XPC

Summary

Gene Symbol: XPC
Description: XPC complex subunit, DNA damage recognition and repair factor
Alias: RAD4, XP3, XPCC, p125, DNA repair protein complementing XP-C cells, mutant xeroderma pigmentosum group C, xeroderma pigmentosum, complementation group C
Species: human
Products:     XPC

Top Publications

  1. El Mahdy M, Zhu Q, Wang Q, Wani G, Praetorius Ibba M, Wani A. Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC. J Biol Chem. 2006;281:13404-11 pubmed
    ..of CUL-4A-based ubiquitin ligase, mediates DDB2 degradation at the damage sites and regulates the recruitment of XPC and the repair of cyclobutane pyrimidine dimers...
  2. Pavanello S, Pulliero A, Siwinska E, Mielzynska D, Clonfero E. Reduced nucleotide excision repair and GSTM1-null genotypes influence anti-B[a]PDE-DNA adduct levels in mononuclear white blood cells of highly PAH-exposed coke oven workers. Carcinogenesis. 2005;26:169-75 pubmed
    ..evaluated the influence of four polymorphisms of nucleotide excision repair (NER) genes [xeroderma pigmentosum-C (XPC)-PAT +/-, xeroderma pigmentosum-A (XPA) 5' non-coding region-A23G, XPD-exon 23 A35931C Lys751Gln, xeroderma ..
  3. Yokoi M, Masutani C, Maekawa T, Sugasawa K, Ohkuma Y, Hanaoka F. The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA. J Biol Chem. 2000;275:9870-5 pubmed
    The xeroderma pigmentosum group C protein complex XPC-HR23B was first isolated as a factor that complemented nucleotide excision repair defects of XP-C cell extracts in vitro...
  4. Li Y, Yan J, Kim I, Liu C, Huo K, Rao H. Rad4 regulates protein turnover at a postubiquitylation step. Mol Biol Cell. 2010;21:177-85 pubmed publisher
    ..However, the mechanism underlying Rad23's function in proteolysis remains unknown. Here, we demonstrate that Rad4, a Rad23-binding protein, also regulates ubiquitylated substrate turnover...
  5. Araki M, Masutani C, Takemura M, Uchida A, Sugasawa K, Kondoh J, et al. Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. J Biol Chem. 2001;276:18665-72 pubmed
    ..DNA damage is recognized by a complex originally thought to contain the XP group C responsible gene product (XPC) and the human homologue of Rad23 B (HR23B)...
  6. Wu Y, Jin M, Liu B, Liang X, Yu Y, Li Q, et al. The association of XPC polymorphisms and tea drinking with colorectal cancer risk in a Chinese population. Mol Carcinog. 2011;50:189-98 pubmed publisher
    The xeroderma pigmentosum complementation group C (XPC) is responsible for removal of bulky helix-distorting DNA lesions. Several polymorphisms of XPC gene may modulate the colorectal cancer (CRC) susceptibility...
  7. Pérez Mayoral J, Pacheco Torres A, Morales L, Acosta Rodríguez H, Matta J, Dutil J. Genetic polymorphisms in RAD23B and XPC modulate DNA repair capacity and breast cancer risk in Puerto Rican women. Mol Carcinog. 2013;52 Suppl 1:E127-38 pubmed publisher
    ..For all study participants, eight single nucleotide polymorphisms (SNPs) in the genes XPC, XPD, and RAD23B were genotyped using a TaqMan PCR, and the DRC levels of UV induced-DNA damage was measured in ..
  8. Fong Y, Inouye C, Yamaguchi T, Cattoglio C, Grubisic I, Tjian R. A DNA repair complex functions as an Oct4/Sox2 coactivator in embryonic stem cells. Cell. 2011;147:120-31 pubmed publisher
    ..Purification, identification, and reconstitution of SCC revealed this coactivator to be the trimeric XPC-nucleotide excision repair complex...
  9. Zhang L, Zhang Z, Yan W. Single nucleotide polymorphisms for DNA repair genes in breast cancer patients. Clin Chim Acta. 2005;359:150-5 pubmed
    ..SSCP and RFLP were used to analyze genotypes of DNA repair genes for NBS1, XPC, XPD and XRCC3. T/C in XRCC3 exon 7 had a somewhat deviation from HWE in BC group (P=0.08)...

More Information

Publications109 found, 100 shown here

  1. De Ruyck K, Szaumkessel M, De Rudder I, Dehoorne A, Vral A, Claes K, et al. Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. Mutat Res. 2007;631:101-10 pubmed
    ..gene polymorphisms (XRCC1 -77 T/C, Arg194Trp, Arg280His and Arg399Gln; APE1 Asp148Glu; OGG1 Ser326Cys; XPA -4 G/A; XPC PAT; XPD Asp312Asn and Lys751Gln) with lung cancer risk in Caucasians...
  2. Hu Z, Wang Y, Ma H, Tan W, Niu J, Lin D, et al. [Association of two exonic genetic polymorphisms in the DNA repair gene XPC with risk of lung cancer in Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:415-8 pubmed
    To explore the relationship between two exonic polymorphisms of DNA repair gene XPC and the susceptibility to lung cancer...
