XRCC1

Summary

Gene Symbol: XRCC1
Description: X-ray repair cross complementing 1
Alias: RCC, SCAR26, DNA repair protein XRCC1, X-ray repair complementing defective repair in Chinese hamster cells 1, X-ray repair cross-complementing protein 1
Species: human
Products:     XRCC1

Top Publications

  1. Akbari M, Solvang Garten K, Hanssen Bauer A, Lieske N, Pettersen H, Pettersen G, et al. Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair (Amst). 2010;9:785-95 pubmed publisher
    ..The DNA repair protein XRCC1 also co-localizes and physically interacts with PCNA...
  2. Heale J, Ball A, Schmiesing J, Kim J, Kong X, Zhou S, et al. Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair. Mol Cell. 2006;21:837-48 pubmed
    ..We show that the association between condensin I, PARP-1, and the base excision repair (BER) factor XRCC1 increases dramatically upon single-strand break damage (SSB) induction...
  3. Li M, Zhou Q, Tu C, Jiang Y. A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk. J Neurooncol. 2013;111:221-8 pubmed publisher
    The associations of the X-ray repair cross complementing group 1 (XRCC1) gene single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, Arg399Gln with the risk of gliomas have been studied recently, but contradictions exist whether ..
  4. Roszak A, Lianeri M, Jagodzinski P. Involvement of the XRCC1 Arg399Gln gene polymorphism in the development of cervical carcinoma. Int J Biol Markers. 2011;26:216-20 pubmed publisher
    ..The association of the XRCC1 Arg399Gln (rs25487) polymorphism with cervical cancer has been demonstrated in some populations.
  5. Guo S, Li X, Gao M, Li Y, Song B, Niu W. The relationship between XRCC1 and XRCC3 gene polymorphisms and lung cancer risk in northeastern Chinese. PLoS ONE. 2013;8:e56213 pubmed publisher
    ..underpinnings, we sought to investigate the association of three well-characterized nonsynonymous polymorphisms in XRCC1 (Arg194Trp and Arg399Gln) and XRCC3 (Thr241Met) genes with lung cancer risk in northeastern Chinese...
  6. Sorour A, Ayad M, Kassem H. The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia. Genet Test Mol Biomarkers. 2013;17:195-201 pubmed publisher
    ..We studied polymorphisms in three DNA repair genes; XRCC1, XRCC3, and XPD. We also assessed the incidence of the NQO1 gene polymorphism...
  7. Wang N, Wu Y, Zhou X, Wu Y. [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population]. Wei Sheng Yan Jiu. 2012;41:251-6 pubmed
    ..in Henan population to investigate the role of CYP1A1-Msp1, CYP1A1-exon7, GSTM1, GSTT1, mEH-exon3, mEH-exon4 and XRCC1 in lung cancer. Genotyping was performed by using PCR based restriction fragment length polymorhphism techniques...
  8. Han X, Xing Q, Li Y, Sun J, Ji H, Huazheng P, et al. Study on the DNA repair gene XRCC1 and XRCC3 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Hepatogastroenterology. 2012;59:2285-9 pubmed
    We conducted a case-control study in China to clarify the association between XRCC1-Arg-399Gin polymorphism and HCC risk. A total of 150 cases and 158 controls were selected from May 2008 to May 2010...
  9. Luo K, Mu S, Wu Z, Shi Y, Peng J. Polymorphisms in DNA repair genes and risk of glioma and meningioma. Asian Pac J Cancer Prev. 2013;14:449-52 pubmed
    ..We included 297 cases and 458 cancer-free controls. Genotyping of XRCC1 Gln399Arg, XRCC1 Arg194Trp, XRCC2 Arg188His, XRCC3 Thr241Met, XRCC4 Ala247Ser, ERCC1 Asn118Asp, ERCC2 Lys751Gln ..

More Information

Publications102 found, 100 shown here

  1. Muñiz Mendoza R, Ayala Madrigal M, Partida Pérez M, Peregrina Sandoval J, Leal Ugarte E, Macias Gomez N, et al. MLH1 and XRCC1 polymorphisms in Mexican patients with colorectal cancer. Genet Mol Res. 2012;11:2315-20 pubmed publisher
    ..We analyzed a possible association of MLH1 -93G>A and 655A>G and XRCC1 Arg194Trp and Arg399Gln polymorphisms with CRC in Mexican patients...
  2. Wei B, Zhou Y, Xu Z, Ruan J, Zhu M, Jin K, et al. XRCC1 Arg399Gln and Arg194Trp polymorphisms in prostate cancer risk: a meta-analysis. Prostate Cancer Prostatic Dis. 2011;14:225-31 pubmed publisher
    Epidemiological studies have evaluated the association between X-ray repair cross-complementing group 1 gene (XRCC1) Arg399Gln and Arg194Trp polymorphisms and risk of prostate cancer (PCa)...
  3. Gencer M, Dasdemir S, Cakmakoglu B, Cetinkaya Y, Varlibas F, Tireli H, et al. DNA repair genes in Parkinson's disease. Genet Test Mol Biomarkers. 2012;16:504-7 pubmed publisher
    ..In the light of these findings, we investigated whether DNA repair gene polymorphisms (XRCC1 Arg399Gln, XRCC3 Thr241Met XPD Lys751Gln, XPG Asp1104His, APE1 Asp148Glu, and HOGG1 Ser326Cys) account for an ..
