    ..addresses the putative pro-apoptotic function of E-cadherin in the context of clear cell renal cell carcinoma (CC-RCC)...
  26. Elimination of Immature Myeloid Cells
    Johannes Vieweg; Fiscal Year: 2009
    ..to eliminate immunosuppressive immature myeloid suppressor cells (ImC) in metastatic renal cell carcinoma patients (RCC)...
  27. Pooled genome-wide analysis of kidney cancer risk
    Ghislaine Scelo; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC) is the 8th most common cancer in the US and the 10th most common form of cancer death, with over 34,000 cases and 12,000 deaths each year...
  28. Metabolomic discovery and validation of urinary biomarkers for kidney cancer
    Robert H Weiss; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Kidney cancer (also known as renal cell carcinoma [RCC]) is diagnosed in 36,000 patients and is the cause of death of 11-13,000 individuals yearly in the US;unfortunately (and for unknown reasons), ..
  29. Targeting the PI3-Kinase/Akt Pathway for the Therapy of Renal Cell Carcinoma
    DANIEL CHANG CHO; Fiscal Year: 2013
    ..has chosen to focus his research career on developing novel therapies for the treatment of renal cell carcinoma (RCC)...
  30. Interferon-induced SLFNs and tumorigenesis
    Leonidas C Platanias; Fiscal Year: 2013
    ..For that purpose malignant melanoma or renal cell carcinoma (RCC) mouse models will be established using mice with the elektra phenotype (Slfn2eka/eka) or Slfn1 or Slfn3 knockout ..
  31. Identifying a Hypoxia Inducible Factor target profile in Renal Cell Carcinoma tum
    Alexandra Arreola; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC) is a highly prevalent malignancy with a high mortality rate...
  32. Characterization and therapeutic targeting of HIF in LKB1 - deficient lung cancer
    William Y Kim; Fiscal Year: 2013
    ..HIF2 has been shown to be a bona fide oncogene in renal cell carcinoma (RCC) and downstream mediators of HIF2 signaling are the relevant therapeutic targets that have resulted in positive ..
  33. Mechanism of Acquired Resistance to VEGF-R Antagonists in RCC
    Rupal S Bhatt; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): One of the key advances in the field of renal ell cancer (RCC) is the development and approval of the tyrosine kinase inhibitors (TKIs), sorafenib and sunitinib...
  34. Inhibiting VHL-positive kidney cancer
    GEORGE VICTOR THOMAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Patients with VHL-positive renal cell carcinoma (RCC) have very few treatment options...
  35. Clinical Impact of B7-H Immune Cell Coregulators in Renal Cell Carcinoma
    Eugene D Kwon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Renal cell carcinoma (RCC) encompasses 90% of kidney cancers and 3% of adult cancers. In the U.S...
  36. Novel treatment strategies for enhancing sunitinib response in renal cell cancer
    Towia A Libermann; Fiscal Year: 2013
    ..While there has been significant progress in management of early stages of clear cell renal cell carcinoma (RCC), metastatic RCC has few effective therapeutic strategies available and a death rate close to the incidence...
  37. Visual Programming Tool for Integrated Gene/Protein Networks in Cancer Research
    Maciek Sasinowski; Fiscal Year: 2011
    ..will be performed in parallel with a multidisciplinary, integrative biological study of renal cell carcinoma (RCC, or kidney cancer)...
  38. Molecular pathways linking obesity and RCC tumorigenesis (PQ1)
    Xifeng Wu; Fiscal Year: 2013
    ..comprehensive epidemiology data including diet, obesity, and physical activity of an ongoing renal cell carcinoma (RCC) case control study from Texas...
  39. Role of NFxB/HIF2a axis in renal cell carcinoma progression
    E Jason Abel; Fiscal Year: 2013
    ..His past record of achievement is exceptional, including 11 manuscripts on renal cell carcinoma (RCC)...
  40. TGF Beta receptor biology in human renal cell carcinoma
    JOHN COPLAND; Fiscal Year: 2009
    Renal cell carcinoma (RCC) is a major health issue. While localized disease can be cured surgically, there is no effective treatment for metastatic disease...