  3. Ahmad Aizat A, Siti Nurfatimah M, Aminudin M, Ankathil R. XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians. World J Gastroenterol. 2013;19:3623-8 pubmed publisher
    To investigate the risk association of xeroderma pigmentosum group C (XPC) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition...
  4. Qiu L, Wang Z, Shi X, Wang Z. Associations between XPC polymorphisms and risk of cancers: A meta-analysis. Eur J Cancer. 2008;44:2241-53 pubmed publisher
    ..PAT+/- and Ala(499)Val) in the DNA nuclear excision repair gene xeroderma pigmentosum complementation group C (XPC) are thought to have significant effects on cancer risk...
  5. Sugasawa K, Okuda Y, Saijo M, Nishi R, Matsuda N, Chu G, et al. UV-induced ubiquitylation of XPC protein mediated by UV-DDB-ubiquitin ligase complex. Cell. 2005;121:387-400 pubmed
    The xeroderma pigmentosum group C (XPC) protein complex plays a key role in recognizing DNA damage throughout the genome for mammalian nucleotide excision repair (NER)...
  6. Shivji M, Eker A, Wood R. DNA repair defect in xeroderma pigmentosum group C and complementing factor from HeLa cells. J Biol Chem. 1994;269:22749-57 pubmed
    ..In transcribed DNA, its role is subsumed by RNA polymerase and/or transcription coupling factors. ..
  7. Yasuda T, Sugasawa K, Shimizu Y, Iwai S, Shiomi T, Hanaoka F. Nucleosomal structure of undamaged DNA regions suppresses the non-specific DNA binding of the XPC complex. DNA Repair (Amst). 2005;4:389-95 pubmed
    The XPC protein complex is a DNA damage detector of human nucleotide excision repair (NER). Although the XPC complex specifically binds to certain damaged sites, it also binds to undamaged DNA in a non-specific manner...
  8. Nishi R, Okuda Y, Watanabe E, Mori T, Iwai S, Masutani C, et al. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. Mol Cell Biol. 2005;25:5664-74 pubmed
    Xeroderma pigmentosum group C (XPC) protein plays a key role in DNA damage recognition in global genome nucleotide excision repair (NER)...
  9. Sak S, Barrett J, Paul A, Bishop D, Kiltie A. Comprehensive analysis of 22 XPC polymorphisms and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:2537-41 pubmed
    Two major risk factors for bladder cancer are smoking and occupational exposure to chemicals. The XPC protein is crucial in the recognition and initiation of the nucleotide excision repair pathway which repairs the DNA adducts formed by ..
  10. Hansen R, Sørensen M, Tjønneland A, Overvad K, Wallin H, Raaschou Nielsen O, et al. XPA A23G, XPC Lys939Gln, XPD Lys751Gln and XPD Asp312Asn polymorphisms, interactions with smoking, alcohol and dietary factors, and risk of colorectal cancer. Mutat Res. 2007;619:68-80 pubmed
    Polymorphisms in the XPD and the XPC gene have been associated with a lower DNA repair capacity...
  11. Legerski R, Peterson C. Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. Nature. 1992;359:70-3 pubmed
    ..protein which is composed of a predicted 823 amino acids and shares limited homology with the product of the yeast DNA repair gene RAD4. The XPCC transcript is undetectable by northern blotting in most XP-C cell lines examined.
  12. Lee G, Jang J, Lee S, Jeon H, Kim K, Choi J, et al. XPC polymorphisms and lung cancer risk. Int J Cancer. 2005;115:807-13 pubmed
    ..To test this hypothesis, we investigated the potential association of 7 XPC polymorphisms (-449G-->C, -371G-->A, -27G-->C, Val499Arg, PAT-/+, IVS11-5C-->A and Lys939Gln) and their ..
  13. Liu D, Wu H, Zhang Y, Kang H, Sun M, Wang E, et al. DNA repair genes XPC, XPG polymorphisms: relation to the risk of colorectal carcinoma and therapeutic outcome with Oxaliplatin-based adjuvant chemotherapy. Mol Carcinog. 2012;51 Suppl 1:E83-93 pubmed publisher
    Xeroderma pigmentosum complementation group C and G (XPC, XPG) play important roles in DNA damage repairing machinery. Genetic variations in the XPC and XPG may be associated with increased risk for colorectal carcinoma (CRC)...
  14. Bergink S, Toussaint W, Luijsterburg M, Dinant C, Alekseev S, Hoeijmakers J, et al. Recognition of DNA damage by XPC coincides with disruption of the XPC-RAD23 complex. J Cell Biol. 2012;196:681-8 pubmed publisher
    ..deoxyribonucleic acid (DNA) lesions by the global genome nucleotide excision repair subpathway is performed by the XPC-RAD23-CEN2 complex...
  15. Khan S, Levy H, Legerski R, Quackenbush E, Reardon J, Emmert S, et al. Xeroderma pigmentosum group C splice mutation associated with autism and hypoglycinemia. J Invest Dermatol. 1998;111:791-6 pubmed
    ..In vitro and in vivo complementation assigned XP22BE to XP group C (XPC) and a markedly reduced level of XPC mRNA was found. Two XPC cDNA bands were identified...