  4. Duman N, Aktan M, Ozturk S, Palanduz S, Cakiris A, Ustek D, et al. Investigation of Arg399Gln and Arg194Trp polymorphisms of the XRCC1 (x-ray cross-complementing group 1) gene and its correlation to sister chromatid exchange frequency in patients with chronic lymphocytic leukemia. Genet Test Mol Biomarkers. 2012;16:287-91 pubmed publisher
    Polymorphisms of the x-ray repair cross-complementing group 1 (XRCC1) gene have been reported to be associated with various forms of cancer...
  5. Wang D, Hu Y, Gong H, Li J, Ren Y, Li G, et al. Genetic polymorphisms in the DNA repair gene XRCC1 and susceptibility to glioma in a Han population in northeastern China: a case-control study. Gene. 2012;509:223-7 pubmed publisher
    Several single nucleotide polymorphisms (SNPs) in the X-ray cross-complementing group 1 (XRCC1) gene have been shown to influence DNA repair and to modify cancer susceptibility...
  6. Della Maria J, Hegde M, McNeill D, Matsumoto Y, Tsai M, Ellenberger T, et al. The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sites. J Biol Chem. 2012;287:39233-44 pubmed publisher
    b>XRCC1 plays a key role in the repair of DNA base damage and single-strand breaks. Although it has no known enzymatic activity, XRCC1 interacts with multiple DNA repair proteins and is a subunit of distinct DNA repair protein complexes...
  7. Hu X, Feng Z, Fan Y, Xiong Z, Huang Q. Polymorphisms in DNA repair gene XRCC1 and increased genetic susceptibility to glioma. Asian Pac J Cancer Prev. 2011;12:2981-4 pubmed
    The XRCC1 gene encodes the XRCC1 protein, which complexes with three other DNA repair enzymes involved in the base-excision repair (BER) pathways...
  8. Mao Y, Xu X, Lin Y, Chen H, Wu J, Hu Z, et al. Quantitative assessment of the associations between XRCC1 polymorphisms and bladder cancer risk. World J Surg Oncol. 2013;11:58 pubmed publisher
    The XRCC1 polymorphisms have been implicated in bladder cancer risk, but individually published studies show inconsistent results. The aim of our study was to clarify the effects of XRCC1 variants on bladder cancer risk...
  9. Zhang H, Wang P, Dai L, Wang K, Yun Y, Zhang J. [Meta-analysis of the relationship between polymorphisms of 399 point of X-ray repair cross complementing gene group 1 and hepatocellular carcinoma]. Wei Sheng Yan Jiu. 2010;39:664-8 pubmed
    Discuss the relationship between the X-ray repair cross complementing gene group 1 (XRCC1) 399 point polymorphisms and risk of hepatocellular carcinoma occurrence...
  10. Ji M, Xu B, Jiang J, Wu J, Li X, Zhao W, et al. Relationship between glutathione S-transferase P1 (GSTP1), X-ray repair cross complementing group 1 (XRCC1) and 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene polymorphisms and response to chemotherapy in advanced gastric cancer. Onkologie. 2013;36:335-40 pubmed publisher
    ..P1 (GSTP1), 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) and X-ray repair cross complementing group 1 (XRCC1) gene polymorphisms and the response to chemotherapy in advanced gastric cancer...
  11. Roberts M, Shields P, Ambrosone C, Nie J, Marian C, Krishnan S, et al. Single-nucleotide polymorphisms in DNA repair genes and association with breast cancer risk in the web study. Carcinogenesis. 2011;32:1223-30 pubmed publisher
    ..polymorphisms in four DNA repair genes (ERCC4 rs1799801, XPC rs2227998, rs2228001, rs2228000, OGG1 rs1052133 and XRCC1 rs25487 and rs25486) and breast cancer risk, examining modification by smoking and alcohol consumption, using data ..
  12. Barbisan G, Pérez L, Difranza L, Fernandez C, Ciancio N, Golijow C. XRCC1 Arg399Gln polymorphism and risk for cervical cancer development in Argentine women. Eur J Gynaecol Oncol. 2011;32:274-9 pubmed
    b>XRCC1 (X-ray repair cross-complementing group 1) plays a central role in the DNA base excision repair mechanism...
  13. Yosunkaya E, Karakurt F, Cetin E, Ozgonenel L, Onaran I, Batar B, et al. Rheumatoid arthritis risk associates with DNA repair gene XRCC1 Arg399Gln polymorphism in Turkish patients. Rheumatol Int. 2012;32:1265-9 pubmed publisher
    ..The polymorphisms in BER repair pathway genes, XRCC1 and OGG1, may change the response to inflammation via altered DNA repair capacity...
  14. Huang G, Cai S, Wang W, Zhang Q, Liu A. Association between XRCC1 and XRCC3 polymorphisms with lung cancer risk: a meta-analysis from case-control studies. PLoS ONE. 2013;8:e68457 pubmed publisher
    Many studies have reported the association of X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln, Arg194Trp, Arg280His, -77T>C, and X-ray repair cross-complementing group 3 (XRCC3) T241M polymorphisms with lung cancer risk, ..
  15. Lv H, Li Q, Qiu W, Xiang J, Wei H, Liang H, et al. Genetic polymorphism of XRCC1 correlated with response to oxaliplatin-based chemotherapy in advanced colorectal cancer. Pathol Oncol Res. 2012;18:1009-14 pubmed
    To examine the association between genetic polymorphisms of XRCC1 Arg399Gln(G?A) and response to oxaliplatin-based chemotherapy in advanced colorectal cancer...
