XPA

Summary

Gene Symbol: XPA
Description: XPA, DNA damage recognition and repair factor
Alias: XP1, XPAC, DNA repair protein complementing XP-A cells, xeroderma pigmentosum group A-complementing protein, xeroderma pigmentosum, complementation group A
Species: human
Products:     XPA

Top Publications

  1. Sugitani N, Shell S, Soss S, Chazin W. Redefining the DNA-binding domain of human XPA. J Am Chem Soc. 2014;136:10830-3 pubmed publisher
    Xeroderma pigmentosum complementation group A (XPA) protein plays a critical role in the repair of DNA damage via the nucleotide excision repair (NER) pathway...
  2. Butkiewicz D, Popanda O, Risch A, Edler L, Dienemann H, Schulz V, et al. Association between the risk for lung adenocarcinoma and a (-4) G-to-A polymorphism in the XPA gene. Cancer Epidemiol Biomarkers Prev. 2004;13:2242-6 pubmed
    ..A common single nucleotide (-4) G-to-A polymorphism was identified previously in the 5' untranslated region of the XPA gene...
  3. Wu X, Shell S, Yang Z, Zou Y. Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. Cancer Res. 2006;66:2997-3005 pubmed
    ..In this study, we present evidence showing that the cellular function of xeroderma pigmentosum group A (XPA), a major nucleotide excision repair (NER) factor, could be modulated by checkpoint kinase ataxia-telangiectasia ..
  4. Shell S, Li Z, Shkriabai N, Kvaratskhelia M, Brosey C, Serrano M, et al. Checkpoint kinase ATR promotes nucleotide excision repair of UV-induced DNA damage via physical interaction with xeroderma pigmentosum group A. J Biol Chem. 2009;284:24213-22 pubmed publisher
    ..Here we show that ATR physically interacts with the NER factor Xeroderma pigmentosum group A (XPA)...
  5. Liu Y, Wang Y, Rusinol A, Sinensky M, Liu J, Shell S, et al. Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. FASEB J. 2008;22:603-11 pubmed
    ..We also found that these progeroid cells exhibited nuclear foci of xeroderma pigmentosum group A (XPA), a unique nucleotide excision repair protein...
  6. Nitta M, Saijo M, Kodo N, Matsuda T, Nakatsu Y, Tamai H, et al. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA. Nucleic Acids Res. 2000;28:4212-8 pubmed
    The xeroderma pigmentosum group A protein (XPA) plays a central role in nucleotide excision repair (NER). To identify proteins that bind to XPA, we screened a HeLa cDNA library using the yeast two-hybrid system...
  7. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland L, et al. Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Carcinogenesis. 2006;27:560-7 pubmed
    ..44 single nucleotide polymorphisms (SNPs) in 20 DNA repair genes including nucleotide excision repair (NER) genes XPA, ERCC1, ERCC2/XPD, ERCC4/XPF and ERCC5/XPG; base excision repair (BER) genes APE1/APEX, OGG1, MPG, XRCC1, PCNA, ..
  8. Miller K, Karagas M, Kraft P, Hunter D, Catalano P, Byler S, et al. XPA, haplotypes, and risk of basal and squamous cell carcinoma. Carcinogenesis. 2006;27:1670-5 pubmed
    ..BCC or SCC risk was influenced by the A23G single nucleotide polymorphism (SNP) in Xeroderma pigmentosum group A (XPA), which codes for an essential protein in NER...
  9. Bomgarden R, Lupardus P, Soni D, Yee M, Ford J, Cimprich K. Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling. EMBO J. 2006;25:2605-14 pubmed
    ..We show here that ultraviolet (UV) radiation-induced ATR signaling is compromised in XPA-deficient human cells during S phase, as shown by defects in ATRIP (ATR-interacting protein) translocation to sites ..

More Information

Publications71

  1. Hirai Y, Kodama Y, Moriwaki S, Noda A, Cullings H, MacPhee D, et al. Heterozygous individuals bearing a founder mutation in the XPA DNA repair gene comprise nearly 1% of the Japanese population. Mutat Res. 2006;601:171-8 pubmed
    ..parts of the world, and more than half of Japanese XP patients are homozygous for the same founder mutation in the XPA gene. We screened archival blood samples from Japanese individuals who resided in Hiroshima or Nagasaki...