  16. Shimizu Y, Iwai S, Hanaoka F, Sugasawa K. Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. EMBO J. 2003;22:164-73 pubmed
    The XPC-HR23B complex recognizes various helix-distorting lesions in DNA and initiates global genome nucleotide excision repair...
  17. Garcia Closas M, Malats N, Real F, Welch R, Kogevinas M, Chatterjee N, et al. Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:536-42 pubmed
    ..in the NER pathway on bladder cancer risk by analyzing 22 single nucleotide polymorphisms (SNP) in seven NER genes (XPC, RAD23B, ERCC1, ERCC2, ERCC4, ERCC5, and ERCC6)...
  18. Bernardes de Jesus B, Bjørås M, Coin F, Egly J. Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC. Mol Cell Biol. 2008;28:7225-35 pubmed publisher
    b>XPC is responsible for DNA damage sensing in nucleotide excision repair (NER). Mutations in XPC lead to a defect in NER and to xeroderma pigmentosum (XP-C)...
  19. Robu M, Shah R, Petitclerc N, Brind Amour J, Kandan Kulangara F, Shah G. Role of poly(ADP-ribose) polymerase-1 in the removal of UV-induced DNA lesions by nucleotide excision repair. Proc Natl Acad Sci U S A. 2013;110:1658-63 pubmed publisher
    ..PARP inhibition abolishes UV-induced interaction of DDB2 with PARP-1 or xeroderma pigmentosum group C (XPC) and also decreases localization of XPC to UV-damaged DNA, which is a key step that leads to downstream events in ..
  20. Araújo S, Nigg E, Wood R. Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Mol Cell Biol. 2001;21:2281-91 pubmed
    ..involved in the damage recognition and incision steps of DNA nucleotide excision repair are XPA, TFIIH complex, XPC-HR23B, replication protein A (RPA), XPG, and ERCC1-XPF...
  21. Mechanic L, Millikan R, Player J, de Cotret A, Winkel S, Worley K, et al. Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. Carcinogenesis. 2006;27:1377-85 pubmed
    ..non-synonymous coding polymorphisms in six NER genes (XPD codons 312 and 751, RAD23B codon 249, XPG codon 1104, XPC codon 939, XPF codons 415 and 662, and ERCC6 codons 1213 and 1230)...
  22. Bunick C, Miller M, Fuller B, Fanning E, Chazin W. Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein. Biochemistry. 2006;45:14965-79 pubmed
    b>XPC is a 940-residue multidomain protein critical for the sensing of aberrant DNA and initiation of global genome nucleotide excision repair...
  23. Yeh K, Wu Y, Lee M, Wang L, Li C, Chen C, et al. XPC mRNA level may predict relapse in never-smokers with non-small cell lung cancers. Ann Surg Oncol. 2012;19:734-42 pubmed publisher
    ..two lung tumors from NSCLC patients and normal lung tissues from 68 noncancer subjects were enrolled to evaluate XPC (xeroderma pigmentosum group C) mRNA expression by quantitative real-time reverse transcriptase polymerase chain ..
  24. Doubaj Y, Laarabi F, Elalaoui S, Barkat A, Sefiani A. Carrier frequency of the recurrent mutation c.1643_1644delTG in the XPC gene and birth prevalence of the xeroderma pigmentosum in Morocco. J Dermatol. 2012;39:382-4 pubmed publisher
    ..Soufir et al. have reported that XPC is the major disease-causing gene with a recurrent mutation in the Mediterranean region. The mutation c...
  25. Liu C, Yin Q, Hu J, Li L, Zhang Y, Wang Y. A meta-analysis of evidences on XPC polymorphisms and lung cancer susceptibility. Tumour Biol. 2013;34:1205-13 pubmed publisher
    Published data regarding the association between the XPC polymorphisms and lung cancer susceptibility remained controversial. This meta-analysis was performed to draw a precise estimation of the relationship...
  26. Soufir N, Ged C, Bourillon A, Austerlitz F, Chemin C, Stary A, et al. A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa. J Invest Dermatol. 2010;130:1537-42 pubmed publisher
    ..b>XPC and XPA mutations were respectively present in 56/66 and 8/66 probands...
  27. Casson A, Zheng Z, Evans S, Veugelers P, Porter G, Guernsey D. Polymorphisms in DNA repair genes in the molecular pathogenesis of esophageal (Barrett) adenocarcinoma. Carcinogenesis. 2005;26:1536-41 pubmed
    ..and Lys751Gln), XRCC1 (Arg194Trp and Arg399Gln) and XRCC3 (Thr241Met), and the poly (AT) insertion/deletion of XPC (PAT)...
  28. Khan S, Oh K, Shahlavi T, Ueda T, Busch D, Inui H, et al. Reduced XPC DNA repair gene mRNA levels in clinically normal parents of xeroderma pigmentosum patients. Carcinogenesis. 2006;27:84-94 pubmed
    Xeroderma pigmentosum group C (XP-C) is a rare autosomal recessive disorder. Patients with two mutant alleles of the XPC DNA repair gene have sun sensitivity and a 1000-fold increase in skin cancers...
  29. Engin A, Karahalil B, Engin A, Karakaya A. DNA repair enzyme polymorphisms and oxidative stress in a Turkish population with gastric carcinoma. Mol Biol Rep. 2011;38:5379-86 pubmed publisher
    ..are recognized and repaired by nucleotid excision repair (NER) enzymes, including xeroderma pigmentosum C and D (XPC, XPD)...