  16. Jacobs D, Bracken M. Association between XRCC1 polymorphism 399 G->A and glioma among Caucasians: a systematic review and meta-analysis. BMC Med Genet. 2012;13:97 pubmed publisher
    The x-ray cross complementing group 1 gene (XRCC1) is crucial to proper repair of DNA damage such as single-strand DNA breaks...
  17. Liu Y, Shi J, Fu L, Zhou B, Wang H, Wu X. Gene polymorphism of XRCC1 Arg399Gln and cervical carcinoma susceptibility in Asians: a meta-analysis based on 1,759 cases and 2,497 controls. Asian Pac J Cancer Prev. 2013;14:189-93 pubmed
    ..have investigated associations between the Arg399Gln gene polymorphism of X-ray repair cross complementing gene 1 (XRCC1) and risk of cervical carcinoma, but no conclusions have been available because of controversial results...
  18. Wang C, Ai Z. Association of XRCC1 polymorphisms with thyroid cancer risk. Tumour Biol. 2014;35:4791-7 pubmed publisher
    ..carried out to explore the relationship between the polymorphisms in the X-ray repair cross-complementing group 1 (XRCC1) gene and thyroid cancer risk. But previous reports have produced conflicting results...
  19. Przybylowska Sygut K, Stanczyk M, Kusinska R, Kordek R, Majsterek I. Association of the Arg194Trp and the Arg399Gln polymorphisms of the XRCC1 gene with risk occurrence and the response to adjuvant therapy among Polish women with breast cancer. Clin Breast Cancer. 2013;13:61-8 pubmed publisher
    The XRCC1 gene encoding the X-ray cross-complementing group 1 protein (XRCC1) is involved in the base excision repair (BER) pathway...
  20. Zhang Y, Wang Y, Wu J, Li L. XRCC1 Arg194Trp polymorphism is associated with oral cancer risk: evidence from a meta-analysis. Tumour Biol. 2013;34:2321-7 pubmed publisher
    Previous studies show that X-ray cross-complementing group 1 (XRCC1) Arg194Trp may result in variations in host's repair efficiency of DNA damage, and this repair deficit may eventually cause individual susceptibility to oral cancer...
  21. Li Q, Lu C, Ye M, Xiao W, Liang J. Evaluation of DNA repair gene XRCC1 polymorphism in prediction and prognosis of hepatocellular carcinoma risk. Asian Pac J Cancer Prev. 2012;13:191-4 pubmed
    We conducted a case-control study in China to clarify the association between XRCC1-Arg399Gln polymorphism and HCC risk...
  22. Gao W, Romkes M, Zhong S, Nukui T, Persad R, Smith P, et al. Genetic polymorphisms in the DNA repair genes XPD and XRCC1, p53 gene mutations and bladder cancer risk. Oncol Rep. 2010;24:257-62 pubmed
    ..the Xeroderma pigmentosum group D (XPD) gene codon 751 and the X-ray repair cross-complementing group 1 (XRCC1) gene codon 399 polymorphisms, were associated with an increased risk of lung cancer, and, in some studies, with a ..
  23. Jiang L, Fang X, Bao Y, Zhou J, Shen X, Ding M, et al. Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies. PLoS ONE. 2013;8:e55597 pubmed publisher
    X-ray repair cross-complementing group 1 (XRCC1) is one of the DNA repair genes encoding a scaffolding protein that participate in base excision repair (BER) pathway...
  24. Liu B, Liu T, You B, You H, Yang J, Li L, et al. Lack of an association between the XRCC1 Arg399Gln polymorphism and gastric cancer based on a meta-analysis. Genet Mol Res. 2012;11:3852-60 pubmed publisher
    Association between the XRCC1 Arg399Gln polymorphism and susceptibility to gastric cancer has been investigated; overall, the results have been inconclusive...
  25. Bănescu C, Duicu C, Trifa A, Dobreanu M. XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia. Leuk Lymphoma. 2014;55:365-70 pubmed publisher
    ..excision repair pathway, the predominant DNA damage repair mechanism, X-ray repair cross-complementing group 1 (XRCC1) gene, has a crucial role. Defects in repair pathways are involved in cancer pathogenesis...
  26. Krupa R, Kasznicki J, Gajecka M, Rydzanicz M, Kiwerska K, Kaczmarczyk D, et al. Polymorphisms of the DNA repair genes XRCC1 and ERCC4 are not associated with smoking- and drinking-dependent larynx cancer in a Polish population. Exp Oncol. 2011;33:55-6 pubmed
    ..The X-ray repair cross complementing 1 (XRCC1) and excision repair cross-complementing rodent repair deficiency, complementation group 4 (ERCC4(XPF)) genes are ..
  27. Yu H, Fu C, Wang J, Xue H, Xu B. Interaction between XRCC1 polymorphisms and intake of long-term stored rice in the risk of esophageal squamous cell carcinoma: a case-control study. Biomed Environ Sci. 2011;24:268-74 pubmed publisher
    ..the roles of three common single nucleotide polymorphisms in the X-ray repair cross-complementing group-1 gene (XRCC1) and of life style factors and their possible interactions in the risk of esophageal squamous cell carcinoma (ESCC)..
  28. Cui Z, Yin Z, Li X, Wu W, Guan P, Zhou B. Association between polymorphisms in XRCC1 gene and clinical outcomes of patients with lung cancer: a meta-analysis. BMC Cancer. 2012;12:71 pubmed publisher
    X-ray repair cross-complementing group 1 (XRCC1) protein plays an important role in the repair of DNA damage and adducts...