  2. Park J, Park S, Choi J, Lee S, Jeon H, Cha S, et al. Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. Cancer Epidemiol Biomarkers Prev. 2002;11:993-7 pubmed
    ..We investigated the association between two polymorphisms of the DNA repair gene XPA and risk of lung cancer in the Korean population...
  3. De Ruyck K, Szaumkessel M, De Rudder I, Dehoorne A, Vral A, Claes K, et al. Polymorphisms in base-excision repair and nucleotide-excision repair genes in relation to lung cancer risk. Mutat Res. 2007;631:101-10 pubmed
    ..repair gene polymorphisms (XRCC1 -77 T/C, Arg194Trp, Arg280His and Arg399Gln; APE1 Asp148Glu; OGG1 Ser326Cys; XPA -4 G/A; XPC PAT; XPD Asp312Asn and Lys751Gln) with lung cancer risk in Caucasians...
  4. Mer G, Bochkarev A, Gupta R, Bochkareva E, Frappier L, Ingles C, et al. Structural basis for the recognition of DNA repair proteins UNG2, XPA, and RAD52 by replication factor RPA. Cell. 2000;103:449-56 pubmed
    ..contains a specific surface that interacts in a similar manner with the DNA repair enzyme UNG2 and repair factors XPA and RAD52, each of which functions in a different repair pathway...
  5. Wakasugi M, Kasashima H, Fukase Y, Imura M, Imai R, Yamada S, et al. Physical and functional interaction between DDB and XPA in nucleotide excision repair. Nucleic Acids Res. 2009;37:516-25 pubmed publisher
    ..Here we show that DDB directly interacts with XPA, one of core NER factors, mainly through DDB2 subunit and the amino-acid residues between 185 and 226 in XPA are ..
  6. Kang T, Lindsey Boltz L, Reardon J, Sancar A. Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase. Proc Natl Acad Sci U S A. 2010;107:4890-5 pubmed publisher
    ..We find that the XPA protein, which plays an essential role in repair of cisplatin damage by nucleotide excision repair, exhibits ..
  7. Park C, Sancar A. Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins. Proc Natl Acad Sci U S A. 1994;91:5017-21 pubmed
    The xeroderma pigmentosum complementation group A (XP-A) protein, XPA, has recently been expressed in Escherichia coli in a soluble and fully functional form. An affinity column was prepared by linking the XPA protein to a solid support...
  8. Fan W, Luo J. SIRT1 regulates UV-induced DNA repair through deacetylating XPA. Mol Cell. 2010;39:247-58 pubmed publisher
    ..Xeroderma pigmentosum group A (XPA) is a core nucleotide excision repair (NER) factor essential for NER process...
  9. Saijo M, Takedachi A, Tanaka K. Nucleotide excision repair by mutant xeroderma pigmentosum group A (XPA) proteins with deficiency in interaction with RPA. J Biol Chem. 2011;286:5476-83 pubmed publisher
    The xeroderma pigmentosum group A protein (XPA) is a core component of nucleotide excision repair (NER)...
  10. He Z, Henricksen L, Wold M, Ingles C. RPA involvement in the damage-recognition and incision steps of nucleotide excision repair. Nature. 1995;374:566-9 pubmed
    ..specifically and directly to two excision repair proteins, the xeroderma pigmentosum damage-recognition protein XPA (refs 8, 9) and the endonuclease XPG (refs 10-13)...
  11. Liu Y, Bernauer A, Yingling C, Belinsky S. HIF1α regulated expression of XPA contributes to cisplatin resistance in lung cancer. Carcinogenesis. 2012;33:1187-92 pubmed publisher
    ..We hypothesized that Xeroderma pigmentosum complementation group A (XPA), because of its dual role in sensing and recruiting other DNA repair proteins to the damaged template, would be ..
  12. King B, Cooper K, Liu K, Hudson L. Poly(ADP-ribose) contributes to an association between poly(ADP-ribose) polymerase-1 and xeroderma pigmentosum complementation group A in nucleotide excision repair. J Biol Chem. 2012;287:39824-33 pubmed publisher
    ..PARP activation following UVR exposure promotes association between PARP-1 and XPA, a central protein in NER...