  30. Senhaji M, Abidi O, Nadifi S, Benchikhi H, Khadir K, Ben Rekaya M, et al. c.1643_1644delTG XPC mutation is more frequent in Moroccan patients with xeroderma pigmentosum. Arch Dermatol Res. 2013;305:53-57 pubmed publisher
    ..Eight genes (XPA to XPG and XPV) are responsible for the disease. Among them, the XPC gene is known to be the most mutated in Mediterranean patients...
  31. Sak S, Barrett J, Paul A, Bishop D, Kiltie A. The polyAT, intronic IVS11-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder. Br J Cancer. 2005;92:2262-5 pubmed
    ..The Xeroderma Pigmentosum Group C (XPC) gene is essential for repair of bulky adducts from carcinogens...
  32. Hoogstraten D, Bergink S, Ng J, Verbiest V, Luijsterburg M, Geverts B, et al. Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC. J Cell Sci. 2008;121:2850-9 pubmed publisher
    To investigate how the nucleotide excision repair initiator XPC locates DNA damage in mammalian cell nuclei we analyzed the dynamics of GFP-tagged XPC...
  33. Fei J, Kaczmarek N, Luch A, Glas A, Carell T, Naegeli H. Regulation of nucleotide excision repair by UV-DDB: prioritization of damage recognition to internucleosomal DNA. PLoS Biol. 2011;9:e1001183 pubmed publisher
    ..the accompanying CUL4A ubiquitin ligase activity is necessary to retain the xeroderma pigmentosum group C (XPC) partner at such internucleosomal repair hotspots that undergo very fast excision kinetics...
  34. Wang Y, Xing D, Tan W, Wang L, Tang P, Lin D. [Poly(AT) polymorphism in DNA repair gene XPC and lung cancer risk]. Zhonghua Zhong Liu Za Zhi. 2003;25:555-7 pubmed
    ..been shown that suboptimal DNA repair capacity is associated with cancer risk and that a poly(AT) polymorphism in XPC gene (XPC PAT) may influence DNA capacity...
  35. Wang Q, Zhu Q, Wani G, El Mahdy M, Li J, Wani A. DNA repair factor XPC is modified by SUMO-1 and ubiquitin following UV irradiation. Nucleic Acids Res. 2005;33:4023-34 pubmed
    ..There are more than 20 proteins involved in NER. Among them, XPC is thought to be one of the first proteins to recognize DNA damage during global genomic repair (GGR), a sub-..
  36. Ben Rekaya M, Messaoud O, Talmoudi F, Nouira S, Ouragini H, Amouri A, et al. High frequency of the V548A fs X572 XPC mutation in Tunisia: implication for molecular diagnosis. J Hum Genet. 2009;54:426-9 pubmed publisher
    ..We report here on the clinical and genetic investigation of XP-C patients in 14 Tunisian families. As the XPC V548A fs X572 mutation has been identified in Algerian and Moroccan populations, Tunisian patients were first ..
  37. Clement F, Kaczmarek N, Mathieu N, Tomas M, Leitenstorfer A, Ferrando May E, et al. Dissection of the xeroderma pigmentosum group C protein function by site-directed mutagenesis. Antioxid Redox Signal. 2011;14:2479-90 pubmed publisher
    ..This mode of action is supported by structural analyses of the yeast Rad4 homologue that identified critical side chains making close contacts with a pair of extrahelical nucleotides...
  38. Gil J, Ramsey D, Stembalska A, Karpinski P, Pesz K, Laczmanska I, et al. The C/A polymorphism in intron 11 of the XPC gene plays a crucial role in the modulation of an individual's susceptibility to sporadic colorectal cancer. Mol Biol Rep. 2012;39:527-34 pubmed publisher
    ..base excision repair (OGG1 Ser326Cys, XRCC1 Trp194Arg and Arg399Gln); nucleotide excision repair [XPA (-4)G/A, XPC C/A (i11) and A33512C (Lys939Gln), XPD Asp312Asn and A18911C (Lys751Gln), XPF Arg415Gln, XPG Asp1104His, ERCC1 ..
  39. Sugasawa K, Ng J, Masutani C, Iwai S, van der Spek P, Eker A, et al. Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. Mol Cell. 1998;2:223-32 pubmed
    The XPC-HR23B complex is specifically involved in global genome but not transcription-coupled nucleotide excision repair (NER). Its function is unknown...
  40. Wood R. DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie. 1999;81:39-44 pubmed
    ..nucleotide excision repair (NER) are the XPA protein, the heterotrimeric RPA protein, the 6 to 9-subunit TFIIH, the XPC-hHR23B complex, the XPG nuclease, and the ERCC1-XPF nuclease...
  41. Qiao Y, Spitz M, Shen H, Guo Z, Shete S, Hedayati M, et al. Modulation of repair of ultraviolet damage in the host-cell reactivation assay by polymorphic XPC and XPD/ERCC2 genotypes. Carcinogenesis. 2002;23:295-9 pubmed
    ..between the repair phenotype of ultraviolet (UV)-induced damage and genotypes of three DNA repair genes, XPC and XPD [involved in nucleotide excision repair (NER)] and XRCC1 [involved in base excision repair (BER)]...