  29. Li Z, Guan W, Li M, Zhong Z, Qian C, Yang X, et al. Genetic polymorphism of DNA base-excision repair genes (APE1, OGG1 and XRCC1) and their correlation with risk of lung cancer in a Chinese population. Arch Med Res. 2011;42:226-34 pubmed publisher
    ..remove oxidative lesions in which 8-oxoguanine glycosylase-1 (OGG1), x-ray repair cross-complementing 1 (XRCC1), and apurinic/apyimidinic endonuclease 1 (APE1) play key roles...
  30. Chiyomaru K, Nagano T, Nishigori C. XRCC1 Arg194Trp polymorphism, risk of nonmelanoma skin cancer and extramammary Paget's disease in a Japanese population. Arch Dermatol Res. 2012;304:363-70 pubmed publisher
    ..259, 95 % CI 0.07-0.96). Our data suggest that the Arg194Trp polymorphism could be associated with nonmelanoma skin cancer and extramammary Paget's disease risk in a Japanese population. ..
  31. Nakao M, Hosono S, Ito H, Watanabe M, Mizuno N, Sato S, et al. Selected polymorphisms of base excision repair genes and pancreatic cancer risk in Japanese. J Epidemiol. 2012;22:477-83 pubmed publisher
    ..of 5 single-nucleotide polymorphisms (SNPs) of BER genes, namely rs1052133 in OGG1, rs1799782 and rs25487 in XRCC1, rs1130409 in APE1, and rs1136410 in PARP1...
  32. Yuan P, Liu L, Wu C, Zhong R, Yu D, Wu J, et al. No association between XRCC1 polymorphisms and survival in non-small-cell lung cancer patients treated with platinum-based chemotherapy. Cancer Biol Ther. 2010;10:854-9 pubmed publisher
    ..investigated whether single nucleotide polymorphisms (SNPs) in the X-ray repair cross complementing protein 1 (XRCC1) gene are associated with survival in non-small-cell lung cancer (NSCLC) patients treated with platinum-based ..
  33. Xue H, Ni P, Lin B, Xu H, Huang G. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and gastric cancer risk: A HuGE review and meta-analysis. Am J Epidemiol. 2011;173:363-75 pubmed publisher
    ..performed a systematic review and meta-analysis of associations of the x-ray repair cross-complementing 1 gene (XRCC1) single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, and Arg399Gln with gastric cancer risk, based on ..
  34. Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment. Mutat Res. 2011;727:1-15 pubmed publisher
    ..b>XRCC1 is involved in base excision repair (BER) of DNA; it has variant genotypes that are associated with modified ..
  35. Canalle R, Silveira V, Scrideli C, Queiroz R, Lopes L, Tone L. Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2011;52:1118-26 pubmed publisher
    The aim of this study was to evaluate the frequency of polymorphisms in the TYMS, XRCC1, and ERCC2 DNA repair genes in pediatric patients with acute lymphoblastic leukemia using polymerase chain reaction (PCR) and PCR-restriction ..
  36. Huang J, Zhang J, Zhao Y, Liao B, Liu J, Li L, et al. The Arg194Trp polymorphism in the XRCC1 gene and cancer risk in Chinese Mainland population: a meta-analysis. Mol Biol Rep. 2011;38:4565-73 pubmed publisher
    The Arg194Trp polymorphism in the X-ray repair cross-complementing group 1 (XRCC1) gene has been proved to be in association with cancer risk in Chinese Mainland population, but a large number of studies have reported inconclusive ..
  37. Chen B, Zhou Y, Yang P, Wu X. Polymorphisms of XRCC1 and gastric cancer susceptibility: a meta-analysis. Mol Biol Rep. 2012;39:1305-13 pubmed publisher
    Studies investigating the association between X-ray repair cross-complementing gene 1 (XRCC1) polymorphisms and gastric cancer (GC) risk have reported conflicting results...
  38. Warchoł T, Mostowska A, Lianeri M, Lacki J, Jagodziński P. XRCC1 Arg399Gln gene polymorphism and the risk of systemic lupus erythematosus in the Polish population. DNA Cell Biol. 2012;31:50-6 pubmed publisher
    ..is reduced in patients with systemic lupus erythematosus (SLE) and that the X-ray repair cross-complementing (XRCC1) Arg399Gln (rs25487) polymorphism may contribute to DNA repair...
  39. Ryu R, Tae K, Min H, Jeong J, Cho S, Lee S, et al. XRCC1 polymorphisms and risk of papillary thyroid carcinoma in a Korean sample. J Korean Med Sci. 2011;26:991-5 pubmed publisher
    Polymorphisms of DNA repair genes, X-ray repair cross-complementing group 1 (XRCC1) might contribute to individual susceptibility to different types of cancers...
  40. Zhang H, Li W, Franklin M, Dudek A. Polymorphisms in DNA repair gene XRCC1 and skin cancer risk: a meta-analysis. Anticancer Res. 2011;31:3945-52 pubmed
    Published data on the association between polymorphisms of the X-ray repair cross-complementing group 1 (XRCC1) gene and skin cancer risk are inconsistent...
  41. Huang G, Guo H, Yu C, Liu X, Li B, Wu J, et al. XRCC1 polymorphisms and risk of nasopharyngeal carcinoma: a meta-analysis. Asian Pac J Cancer Prev. 2011;12:2329-33 pubmed
    Previous studies on the association between X-ray repair cross-complementing protein 1 (XRCC1) polymorphisms and nasopharyngeal carcinoma (NPC) risk showed inconsistent results...