  13. Tripsianes K, Folkers G, Zheng C, Das D, Grinstead J, Kaptein R, et al. Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization. Nucleic Acids Res. 2007;35:5789-98 pubmed
    ..reveals a completely distinct function for the ERCC1 central domain by performing interactions with both XPA and single-stranded DNA...
  14. Wang Y, Spitz M, Lee J, Huang M, Lippman S, Wu X. Nucleotide excision repair pathway genes and oral premalignant lesions. Clin Cancer Res. 2007;13:3753-8 pubmed
    ..study of 144 OPL patients and 288 controls, we genotyped 11 polymorphisms in 8 major NER genes, including XPA [A23G at 5' untranslated region (UTR)], XPD (Asp312Asn, Lys751Gln), XPC (Ala499Val, Lys939Gln), XPG (His1104Asp), ..
  15. Yang Z, Roginskaya M, Colis L, Basu A, Shell S, Liu Y, et al. Specific and efficient binding of xeroderma pigmentosum complementation group A to double-strand/single-strand DNA junctions with 3'- and/or 5'-ssDNA branches. Biochemistry. 2006;45:15921-30 pubmed
    Human XPA is an important DNA damage recognition protein in nucleotide excision repair (NER). We previously observed that XPA binds to the DNA lesion as a homodimer [Liu, Y., Liu, Y., Yang, Z., Utzat, C., Wang, G., Basu, A. K...
  16. Bunick C, Miller M, Fuller B, Fanning E, Chazin W. Biochemical and structural domain analysis of xeroderma pigmentosum complementation group C protein. Biochemistry. 2006;45:14965-79 pubmed
    ..and protease protection assays demonstrated that XPC(156-325) physically interacts with the DNA repair factor XPA, establishing the first functional role for XPC-N...
  17. Fousteri M, Vermeulen W, Van Zeeland A, Mullenders L. Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Mol Cell. 2006;23:471-82 pubmed
    ..These results give insight into the nature and order of molecular events that take place during TCR in the context of chromosomal DNA. ..
  18. Camenisch U, Dip R, Schumacher S, Schuler B, Naegeli H. Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair. Nat Struct Mol Biol. 2006;13:278-84 pubmed
    The function of human XPA protein, a key subunit of the nucleotide excision repair pathway, has been examined with site-directed substitutions in its putative DNA-binding cleft...
  19. Miura N, Miyamoto I, Asahina H, Satokata I, Tanaka K, Okada Y. Identification and characterization of xpac protein, the gene product of the human XPAC (xeroderma pigmentosum group A complementing) gene. J Biol Chem. 1991;266:19786-9 pubmed
    We have cloned human xeroderma pigmentosum group A complementing (XPAC) cDNA that encodes a "zinc finger" protein with a predicted size of 31 kDa...
  20. Yang Z, Liu Y, Mao L, Zhang J, Zou Y. Dimerization of human XPA and formation of XPA2-RPA protein complex. Biochemistry. 2002;41:13012-20 pubmed
    b>XPA plays an important role in the DNA damage recognition during human nucleotide excision repair. Here we report that the XPA is a homodimer either in the free state or as a complex with human RPA in solution under normal conditions...
  21. States J, McDuffie E, Myrand S, McDowell M, Cleaver J. Distribution of mutations in the human xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein. Hum Mutat. 1998;12:103-13 pubmed
    ..pigmentosum group A cell lines from 19 patients and cell lines from 13 other family members were examined for XPA mutations to find previously unidentified mutations from American and European patients, to establish pedigrees in ..
  22. Li L, Elledge S, Peterson C, Bales E, Legerski R. Specific association between the human DNA repair proteins XPA and ERCC1. Proc Natl Acad Sci U S A. 1994;91:5012-6 pubmed
    ..both in vivo, using the two-hybrid system, and in vitro, using recombinant proteins, that the human repair factors XPA and ERCC1 specifically interact...
  23. Park C, Mu D, Reardon J, Sancar A. The general transcription-repair factor TFIIH is recruited to the excision repair complex by the XPA protein independent of the TFIIE transcription factor. J Biol Chem. 1995;270:4896-902 pubmed
    ..In contrast, the human damage recognition protein XPA specifically binds to TFIIH and apparently recruits it to the damage site...