  42. You J, Wang M, Lee S. Biochemical analysis of the damage recognition process in nucleotide excision repair. J Biol Chem. 2003;278:7476-85 pubmed
    XPA, XPC-hHR23B, RPA, and TFIIH all are the damage recognition proteins essential for the early stage of nucleotide excision repair. Nonetheless, it is not clear how these proteins work together at the damaged DNA site...
  43. Sanyal S, Festa F, Sakano S, Zhang Z, Steineck G, Norming U, et al. Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis. 2004;25:729-34 pubmed
    ..of urinary bladder cancer with genetic polymorphisms in the xeroderma pigmentosum complementation group C (XPC), group D (XPD) and group G (XPG), X-ray repair cross-complementing group 1 (XRCC1) and group 3 (XRCC3), Nijmegen ..
  44. Vodicka P, Kumar R, Stetina R, Sanyal S, Soucek P, Haufroid V, et al. Genetic polymorphisms in DNA repair genes and possible links with DNA repair rates, chromosomal aberrations and single-strand breaks in DNA. Carcinogenesis. 2004;25:757-63 pubmed
    ..in genes coding for DNA repair enzymes XPD (exon 23 A --> C, K751Q), XPG (exon 15 G --> C, D1104H), XPC (exon 15 A --> C, K939Q), XRCC1 (exon 10 G --> A, R399Q) and XRCC3 (exon 7 C --> T, T241 M) and the levels ..
  45. Wang G, Chuang L, Zhang X, Colton S, Dombkowski A, Reiners J, et al. The initiative role of XPC protein in cisplatin DNA damaging treatment-mediated cell cycle regulation. Nucleic Acids Res. 2004;32:2231-40 pubmed
    b>XPC is an important DNA damage recognition protein involved in DNA nucleotide excision repair. We have studied the role of the XPC protein in cisplatin treatment-mediated cell cycle regulation...
  46. Blankenburg S, Konig I, Moessner R, Laspe P, Thoms K, Krueger U, et al. Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study. Carcinogenesis. 2005;26:1085-90 pubmed
    ..We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 ..
  47. D Errico M, Parlanti E, Teson M, de Jesus B, Degan P, Calcagnile A, et al. New functions of XPC in the protection of human skin cells from oxidative damage. EMBO J. 2006;25:4305-15 pubmed
    ..Here, we show that XPC plays an unexpected and multifaceted role in cell protection from oxidative DNA damage...
  48. Zhou R, Li Y, Wang N, Zhang X, Dong X, Guo W. [Correlation of XPC Ala499Val and Lys939Gln polymorphisms to risks of esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma]. Ai Zheng. 2006;25:1113-9 pubmed
    Xeroderma pigmentosum group C(XPC) gene is involved in nucleotide excision repair (NER). Single nucleotide polymorphisms (SNP) in XPC gene may affect DNA repairing capacity and genetic susceptibility to cancer...
  49. López Cima M, González Arriaga P, García Castro L, Pascual T, Marrón M, Puente X, et al. Polymorphisms in XPC, XPD, XRCC1, and XRCC3 DNA repair genes and lung cancer risk in a population of northern Spain. BMC Cancer. 2007;7:162 pubmed
    ..We investigated the relationship between polymorphisms in two NER genes, XPC (poly (AT) insertion/deletion: PAT-/+) and XPD (Asp312Asn and Lys751Gln), the BER gene XRCC1 (Arg399Gln), and the ..
  50. Camenisch U, Träutlein D, Clement F, Fei J, Leitenstorfer A, Ferrando May E, et al. Two-stage dynamic DNA quality check by xeroderma pigmentosum group C protein. EMBO J. 2009;28:2387-99 pubmed publisher
    Xeroderma pigmentosum group C (XPC) protein initiates the DNA excision repair of helix-distorting base lesions...
  51. Stern M, Lin J, Figueroa J, Kelsey K, Kiltie A, Yuan J, et al. Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer. Cancer Res. 2009;69:6857-64 pubmed publisher
    ..01-1.19; P = 0.021], NBN E185Q (rs1805794; per-allele OR, 1.09; 95% CI, 1.01-1.18; P = 0.028), and XPC A499V (rs2228000; per-allele OR, 1.10; 95% CI, 1.00-1.21; P = 0.044)...
  52. Takedachi A, Saijo M, Tanaka K. DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. Mol Cell Biol. 2010;30:2708-23 pubmed publisher
    ..of cullin-based ubiquitin ligases, dissociates from the DDB2 complex when the complex binds to damaged DNA and that XPC and Ku oppositely regulate the ubiquitin ligase activity, especially around damaged sites...
  53. Rouissi K, Bahria I, Bougatef K, Marrakchi R, Stambouli N, Hamdi K, et al. The effect of tobacco, XPC, ERCC2 and ERCC5 genetic variants in bladder cancer development. BMC Cancer. 2011;11:101 pubmed publisher
    ..we have conducted a case-control study in order to assess the effect of tobacco and three genetic polymorphisms in XPC, ERCC2 and ERCC5 genes (rs2228001, rs13181 and rs17655) in bladder cancer development in Tunisia...