  42. Wang R, Hu X, Zhou Y, Feng Q, Su L, Long J, et al. XRCC1 Arg399Gln and Arg194Trp polymorphisms in childhood acute lymphoblastic leukemia risk: a meta-analysis. Leuk Lymphoma. 2013;54:153-9 pubmed publisher
    The purpose of this study was to evaluate the association between X-ray repair cross-complementing group 1 (XRCC1) gene Arg399Gln and Arg194Trp polymorphisms and childhood acute lymphoblastic leukemia risk (ALL) risk...
  43. Dai L, Duan F, Wang P, Song C, Wang K, Zhang J. XRCC1 gene polymorphisms and lung cancer susceptibility: a meta-analysis of 44 case-control studies. Mol Biol Rep. 2012;39:9535-47 pubmed publisher
    X-ray repair cross-complementing group 1 gene (XRCC1) has been implicated in risk for lung cancer. However, the results from different studies remain controversial...
  44. dos Reis M, Losi Guembarovski R, de Souza Fonseca Ribeiro E, Cavalli I, Morita M, Ramos G, et al. Allelic variants of XRCC1 and XRCC3 repair genes and susceptibility of oral cancer in Brazilian patients. J Oral Pathol Med. 2013;42:180-5 pubmed publisher
    ..the relationship between the presence of allelic variants Arg194Trp (rs:1799782) and Arg399Gln (rs: 25487) of XRCC1 gene and Thr241Met (rs: 861539) of XRCC3 gene and susceptibility to oral cancer...
  45. Saadat I, Beyzaei Z, Aghaei F, Kamrani S, Saadat M. Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia. Arch Gynecol Obstet. 2012;286:1459-62 pubmed publisher
    ..b>XRCC1 (MIM: 194360) and XRCC7 (MIM: 600899) play a crucial role in the DNA repair pathways...
  46. Xie T, Wang Z, Zhang J, Liu H. X-ray repair cross-complementing group 1 polymorphisms and hepatocellular carcinoma: a meta-analysis. World J Gastroenterol. 2012;18:4207-14 pubmed publisher
    ..a systematic meta-analysis to investigate the association between X-ray repair cross-complementing group 1 (XRCC1) polymorphisms and hepatocellular carcinoma (HCC) risk...
  47. Zhang K, Zhou B, Wang Y, Rao L, Zhang L. The XRCC1 Arg280His polymorphism contributes to cancer susceptibility: an update by meta-analysis of 53 individual studies. Gene. 2012;510:93-101 pubmed publisher
    The X-ray repair cross-complementing group 1 (XRCC1) protein plays a central role in DNA repair pathways...
  48. Li J, Li Z, Feng L, Guo W, Zhang S. Polymorphisms of DNA repair gene XRCC1 and hepatocellular carcinoma risk among East Asians: a meta-analysis. Tumour Biol. 2013;34:261-9 pubmed publisher
    Association studies on the X-ray repair cross-complementing group 1 (XRCC1) polymorphisms (Arg194Trp, Arg280His, and Arg399Gln) in hepatocellular carcinoma (HCC) have shown conflicting results...
  49. Khlifi R, Rebai A, Hamza Chaffai A. Polymorphisms in human DNA repair genes and head and neck squamous cell carcinoma. J Genet. 2012;91:375-84 pubmed
    ..Xeroderma pigmentosum group D (XPD) and X-ray repair cross-complementing proteins 1 (XRCC1) and 3 (XRCC3) genes are involved in DNA repair and were found to be associated with HNSCC in numerous studies...
  50. Bose S, Tripathi D, Sukriti -, Sakhuja P, Kazim S, Sarin S. Genetic polymorphisms of CYP2E1 and DNA repair genes HOGG1 and XRCC1: association with hepatitis B related advanced liver disease and cancer. Gene. 2013;519:231-7 pubmed publisher
    ..PCR-RFLP was used for the genotyping of Cyp2E1*5B, hOGG1 codon 326 and XRCC1 codon 399...
  51. Du Y, Han L, Li D, Liu H, Gao Y, Sun D. Associations between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and risk of differentiated thyroid carcinoma: a meta-analysis. Asian Pac J Cancer Prev. 2013;14:5483-7 pubmed
    Associations between Arg399Gln, Arg194Trp and Arg280His polymorphisms of the XRCC1 gene and risk of differentiated thyroid carcinoma (DTC) have been widely studied but the findings are contradictory...
  52. Yi L, Xiao Feng H, Yun tao L, Hao L, Ye S, Song tao Q. Association between the XRCC1 Arg399Gln polymorphism and risk of cancer: evidence from 297 case-control studies. PLoS ONE. 2013;8:e78071 pubmed publisher
    The Arg399Gln polymorphism in the X-ray cross-complementing group 1 (XRCC1) had been implicated in cancer susceptibility...
  53. Kim I, Lee G, Kim D, Kim H, Kim S, Oh S, et al. Polymorphisms and haplotypes in the XRCC1 gene and the risk of advanced non-small cell lung cancer. J Thorac Oncol. 2010;5:1912-21 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) and haplotypes in the x-ray repair cross-complementing group 1 (XRCC1) gene, which is one of the base excision repair genes, are thought to be associated with the risk of non-small cell lung cancer (..
  54. Liu L, Yuan P, Wu C, Zhang X, Wang F, Guo H, et al. Assessment of XPD Lys751Gln and XRCC1 T-77C polymorphisms in advanced non-small-cell lung cancer patients treated with platinum-based chemotherapy. Lung Cancer. 2011;73:110-5 pubmed publisher
    ..This study tested whether XPD Lys751Gln and XRCC1 T-77C polymorphisms were associated with survival in platinum-treated patients with advanced non-small-cell lung ..