  24. Patrick S, Turchi J. Xeroderma pigmentosum complementation group A protein (XPA) modulates RPA-DNA interactions via enhanced complex stability and inhibition of strand separation activity. J Biol Chem. 2002;277:16096-101 pubmed
    ..A direct interaction between RPA and the xeroderma pigmentosum group A protein (XPA) facilitates the assembly of a preincision complex during the processing of DNA damage by the nucleotide excision ..
  25. Vasquez K, Christensen J, Li L, Finch R, Glazer P. Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proc Natl Acad Sci U S A. 2002;99:5848-53 pubmed
    ..Xeroderma pigmentosum complementation group A protein (XPA) is an essential component of the repair machinery, and it is thought to be involved in the initial step as a DNA ..
  26. Wu X, Zhao H, Wei Q, Amos C, Zhang K, Guo Z, et al. XPA polymorphism associated with reduced lung cancer risk and a modulating effect on nucleotide excision repair capacity. Carcinogenesis. 2003;24:505-9 pubmed
    b>XPA, a DNA binding protein in the nucleotide excision repair (NER) pathway, modulates damage recognition...
  27. Rademakers S, Volker M, Hoogstraten D, Nigg A, Moné M, Van Zeeland A, et al. Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions. Mol Cell Biol. 2003;23:5755-67 pubmed
    ..The xeroderma pigmentosum group A protein (XPA) has been suggested to function as a central organizer and damage verifier in NER...
  28. Welsh C, Day R, McGurk C, Masters J, Wood R, Köberle B. Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines. Int J Cancer. 2004;110:352-61 pubmed
    ..cisplatin-induced DNA damage and found that they had low levels of the DNA nucleotide excision repair proteins XPA, ERCC1 and XPF...
  29. Popanda O, Schattenberg T, Phong C, Butkiewicz D, Risch A, Edler L, et al. Specific combinations of DNA repair gene variants and increased risk for non-small cell lung cancer. Carcinogenesis. 2004;25:2433-41 pubmed
    Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA (-4G/A), XPD (Lys751Gln and Asp312Asn), XRCC1 (Arg399Gln), APE1 (Asp148Glu) and XRCC3 (Thr241Met)...
  30. Vogel U, Overvad K, Wallin H, Tjønneland A, Nexø B, Raaschou Nielsen O. Combinations of polymorphisms in XPD, XPC and XPA in relation to risk of lung cancer. Cancer Lett. 2005;222:67-74 pubmed
    Inherited polymorphisms in DNA repair genes may contribute to genetic susceptibility to cancer. XPA, XPC and XPD all encode proteins that are part of the nucleotide excision repair pathway...
  31. Tanaka K, Miura N, Satokata I, Miyamoto I, Yoshida M, Satoh Y, et al. Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain. Nature. 1990;348:73-6 pubmed
    ..We have cloned the mouse DNA repair gene that complements the defect of group A, the XPAC gene. Here we report molecular cloning of human and mouse XPAC complementary DNAs...
  32. Miyamoto I, Miura N, Niwa H, Miyazaki J, Tanaka K. Mutational analysis of the structure and function of the xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair. J Biol Chem. 1992;267:12182-7 pubmed
    We showed previously that the xeroderma pigmentosum group A complementing (XPAC) protein involved in the DNA excision repair pathway contains a zinc-finger motif and is localized in the nucleus of normal human cells...
  33. Li L, Lu X, Peterson C, Legerski R. An interaction between the DNA repair factor XPA and replication protein A appears essential for nucleotide excision repair. Mol Cell Biol. 1995;15:5396-402 pubmed
    ..Here we report that RPA and the human repair protein XPA specifically interact both in vitro and in vivo...
  34. Köberle B, Roginskaya V, Wood R. XPA protein as a limiting factor for nucleotide excision repair and UV sensitivity in human cells. DNA Repair (Amst). 2006;5:641-8 pubmed
    ..We studied sensitivity to UV radiation and repair of DNA damage with regard to XPA, one of the core factors in the NER incision complex...