  41. Immunotherapy for Renal Cell Carcinoma
    Marc S Ernstoff; Fiscal Year: 2010
    ..Bevacizumab, an FDA approved anti-VEGF antibody with activity in mRCC, is safe to administer with IL-2 or IFNa. RCC removed as standard care will be processed for autologous vaccine...
  42. TAS::75 0849::TAS TOPIC 255 SELECTIVE AND POTENT INHIBITORS OF TUMOR SPECIFIC GL
    Paul Pearson; Fiscal Year: 2011
    Previously, we employed a novel, chemical synthetiC lethal screening approach in VHL-deficient renal cell carcinoma (RCC VHL-) to identify inhibitors of GLUT1, a glucose transporter critical for RCC energy metabolism and survival...
  43. Regulation of MDSC function and trafficking
    James H Finke; Fiscal Year: 2013
    ..and angiogenic G-MDSCs that infiltrate inflammatory murine tumors is paralleled in human renal cell carcinoma (RCC) tumors, which also accumulate mostly G-MDSCs...
  44. Prostaglandin Receptor Regulation of Kidney Cancer
    Yehia Daaka; Fiscal Year: 2013
    ..Although surgery is highly effective for the treatment of localized renal cell carcinoma (RCC), treatment options available for patients with metastatic disease are very limited...
  45. Genotype and phenotype predictors in therapy response in renal cell carcinoma
    Katherine L Nathanson; Fiscal Year: 2013
    ABSTRACT Therapy of renal cell carcinoma (RCC) has been transformed in recent years by the efficacy of targeted agents that inhibit kinases involved in critical cellular signaling pathways and VEGF, a primary driver of tumor ..
  46. TRAIL Mediated Apoptosis in Renal Cell Carcinoma
    Peter Clark; Fiscal Year: 2009
    ..Advanced renal cell carcinoma (RCC) is a deadly, chemotherapy resistant disease usually treated with biologic therapy such as interferon alpha (IFNa)...
  47. Non-invasive Physiologic Predictors of Aggressiveness in Renal Cell Carcinoma
    Ivan Pedrosa; Fiscal Year: 2013
    ..imaging has resulted in a significant increase in the age-adjusted incidence of renal cell carcinoma (RCC)...
  48. Genetic Events in Renal Cell Carcinoma
    CAROLINE MARTZ LEE; Fiscal Year: 2010
    ..mutation of the von Hippel-Lindau (VHL) tumor suppressor gene is associated with sporadic renal cell carcinoma (RCC), and germline VHL mutation results in VHL disease with predisposition to RCC and/or other neoplasms...
  49. Renal Morbidity Following Kidney Cancer Surgery
    JOHN THOMAS LEPPERT; Fiscal Year: 2013
    ..Patients with renal cell carcinoma (RCC) tend to be older, often have co-morbid conditions associated with lower baseline kidney function, and may be ..
  50. Renal Cell Tumor-Mediated Trans-differentiation of Natural Killer Cells
    ANDREW CHRISTROPHER WILBER; Fiscal Year: 2013
    ..We propose that similar trans-differentiation of peripheral NK (pNK) cells occurs in renal cell carcinoma (RCC) which then favors growth and metastasis of the tumor...
  51. Targeting HIF-1alpha in renal cell carcinoma: the role of HDAC inhibitors
    Roberto Pili; Fiscal Year: 2010
    ..angiogenesis with novel combination strategies involving HDAC inhibitors for the treatment of renal cell carcinoma (RCC)...
  52. 3D-adhesion stromagenesis in cancer permissiveness
    Edna Cukierman; Fiscal Year: 2013
    ..3. Assess the clinical importance of stromal activation in human renal cell carcinoma (RCC).
  53. Design and Validation of a Biomarker-enhanced System to Predict RCC Progression
    Alexander S Parker; Fiscal Year: 2013
    PROJECT/SUMMARY ABSTRACT Incidence rates for renal cell carcinoma (RCC) have risen steadily over the past three decades, with the majority of this increase seen among localized tumors...
  54. TAS::75 0849::TAS PHARMACODYNAMIC ASSAYS FOR WNT/FRIZZLED AND HGF/C-MET SIGNALIN
    ANU MATHEW; Fiscal Year: 2010
    ..the Wnt/Frizzled and HGF/c-Met signaling pathways implicated in many malignancies, including renal cell carcinoma (RCC)...