  55. Pramanik S, Devi S, Chowdhary S, Surendran S, Krishnamurthi K, Chakrabarti T. DNA repair gene polymorphisms at XRCC1, XRCC3, XPD, and OGG1 loci in Maharashtrian population of central India. Chemosphere. 2011;82:941-6 pubmed publisher
    ..The present study was undertaken to determine the allele and genotype frequencies of four non-synonymous SNPs, XRCC1 Arg399Gln (C>T, rs25487), XRCC3 Thr241Met (G>A, rs861539), XPD Lys751Gln (T>G, rs13181), and OGG1 ..
  56. Gsur A, Bernhart K, Baierl A, Feik E, Führlinger G, Höfer P, et al. No association of XRCC1 polymorphisms Arg194Trp and Arg399Gln with colorectal cancer risk. Cancer Epidemiol. 2011;35:e38-41 pubmed publisher
    X-ray repair cross complementation group 1 (XRCC1) plays a key role in base excision repair...
  57. Liu F, Li B, Wei Y, Yan L, Wen T, Zhao J, et al. XRCC1 genetic polymorphism Arg399Gln and hepatocellular carcinoma risk: a meta-analysis. Liver Int. 2011;31:802-9 pubmed publisher
    Studies investigating the association between X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphism Arg399Gln and hepatocellular carcinoma (HCC) risk report conflicting results...
  58. Kumar A, Pant M, Singh H, Khandelwal S. Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population. Mutat Res. 2012;729:24-34 pubmed publisher
    ..Genotypes of XRCC1 gene-Arg194Trp, Arg280His, Arg399Gln and XPD Lys751Gln, by PCR-RFLP were studied in 278 SCCHN patients and an ..
  59. Engin A, Karahalil B, Karakaya A, Engin A. Association between XRCC1 ARG399GLN and P53 ARG72PRO polymorphisms and the risk of gastric and colorectal cancer in Turkish population. Arh Hig Rada Toksikol. 2011;62:207-14 pubmed publisher
    ..tumour suppression, it would help to understand the role of the polymorphisms of nucleotide excision repair enzyme XRCC1 and of tumour suppressor gene p53 in gastric and colorectal cancers...
  60. Fard Esfahani P, Fard Esfahani A, Fayaz S, Ghanbarzadeh B, Saidi P, Mohabati R, et al. Association of Arg194Trp, Arg280His and Arg399Gln polymorphisms in X-ray repair cross-complementing group 1 gene and risk of differentiated thyroid carcinoma in Iran. Iran Biomed J. 2011;15:73-8 pubmed
    X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA repair gene and its non-synonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer ..
  61. Trabulus S, Guven G, Altiparmak M, Batar B, Tun O, Yalin A, et al. DNA repair XRCC1 Arg399Gln polymorphism is associated with the risk of development of end-stage renal disease. Mol Biol Rep. 2012;39:6995-7001 pubmed publisher
    ..repair enzyme genes, Xeroderma pigmentosum complementation group D (XPD) and X-ray cross-complementing group 1 (XRCC1), in patients with ESRD and to evaluate their association with ESRD development...
  62. Zhou L, Ma Z, SHI X, Yin X, Huang K, Jiu Z, et al. Polymorphisms of DNA repair gene XRCC1 and risk of glioma: a case-control study in Southern China. Asian Pac J Cancer Prev. 2011;12:2547-50 pubmed
    ..Controls were hospitalized individuals without cancer, frequency matched by sex and age. Three SNPs in XRCC1 gene, Arg399Gln (rs25487), Arg194Trp (rs1799782) and Arg280His (rs25489), were analyzed by the polymerase chain ..
  63. Kostrzewska Poczekaj M, Gawecki W, Illmer J, Rydzanicz M, Gajecka M, Szyfter W, et al. Polymorphisms of DNA repair genes and risk of squamous cell carcinoma of the head and neck in young adults. Eur Arch Otorhinolaryngol. 2013;270:271-6 pubmed publisher
    ..Three polymorphisms in DNA repair genes were analyzed: XPD ex23: A35931C, XRCC1 ex10: G28152A, and XRCC3 ex7: C18067T...
  64. Cho E, Juhnn Y. The cAMP signaling system inhibits the repair of ?-ray-induced DNA damage by promoting Epac1-mediated proteasomal degradation of XRCC1 protein in human lung cancer cells. Biochem Biophys Res Commun. 2012;422:256-62 pubmed publisher
    ..Expression of G?sQL or treatment with forskolin or isoproterenol inhibited the radiation-induced expression of the XRCC1 protein, and exogenous expression of XRCC1 abolished the DNA repair-inhibiting effect of forskolin...
  65. Li Y, Liu F, Tan S, Wang Y, Li S. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and cervical cancer risk: a huge systematic review and meta-analysis. PLoS ONE. 2012;7:e44441 pubmed publisher
    Previous studies investigating the association between X-ray repair cross-complementation group 1(XRCC1) polymorphisms and cervical cancer (CC) risk has provided inconsistent results...
  66. Wei X, Chen D, Lv T. A functional polymorphism in XRCC1 is associated with glioma risk: evidence from a meta-analysis. Mol Biol Rep. 2013;40:567-72 pubmed publisher
    ..Overall, there was a significant association between XRCC1 Arg399Gln polymorphism and glioma risk in two genetic models (for ArgGln vs ArgArg: OR = 1.30, 95 % CI 1.01-1...