  35. Li Z, Musich P, Serrano M, Dong Z, Zou Y. XPA-mediated regulation of global nucleotide excision repair by ATR Is p53-dependent and occurs primarily in S-phase. PLoS ONE. 2011;6:e28326 pubmed publisher
    ..Here we demonstrate that nucleotide excision repair (NER) is regulated by the ATR/p53 checkpoint via modulation of XPA nuclear import and that this regulation occurs in a cell cycle-dependent manner...
  36. Messaoud O, Rekaya M, Ouragini H, Benfadhel S, Azaiez H, Kefi R, et al. Severe phenotypes in two Tunisian families with novel XPA mutations: evidence for a correlation between mutation location and disease severity. Arch Dermatol Res. 2012;304:171-6 pubmed publisher
    ..Among Tunisian XP patients with an intermediate skin phenotype, 92% presented neurological abnormalities related to XPA gene deficiency. Clinical variability of the XP-A phenotype is associated with a mutational heterogeneity...
  37. Gilljam K, Müller R, Liabakk N, Otterlei M. Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA. PLoS ONE. 2012;7:e49199 pubmed publisher
    ..The xeroderma pigmentosum group A (XPA) protein, with a central but somewhat elusive role in nucleotide excision repair (NER), contains the APIM sequence ..
  38. Takahashi Y, Endo Y, Sugiyama Y, Inoue S, Iijima M, Tomita Y, et al. XPA gene mutations resulting in subtle truncation of protein in xeroderma pigmentosum group A patients with mild skin symptoms. J Invest Dermatol. 2010;130:2481-8 pubmed publisher
    Comparisons of the clinical manifestations with gene mutations in patients with xeroderma pigmentosum group A (XPA) have suggested that those with mutations closer to the C-terminal coding region of the XPA gene have milder neurological ..
  39. Orelli B, McClendon T, Tsodikov O, Ellenberger T, Niedernhofer L, SCHARER O. The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways. J Biol Chem. 2010;285:3705-12 pubmed publisher
    ..b>XPA, another key factor in NER, interacts with ERCC1 and recruits it to sites of damage...
  40. Wood R. DNA damage recognition during nucleotide excision repair in mammalian cells. Biochimie. 1999;81:39-44 pubmed
    ..the core protein factors needed for damage recognition and incision during nucleotide excision repair (NER) are the XPA protein, the heterotrimeric RPA protein, the 6 to 9-subunit TFIIH, the XPC-hHR23B complex, the XPG nuclease, and ..
  41. Liu Y, Liu Y, Yang Z, Utzat C, Wang G, Basu A, et al. Cooperative interaction of human XPA stabilizes and enhances specific binding of XPA to DNA damage. Biochemistry. 2005;44:7361-8 pubmed
    Human xeroderma pigmentosum group A (XPA) is an essential protein for nucleotide excision repair (NER). We have previously reported that XPA forms a homodimer in the absence of DNA...
  42. You J, Wang M, Lee S. Biochemical analysis of the damage recognition process in nucleotide excision repair. J Biol Chem. 2003;278:7476-85 pubmed
    b>XPA, XPC-hHR23B, RPA, and TFIIH all are the damage recognition proteins essential for the early stage of nucleotide excision repair. Nonetheless, it is not clear how these proteins work together at the damaged DNA site...
  43. Nakatsu Y, Asahina H, Citterio E, Rademakers S, Vermeulen W, Kamiuchi S, et al. XAB2, a novel tetratricopeptide repeat protein involved in transcription-coupled DNA repair and transcription. J Biol Chem. 2000;275:34931-7 pubmed
    ..Here we report the identification of a novel protein designated XAB2 (XPA-binding protein 2) that was identified by virtue of its ability to interact with XPA, a factor central to both ..
  44. Camenisch U, Dip R, Vitanescu M, Naegeli H. Xeroderma pigmentosum complementation group A protein is driven to nucleotide excision repair sites by the electrostatic potential of distorted DNA. DNA Repair (Amst). 2007;6:1819-28 pubmed
    The presumed DNA-binding cleft of xeroderma pigmentosum group A (XPA) protein, a key regulatory subunit of the eukaryotic nucleotide excision repair complex, displays a distinctive array of 6 positively charged amino acid side chains...