  55. Analysis of the Novel Kinase ROR2: A New Molecular Target in Renal Cell Carcinoma
    Tricia M Wright; Fiscal Year: 2010
    Renal cell carcinoma (RCC), a notoriously hard to treat solid tumor and the most common form of kidney cancer, has minimal sensitivity to traditional chemotherapy...
  56. Molecular Mechanisms of Renal Cancer
    Maria F Czyzyk-Krzeska; Fiscal Year: 2013
    ..Our hypothesis is that the effects of TRPM3 on autophagic programs play an essential role in its ability to promote RCC tumor growth, and that the effects of TRPM3 on autophagic programs are mediated through regulation of intracellular ..
  57. MOLECULAR-GENETIC ANALYSIS OF 3P14 GENOMIC STABILITY
    Harry Drabkin; Fiscal Year: 2006
    ..of any protein that interacts with VHL and its function may be germane to the development of renal cell carcinoma (RCC)...
  58. MDA-7/IL-24 and free radicals in renal cancer therapy
    Paul Dent; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Renal Cell Carcinoma (RCC) is among the most lethal and difficult tumors to treat, particularly when disease has spread beyond the kidney and into the surrounding fascia;even intensive combinations ..
  59. Autoimmune Mechanisms in the Response to Renal Cancer
    Julie Ellerhorst; Fiscal Year: 2006
    ..on the hypothesis that mechanisms of autoimmunity are utilized to control or kill metastatic renal cell carcinoma (RCC), and that RCC patients who have genotypic or biologic features associated with autoimmune disorders are more ..
  60. Dendritic Cell Strategies to Tumor Reactive T Cells
    Walter Storkus; Fiscal Year: 2007
    ..few tumor antigens have been characterized and specific therapies have been developed for renal cell carcinoma (RCC)...
  61. B7 1 GENE MODIFIED TUMOR CELL VACCINE FOR RENAL CELL CA
    Scott Antonia; Fiscal Year: 2002
    ..immunologic approaches to malignancies, and there is good evidence that the growth of renal cell carcinoma (RCC) can be modulated by the host's immune system...
  62. Urinary MMP activity to detect renal cell carcinoma
    Thomas Weimbs; Fiscal Year: 2005
    The survival rates for patients diagnosed with renal cell carcinoma (RCC) -the most common type of kidney cancer- are extremely low...
  63. WORKER GENETIC SUSCEPTIBILITY TO MUTAGENIC RISK
    Paul W Brandt-Rauf; Fiscal Year: 2013
    ..intermediates that generate pro-mutagenic etheno-DNA adducts that can be removed by base excision repair (via XRCC1) or nucleotide excision repair (via XPD), or, if not repaired, result in specific mutations in cancer-related ..
  64. Optimization of DNA Repair by Abh8
    Lauren Endres; Fiscal Year: 2013
    ..e., for SSBR, PARP, XRCC1 and polynucleotide kinase;for DSBR, RAD family proteins, XRCC2 and 3, BRCA1 and 2, Ku70 and 86, and DNAPK)...
  65. Molecular Epidemiology of Chronic Liver Diseases
    Manal Hassan; Fiscal Year: 2009
    ..e., hOGG1 and XRCC1) between group 1 and group. 2)...
  66. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    ..with and can be stimulated by various factors including hHR23A/B (a nucleotide excision repair protein) and XRCC1 (a BER protein)...
  67. Repair of oxidative DNA damage in mammalian cells
    Tadahide Izumi; Fiscal Year: 2013
    ..and appears to have significant effects on the functions of APE1 and other cellular proteins, including XRCC1 (X-ray cross-complementation 1), p53, and HDAC1, that interact directly with APE1...
  68. Role of poly (ADP-ribose)in the Repair of Ultraviolet Induced DNA Damage
    BRENEE SHEMEIR KING; Fiscal Year: 2012
    ..Several papers have noted its direct interaction with proteins within the pathway (i.e. XRCC1, DNA polymerase 2, and DNA Ligase III)...