  67. Duan W, Zhu Z, Liu J, Dong M, Chen J, Liu Q, et al. XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population: a meta-analysis. Asian Pac J Cancer Prev. 2012;13:3601-4 pubmed
    Numerous studies have evaluated the association between XRCC1 Arg399Gln gene polymorphism and hepatocellular carcinoma risk in the Chinese Han population. However, the results have been inconsistent...
  68. Hanssen Bauer A, Solvang Garten K, Akbari M, Otterlei M. X-ray repair cross complementing protein 1 in base excision repair. Int J Mol Sci. 2012;13:17210-29 pubmed publisher
    X-ray Repair Cross Complementing protein 1 (XRCC1) acts as a scaffolding protein in the converging base excision repair (BER) and single strand break repair (SSBR) pathways...
  69. Hu Z, Hu X, Long J, Su L, Wei B. XRCC1 polymorphisms and differentiated thyroid carcinoma risk: a meta-analysis. Gene. 2013;528:67-73 pubmed publisher
    ..derive a more precise estimation of the association between X-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms and differentiated thyroid carcinoma risk...
  70. Yuan P, Liu L, Wu C, Zhang X, Guo H, Zhong R, et al. A functional -77T>C polymorphism in XRCC1 is associated with risk of breast cancer. Breast Cancer Res Treat. 2011;125:479-87 pubmed publisher
    X-ray repair cross-complementing 1 (XRCC1) plays a critical role in base excision repair and genetic variations of XRCC1 may be associated with cancer susceptibility...
  71. Yosunkaya E, Kucukyuruk B, Onaran I, Gurel C, Uzan M, Kanigur Sultuybek G. Glioma risk associates with polymorphisms of DNA repair genes, XRCC1 and PARP1. Br J Neurosurg. 2010;24:561-5 pubmed publisher
    ..b>XRCC1 and PARP1 are two proteins that act cooperatively in base excision repair (BER) of DNA...
  72. Settheetham Ishida W, Yuenyao P, Natphopsuk S, Settheetham D, Ishida T. Genetic risk of DNA repair gene polymorphisms (XRCC1 and XRCC3) for high risk human papillomavirus negative cervical cancer in Northeast Thailand. Asian Pac J Cancer Prev. 2011;12:963-6 pubmed
    ..papillomavirus infection for the development of cervical cancer, functional polymorphisms of DNA repair genes, XRCC1 Arg399Gln and Arg194Trp and XRCC3 Thr241Met, were studied among Northeastern Thai women...
  73. Kang H, Lee Y, Shin J, Andrabi S, Chi Z, Gagné J, et al. Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage. Proc Natl Acad Sci U S A. 2011;108:14103-8 pubmed publisher
    ..are either PARsylated or bind PAR including PAR polymerase-1, 2 (PARP1, 2), nucleolin, DNA ligase III, KU70, KU86, XRCC1, and histones...
  74. Hanssen Bauer A, Solvang Garten K, Gilljam K, Torseth K, Wilson D, Akbari M, et al. The region of XRCC1 which harbours the three most common nonsynonymous polymorphic variants, is essential for the scaffolding function of XRCC1. DNA Repair (Amst). 2012;11:357-66 pubmed publisher
    b>XRCC1 functions as a non-enzymatic, scaffold protein in single strand break repair (SSBR) and base excision repair (BER). Here, we examine different regions of XRCC1 for their contribution to the scaffolding functions of the protein...
  75. Wu K, Su D, Lin K, Luo J, Au W. XRCC1 Arg399Gln gene polymorphism and breast cancer risk: a meta-analysis based on case-control studies. Asian Pac J Cancer Prev. 2011;12:2237-43 pubmed
    The Arg399Gln polymorphism in the XRCC1 DNA repair gene is likely to be involved with the development of breast cancer (BC). However, there have been inconsistent reports of association...
  76. Pan H, Liang J, Yu Z, Lun L, Li H, Wang Q. Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population. Asian Pac J Cancer Prev. 2011;12:2947-50 pubmed
    We conducted a case-control study in China to clarify the association between the XRCC1-Arg399Gln polymorphism and HCC risk...
  77. Santonocito C, Scapaticci M, Penitente R, Paradisi A, Capizzi R, Lanza Silveri S, et al. Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population. Clin Chim Acta. 2012;413:1519-24 pubmed publisher
    ..We hypothesized that common nsSNPs of BER genes, specifically ADPRT rs1136410, XRCC1 rs25487, rs25489, rs1799782, APEX1 rs1130409, OGG1 rs1052133, LIG3 rs3136025 and MUTYH rs3219466, may contribute ..
  78. Wang N, Wu Y, Zhou X, Wu Y. [The polymorphisms of XRCC1 gene and susceptibility to pulmonary cancer]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2012;30:41-4 pubmed
    To explore the relationship between the polymorphisms of DNA repair gene XRCC1 and susceptibility to pulmonary cancer...
  79. Sun J, Zhang C, Zhang Z, Dong Y, Zhang A, Wang Z, et al. Association between XRCC1 gene polymorphisms and risk of glioma development: a meta-analysis. Asian Pac J Cancer Prev. 2012;13:4783-8 pubmed
    Previous studies of the association between X-ray cross-complementing group 1 (XRCC1) gene polymorphisms and the gliomas risk have yielded conflicting results, and thus a meta-analysis was performed to provide a more accurate estimation...
  80. Liu L, Miao L, Ji G, Qiang F, Liu Z, Fan Z. Association between XRCC1 and XRCC3 polymorphisms and colorectal cancer risk: a meta-analysis of 23 case-control studies. Mol Biol Rep. 2013;40:3943-52 pubmed publisher
    Several potential functional polymorphisms in the DNA repair gene X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln (rs25487), Arg194Trp (rs1799782), Arg280His (rs25489) and X-ray repair cross-complementing group 3 (XRCC3) T241M ..