  54. Renaud E, Miccoli L, Zacal N, Biard D, Craescu C, Rainbow A, et al. Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells. DNA Repair (Amst). 2011;10:835-47 pubmed publisher
    ..The first step of NER is mediated by a protein complex composed of XPC, RAD23B, an ubiquitin receptor and CENTRIN 2, an EF-hand calcium binding protein...
  55. He J, Shi T, Zhu M, Wang M, Li Q, Wei Q. Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: a meta-analysis. Int J Cancer. 2013;133:1765-75 pubmed publisher
    b>XPC polymorphisms may alter DNA repair capacity, thus leading to genetic instability and carcinogenesis...
  56. Letkova L, Matakova T, Musak L, Sarlinova M, Krutakova M, Slovakova P, et al. DNA repair genes polymorphism and lung cancer risk with the emphasis to sex differences. Mol Biol Rep. 2013;40:5261-73 pubmed publisher
    ..In the present study, we investigated the polymorphisms of following selected DNA repair genes: XPC (Lys939Gln), XPD (Lys751Gln), hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), and the risks they present towards the ..
  57. Masutani C, Sugasawa K, Yanagisawa J, Sonoyama T, Ui M, Enomoto T, et al. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. EMBO J. 1994;13:1831-43 pubmed
    ..The 125 kDa subunit is an N-terminally extended version of previously reported XPCC gene product which is thought to represent the human homologue of the Saccharomyces cerevisiae repair gene RAD4...
  58. Li L, Peterson C, Legerski R. Sequence of the mouse XPC cDNA and genomic structure of the human XPC gene. Nucleic Acids Res. 1996;24:1026-8 pubmed
    The full length-mouse XPC cDNA contains a 2703 bp orf which encodes a polypeptide containing 900 amino acids. Overall, there is 75% identity in nucleotide sequence and 73% identity in amino acid sequence between mouse and human genes...
  59. van der Spek P, Eker A, Rademakers S, Visser C, Sugasawa K, Masutani C, et al. XPC and human homologs of RAD23: intracellular localization and relationship to other nucleotide excision repair complexes. Nucleic Acids Res. 1996;24:2551-9 pubmed
    ..The XPC protein is complexed with HHR23B, one of the two human homologs of the yeast NER protein, RAD23 (Masutani at al...
  60. Sugasawa K, Shimizu Y, Iwai S, Hanaoka F. A molecular mechanism for DNA damage recognition by the xeroderma pigmentosum group C protein complex. DNA Repair (Amst). 2002;1:95-107 pubmed
    The XPC-HR23B complex is involved in DNA damage recognition and the initiation of global genomic nucleotide excision repair (GG-NER)...
  61. Ng J, Vermeulen W, van der Horst G, Bergink S, Sugasawa K, Vrieling H, et al. A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. Genes Dev. 2003;17:1630-45 pubmed
    ..in mammalian global genome nucleotide excision repair (GG-NER) is performed by the xeroderma pigmentosum group C (XPC)/HR23B protein complex...
  62. Ye W, Kumar R, Bacova G, Lagergren J, Hemminki K, Nyren O. The XPD 751Gln allele is associated with an increased risk for esophageal adenocarcinoma: a population-based case-control study in Sweden. Carcinogenesis. 2006;27:1835-41 pubmed
    ..population-based case-control study, we examined associations of polymorphisms in the DNA repair genes XPD, XPC, XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia ..
  63. Zhu Y, Lai M, Yang H, Lin J, Huang M, Grossman H, et al. Genotypes, haplotypes and diplotypes of XPC and risk of bladder cancer. Carcinogenesis. 2007;28:698-703 pubmed
    Xeroderma pigmentosum complementation group C (XPC) is responsible for DNA damage recognition in the initial steps of the nucleotide excision repair pathway...
  64. Berndt S, Platz E, Fallin M, Thuita L, Hoffman S, Helzlsouer K. Genetic variation in the nucleotide excision repair pathway and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev. 2006;15:2263-9 pubmed
    ..64; 95% CI, 1.53-4.58 for the RG and GG genotypes respectively with P(trend) = 0.0006). Having at least one XPC 492H allele was also associated with an increased risk of colorectal cancer (RR, 1.75; 95% CI, 1.20-2.57)...
  65. Yasuda G, Nishi R, Watanabe E, Mori T, Iwai S, Orioli D, et al. In vivo destabilization and functional defects of the xeroderma pigmentosum C protein caused by a pathogenic missense mutation. Mol Cell Biol. 2007;27:6606-14 pubmed
    Xeroderma pigmentosum group C (XPC) protein plays an essential role in DNA damage recognition in mammalian global genome nucleotide excision repair (NER)...
  66. Raaschou Nielsen O, Sørensen M, Overvad K, Tjønneland A, Vogel U. Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer. Lung Cancer. 2008;59:171-9 pubmed
    ..We included polymorphisms in the XPC, XPA and XPD genes involved in the nucleotide excision DNA repair pathway and analysed possible interactions with ..
  67. Lin J, Swan G, Shields P, Benowitz N, Gu J, Amos C, et al. Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation. Cancer Epidemiol Biomarkers Prev. 2007;16:2065-71 pubmed
    ..nucleotide polymorphisms examined, we found that BPDE sensitivity was modified by individual polymorphisms in XPC, RAD23B, and XPA genes. Specific haplotypes and diplotypes of XPC also modified BPDE sensitivity profiles...