  45. Ding X, Zhou X, Cooper K, Huestis J, Hudson L, Liu K. Differential sensitivities of cellular XPA and PARP-1 to arsenite inhibition and zinc rescue. Toxicol Appl Pharmacol. 2017;331:108-115 pubmed publisher
    ..of arsenite and zinc on the zinc finger nucleotide excision repair (NER) protein xeroderma pigmentosum group A (XPA)...
  46. Monzo M, Brunet S, Urbano Ispizua A, Navarro A, Perea G, Esteve J, et al. Genomic polymorphisms provide prognostic information in intermediate-risk acute myeloblastic leukemia. Blood. 2006;107:4871-9 pubmed
    ..allelic discrimination method to identify polymorphisms in GSTT1, SULT1C2, CDA, SXR (drug metabolic pathways), XPD, XPA, XPG, ERCC1, TOP2A (DNA repair), VEGF (angiogenesis), and MDR1 (multidrug resistance) genes in 110 adult patients ..
  47. Pei H, Shao Y, Chanway C, Hu W, Meng P, Li Z, et al. Bioaugmentation in a pilot-scale constructed wetland to treat domestic wastewater in summer and autumn. Environ Sci Pollut Res Int. 2016;23:7776-85 pubmed publisher
    ..b>XP1 in Northern China...
  48. Powrózek T, Mlak R, Krawczyk P, Homa I, Ciesielka M, Kozioł P, et al. The relationship between polymorphisms of genes regulating DNA repair or cell division and the toxicity of platinum and vinorelbine chemotherapy in advanced NSCLC patients. Clin Transl Oncol. 2016;18:125-31 pubmed publisher
    ..the relationship between the fourteen SNPs in nine DNA repair and cell division regulating genes: ERCC1, XPD, XPA, XPC, XRCC1, XPG, RRM1, BRCA1, STMN1 and the toxicity of first-line chemotherapy in NSCLC patients were ..
  49. Buchko G, Hess N, Kennedy M. Cadmium mutagenicity and human nucleotide excision repair protein XPA: CD, EXAFS and (1)H/(15)N-NMR spectroscopic studies on the zinc(II)- and cadmium(II)-associated minimal DNA-binding domain (M98-F219). Carcinogenesis. 2000;21:1051-7 pubmed
    Human XPA is a 31 kDa protein involved in nucleotide excision repair (NER), a ubiquitous, multi-enzyme pathway responsible for processing multiple types of DNA damage in the eukaryotic genome...
  50. Raaschou Nielsen O, Sørensen M, Overvad K, Tjønneland A, Vogel U. Polymorphisms in nucleotide excision repair genes, smoking and intake of fruit and vegetables in relation to lung cancer. Lung Cancer. 2008;59:171-9 pubmed
    ..We included polymorphisms in the XPC, XPA and XPD genes involved in the nucleotide excision DNA repair pathway and analysed possible interactions with ..
  51. Goekkurt E, Al Batran S, Hartmann J, Mogck U, Schuch G, Kramer M, et al. Pharmacogenetic analyses of a phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil and leucovorin plus either oxaliplatin or cisplatin: a study of the arbeitsgemeinschaft internistische onkologie. J Clin Oncol. 2009;27:2863-73 pubmed publisher
    ..Polymorphisms within genes of TS, MTHFR, MTR, OPRT, XPD, ERCC1, XRCC1, XPA, GSTP1, GSTT1, and GSTM1 were genotyped using polymerase chain reaction-based techniques...
  52. Imoto K, Nadem C, Moriwaki S, Nishigori C, Oh K, Khan S, et al. Ancient origin of a Japanese xeroderma pigmentosum founder mutation. J Dermatol Sci. 2013;69:175-6 pubmed publisher
  53. Tamhankar P, Iyer S, Ravindran S, Gupta N, Kabra M, Nayak C, et al. Clinical profile and mutation analysis of xeroderma pigmentosum in Indian patients. Indian J Dermatol Venereol Leprol. 2015;81:16-22 pubmed publisher
    ..Ten families with 13 patients with XP were referred to our clinic over 2 years. The genes XPA, XPB and XPC were sequentially analyzed till a pathogenic mutation was identified...