  81. Qian K, Liu K, Xu F, Chen X, Chen G, Yi W, et al. X-ray repair cross-complementing group 1(XRCC1) genetic polymorphisms and thyroid carcinoma risk: a meta-analysis. Asian Pac J Cancer Prev. 2012;13:6385-90 pubmed
    A number of studies have been conducted to explore the association of XRCC1 polymorphisms with thyroid cancer risk, but the results have been inconsistent...
  82. Fang Z, Chen F, Wang X, Yi S, Chen W, Ye G. XRCC1 Arg194Trp and Arg280His polymorphisms increase bladder cancer risk in Asian population: evidence from a meta-analysis. PLoS ONE. 2013;8:e64001 pubmed publisher
    A lot of studies have investigated the correlation between x-ray cross complementing group 1 (XRCC1) polymorphisms and bladder cancer risk, but the results in Asian population were still inconclusive...
  83. Tian Z, Li Y, Liu J. XRCC1 Arg399Gln polymorphism contributes to increased risk of colorectal cancer in Chinese population. Mol Biol Rep. 2013;40:4147-51 pubmed publisher
    Previous studies investigating the association between X-ray repair cross-complementation group 1 (XRCC1) Arg399Gln polymorphism and colorectal cancer risk in Chinese provided inconsistent findings...
  84. Al Mutairi F, Alanazi M, Shalaby M, Alabdulkarim H, Pathan A, Parine N. Association of XRCC1 gene polymorphisms with breast cancer susceptibility in Saudi patients. Asian Pac J Cancer Prev. 2013;14:3809-13 pubmed
    X-ray repair cross-complementing group 1 (XRCC1) plays a key role in the base excision repair pathway, as a scaffold protein that brings together proteins of the DNA repair complex...
  85. Yuan T, Deng S, Chen M, Chen W, Lu W, Huang H, et al. Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population. Cancer Epidemiol. 2011;35:170-4 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) of xeroderma pigmentosum group D (XPD) and X-ray repair cross complement 1 (XRCC1) genes were genotyped in gastric cancer and control subjects in a population from Southwestern China for their ..
  86. Jiang J, Liang X, Zhou X, Huang R, Chu Z, Zhan Q, et al. DNA repair gene X-ray repair cross complementing group 1 Arg194Trp polymorphism on the risk of lung cancer: a meta-analysis on 22 studies. J Thorac Oncol. 2010;5:1741-7 pubmed publisher
    DNA repair gene X-ray repair cross complementing group 1 (XRCC1) Arg194Trp polymorphism has been investigated widely on lung cancer risk. However, the results are inconclusive...
  87. Zhou L, Xia J, Li H, Dai J, Hu Y. Association of XRCC1 variants with acute skin reaction after radiotherapy in breast cancer patients. Cancer Biother Radiopharm. 2010;25:681-5 pubmed publisher
    ..association of single nucleotide polymorphisms of BER DNA repair X-ray repair cross-complementing group 1 protein (XRCC1) and risk of radiotherapy-induced ?grade 2 acute skin reaction in patients with breast cancer was examined...
  88. Kudo K, Gavin E, Das S, Amable L, Shevde L, Reed E. Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1, and inhibition of platinum-DNA adduct repair. Oncogene. 2012;31:4718-24 pubmed publisher
    ..We therefore studied the possible relationships between Gli1, c-jun, and the upregulation of ERCC1, XPD and XRCC1 in cisplatin-resistant human ovarian cancer cells...
  89. Wang S, Wu X, Chen Y, Zhang J, Ding J, Zhou Y, et al. Prognostic and predictive role of JWA and XRCC1 expressions in gastric cancer. Clin Cancer Res. 2012;18:2987-96 pubmed publisher
    ..the expression pattern and significance of DNA repair genes JWA and X-ray repair cross complement group 1 (XRCC1) in gastric cancer...
  90. Wang L, Yin F, Xu X, Hu X, Zhao D. X-ray repair cross-complementing group 1 (XRCC1) genetic polymorphisms and risk of childhood acute lymphoblastic leukemia: a meta-analysis. PLoS ONE. 2012;7:e34897 pubmed publisher
    Recently, there have been a number of studies on the association between XRCC1 polymorphisms and childhood acute lymphoblastic leukemia (ALL) risk. However, the results of previous reports are inconsistent...
  91. Wu J, Liu J, Zhou Y, Ying J, Zou H, Guo S, et al. Predictive value of XRCC1 gene polymorphisms on platinum-based chemotherapy in advanced non-small cell lung cancer patients: a systematic review and meta-analysis. Clin Cancer Res. 2012;18:3972-81 pubmed publisher
    ..data have shown conflicting results about the relationship between X-ray repair cross-complementing group 1 (XRCC1) gene polymorphisms (Arg399Gln and Arg194Trp) and clinical outcome of platinum-based chemotherapy in patients with ..
  92. Annamaneni S, Gorre M, Kagita S, Addepalli K, Digumarti R, Satti V, et al. Association of XRCC1 gene polymorphisms with chronic myeloid leukemia in the population of Andhra Pradesh, India. Hematology. 2013;18:163-8 pubmed publisher
    ..Using case-control study design, we explored possible association of the repair gene, XRCC1, particularly the codons 399, 280, and 194 polymorphisms screened through PCR-RFLP, with the CML in the sample of ..