  68. Gowda S, Kumaran M, Suma B, Rao M. Single nucleotide polymorphism analysis of the nucleotide excision repair genes XPC, XPA, and XPG in the Indian population. Hum Biol. 2007;79:545-62 pubmed
    We have analyzed single nucleotide polymorphisms (SNPs) in the XPC, XPA, and XPG genes of the nucleotide excision repair (NER) pathway in the Indian population...
  69. Khan S, Oh K, Emmert S, Imoto K, Tamura D, DiGiovanna J, et al. XPC initiation codon mutation in xeroderma pigmentosum patients with and without neurological symptoms. DNA Repair (Amst). 2009;8:114-25 pubmed publisher
    ..pigmentosum (XP) patients, with and without neurological abnormalities, respectively, had identical defects in the XPC DNA nucleotide excision repair (NER) gene...
  70. De Verdier P, Sanyal S, Bermejo J, Steineck G, Hemminki K, Kumar R. Genotypes, haplotypes and diplotypes of three XPC polymorphisms in urinary-bladder cancer patients. Mutat Res. 2010;694:39-44 pubmed publisher
    The XPC gene is involved in DNA damage recognition in the nucleotide excision repair pathway (NER)...
  71. Ming M, Shea C, Guo X, Li X, Soltani K, Han W, et al. Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C. Proc Natl Acad Sci U S A. 2010;107:22623-8 pubmed publisher
    ..The xeroderma pigmentosum C (XPC) protein is essential for initiating global genome NER by recognizing the DNA lesion and recruiting downstream ..
  72. Cartault F, Nava C, Malbrunot A, Munier P, Hébert J, N guyen P, et al. A new XPC gene splicing mutation has lead to the highest worldwide prevalence of xeroderma pigmentosum in black Mahori patients. DNA Repair (Amst). 2011;10:577-85 pubmed publisher
    ..All patients exhibited a new G?C homozygous substitution at 3'-end of XPC intron 12 (IVS 12-1G>C) leading to the abolition of an acceptor splicing site and the absence of the XPC protein...
  73. Menoni H, Hoeijmakers J, Vermeulen W. Nucleotide excision repair-initiating proteins bind to oxidative DNA lesions in vivo. J Cell Biol. 2012;199:1037-46 pubmed publisher
    ..excision repair factor (TC-NER) Cockayne syndrome group B (CSB) and the global genome NER-initiating factor XPC are implicated in the protection of cells against oxidative DNA damages...
  74. Yue A, Xie Z, Zhao H, Guo S, Shen Y, Wang H. Associations of ABCB1 and XPC genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis in a Chinese population. Asian Pac J Cancer Prev. 2013;14:3085-91 pubmed
    Associations between ABCB1 and XPC genetic polymorphisms and risk of developing colorectal cancer (CRC) as well as clinical outcomes in CRCs with chemotherapy were investigated...
  75. Puumalainen M, Lessel D, Rüthemann P, Kaczmarek N, Bachmann K, Ramadan K, et al. Chromatin retention of DNA damage sensors DDB2 and XPC through loss of p97 segregase causes genotoxicity. Nat Commun. 2014;5:3695 pubmed publisher
    DNA damage recognition subunits such as DDB2 and XPC protect the human skin from ultraviolet (UV) light-induced genome instability and cancer, as demonstrated by the devastating inherited syndrome xeroderma pigmentosum...
  76. Li L, Bales E, Peterson C, Legerski R. Characterization of molecular defects in xeroderma pigmentosum group C. Nat Genet. 1993;5:413-7 pubmed
    ..We recently reported the isolation of a gene XPCC that complements the repair deficiency of cultured XP-C cells...
  77. Batty D, Rapic Otrin V, Levine A, Wood R. Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites. J Mol Biol. 2000;300:275-90 pubmed
    ..from humans with xeroderma pigmentosum group C do not perform NER in the bulk of the genome and are corrected by XPC protein, which forms a complex with hHR23B protein...
  78. Adimoolam S, Ford J. p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. Proc Natl Acad Sci U S A. 2002;99:12985-90 pubmed
    ..In this study, we demonstrate that the mRNA and protein products of the xeroderma pigmentosum group C (XPC) gene are UV-inducible in a time- and dose-dependent manner in human WI38 fibroblasts and HCT116 colorectal cancer ..
  79. Fitch M, Nakajima S, Yasui A, Ford J. In vivo recruitment of XPC to UV-induced cyclobutane pyrimidine dimers by the DDB2 gene product. J Biol Chem. 2003;278:46906-10 pubmed
    ..It is believed that the heterodimeric proteins XPC/hHR23B and UV-DDB (UV-damaged DNA binding factor, composed of the p48 and p127 subunits) perform this function in ..
  80. Hu Z, Wang Y, Wang X, Liang G, Miao X, Xu Y, et al. DNA repair gene XPC genotypes/haplotypes and risk of lung cancer in a Chinese population. Int J Cancer. 2005;115:478-83 pubmed
    ..Newly identified polymorphisms of xeroderma pigmentosum group C (XPC), one of the nucleotide excision repair genes, were shown to contribute to genetic susceptibility to cancer...