  54. Pavanello S, Pulliero A, Clonfero E. Influence of GSTM1 null and low repair XPC PAT+ on anti-B[a]PDE-DNA adduct in mononuclear white blood cells of subjects low exposed to PAHs through smoking and diet. Mutat Res. 2008;638:195-204 pubmed
    The influence of low-activity NER genotypes (XPC PAT-/+, XPA-A23G, XPD Asp312Asn, XPD Lys751Gln) and GSTM1 (active or null) was evaluated on anti-benzo[a]pyrene diol epoxide-(B[a]PDE)-DNA adduct formed in the lymphocyte plus monocyte ..
  55. Sun Z, Zhang J, Guo Y, Ni C, Liang J, Cheng R, et al. Genotype-phenotype correlation of xeroderma pigmentosum in a Chinese Han population. Br J Dermatol. 2015;172:1096-102 pubmed publisher
    ..This cohort was composed of four patients with XP-C (XPC), two with XP-G (ERCC5), three with XP-A (XPA) and three with XP-V (POLH)...
  56. Sassa A, Kamoshita N, Kanemaru Y, Honma M, Yasui M. Xeroderma Pigmentosum Group A Suppresses Mutagenesis Caused by Clustered Oxidative DNA Adducts in the Human Genome. PLoS ONE. 2015;10:e0142218 pubmed publisher
    ..vivo protective roles of NER, we established a human cell line lacking the NER gene xeroderma pigmentosum group A (XPA). XPA knockout (KO) cells were generated from TSCER122 cells derived from the human lymphoblastoid TK6 cell line...
  57. Sugimura T, Kumimoto H, Tohnai I, Fukui T, Matsuo K, Tsurusako S, et al. Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. J Oral Pathol Med. 2006;35:11-8 pubmed
    ..The risk of OSCC was evaluated in 10 genetic polymorphisms of nine genes, such as CYP1A1, CYP2E1, GSTM1, GSTT1, XPA, XPC, XPC, XPF and ERCC1. Gene-environment interaction was also evaluated...
  58. Hilton B, Shkriabai N, Musich P, Kvaratskhelia M, Shell S, Zou Y. A new structural insight into XPA-DNA interactions. Biosci Rep. 2014;34:e00162 pubmed publisher
    b>XPA (xeroderma pigmentosum group A) protein is an essential factor for NER (nucleotide excision repair) which is believed to be involved in DNA damage recognition/verification, NER factor recruiting and stabilization of repair ..
  59. Lench N, Telford E, Andersen S, Moynihan T, Robinson P, Markham A. An EST and STS-based YAC contig map of human chromosome 9q22.3. Genomics. 1996;38:199-205 pubmed
    ..Together these maps provide a valuable resource for fine structure mapping and DNA sequencing across the region as well as for the identification of disease gene loci and the isolation of novel coding sequences. ..
  60. Shi J, Ren Z, Jiao B, Xiao R, Yun H, Chen B, et al. Genetic variations of DNA repair genes and their prognostic significance in patients with acute myeloid leukemia. Int J Cancer. 2011;128:233-8 pubmed publisher
    ..These results uncover novel prognostic factors for AML patients treated with chemotherapy and may also indicate an etiological role of XPD in this disease...
  61. Ricceri F, Guarrera S, Sacerdote C, Polidoro S, Allione A, Fontana D, et al. ERCC1 haplotypes modify bladder cancer risk: a case-control study. DNA Repair (Amst). 2010;9:191-200 pubmed publisher
    ..A detailed characterization of DNA repair genetic variation is warranted and might ultimately help to identify multiple susceptibility variants that could be responsible for joint effects on the risk. ..
  62. Wang H, van Spyk E, Liu Q, Geyfman M, Salmans M, Kumar V, et al. Time-Restricted Feeding Shifts the Skin Circadian Clock and Alters UVB-Induced DNA Damage. Cell Rep. 2017;20:1061-1072 pubmed publisher
    ..However, RF alters both diurnal sensitivity to UVB-induced DNA damage and expression of the key DNA repair gene, Xpa. Together, our findings indicate regulation of skin function by time of feeding and emphasize a link between ..