  69. Genetic Susceptibility Modifiers in Renal Cell Carcinoma
    Xifeng Wu; Fiscal Year: 2007
    ..Tobacco exposure is an established risk factor for renal cell carcinoma (RCC)...
  70. Role of Bin1 in Cancer Chemosensitization
    Daitoku Sakamuro; Fiscal Year: 2013
    ..between the automodification domain of PARP-1 and Bin1 are direct and (ii) how Bin1 disrupts the PARP-1-XRCC1 interaction in vivo, an essential step for PARP-1-mediated base excision repair (BER)...
  71. Roles of Lig3 and XRCC1 Genes in Genome Stability
    Alan E Tomkinson; Fiscal Year: 2013
    ..Interestingly, the DNA ligase III[unreadable]-associated proteins, poly (ADP-ribose) polymerase 1 (PARP-1), XRCC1 and DNA polymerase (Pol) [unreadable], each of which have been implicated in base excision repair and the repair ..
  72. Microfluidics-assisted display of stretched DNA in the study of DNA repair in viv
    Julia Sidorova; Fiscal Year: 2012
    ..Using cells with dosage or mutation defects in XRCC1, a protein critical for BER, I will determine whether my approach allows measuring relatively small variations in ..
  73. CELLULAR AND MOLECULAR RESPONSE TO DNA REPAIR DEFICIENCY
    Renee Reijo Pera; Fiscal Year: 2000
    ..This research team has recently created a mouse that is heterozygous for a null mutation in the DNA repair gene XRCC1 (X-ray repair cross-complementing)...
  74. Mechanisms of Trinucleotide Repeat Expansion via Oxidative DNA Damage and Repair
    Yuan Liu; Fiscal Year: 2012
    ..by efficient processing of ssDNA break intermediates through BER protein interactions between APE1 and Pol p, XRCC1 and Pol 3, as well as BLM and FEN1. Under Dr...
  75. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..DNA samples from mother and infant will be used to type genetic polymorphisms (CYP1A1, GSTM1, GSTT1, GSTP1, Xrcc1, XPD) relevant to the hypothesized mechanisms...
  76. Cancer susceptibility of XRCC1 mutant mice
    Warren Ladiges; Fiscal Year: 2009
    The main focus of this proposal is investigation of the concept that functional variation in the DNA repair gene XRCC1 can influence susceptibility to carcinogen-induced tumorigenesis...
  77. THREE VHL TUMOR SUPPRESSOR TARGETS IN RENAL CANCER
    Vikas Sukhatme; Fiscal Year: 2002
    ..Clear cell renal carcinoma (RCC) is the most frequent cause of death...
  78. CHROMOSOME BREAKPOINTS, RENAL & SMALL CELL LUNG CANCER
    David Smith; Fiscal Year: 2000
    ..close to a translocation breakpoint observed in a family with inherited predisposition to renal cell carcinoma (RCC)...
  79. BIOPHYSICAL AND SCANNING FORCE MICROSCOPY STUDIES
    DOROTHY ERIE; Fiscal Year: 2001
    ..subsequently sealed by a DNA ligase (either DNA ligase I or DNA ligase III in the presence of the repair protein XRCC1). BER involves a complex set of interactions between the repair proteins and DNA...
  80. Prenatal Exposures & Procarcinogenic Mutations
    Manuela Orjuela; Fiscal Year: 2007
    ..Infant DNA repair capacity (XPD/XRCC1) probably also plays a role in the persistence of chromosomal damage...
  81. Analgesic Use and Kidney Cancer
    Eunyoung Cho; Fiscal Year: 2009
    ..The majority of kidney cancer is renal cell cancer (RCC), with the remainder of cases mostly renal pelvis cancer. The incidence of kidney cancer has been rising in the U.S...
  82. Chemoresistance in Renal Cell Cancer
    JESSIE AU; Fiscal Year: 2006
    Patients with metastatic renal cell cancer (RCC) have a bleak prognosis with an average survival time of less than 18 months. Hence, there is an urgent need of more effective treatments...
  83. Implementation of Resident-Centered Care
    MELANIE KRAUSE; Fiscal Year: 2009
    ..Providing resident-centered care (RCC) is seen by long-term care stakeholders as a promising strategy for achieving higher quality of care and quality of ..