  81. Vogel U, Overvad K, Wallin H, Tjønneland A, Nexø B, Raaschou Nielsen O. Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. Cancer Lett. 2005;222:67-74 pubmed
    Inherited polymorphisms in DNA repair genes may contribute to genetic susceptibility to cancer. XPA, XPC and XPD all encode proteins that are part of the nucleotide excision repair pathway...
  82. Shen M, Berndt S, Rothman N, DeMarini D, Mumford J, He X, et al. Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China. Int J Cancer. 2005;116:768-73 pubmed
    ..SNPs) and their corresponding haplotypes in 6 genes (ERCC1, ERCC2/XPD, ERCC4/XPF, ERCC5/XPG, RAD23B and XPC) involved in NER in a population-based case-control study of lung cancer in Xuan Wei...
  83. Kietthubthew S, Sriplung H, Au W, Ishida T. Polymorphism in DNA repair genes and oral squamous cell carcinoma in Thailand. Int J Hyg Environ Health. 2006;209:21-9 pubmed
    ..SNPs) in five common DNA repair genes were investigated: XRCC1 (Arg194Trp and Arg399Gln); XRCC3 (Thr241Met); XPC (PAT and Lys939Gln); XPD (exon 6, and Lys751Gln); and MGMT (Trp65Cys and Leu84Phe)...
  84. Sugasawa K. UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitin ligase complex, and DNA repair. J Mol Histol. 2006;37:189-202 pubmed
    ..of the repair reaction at the genome-wide level, a complex containing one of the gene products involved in XP, the XPC protein, must bind to the damaged DNA site...
  85. Bai Y, Xu L, Yang X, Hu Z, Yuan J, Wang F, et al. Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study. BMC Cancer. 2007;7:81 pubmed
    The nucleotide excision repair (NER) protein, xeroderma pigmentosum C (XPC), participates in recognizing DNA lesions and initiating DNA repair in response to DNA damage...
  86. Dong Z, Guo W, Zhou R, Wan L, Li Y, Wang N, et al. Polymorphisms of the DNA repair gene XPA and XPC and its correlation with gastric cardiac adenocarcinoma in a high incidence population in North China. J Clin Gastroenterol. 2008;42:910-5 pubmed publisher
    Investigated the association of DNA repair gene xeroderma pigmentosum group A(XPA) and C(XPC) polymorphisms with the risk of gastric cardiac adenocarcinoma (GCA) in a high incidence region in north China...
  87. El Zein R, Monroy C, Etzel C, Cortes A, Xing Y, Collier A, et al. Genetic polymorphisms in DNA repair genes as modulators of Hodgkin disease risk. Cancer. 2009;115:1651-9 pubmed publisher
    ..evaluated the relation between polymorphisms in 3 nucleotide excision repair pathway genes (XPD [Lys751Gln], XPC [Lys939Gln], and XPG [Asp1104His]), the base excision repair XRCC1 (Arg399Gln), and double-strand break repair ..
  88. Agalliu I, Kwon E, Salinas C, Koopmeiners J, Ostrander E, Stanford J. Genetic variation in DNA repair genes and prostate cancer risk: results from a population-based study. Cancer Causes Control. 2010;21:289-300 pubmed publisher
    ..28 single-nucleotide polymorphisms (SNPs) in nine DNA repair genes (APEX1, BRCA2, ERCC2, ERCC4, MGMT, MUTYH, OGG1, XPC, and XRCC1) and prostate cancer risk...
  89. Gangwar R, Mandhani A, Mittal R. XPC gene variants: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy. J Cancer Res Clin Oncol. 2010;136:779-86 pubmed publisher
    To investigate the association between two Xeroderma pigmentosum group C polymorphism (XPC Lys939Gln and insertion/deletion PAT -/+ in intron 9) and bladder cancer (BC) susceptibility...
  90. Sugasawa K, Akagi J, Nishi R, Iwai S, Hanaoka F. Two-step recognition of DNA damage for mammalian nucleotide excision repair: Directional binding of the XPC complex and DNA strand scanning. Mol Cell. 2009;36:642-53 pubmed publisher
    ..repair (NER), DNA lesions are recognized in at least two steps involving detection of unpaired bases by the XPC protein complex and the subsequent verification of injured bases...
  91. Long X, Ma Y, Huang Y, Yi Y, Liang Q, Ma A, et al. Genetic polymorphisms in DNA repair genes XPC, XPD, and XRCC4, and susceptibility to Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi population, China. Mol Carcinog. 2010;49:611-8 pubmed publisher
    ..any evidence of tumors, was designed to evaluate the association between the polymorphisms of DNA repair genes XPC Ala499Val (RS#2228000) and Lys939Gln (RS#2228001), XPD Lys751Gln (RS#13181), and XRCC4 Ala247Ser (RS#3734091) and ..
  92. Engin A, Karahalil B, Engin A, Karakaya A. Oxidative stress, Helicobacter pylori, and OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln polymorphisms in a Turkish population with colorectal carcinoma. Genet Test Mol Biomarkers. 2010;14:559-64 pubmed publisher
    The contribution of polymorphisms of DNA repair genes OGG1 Ser326Cys, XPC Lys939Gln, and XPD Lys751Gln in developing colorectal carcinoma is controversial...